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Design, synthesis, and biological evaluation of ligustrazine/resveratrol hybrids as potential anti-ischemic stroke agents

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Chinese Journal of Natural Medicines 2020年第8期18卷 633-640页

作者： ZHANG Yin-Qiu wu jian-bing YIN Wei ZHANG Yi-Hua HUANG Zhang-jian State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Drug DiscoveryChina Pharmaceutical UniversityNanjing 210009China

To search for potent anti-ischemic stroke agents,a series of tetramethylpyrazine(TMP)/resveratrol(RES)hybrids 6 a-t were designed and *** hybrids inhibited adenosine diphosphate(ADP)-or arachidonic acid(AA)-induced platelet aggregation,among them,6 d,6 g-i,6 o and 6 q were more active than *** most active compound 6 h exhibited more potent antiplatelet aggregation activity than TMP,RES,as well as positive control ticlopidine(Ticlid)and aspirin(ASP).Furthermore,6 h exerted strong antioxidative activity in a dose-dependent manner in rat pheochromocytoma PC12 cells which were treated with hydrogen peroxide(H2 O2)or hydroxyl radical(·OH).Importantly,6 h significantly protected primary neuronal cells suffered from oxygen-glucose deprivation/reoxygenation(OGD/R)injury,comparable to an anti-ischemic drug edaravone(Eda).Together,our findings suggest that 6 h may be a promising candidate warranting further investigation for the intervention of ischemic stroke.

关键词： Ligustrazine Resveratrol Hybrids Anti-platelet aggregation Antioxidant Ischemic stroke

Nitric oxide donating anti-glaucoma drugs:advances and prospects

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Chinese Journal of Natural Medicines 2020年第4期18卷 275-283页

作者： MAO Yu-Jie wu jian-bing YANG Ze-Qiu ZHANG Yi-Hua HUANG Zhang-jian State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Drug DiscoveryChina Pharmaceutical UniversityNanjing 210009China

Glaucoma is a disease that causes irreversible blindness. Reducing intraocular pressure(IOP) is the main treatment at present. Nitric oxide(NO), an endogenous gas signaling molecule, can increase aqueous humor outflow facility, inhibit aqueous humor production thereby reducing IOP, as well as regulate eye blood flow and protect the optic nerve. Therefore, NO donating antiglaucoma drugs have broad research prospects. In this review, we summarize NO-mediated therapy for glaucoma, and the state of the art of some NO donating molecules, including latanoprostene bunod in market and some other candidate compounds, for the intervention of glaucoma, as well as prospects and challenges ahead in this field.

关键词： Nitric oxide Glaucoma Intraocular pressure Trabecular meshwork Prostaglandin analogues

Inclusions modification by rare earth in steel and the resulting properties: A review

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Journal of Rare Earths 2024年第3期42卷 431-445,I0001页

作者： Xiaoqiang Wang Zhiwei wu bing Li Wenxiong Chen Jun Zhang jian Mao College of Materials Science and Engineering Sichuan UniversityChengdu610065China Chengdu Advanced Metal Materials Industry Technology Research Institute Co. Ltd.Chengdu610303China State Key Laboratory of Metal Material for Marine Equipment and Application Anshan114009China

Rare earth(RE) elements are excellent modifiers for non-metallic inclusions that inevitably appear in steel and affect steel properties. This paper reviews the research status of inclusions modification by RE elements and the changes it cause on steel properties. First, the inclusion changes caused by RE modification are described. Generally, after adding pure RE, the main evolution of inclusions occurs as M →M + RE-Al-O → RE-Al-O + RE_(2)O_(2)S → RE_(2)O_(2)S + RE—S/RE_(2)O_(2)S + RE-O with an increase in the RE content(M represents the inclusions before RE addition). The type of final inclusion obtained after RE modification is related to the relative contents of S and O in the steel. Moreover, fine, regular, and uniformly distributed inclusions can be obtained with appropriate RE addition. However, the effectiveness of inclusions modification by adding both RE and non-RE elements is closely related to the order of their addition. Second, the applications and advantages of thermodynamic calculations in the study of RE-modified inclusions are introduced. Third, the changes in the corrosion resistance, impact properties,and other properties of steel caused by the modification of inclusions by RE are reviewed. Finally, the perspectives and trends of inclusions modified by RE elements in the steel industry are presented.

关键词： Rare earths Inclusions Modification Thermodynamic calculation Properties change

茶叶、袋装茶以及茶粉中15种金属及类金属含量及健康风险评估

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食品安全质量检测学报 2024年第16期15卷 98-106页

作者：吴梅陈祝军陈蓉吴建兵秦园沈怡佳朱楠张珊张家港市疾病预防控制中心苏州215600

目的研究茶叶、袋装茶以及茶粉的茶汤中Li、Al、Cr、Mn、Fe、Ni、Cu、Zn、As、Se、Mo、Cd、Sb、Ba、Pb 15种金属及类金属含量情况,评估饮用茶汤对人群健康的风险。方法随机抽取不同的茶叶、袋装茶以及茶粉共39份样品,用100℃水冲泡茶叶... 详细信息

目的研究茶叶、袋装茶以及茶粉的茶汤中Li、Al、Cr、Mn、Fe、Ni、Cu、Zn、As、Se、Mo、Cd、Sb、Ba、Pb 15种金属及类金属含量情况,评估饮用茶汤对人群健康的风险。方法随机抽取不同的茶叶、袋装茶以及茶粉共39份样品,用100℃水冲泡茶叶、袋装茶以及茶粉60min,3种茶汤用电感耦合等离子体质谱法(inductively coupled plasma-mass spectrometry,ICP-MS)直接测定15种金属及类金属溶出量。运用单项污染评价、内梅罗法综合污染评价,靶标危害系数(target hazard quotient,THQ)和危害指数(hazard index,HI),以及美国环境保护署(*** Protection Agency,US EPA)和国际致癌研究署(International Agency for Research on Cancer,IARC)推荐的健康风险评价模型对3种茶汤进行健康风险评价。结果茶叶、袋装茶以及茶粉3种茶汤中单项污染指数和内梅罗综合污染评价指数均小于0.7,污染等级分别为优良、安全。THQ值和HI值均小于1。HI排名依次是绿茶茶粉>红茶茶粉>乌龙茶粉>绿茶袋装茶>红茶茶叶>乌龙袋装茶>乌龙茶茶叶>绿茶茶叶>红茶袋装茶,HI中占比较大的元素整体上为Al、Mn、Ni、Cu。茶汤中个人健康危害年风险总和为9.01×10^(–6)~3.73×10^(–5)a^(–1),低于USEPA和国际辐射防护委员会(International Commissionon Radiological Protection,ICRP)推荐的最大可接受风险水平。结论茶叶、袋装茶以及茶粉茶汤中15种金属及类金属对暴露人群的健康风险较低。茶叶、袋装茶以及茶粉均处于安全饮用范围。

关键词：茶叶袋装茶茶粉茶汤金属健康风险评估

Layer-by-layer assembly of chitosan and carbon nanotube on cotton fabric for strain and temperature sensing

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Journal of Materials Science & Technology 2024年第6期173卷 114-120页

作者： Ye-Xin Zhang Yi-Dong Li An-Ke Du Yuanpeng wu jian-bing Zeng Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China Chongqing Academy of Science and Technology Chongqing 401123China School of New Energy and Materials State Key Laboratory of Oil and Gas Reservoir Geology and ExploitationSouthwest Petroleum UniversityChengdu 610500China

Layer-by-layer(LBL)assembly shows great potential in fabrication of flexible conductive cotton fabrics(FCCF)with carbon nanotubes(CNT)as conductive components but is limited because complicated chemical modification of CNT is usually ***,we reported a facile and eco-friendly LBL approach to fabricating FCCF by dipping in chitosan(CS)aqueous solution and poly(sodium 4-styrenesulfonate)(PSS)wrapped CNT aqueous dispersion *** FCCF with electrical conductivity higher than 30 S/m was achieved when 4 layers of CNT were coated on the cotton fabric(CF).The obtained FCCF possessed outstanding mechanical stability with electrical resistivity almost unchanged after exposure to 500 times mechanical abrasion and 500 circles of tape *** FCCF showed excellent strain sensing performance with high sensitivity(with a gauge factor up to 35.1)and a fast response time(70 ms).It can be used as a strain sensor to accurately detect various human deformations such as finger bending and joint *** FCCF could be used as a temperature sensor in that it exhibited stable and reproducible negative temperature sensing behavior in the temperature range of 30-100℃.

关键词： Flexible conductive cotton fabric Layer-by-layer Temperature sensing Strain sensing

减反射涂层用含氟超支化聚氨酯丙烯酸酯的合成及其性能

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热固性树脂 2024年第4期39卷 1-6,12页

作者：郑可心凌丽霞吴建兵王宝俊太原理工大学化学工程与技术学院山西太原030024 山西省应用化学研究所(有限公司) 山西太原030027 太原理工大学煤基能源清洁高效利用国家重点实验室山西太原030024

采用异佛尔酮二异氰酸酯(IPDI)、四氟丙醇(TFP)与三羟甲基丙烷(TMP)合成了一种含氟二元醇F-TMP,并将其作为扩链剂对超支化聚氨酯丙烯酸酯(PUA)改性,合成了一系列用于减反射涂层不同氟含量的超支化聚氨酯丙烯酸酯(FPUA)树脂。采用傅里叶... 详细信息

采用异佛尔酮二异氰酸酯(IPDI)、四氟丙醇(TFP)与三羟甲基丙烷(TMP)合成了一种含氟二元醇F-TMP,并将其作为扩链剂对超支化聚氨酯丙烯酸酯(PUA)改性,合成了一系列用于减反射涂层不同氟含量的超支化聚氨酯丙烯酸酯(FPUA)树脂。采用傅里叶红外光谱(FT-IR)对FPUA的结构进行了表征,并对固化过程中的双键转化率进行了固化动力学监测。结果表明:氟元素有效地接入了FPUA树脂中,其双键转化率与光固化涂料的初始粘度有关。进一步测试了光固化涂层的光学性能、附着力、硬度、柔韧性、耐水性以及热稳定性。结果表明,氟改性后涂层综合性能得到显著改善,耐水和耐化学品性能均有提高,当聚己二醇新戊二醇酯(PNA)与F-TMP的物质的量比为1∶0.5时,涂层的光透过率达到93.7%,光折射率为1.413,反射率2.11%,具有优异的光学性能,同时还具有最佳的热稳定性以及力学性能,附着力等级0,硬度可达91.5HD,柔韧性低至2 mm。

关键词：紫外光固化含氟聚氨酯丙烯酸酯折射率减反射涂层

Unlocking the Potential of Poly(butylene succinate)through Incorporation of Vitrimeric Network Based on Dynamic Imine Bonds

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Chinese Journal of Polymer Science 2024年第10期42卷 1414-1424,I0006页

作者： Shan-Song wu Hui-Juan Lu Yi-Dong Li Shui-Dong Zhang jian-bing Zeng Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing400715China School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou510640China

Poly(butylene succinate)(PBS)exhibits many advantages,such as renewability,biodegradability,and impressive thermal and mechanical properties,but is limited by the low melt viscosity and strength resulted from the linear *** address this,vitrimeric network was introduced to synthesize PBS vitrimers(PBSVs)based on dynamic imine bonds through melt polymerization of hydroxyl-terminated PBS with vanillin derived imine containing compound and hexamethylene diisocyanate using trimethylolpropane as a crosslinking *** with different crosslinking degrees were synthesized through changing the content of the crosslinking *** effect of crosslinking degree on the thermal,theological,mechanical properties,and stress relaxation behavior of the PBSVs was studied in *** results demonstrated that the melt viscosity,melt strength,and heat resistance were enhanced substantially without obvious depression in crystallizability,thermal stability,and mechanical properties through increasing crosslinking *** addition,the PBSVs exhibit thermal reprocessability with mechanical properties recovered by more than 90%even after processing for three ***,PBSV with improved melt properties shows significantly improved foamability compared to commercial *** research contributes to the advancement of polymer technology by successfully developing PBS vitrimers with improved properties,showcasing their potential applications in sustainable and biodegradable materials.

关键词： Poly(butylene succinate) Vitrimer Imine bonds Foamability

Impact of preoperative inflammatory and nutritional markers on the prognosis of patients with peritoneal metastasis of colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3865-3874页

作者： Zhi-Jie wu bing Lan jian Luo Ayniyazi Ameti Hui Wang Qiong-Yu Hu Department of General Surgery(Colorectal Surgery) The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Anesthesiology Kashgar First People’s HospitalKashgar 844000Xinjiang Uygur Autonomous RegionChina Department of Anesthesiology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Identifying patients with peritoneal metastasis(PMs)of colorectal cancer(CRC)who will benefit from cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is crucial before *** and nutritional indicators play essential roles in cancer development and *** To investigate the association of preoperative inflammatory and nutritional markers with prognosis in patients with *** We included 133 patients diagnosed with CRC-PM between July 2012 and July ***’demographics,overall survival(OS),and preoperative inflammatory and nutritional markers were *** Kaplan-Meier method and log-rank test were used to estimate *** Of the 133 patients,94(70.6%)had normal hemoglobin(Hb)and 54(40.6%)had a high neutrophil-to-lymphocyte ratio(NLR).The median OS(mOS)was significantly lower for patients with high NLR(7.9 months)than for those with low NLR(25.4 months;P=0.002).Similarly,patients with normal Hb had a longer mOS(18.5 months)than those with low Hb(6.3 months;P<0.001).Multivariate analysis identified age,carbohydrate antigen 199 levels,NLR,Hb,and peritoneal cancer index as independent predictors of *** on these findings,a nomogram was constructed,which demonstrated a good capacity for prediction,with a C-index of 0.715(95%confidence interval:0.684-0.740).Furthermore,the 1-and 2-year survival calibration plots showed good agreement between predicted and actual OS *** areas under the curve for the 1-and 2-year survival predictions of the nomogram were 0.6238 and 0.6234,*** High NLR and low Hb were identified as independent predictive risk factors for poor prognosis in patients with *** established nomogram demonstrated high accuracy in predicting OS for patients with CRC-PM,indicating its potential as a valuable prognostic tool for this patient population.

关键词： Colorectal cancer Peritoneal metastasis Neutrophil-to-lymphocyte ratio Hemoglobin Prognosis Overall survival

Optimal Risk Sharing for Maxmin Choquet Expected Utility Model

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 430-444页

作者： De-jian TIAN Shang-ri wu School of Mathematics China University of Mining and TechnologyXuzhou 221116China

This article analyzes the Pareto optimal allocations,agreeable trades and agreeable bets under the maxmin Choquet expected utility(MCEU)*** provide several useful characterizations for Pareto optimal allocations for risk averse *** derive the formulation descriptions for non-existence agreeable trades or agreeable bets for risk neutral *** build some relationships between ex-ante stage and interim stage on agreeable trades or bets when new information arrives.

关键词： maxmin Choquet expected utility model Pareto optimal allocation agreeable trade agreeable bet