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Pretreatment can alleviate programmed cell death in mesenchymal stem cells

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World Journal of Stem Cells 2024年第8期16卷 773-779页

作者： xin-xing Wan xi-min hu Qi Zhang Kun xiong Department of Endocrinology Third Xiangya HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Anatomy and Neurobiology Central South UniversityChangsha 410000Hunan ProvinceChina Department of Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 410013Hunan ProvinceChina

In this editorial,we delved into the article titled“Cellular preconditioning and mesenchymal stem cell ferroptosis.”This groundbreaking study underscores a pivotal discovery:Ferroptosis,a type of programmed cell death,drastically reduces the viability of donor mesenchymal stem cells(MSCs)after engraftment,thereby undermining the therapeutic value of cell-based ***,the article proposes that by manipulating ferroptosis mechanisms through preconditioning,we can potentially enhance the survival rate and functionality of MSCs,ultimately amplifying their therapeutic *** the crucial role ferroptosis plays in shaping the therapeutic outcomes of MSCs,we deem it im-perative to further investigate the intricate interplay between programmed cell death and the therapeutic effectiveness of MSCs.

关键词： Mesenchymal stem cells Programmed cell death Apoptosis Autophagy Ferroptosis

Multiple pretreatments can effectively improve the functionality of mesenchymal stem cells

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World Journal of Stem Cells 2024年第2期16卷 58-63页

作者： xin-xing Wan xi-min hu Kun xiong Department of Endocrinology Third Xiangya HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 410013Hunan ProvinceChina

In this editorial,we offer our perspective on the groundbreaking study entitled“Hypoxia and inflammatory factor preconditioning enhances the immunosup-pressive properties of human umbilical cord mesenchymal stem cells”,recently published in World Journal of Stem *** over three decades of research on the clinical application of mesenchymal stem cells(MSCs),only a few therapeutic products have made it to clinical use,due to multiple preclinical and clinical challenges yet to be *** study proved the hypoxia and inflammatory factor preconditioning led to higher immunosuppressive effects of MSCs without damaging their biological characteristics,which revealed the combination of inflammatory factors and hypoxic preconditioning offers a promising approach to enhance the function of *** we delve deeper into the intricacies of pretreat-ment methodologies,we anticipate a transformative shift in the landscape of MSC-based therapies,ultimately contributing to improved patient outcomes and advancing the field as a whole.

关键词： Mesenchymal stem cells Inflammatory factor Hypoxia Pretreatment

Insight into Crosstalk Between Mitophagy and Apoptosis/Necroptosis:Mechanisms and Clinical Applications in Ischemic Stroke

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Current Medical Science 2022年第2期42卷 237-248页

作者： Yan-di YANG Zi-xin LI xi-min hu Hao WAN Qi ZHANG Rui xiAO Kun xiONG Department of Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 410013China Clinical Medicine Eight-year Program 03 Class18 GradeXiangya School of MedicineCentral South UniversityChangsha 410013China Clinical Medicine Eight-Year Program 02 Class17 GradeXiangya School of MedicineCentral South UniversityChangsha 410013China Administrative Office the Third Xiangya HospitalCentral South UniversityChangsha 410013China hunan Key Laboratory of Ophthalmology Changsha 410008China Key Laboratory of Emergency and Trauma Ministry of EducationCollege of Emergency and TraumaHainan Medical UniversityHaikou 571199China

Ischemic stroke is a serious cerebrovascular disease with high morbidity and *** a result of ischemia-reperfusion,a cascade of pathophysiological responses is triggered by the imbalance in metabolic supply and demand,resulting in cell *** cellular injuries follow various molecular mechanisms solely or in combination with this *** play a driving role in the pathophysiological processes of ischemic *** ischemic stroke occurs,damaged cells would respond to such stress through *** is known as a conservatively selective autophagy,contributing to the removal of excessive protein aggregates and damaged intracellular components,as well as aging *** mitophagy may exert neuroprotection against *** pathways associated with the mitochondrial network collectively contribute to recovering the homeostasis of the neurovascular ***,excessive mitophagy would also promote ischemia-reperfusion ***,mitophagy is a double-edged sword,which suggests that maximizing the benefits of mitophagy is one of the direction of future *** review emphasized the role of mitophagy in ischemic stroke,and highlighted the crosstalk between mitophagy and apoptosis/necroptosis.

关键词： mitophagy ischemic stroke apoptosis necroptosis clinical application crosstalk

Research trends, hot spots and prospects for necroptosis in the field of neuroscience

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Neural Regeneration Research 2021年第8期16卷 1628-1637页

作者： Wei-Tao Yan Shuang Lu Yan-Di Yang Wen-Ya Ning Yan Cai xi-min hu Qi Zhang Kun xiong Department of Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangshaHunan ProvinceChina Third xiangya Hospital of Central South University ChangshaHunan ProvinceChina Department of Histology and Embryology School of Basic Medical ScienceCentral South UniversityChangshaHunan ProvinceChina hunan Key Laboratory of Ophthalmology ChangshaHunan ProvinceChina

There are two types of cell death-apoptosis and necrosis. Apoptosis is cell death regulated by cell signaling pathways, while necrosis has until recently been considered a passive mechanism of cell death caused by environmental pressures. However, recent studies show that necrosis can also be regulated by specific cell signaling pathways. This mode of death, termed necroptosis, has been found to be related to the occurrence and development of many diseases. We used bibliometrics to analyze the global output of literature on necroptosis in the field of neuroscience published in the period 2007–2019 to identify research hotspots and prospects. We included 145 necroptosisrelated publications and 2239 references published in the Web of Science during 2007–2019. Visualization analysis revealed that the number of publications related to necroptosis has increased year by year, reaching a peak in 2019. China is the country with the largest number of publications. Key word and literature analyses demonstrated that mitochondrial function change, stroke, ischemia/reperfusion and neuroinflammation are likely the research hotspots and future directions of necroptosis research in the nervous system. The relationship between immune response-related factors, damage-associated molecular patterns, pathogen-associated molecular patterns and necroptosis may become a potential research hotspot in the future. Taken together, our findings suggest that although the inherent limitations of bibliometrics may affect the accuracy of the literature-based prediction of research hotspots, the results obtained from the included publications can provide a reference for the study of necroptosis in the field of neuroscience.

关键词： bibliometric analysis citations CiteSpace h-index necroptosis network analysis neuroscience output VOSviewer Web of Science

PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons

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Neural Regeneration Research 2023年第2期18卷 357-363页

作者： Wei-Tao Yan Wen-Juan Zhao xi-min hu xiao-xia Ban Wen-Ya Ning Hao Wan Qi Zhang Kun xiong Department of human Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangshaHunan ProvinceChina Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of human Resources Third Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina hunan Key Laboratory of Ophthalmology ChangshaHunan ProvinceChina Key Laboratory of Emergency and Trauma Ministry of EducationCollege of Emergency and TraumaHainan Medical UniversityHaikouHainan ProvinceChina

PANoptosis is a newly identified type of regulated cell death that consists of pyroptosis,apoptosis,and nec roptosis,which simultaneously occur during the pathophysiological process of infectious and inflammatory *** our previous lite rature mining study suggested that PANoptosis might occur in neuronal ischemia/repe rfusion injury,little experimental research has been reported on the existence of *** this study,we used in vivo and in vitro retinal neuronal models of ischemia/repe rfusion injury to investigate whether PAN optosis-like cell death(simultaneous occurrence of pyroptosis,apo ptosis,and necroptosis)exists in retinal neuronal ischemia/repe rfusion *** results showed that ischemia/repe rfusion injury induced changes in morphological features and protein levels that indicate PANoptosis-like cell death in retinal neurons both in vitro and in ***/repe rfusion inju ry also significantly upregulated caspase-1,caspase-8,and NLRP3 expression,which are important components of the *** results indicate the existence of PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons and provide preliminary experimental evidence for future study of this new type of regulated cell death.

关键词： apoptosis gasdermin-D(GSDMD) ischemia/reperfusion mixed lineage kinase domain-like protein(MLKL) necroptosis NOD-like receptor protein 3(NLRP3) PANoptosis pyroptosis receptor-interacting protein kinase 3(RIPK3) retinal neuron

Integration of Theory and Practice in Medical Morphology Curriculum in Postgraduate Training:A Flipped Classroom and Case-based Learning Exercise

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Current Medical Science 2023年第4期43卷 741-748页

作者： xi-min hu Zhi-xin LI Jing DENG Yang HAN Shuang LU Qi ZHANG Zi-qiang LUO Kun xiONG Department of Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 410000China Clinical Medicine Eight-year Program 02 Class18 GradeXiangya School of MedicineCentral South UniversityChangsha 410000China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410000China Department of Physiology School of Basic Medical ScienceCentral South UniversityChangsha 410008China hunan Key Laboratory of Ophthalmology Changsha 410000China Key Laboratory of Emergency and Trauma Ministry of EducationCollege of Emergency and TraumaHainan Medical UniversityHaikou 016000China

Objective:The integration of training in theory and practice across the medical education spectrum is being encouraged to increase student understanding and skills in the *** study aimed to determine the deciding factors that drive students'perceived advantages in class to improve precision education and the teaching ***:A mixed strategy of an existing flipped classroom(FC)and a case-based learning(CBL)model was conducted in a medical morphology curriculum for 575 postgraduate *** subjective learning evaluation of the individuals(learning time,engagement,study interest and concentration,and professional integration)was collected and analyzed after FC-CBL model ***:The results from the general evaluation showed promising results of the medical morphology in the FC-CBL *** felt more engaged by instructors in person and benefited in terms of time-saving,flexible arrangements,and professional *** study contributed to the FC-CBL model in Research Design in postgraduate training in 4 categories:1)advancing a guideline of precision teaching according to individual characteristics;2)revealing whether a learning background is needed for a Research Design course to guide setting up a preliminary course;3)understanding the perceived advantages and their interfaces;and 4)barriers and/or improvement to implement the FC-CBL model in the Research Design class,such as a richer description of e-learning and hands-on ***:Undertaking a FC-CBL combined model could be a useful addition to pedagogy for medical morphology learning in postgraduate training.

关键词： flipped classroom case-based learning medical morphology curriculum research design postgraduate

Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies

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Neural Regeneration Research 2022年第8期17卷 1761-1768页

作者： Wei-Tao Yan Yan-Di Yang xi-min hu Wen-Ya Ning Lyu-Shuang Liao Shuang Lu Wen-Juan Zhao Qi Zhang Kun xiong Department of Neurobiology and human Anatomy School of Basic Medical ScienceCentral South UniversityChangshaHunan ProvinceChina Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of human Resources Third Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina hunan Key Laboratory of Ophthalmology ChangshaHunan ProvinceChina

Some scholars have recently developed the concept of PANoptosis in the study of infectious diseases where pyroptosis,apoptosis and necroptosis act in consort in a multimeric protein complex,*** allows all the components of PANoptosis to be regulated *** provides a new way to study the regulation of cell death,in that different types of cell death may be regulated at the same *** test whether PANoptosis exists in diseases other than infectious diseases,we chose cerebral ischemia/reperfusion injury as the research model,collected articles researching cerebral ischemia/reperfusion from three major databases,obtained the original research data from these articles by bibliometrics,data mining and other methods,then integrated and analyzed these *** selected papers that investigated at least two of the components of PANoptosis to check its occurrence in ischemia/*** the cell model simulating ischemic brain injury,pyroptosis,apoptosis and necroptosis occur together and this phenomenon exists widely in different passage cell lines or primary ***,apoptosis and necroptosis also occurred in rat and mouse models of ischemia/reperfusion *** confirms that PANoptosis is observed in ischemic brain injury and indicates that PANoptosis can be a target in the regulation of various central nervous system diseases.

关键词： apoptosis brain central nervous system ischemia/reperfusion middle cerebral artery occlusion necroptosis oxygen and glucose deprivation PANoptosis pyroptosis regulated cell death

Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications

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World Journal of Stem Cells 2021年第5期13卷 386-415页

作者： xi-min hu Qi Zhang Rui-xin Zhou Yan-Lin Wu Zhi-xin Li Dan-Yi Zhang Yi-Chao Yang Rong-hua Yang Yong-Jun hu Kun xiong Department of Anatomy and Neurobiology School of Basic Medical SciencesCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Burns Fo Shan Hospital of Sun Yat-Sen UniversityFoshan 528000Guangdong ProvinceChina Department of Cardiovascular Medicine Hunan People's Hospital the First Affiliated Hospital of Hunan Normal UniversityChangsha 410005Hunan ProvinceChina

Stem cell-based therapy raises hopes for a better approach to promoting tissue repair and functional ***,transplanted stem cells show a high death percentage,creating challenges to successful transplantation and ***,it is necessary to investigate the mechanisms underlying stem cell death,such as apoptotic cascade activation,excessive autophagy,inflammatory response,reactive oxygen species,excitotoxicity,and ischemia/*** the molecular pathways involved may be an efficient strategy to enhance stem cell viability and maximize transplantation ***,a more complex network of cell death receives more attention than one crucial pathway in determining stem cell fate,highlighting the challenges in exploring mechanisms and therapeutic *** this review,we focus on programmed cell death in transplanted stem *** also discuss some promising strategies and challenges in promoting survival for further study.

关键词： Programmed cell death Apoptosis Autophagy Stem cell Therapeutic strategies

Copper Metabolism and Cuproptosis:Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

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Current Medical Science 2024年第1期44卷 28-50页

作者： xiao-xia BAN Hao WAN xin-xing WAN Ya-ting TAN xi-min hu Hong-xia BAN xin-yu CHEN Kun huANG Qi ZHANG Kun xiONG Department of human Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 430013China Department of Endocrinology Third Xiangya HospitalCentral South UniversityChangsha 430013China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 430013China Affiliated Hospital Inner Mongolia Medical UniversityHohhot 010050China Key Laboratory of Emergency and Trauma of ministry of Education Hainan Medical UniversityHaikou 571199China hunan Key Laboratory of Ophthalmology Changsha 430013China

Copper is an essential trace element,and plays a vital role in numerous physiological processes within the human *** normal metabolism,the human body maintains copper *** deficiency or excess can adversely affect cellular ***,copper homeostasis is stringently *** studies suggest that copper can trigger a specific form of cell death,namely,cuproptosis,which is triggered by excessive levels of intracellular *** induces the aggregation of mitochondrial lipoylated proteins,and the loss of iron-sulfur cluster *** neurodegenerative diseases,the pathogenesis and progression of neurological disorders are linked to copper *** review summarizes the advances in copper homeostasis and cuproptosis in the nervous system and neurodegenerative *** offers research perspectives that provide new insights into the targeted treatment of neurodegenerative diseases based on cuproptosis.

关键词： cuproptosis copper metabolism copper homeostasis neurodegeneration neurodegenerativedisease