检索结果-南通市图书馆

The design and performance of charged particle detector onboard the GECAM mission

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2022年第1期6卷 53-62页

作者： y.B.xu x.Q.Li x.L.Sun S.yang H.Wang W.x.Peng x.H.Liang K.Gong y.Q.Liu D.y.Guo x.y.Zhao C.y.Li Z.H.An J.J.He x.J.Liu x.y.wen S.L.xiong Fan Zhang D.L.Zhang C.y.Zhang C.Cai Z.Chang G.Chen C.Chen y.y.Du M.Gao R.Gao D.J.Hou y.G.Li G.Li L.Li x.F.Li M.S.Li F.J.Lu H.Lu B.Meng F.Shi J.Z.Wang y.S.Wang H.Z.Wang x.wen S.xiao y.P.xu J.W.yang Q.B.yi S.N.Zhang C.M.Zhang F.Zhang y.Zhao x.Zhou Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Background The Gravitational wave highly energetic Electromagnetic Counterpart All-sky Monitor(GECAM)is dedicated to detecting gravitational wave gamma-ray *** is capable of all-sky monitoring over and discovering gamma-ray bursts and new radiation *** consists of two microsatellites,each equipped with 8 charged particle detectors(CPDs)and 25 gamma-ray detectors(GRDs).Purpose The CPD is used to measure charged particles in the space environment,monitor energy and flow intensity changes,and identify between gamma-ray bursts and space charged particle events in conjunction with *** CPD uses plastic scintillator as the sensitive material for detection,silicon photomultiplier array as the optically readable device,and the inlaid Am-241 radioactive source as the onboard calibration *** In this paper,we will present the working principle,physical design,functional implementation and preliminary performance test results of the *** a result,the energy range of electron,gamma-ray detection efficiency and dead time are tested to be better than the indexes required through the ground calibration experiment.

关键词： GECAM CPD SiPM

The data acquisition algorithm designed for the SiPM-based detectors of GECAM satellite

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2022年第1期6卷 70-77页

作者： y.Q.Liu K.Gong x.Q.Li x.y.wen Z.H.An C.Cai Z.Chang G.Chen C.Chen y.y.Du M.Gao R.Gao D.y.Guo J.J.He D.J.Hou y.G.Li C.y.Li G.Li L.Li x.F.Li M.S.Li x.H.Liang x.J.Liu F.J.Lu H.Lu B.Meng W.x.Peng F.Shi x.L.Sun H.Wang J.Z.Wang y.S.Wang H.Z.Wang x.wen S.xiao S.L.xiong y.B.xu y.P.xu S.yang J.W.yang Q.B.yi Fan Zhang D.L.Zhang S.N.Zhang C.y.Zhang C.M.Zhang Fei Zhang x.y.Zhao y.Zhao x.Zhou Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Physics and Space Science College China West Normal UniversityNanchong 637002China

Background The Gravitational Wave High-energy Electromagnetic Counterpart All-sky Monitor(GECAM)consists of 2 microsatellites,each of which contains 25 GRD(LaBr3)detectors and 8 CPD(plastic scintillator)*** silicon photomultiplier(SiPM)array is used to read each *** output signal of these detectors with SiPM array is very special and challenging to *** this study,a novel data acquisition(DAQ)algorithm for these detectors is designed and implemented,and the content of the output event packet is *** and Conclusion The performances,including the event acquisition efficiency of this DAQ algorithm,are extensively verified through experimental *** the on-ground and in-flight tests,this algorithm has excellent performance despite the very limited resources and short development time of GECAM mission.

关键词： Silicon photomultiplier Digital waveform processing Data acquisition

Dedicated SiPM array for GRD of GECAM

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2022年第1期6卷 63-69页

作者： D.L.Zhang x.L.Sun Z.H.An x.Q.Li x.y.wen K.Gong C.Cai Z.Chang G.Chen C.Chen y.y.Du M.Gao R.Gao D.y.Guo J.J.He D.J.Hou y.G.Li C.y.Li G.Li L.Li x.F.Li M.S.Li x.H.Liang x.J.Liu y.Q.Liu F.J.Lu H.Lu B.Meng W.x.Peng F.Shi H.Wang J.Z.Wang y.S.Wang H.Z.Wang x.wen S.xiao S.L.xiong y.B.xu y.P.xu S.yang1 x.Zhou J.W.yang Fan Zhang S.N.Zhang C.y.Zhang C.M.Zhang Fei Zhang x.y.Zhao Institute of High Energy Physics CASBeijing 100049China State Key Laboratory of Particle Detection and Electronics Beijing 100049China

Purpose The discovery of gravitational waves and gamma-ray bursts heralds the era of multi-messenger *** the adoption of two small satellites to achieve the all-sky monitoring of gamma-ray bursts,the gravitational wave highenergy electromagnetic counterpart all-sky monitor(GECAM)possesses a quasi-real-time early warning ability and plays an important role in positioning the sources of gravitational waves and in subsequent *** satellite of GECAM was fitted with 253-inch-diameter gamma-ray detectors(GRD),covering an energy range of 8–2 *** have adopted silicon photomultiplier tubes(SiPM)in lieu of photomultiplier tubes(PMT)to adapt to the dimensional limitations of *** A unique 3-inch circular SiPM array was *** this design,646×6 mm chips were arranged evenly in a circular manner with the seams filled with reflecting films,thus achieving satisfactory uniformity of light *** integrated pre-amplifier circuit on the back of the SiPM array adopted two-level grouping and summing;further,it achieved a satisfactory signal-to-noise *** high-gain and low-gain channels were adopted to achieve a large dynamic range,and two independent power supply units were used,where each unit can be closed separately,thus improving *** Performance studies show that this SiPM array meets the requirements of *** A 3-inch SiPM array have been developed that uses grouped summation,reflective films,a circular arrangement,two groups of independent power supplies,high-and low-gain signals,differential signal output technologies,*** solution can be used not only for GECAM,but also as a general solution for SiPM-based scintillation detectors.

关键词： SiPM GECAM Gamma-ray Signal-to-noise ratio Reflecting film Pre-amplifier

Quality assurance test and failure analysis of SiPM arrays of GECAM satellites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2022年第1期6卷 35-42页

作者： D.L.Zhang M.Gao x.L.Sun x.Q.Li Z.H.An x.y.wen C.Cai Z.Chang G.Chen C.Chen y.y.Du R.Gao K.Gong D.y.Guo J.J.He D.J.Hou y.G.Li C.y.Li G.Li L.Li x.F.Li M.S.Li x.H.Liang x.J.Liu y.Q.Liu F.J.Lu H.Lu B.Meng W.x.Peng F.Shi H.Wang J.Z.Wang y.S.Wang H.Z.Wang x.wen S.xiao S.L.xiong y.B.xu y.P.xu S.yang J.W.yang Fan.Zhang S.N.Zhang C.y.Zhang C.M.Zhang Fei Zhang x.y.Zhao x.Zhou Institute of High Energy Physics CASBeijing 100049People’s Republic of China

Background The Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)satellite developed a SiPM-based gamma-ray detector to monitor the gravitational wave-related GRBs and guide subsequent observations in other wavelengths of *** As all the available SiPM devices belong to commercial grade,quality assurance tests need to be performed in accordance with the aerospace *** In the SiPM application of GECAM,quality assurance experiments were *** mechanism of the failure of SiPM devices was analyzed during the development *** Based on the quality assurance test results,the fnal pass rate of SiPM array was 95%.Based on the failure analysis,it was found that a piece of SiPM had a leakage channel after longtime operation due to device *** According to the accumulated experience,in the reliability test of SiPM,it is necessary to pay special attention to test the impedance of each pin of SiPM to ground and confrm that the power switch state of SiPM is controllable.

关键词： Gravitational waves Gamma-ray detectors Silicon photomultipliers Quality assurance test Failure analysis

The design and performance of GRD onboard the GECAM satellite

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2022年第1期6卷 43-52页

作者： Z.H.An x.L.Sun D.L.Zhang S.yang x.Q.Li x.y.wen K.Gong x.H.Liang x.J.Liu y.Q.Liu y.G.Li S.L.xiong y.B.xu Fan Zhang x.y.Zhao C.Cai Z.Chang G.Chen C.Chen y.y.Du P.y.Feng M.Gao R.Gao D.y.Guo J.J.He D.J.Hou C.y.Li G.Li L.Li x.F.Li M.S.Li F.J.Lu H.Lu B.Meng W.x.Peng F.Shi H.Wang J.Z.Wang y.S.Wang H.Z.Wang x.wen S.xiao y.P.xu J.W.yang Q.B.yi S.N.Zhang C.y.Zhang C.M.Zhang Fei Zhang y.Zhao x.Zhou CAS Institute of High Energy PhysicsBeijing 100049China State Key Laboratory of Particle Detection and Electronics Beijing 100049China 3 Xiangtan UniversityXiangtan 411105China 4 Beijing Normal UniversityBeijing 110875China xiangtan University Xiangtan 411105China Beijing Normal University Beijing 110875China

Background Each GECAM satellite payload contains 25 gamma-ray detectors(GRDs),which can detect gamma-rays and particles and can roughly localize the Gamma-Ray Bursts(GRBs).GRD was designed using lanthanum bromide(LaBr3)crystal as the sensitive material with the rear end coupled with silicon photomultiplier(SiPM)array for *** In aerospace engineering design of GRD,there are many key points to be *** this paper,we present the specific design scheme of GRD,the assembly and the performance test results of *** Based on Monte Carlo simulation and experimental test results,the specific schematic design and assembling process of GRD were *** being fully assembled,the GRDs were conducted performance tests by using radioactive source and also conducted random vibration *** and conclusion The test results show that all satellite-borne GRDs have energy resolution<16%at 59.5 keV,meeting requirements of satellite in scientific *** random vibration test shows that GRD can maintain in a stable performance,which meets the requirement of spatial application.

关键词： Lanthanum bromide scintillator SiPM array GECAM Gamma-ray detector Energy resolution

The technology for detection of gamma-ray burst with GECAM satellite

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2022年第1期6卷 12-25页

作者： x.Q.Li x.y.wen Z.H.An C.Cai Z.Chang G.Chen C.Chen y.y.Du M.Gao R.Gao K.Gong D.y.Guo J.J.He D.J.Hou y.G.Li C.y.Li G.Li L.Li x.F.Li M.S.Li x.H.Liang x.J.Liu y.Q.Liu F.J.Lu H.Lu B.Meng W.x.Peng F.Shi x.L.Sun H.Wang J.Z.Wang y.S.Wang H.Z.Wang x.wen S.xiao S.L.xiong y.B.xu y.P.xu S.yang J.W.yang Q.B.yi D.L.Zhang Fan Zhang S.N.Zhang C.y.Zhang C.M.Zhang Fei Zhang x.y.Zhao y.Zhao x.Zhou C.S.Zhang J.P.yu L.Chang K.K.Zhang J.Huang y.M.Chen x.B.Han Institute of High Energy Physics CASBeijing 100049China xiangtan University Xiangtan 411105China Beijing Normal University Beijing 110875China Beijing Glass Research Institute Beijing 101100China Innovation Academy for Microsatellites of CAS Shanghai 201204China

Introduction The main physical objective of the GECAM satellite is to detect gamma-ray bursts,which is related to gravitational waves of double compact object *** GECAM satellite also detects and investigates various bursts of high-energy celestial *** and methods In this study,we designed,developed and calibrated the payload and launched it into orbit with GECAM *** payload consists of the gamma ray detector(GRD,for detecting 4 keV–4 MeV x/γray),the charged particle detector(CPD,for detecting 150 keV–5 MeV charged particle),and the electronic box(EBOx).The all-sky field coverage is achieved via two 229-degree large-area satellites positioned 180 degrees apart and are on opposite sides of the *** satellite is equipped with 25 GRDs and 8 CPDs;thus,the satellite can identify charged particle bursts in ***-ray detectors adopt lanthanum bromide crystal technology combined with silicon *** is the first time that this technology was used massively in space *** The GECAM satellite can quickly determine the direction of gamma-ray bursts(positioning)via indexing and fitting method,while the transmit variability,energy spectrum and direction of the gamma-ray bursts guide subsequent observations through the Beidou-3 RDSS in quasi-real *** will play an important role in the study of high energy celestial bursts.

关键词： GECAM Gamma-ray burst Lanthanum bromide crystal Silicon photomultiplier Beidou short message

Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 199-212页

作者： wen yANG BIN TANG DAN xU wenxIU yANG Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-Ly3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(py clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

Mesh-supported V2O5-WO3/TiO2 nanosheet array catalysts for efficient removal of NOx

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tungsten 2025年第1期7卷 100-111页

作者： Zhi-Qi Zhang Liu yang wen Luo Vladimir An Jing Li Bao-Dan Liu School of Materials Science and Engineering Northeastern University Foshan Graduate School of Innovation Northeastern University Kizhner Research Center School of Advanced Manufacturing Technologies Tomsk Polytechnic University

The design and synthesis of vanadium-based denitration catalysts with low-temperature activity pose significant challenges in the field of toxic gas *** this study,we have developed a novel approach to fabricate highly efficient V2O5-WO3/TiO2monolithic mesh catalysts for NOxreduction at low ***,TiO2nanosheets with strong adhesion and large surface area were grown on Ti mesh using plasma electrolytic oxidation technology and hydrothermal ***,super-small traces of WO3and V2O5active nano-species were subsequently deposited on TiO2nanosheets using the deposition-precipitation *** to traditional ceramic-based V2O5-WO3/TiO2catalysts,our V2O5-WO3/TiO2monolithic mesh catalyst exhibits superior mechanical performance,excellent thermal conductivity,lower pressure drop,higher utilization of active components,and stronger synergistic ***,the V2O5-WO3/TiO2monolithic mesh catalysts exhibited excellent low-temperature catalytic activity with 98% of NOxconversion at 220℃,and remarkable long-term SO2tolerance and water resistance in the selective catalytic reduction（SCR） of NOxwith *** SCR reaction of tiny V2O5and WO3active species supported on TiO2nanosheets directly demonstrated to follow the Eley-Rideal mechanism by in situ infrared spectra.

关键词： Low temperature activity Monolithic mesh catalysts NH3-SCR SO2 tolerance V2O5-WO3/TiO2

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 134-168页

作者： yijie Wang Congrui Liu Chao Fang Qiuxia Peng wen Qin xuebing yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway