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Advances in regional nodal management of early-stage breast cancer

Chinese Journal of Cancer Research 2024年第2期36卷 215-225页

作者： zhao bi Yongsheng Wang Breast Cancer Center Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250017China

With the continuous improvement of systemic treatment, reasonable local regional control of early-stage breast cancer can be translated into survival benefits. The optimization of regional nodal management in patients with limited sentinel lymph node(SLN) metastasis needs to be weighed by surgical complications, regional recurrence risk, and lymph node status, as well as other escalating treatment(systemic/radiotherapy) that may result from deescalating surgery. With the effective support and supplementation of systemic therapy and radiotherapy, the management of axillary surgery is developing in a de-escalating trend. The widespread application of neoadjuvant therapy has contributed to optimizing the management of patients with clinically node-negative/imaging nodepositive disease. In clinical practice, it is necessary to consider the residual tumor burden of regional lymph nodes when formulating the optimal irradiation fields in patients with limited positive SLN without axillary lymph node dissection. The combined application of genomic tests and American College of Surgeons Oncology Group z0011/AMAROS criteria could provide patients with a better strategy of dual de-escalation treatment, which includes the de-escalation of both axillary surgery and systemic treatment. In the era of sentinel lymph node biopsy(SLNB), the regional nodal management of breast cancer should adhere to the concept of “updating ideas, making bold assumptions, and carefully seeking proof”, make full use of the benefits of systemic therapy and radiotherapy to reduce the scope of surgery and complications, and expand the “net benefit” of efficacy and quality of life. This review discusses the optimization of regional nodal management in the era of SLNB, in order to provide reference information for clinicians.

关键词： Breast cancer sentinel lymph node biopsy internal mammary lymph node radiotherapy surgery

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Tripartite motif-containing protein 11(TRIM11):a novel weapon against Alzheimer’s disease

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Signal Transduction and Targeted Therapy 2024年第2期9卷 339-340页

作者： Yichu Fu bi zhang Jianfeng Liu College of Life Science and Technology Key Laboratory of Molecular Biophysics of MOEHuazhong University of Science and TechnologyWuhanHubei 430074China

In a recent study published in Science,zhang et *** that tripartite motif-containing(TRIM)protein 11(TRIM11)exhibited strong inhibition on tau aggregation,which is a pathological characteristic of tauopathies including Alzheimer’s disease(AD).1 This makes TRIM11 a promising novel target for the treatment of AD and other tauopathies.

关键词： Alzheimer tau TRIM

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bipolar membrane electrodialysis integrated with in-situ CO_(2)absorption for simulated seawater concentrate utilization,carbon storage and production of sodium carbonate

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Journal of Environmental Sciences 2024年第8期142卷 21-32页

作者： Jingtao bi Tianyi Chen Yue xie Ruochen Shen bin Li Mengmeng Sun xiaofu Guo Yingying zhao School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300401China Engineering Research Center of Seawater Utilization Technology of Ministry of Education School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300401China Hebei Collaborative Innovation Center of Modern Marine Chemical Technology Tianjin 300401China Tianjin Key Laboratory of Chemical Process Safety Tianjin 300130China Shandong Technology Innovation Center of Seawater and Brine Efficient Utilization Weifang 262737China

In the context of carbon capture,utilization,and storage,the high-value utilization of carbon storage presents a significant *** address this challenge,this study employed the bipolar membrane electrodialysis integrated with carbon utilization technology to prepare Na_(2)CO_(3)products using simulated seawater concentrate,achieving simultaneous saline wastewater utilization,carbon storage and high-value production of Na_(2)CO_(3).The effects of various factors,including concentration of simulated seawater concentrate,current density,CO_(2)aeration rate,and circulating flow rate of alkali chamber,on the quality of Na_(2)CO_(3)product,carbon sequestration rate,and energy consumption were *** the optimal condition,the CO_(3)^(2-)concentration in the alkaline chamber reached a maximum of 0.817 mol/L with 98 mol%*** resulting carbon fixation rate was 70.50%,with energy consumption for carbon sequestration and product production of 5.7 k Whr/m^(3)CO_(2)and1237.8 k Whr/ton Na_(2)CO_(3),*** coupling design provides a triple-win outcome promoting waste reduction and efficient utilization of resources.

关键词： bipolar membrane electrodialysis(BMED) Carbon capture Utilization and storage(CCUS) Seawater concentrate Sodium carbonate

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Vinyltrimethylsilane as a novel electrolyte additive for improving interfacial stability of Li-rich cathode working in high voltage

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Chinese Chemical Letters 2024年第2期35卷 534-538页

作者： bing Jiang Hao Li bi Luo Lehao Liu Lihua Chu Qiaobao zhang Meicheng Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources School of New EnergyNorth China Electric Power UniversityBeijing 102206China State Key Laboratory of Physical Chemistry of Solid Surfaces College of MaterialsXiamen UniversityXiamen 361005China

Boosting the interfacial stability between electrolyte and Li-rich cathode material at high operating voltage is vital important to enhance the cycling stability of Li-rich cathode materials for high-performance Li-ion *** this work,vinyltrimethylsilane as a new type of organic silicon electrolyte additive is studied to address the interfacial instability of Li-rich cathode material at high operating *** cells using vinyltrimethylsilane additive shows the high capacity retention of 73.9%after 300 cycles at 1 C,whereas the cells without this kind of additive only have the capacity retention of 58.9%.The improvement of stability is mainly attributed to the additive helping to form a more stable surface film for Li-rich cathode material,thus avoiding direct contact between the electrolyte and the cathode material,slowing down the dissolution of metal ions and the decomposition of the electrolyte under high operating *** findings in this work shed some light on the design of stable cycling performance of Li-rich cathode toward advanced Li-ion batteries.

关键词： Vinyltrimethylsilane Electrolyte additive Li-rich cathode Interfacial stability Capacity retention

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The Lobster Eye Imager for Astronomy Onboard the SATech-01 Satellite

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天文和天体物理学研究:英文版 2023年第9期23卷 66-78页

作者： z.x.Ling x.J.Sun C.zhang S.L.Sun G.Jin S.N.zhang x.F.zhang J.B.Chang F.S.Chen Y.F.Chen z.W.Cheng W.Fu Y.x.Han H.Li J.F.Li Y.Li z.D.Li P.R.Liu Y.H.Lv x.H.Ma Y.J.Tang C.B.Wang R.J.xie Y.L.xue A.L.Yan Q.zhang C.Y.Bao H.B.Cai H.Q.Cheng C.z.Cui Y.F.Dai D.W.Fan H.B.Hu J.W.Hu M.H.Huang z.Q.Jia C.C.Jin D.Y.Li J.Q.Li H.Y.Liu M.J.Liu Y.Liu H.W.Pan Y.L.Qiu M.Sugizaki H.Sun W.x.Wang Y.L.Wang Q.Y.Wu x.P.xu Y.F.xu H.N.Yang x.Yang B.zhang M.zhang W.D.zhang z.zhang D.H.zhao x.Q.Cong B.W.Jiang L.H.Li x.B.Qiu J.N.Sun D.T.Su J.Wang C.Wu z.xu x.M.Yang S.K.zhang z.zhang N.zhang Y.F.zhu H.Y.Ban x.z.bi z.M.Cai W.Chen x.Chen Y.H.Chen Y.Cui x.L.Duan z.G Feng Y.Gao J.W.He T.He J.J.Huang F.Li J.S.Li T.J.Li T.T.Li H.Q.Liu L.Liu R.Liu S.Liu N.Meng Q.Shi A.T.Sun Y.M.Wang Y.B.Wang H.C.Wu D.x xu Y.Q Yang Y.Yang x.S.Yu K.x.zhang Y.L.zhang Y.H.zhang Y.T.zhang H.zhou x.C.zhu J.S.Cheng L.Qin L.Wang Q.L.Wang M.Bai R.L.Gao z.Ji Y.R.Liu F.L.Ma Y.J.Shi J.Su Y.Y.Tan J.z.Tong H.T.xu C.B.xue G.F.xue W.Yuan National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China North Night Vision Technology Co. LTDNanjing 211106China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Science and Technology on Low-Light-Level Night Vision Laboratory Xi'an 710065China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201204China Institute of Electrical Engineering Chinese Academy of ScienceBeijing 100190China National Space Science Center Chinese Academy of ScienceBeijing 100190China

The Lobster Eye Imager for Astronomy(LEIA),a pathfinder of the Wide-field x-ray Telescope of the Einstein Probe mission,was successfully launched onboard the SATech-01 satellite of the Chinese Academy of Sciences on2022 July *** this paper,we introduce the design and on-ground test results of the LEIA *** stateof-the-art Micro-Pore Optics(MPO),a wide field of view of 346 square degrees(18.6°×18.6°)of the x-ray imager is *** optical assembly composed of 36 MPO chips is used to focus incident x-ray photons,and four large-format complementary metal-oxide semiconductor(CMOS)sensors,each of size 6 cm×6 cm,are used as the focal plane *** instrument has an angular resolution of 4’-8’(in terms of FWHM)for the central focal spot of the point-spread function,and an effective area of 2-3 cm^(2) at 1 keV in essentially all the directions within the field of *** detection passband is 0.5-4 keV in soft x-rays and the sensitivity is2-3×10^(-11) erg s^(-1) cm^(-2)(about 1 milliCrab)with a 1000 s *** total weight of LEIA is 56 kg and the power is 85 *** satellite,with a design lifetime of 2 yr,operates in a Sun-synchronous orbit of 500 km with an orbital period of 95 *** is paving the way for future missions by verifying in flight the technologies of both novel focusing imaging optics and CMOS sensors for x-ray observation,and by optimizing the working setups of the instrumental *** addition,LEIA is able to carry out scientific observations to find new transients and to monitor known sources in the soft x-ray band,albeit with limited useful observing time available.

关键词： instrumentation detectors-space vehicles instruments-telescopes-x-rays genera

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Wearable synthetic leather-based high-performance x-ray shielding materials enabled by the plant polyphenol-and hierarchical structure-facilitated dispersion

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胶原与皮革（英文） 2024年第1期6卷 113-126页

作者： Linping Yan Jibo zhou Hao Li Rui zhong Junxin zhuang xiaohui xu Yaping Wang xuepin Liao bi Shi College of biomass Science and Engineering Sichuan UniversityChengdu 610065People's Republic of China Key Laboratory of Radiation Physics and Technology Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610065People's Republic of China Mingxin Automotive Leather Co. Ltd.Jiaxing 314006People's Republic of China Department of Chemistry Materials Innovation FactoryUniversity of LiverpoolLiverpool L7 3NYUK College of biomass Science and Engineering Sichuan UniversityChengdu 610065People's Republic of China National Engineering Labora-tory for Clean Technology of Leather Manufacture Sichuan UniversityChengdu 610065People's Republic of China

Effective protection against x-ray is the premise of utilizing the x-ray,thus it is critical to develop novel x-ray shield-ing materials with both low density and high x-ray attenuation *** the even distribution of high-z element components is of great significance for increasing the attenuation efficiency of x-ray shielding materials,in this study,the microfiber membrane(MFM),a type of synthetic leather featuring hierarchical structure was chosen to provide large surface area for the dispersion of rare earth(RE)***,plant polyphenol was utilized to achieve the stable loading and uniform dispersion of the Ce or Er into *** from the assistance of polyphenol and hierarchical structure of MFM,the even dispersion of RE element was successfully *** resultant shielding materials displayed approximately 10％superior x-ray attenuation efficiency compared to that without polyphenol,and an averagely 9％increment in x-ray attenuation efficiency than that without hierarchical ***,the obtained composite with a thickness of 2.8 mm displayed superior x-ray shielding performance compared to 0.25 mm lead sheet in 16-83 keV and retained an ultralow density of 1.4 g *** research results would shed new light on the manufacture of high-performance x-ray shielding materials with excellent x-ray shielding performance.

关键词： x-ray shielding Plant polyphenol Microfiber membrane Synthetic leather Hierarchical structure Dispersity

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Protective effects of baffles with different positions,row spacings,heights on debris flow impact

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Journal of Mountain Science 2024年第7期21卷 2352-2367页

作者： SUN xinpo CHEN Min bi Yuzhang zHENG Lu CHE Chi xU Ao TIAN zijian JIANG zheyuan College of Civil Engineering Sichuan University of Science and EngineeringZigong 643000China College of Resources and Environment Fujian Agriculture and Forestry UniversityFuzhou 350002China School of Civil Engineering Fuzhou UniversityFuzhou 350108China Jiangsu Key Laboratory of Urban Underground Engineering&Environmental Safety Institute of Geotechnical EngineeringSoutheast UniversityNanjing 210096China Beijing Urban Construction Science Technology Promoting Association Beijing 100055China SUSE-Bz Geoenvironmental Engineering Joint Laboratory Sichuan University of Science and EngineeringZigong 643000China

The baffle effectively slowed down debris flow velocity,reduced its kinetic energy,and significantly shortened the distance of debris flow ***,they are widely used for protection against natural hazards such as landslides and *** study,based on the threedimensional DEM(Discrete Element Method),investigated the impact of different baffle positions on debris flow *** flow velocity and kinetic energy variations were studied through single-factor *** baffle positions were preliminarily selected by analyzing the influence of the first-row baffle position on the impact force and accumulation mass of debris ***,based on the selected baffle positions and four factors influencing the effectiveness of baffle protection(baffle position(P),baffle height(h),row spacing(S_(r)),and angle of transit area(α)),an orthogonal design was employed to further explore the optimal arrangement of *** research results indicate that the use of a baffle structure could effectively slow down the motion velocity of debris flows and dissipate their *** the baffle is placed in the transit area,the impact force on the first-row baffle is greater than that when the baffle is placed in the deposition ***,when the baffle is placed in the transit area,the obstruction effect on debris flow mass is also greater than that when the baffle is placed in the deposition *** orthogonal experimental range analysis,when the impact on the first row of baffles is used as the evaluation criterion,the importance of each influencing factor is ranked asα>P>S_(r)>*** the mass of debris flow behind the baffle is regarded as the evaluation criterion,the rank is changed to P>α>S_(r)>*** experimental simulation results show that the optimal baffle arrangement is:P_(5),S_(r)=16,α=35°,h=9.

关键词： Debris flow Baffle Protective effect Discrete element

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A high-performance electromagnetic energy harvester for scavenging ultra-low frequency vibration energy of human foot movement

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Science China(Technological Sciences) 2024年第5期67卷 1391-1400页

作者： HU JiaJun QIAN Shuo WU Hui HU Dongxu NIU Lixin bi xiaoxue zHANG Jie HOU xiaoJuan GENG WenPing MU JiLiang HE Jian CHOU xiuJian Science and Technology on Electronic Test and Measurement Laboratory North University of ChinaTaiyuan030051China School of Software North University of ChinaTaiyuan030051China

In our daily lives,low-frequency kinetic energy primarily manifests as ***,effective harnessing of lowfrequency kinetic energy remains a formidable *** paper proposes a rope-driven rotor that rotates around an axis and consists of an ultra-high-molecular-weight polyethylene(UHMWPE)wire wrapped around a metal *** rotor can convert ultra-low frequency vibration/linear motion into rapid rotation by pressing the top at low frequencies and driving the rope for a quick *** harvester can generate up to 36.25 m W power using a 0.1-mm-diameter UHMWPE wire as the rotor when periodically pressed down to 20 mm at a frequency of 1 Hz.A simple power generation floor is assembled,generating 28.58-m W power with a matching load at a frequency of 1.5 ***,the harvester can increase the charging voltage of a 0.47-F supercapacitor from 0 to 6.8 V within 10 *** addition,the harvester can harvest energy through a light finger press motion,and the energy obtained can also support the continuous operation of multiple electronic devices *** study introduces an effective method for harvesting ultra-low frequency energy and has great prospects in the field of power generation floor and human movement energy harvesting.

关键词： electromagnetic energy harvester rope-shaft coupling structure human motion ultra-low frequency

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Accelerated generation of holograms with ultra-low memory symmetrically high-compressed look-up table

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Chinese Physics B 2024年第4期33卷 466-471页

作者：杨燕朱建英孙敏远毕勇 Applied Laser Research Center Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Computer-generated holography technology has been widely applied,and as research in this field deepens,the demand for memory and computational power in small AR and VR devices continues to *** paper presents a hologram generation method,i.e.,a symmetrically high-compressed look-up table method,which can reduce memory usage by50%.In offline computing,half of the basic horizontal and vertical modulation factors are stored,halving the memory requirements without affecting inline ***,its potential extends to various holographic applications,including the production of optical diffraction elements.

关键词： computergenerated hologram look-up table holography

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CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1029-1045页

作者： Wen-Qian Ma Ming-Chang Miao Ping-An Ding bi-Bo Tan Wen-Bo Liu Shuo Guo Li-Mian Er zhi-Dong zhang Qun zhao Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer Shijiazhuang 050011Hebei ProvinceChina Department of Radiotherapy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Third Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors,including gastric cancer(GC),and is associated with tumor progression and immune infiltration;however,the roles and mechanisms of CALD1 in epithe-lial-mesenchymal transition(EMT)in GC are *** To investigate the role and mechanism of CALD1 in GC progression,invasion,and *** In this study,the relationship between CALD1 and GC,as well as the possible network regulatory mechanisms of CALD1,was investigated by bioinformatics and validated by ***1-siRNA was synthesized and used to trans-fect GC *** activity was measured using the CCK-8 method,cell migration and invasive ability were measured using wound healing assay and Transwell assay,and the expression levels of relevant genes and proteins in each group of cells were measured using qRT-PCR and Western blot.A GC cell xenograft model RESULTS bioinformatics results showed that CALD1 was highly expressed in GC tissues,and CALD1 was significantly higher in EMT-type GC tissues than in tissues of other types of *** prognosis of patients with high expression of CALD1 was worse than that of patients with low expression,and a prognostic model was constructed and *** experimental results were consistent with the results of the bioinformatics *** expression level of CALD1 in GC cell lines was all higher than that in gastric epithelial cell line GES-1,with the strongest expression found in AGS and MKN45 *** activity was significantly reduced after CALD1-siRNA trans-fection of AGS and MKN45 *** ability of AGS and MKN45 cells to migrate and invade was reduced after CALD1-siRNA transfection,and the related mRNA and protein expression was *** to bioinfor-matics findings in GC samples,the CALD1 gene was significantly associated with the expression of members of the PI3K-AKT-mTOR signaling pathway as well as the EMT signaling pathway,and was closely rel

关键词： Gastric tumor CALD1 Epithelial-mesenchymal transition Gene disruption Invasion Migration bioinformatics

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