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Performance,microbial community and inhibition kinetics of long-term Cu2+ stress on an air-lift nitritation reactor with self-recirculation

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Journal of Environmental Sciences 2020年第5期32卷 117-127页

作者： Fan Feng Cheng-Shan Duan xi Tang xi Chen Xuan Lu xi-lin chai Qaisar Mahmood Chong-Jian Tang Li-Yuan chai Department of Environmental Engineering School of Metallurgy and EnvironmentCentral South UniversityChangsha410083China National Engineering Research Centre for Control and Treatment of Heary Metal Pollution Changsha410083China The Jiangxi Provincial Collaborative Research Institute for Environmental Protection Industry Wannian335500China Jiangxi Gaia Environmental Science&Technology Co. Ltd.Shangrao334000China Department of Environmental Sciences COMSATS UniversityAbbottabadPakistan

Biological nitrogen removal process could be affected due to the presence of heavy metals owing to their toxicity and accumulation in the *** this study,the impact of Cu2+shock on a long-term nitritation operation was investigated in an air-lift reactor with *** the dynamics of microbial community and inhibition kinetics under Cu2+stress were *** results showed that Cu2+exerted severe inhibition on nitritation performance of an air-lift reactor(ALR)at 25 mg/*** corresponding NH4+-N removal efficiency decreased to below 50%,which was mainly due to the variation of microbial community structure,especially the inhibition of nitrifiers like Nitrosomonas(the relative abundance decreased from 30%to 1%after Cu2+inhibition).Kinetic parameters were obtained and compared after fitting the Haldane *** long-term Cu2+stress on the ALR aggravated the ammonium affinity and the resistance to substrate self-inhibition of the nitritation sludge,but reduced the resistance to Cu2+***,Cu2+acted as uncompetitive inhibitor on nitritation *** results provide new insights into the nitritation characteristics under long-term Cu2+stress.

关键词： Nitritation Cu2+inhibition Microbial structure Haldane model Kinetics

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拟B样条离散曲面分层修改的研究

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微机发展 1995年第1期5卷 24-28页

作者：胡光孙文焕程树林柴琳西安电子科技大学电子机械系西安空军电讯工程学院西安公路学院机械系

拟Ｂ样条离散曲面在曲面造型中是十分灵活的，但当对它进行局部修改时却存在一些不足。针对这一问题，本文提出了一种所谓分层修改的方法。这一方法为设计者提供了新的有力的编辑工具。

关键词： B样条离散曲面分层修改几何造型

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Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai chai Meng Tian Huali Yu xiaoxiao He xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

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Pretreatment red blood cell distribution width as a predictive marker for postoperative complications after laparoscopic pancreatoduodenectomy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 143-157页

作者： xian-Rang Cao Yin-Long Xu Jia-Wei chai Kai Zheng Jun-Jie Kong Jun Liu Shun-Zhen Zheng Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Breast and Thyroid Surgery Shandong Provincial Maternal and Child Health Care HospitalJinan 250014Shandong ProvinceChina

BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various *** To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively *** between pretreatment RDW and clinicopathological characteristics and short-term outcomes were *** Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal *** pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,P<0.001)and severe POCs of grade IIIa or higher(hazard ratio=3.138,95%confidence interval:2.042-4.824,P<0.001)based on the Clavien-Dino classification *** analysis showed that high pretreatment RDW was an independent risk factor for Clavien-Dino classi-fication grade IIIb or higher POCs,a comprehensive complication index score≥26.2,severe postoperative pancreatic fistula,severe bile leakage and severe *** pretreatment RDW was positively associated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and was negatively associated with albumin and the prognostic nutritional *** Pretreatment RDW was a special parameter for patients who underwent *** was associated with malnutrition,severe inflammatory status and poorer short-term *** could be a surrogate marker for nutritional and inflammatory status in identifying patients who were at high risk of developing POCs after LPD.

关键词： Biomarker Laparoscopic pancreatoduodenectomy Postoperative complication Red blood cell distribution width Short-term outcomes

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Conformational Behavior of Single Circular Semiflexible Polyelectrolyte in the Presence of Multivalent Counterions

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Chinese Journal of Polymer Science 2023年第3期41卷 448-458,I0010页

作者： Zhi-Yong Yang Wen-Long lin Ai-Hua chai Dan Lu Nian-Qian Kang lin-xi Zhang Department of Physics Jiangxi Agricultural UniversityNanchang 330045China Lucheng College Wenzhou PolytechnicWenzhou 325006China College of data science Jiaxing UniversityJiaxing 314001China Department of Physics Zhejiang UniversityHangzhou 310027China

Langevin dynamics simulations are employed to explore the effects of chain stiffness and electrostatic interaction(EI) on the conformational behavior of a circular semiflexible polyelectrolyte(CSPE) in presence of trivalent *** investigate the effect of bending energy b and the dimensionless Bjerrum length A on the conformational behavior of the CSPE with a fixed chain *** competition among the EIs,chain stiffness and entropy of the system leads to rich conformations for the *** the b is less than or equal to 50,The shape of the CSPE changes from a oblate ring to a rod at small A,then to a toroid at intermediate A,and finally to a globule at very large ***,the globular conformation is not observed for large *** addition,we find that the number of torus ring increases with A increase,while decreases with b *** study should be helpful in gaining insight into the conformational behaviour of charged biopolymer.

关键词： Langevin dynamics simulation Circular semiflexible polyelectrolyte Trivalent counterions Electrostatic interaction

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STATE FEEDBACK STABILIZATION FOR A CLASS OF NONlinEAR TIME-DELAY SYSTEMS VIA DYNAMIC linEAR CONTROLLERS

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Journal of Systems Science & Complexity 2014年第3期27卷 453-462页

作者： chai lin QIAN Chunjiang School of Automation Southeast University Key Laboratory of Measurement and Control of Complex Systems of Engineering Southeast University Department of Electrical and Computer Engineering University of Texas at San AntonioSan AntonioTX 78249USA

The dynamic linear state feedback control problem is addressed for a class of nonlinear systems subject to ***,using the dynamic change of coordinates,the problem of global state feedback stabilization is solved for a class of time-delay systems under a type of nonhomogeneous growth *** the aid of an appropriate Lyapunov-Krasovskii functional and the adaptive strategy used in coordinates,the closed-loop system can be globally asymptotically stabilized by the dynamic linear state feedback *** growth condition in perturbations are more general than that in the existing *** correctness of the theoretical results are illustrated with an academic simulation example.

关键词： Dynamic linear controller global stabilization nonlinear time-delay systems state feed-back control.

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Control synthesis of linear distributed parameter switched systems

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Journal of Systems Engineering and Electronics 2015年第3期26卷 565-572页

作者： Leping Bao Shumin Fei lin chai School of Automation Southeast University Department of Automation Taiyuan Institute of Technology

The control synthesis for switched systems is extended to distributed parameter switched systems in Hilbert space. Based on semigroup and operator theory, by means of multiple Lyapunov method incorporated average dwell time approach, sufficient con- ditions are derived in terms of linear operator inequalities frame- work for distributed parameter switched systems. Being applied to one dimensional heat propagation switched systems, these lin- ear operator inequalities are reduced to linear matrix inequalities subsequently. In particular, the state feedback gain matrices and the switching law are designed, and the state decay estimate is explicitly given whose decay coefficient completely depends on the system＇s parameter and the boundary condition. Finally, two numerical examples are given to illustrate the proposed method.

关键词： distributed parameter switched systems multiple Lya-punov method stabilization linear operator inequalitie average dwell time.

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Top-level modeling theory of multi-discipline virtual prototype

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Journal of Systems Engineering and Electronics 2012年第3期23卷 425-437页

作者： Tingyu lin Xudong chai Bohu Li School of Automatic Science and Electrical Engineering Beihang University Beijing 100191 P. R. China Beijing Simulation Center Second Academy of China Aerospace Science ＆ Industry Corporation Beijing 100854 P. R. China

Multi-disciplinary virtual prototypes of complex products are increasingly and widely used in modern advanced manufactur- ing. How to effectively address the problems of unified modeling, composition and reuse based on the multi-disciplinary heteroge- neous models has brought great challenges to the modeling and simulation （M＆S） science and technology. This paper presents a top-level modeling theory based on the meta modeling framework （M2F） of the COllaborative SIMulation （COSlM） theory of virtual prototyping to solve the problems. Firstly the fundamental prin- ciples of the top-level modeling theory are decribed to expound the premise, assumptions, basic conventions and special require- ments in the description of complex heterogeneous systems. Next the formalized definitions for each factor in top level modeling are proposed and the hierarchical nature of them is illustrated. After demonstrating that they are self-closing, this paper divides the top- level modeling into two views, static structural graph and dynamic behavioral graph. Finally, a case study is discussed to demon- strate the feasibility of the theory.

关键词： top-level modeling virtual prototype complex product multi-discipline modeling and simulation.

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Semi-Global Stabilization via Homogeneous Output Feedback for a Class of Nonlinear Time-Delay Systems

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Journal of Systems Science & Complexity 2016年第6期29卷 1538-1552页

作者： WANG Pan chai lin FEI Shumin Key Laboratory of Measurement and Control of Complex Systems of Engineering Ministry of Education School of Automation Southeast University

The semi-global stabilization problem for a class of nonlinear systems with state time-delay is addressed in this paper. By using Lyapunov-Krasovskii functional method and homogeneous dom- ination approach, a homogeneous observer and an output feedback controller with a scaling gain are designed. Then the sealing gain is adjusted such that the closed-loop system is semi-global asymptoti- cally stable. A numerical example is presented to illustrate the effectiveness of the obtained results in this paper.

关键词： Homogeneous domination approach Lyapunov-Krasovskii functional nonlinear time-delay systems output feedback semi-global.

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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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