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A new horizon for neuroscience:terahertz biotechnology in brain research

Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu wu zhongjie Zhu Hongwei Zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

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Bidirectional relationship between type 2 diabetes mellitus and coronary artery disease:Prospective cohort study and genetic analyses

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Chinese Medical Journal 2024年第5期137卷 577-587页

作者： Wenqiang Zhang li Zhang Chenghan Xiao Xueyao wu Huijie Cui Chao Yang Peijing Yan Mingshuang Tang Yutong Wang lin Chen Yunjie liu Yanqiu Zou ling Zhang Chunxia Yang Yuqin Yao Jiayuan li Zhenmi liu Xia Jiang Ben Zhang Department of Epidemiology and Biostatistics Institute of Systems EpidemiologyWest China-Peking Union Medical College C.C.Chen Institute of HealthWest China School of Public Health and West China Fourth HospitalSichuan UniversityChengduSichuan 610041China Department of Maternal Child and Adolescent HealthWest China School of Public Health and West China Fourth HospitalSichuan UniversityChengduSichuan 610041China Department of Iatrical Polymer Material and Artificial Apparatus School of Polymer Science and EngineeringSichuan UniversityChengduSichuan 610041China Department of Occupational and Environmental Health West China School of Public Health and West China Fourth HospitalSichuan UniversityChengduSichuan 610041China Department of Nutrition and Food Hygiene West China School of Public Health and West China Fourth HospitalSichuan UniversityChengduSichuan 610041China Department of Clinical Neuroscience Karolinska InstitutetStockholm 17177Sweden

Background:While type 2 diabetes mellitus(T2DM)is considered a putative causal risk factor for coronary artery disease(CAD),the intrinsic link underlying T2DM and CAD is not fully *** aimed to highlight the importance of integrated care targeting both diseases by investigating the phenotypic and genetic relationships between T2DM and ***:We evaluated phenotypic associations using data from the United Kingdom Biobank(N=472,050).We investigated genetic relationships by leveraging genomic data conducted in European ancestry for T2DM,with and without adjustment for body mass index(BMI)(T2DM:N_(case)/N_(control)=74,124/824,006;T2DM adjusted for BMI[T2DM_(adj)BMI]:N_(case)/N_(control)=50,409/523,897)and for CAD(N_(case)/N_(control)=181,522/984,168).We performed additional analyses using genomic data conducted in multiancestry individuals for T2DM(N_(case)/N_(control)=180,834/1,159,055).Results:Observational analysis suggested a bidirectional relationship between T2DM and CAD(T2DM→CAD:hazard ratio[HR]=2.12,95%confidence interval[CI]:2.01–2.24;CAD→T2DM:HR=1.72,95%CI:1.63–1.81).A positive overall genetic correlation between T2DM and CAD was observed(r_(g)=0.39,P=1.43×10^(-75)),which was largely independent of BMI(T2DM_(adj)BMI–CAD:r_(g)=0.31,P=1.20×10^(–36)).This was corroborated by six local signals,among which 9p21.3 showed the strongest genetic ***-trait meta-analysis replicated 101 previously reported loci and discovered six novel pleiotropic *** randomization analysis supported a bidirectional causal relationship(T2DM→CAD:odds ratio[OR]=1.13,95%CI:1.11-1.16;CAD→T2DM:OR=1.12,95%CI:1.07-1.18),which was confirmed in multiancestry individuals(T2DM→CAD:OR=1.13,95%CI:1.10-1.16;CAD→T2DM:OR=1.08,95%CI:1.04-1.13).This bidirectional relationship was significantly mediated by systolic blood pressure and intake of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors,with mediation proportions of 54.1%(95%CI:24.9-83.4%)and 90.4%(95%CI

关键词： Type 2 diabetes mellitus Coronary artery disease Phenotypic association Genetic correlation Mendelian randomization

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Therapy of acute severe pancreatitis awaits further improvement

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World Journal of Gastroenterology 1998年第4期4卷 13-14页

作者： wu Xianzhong Tianjin Inst. of Acute Abdom. Dis. Tianjin 300100 China Faculty of Medicine Shenyang Medical College China Department of Surgery China Chinese Assoc. Intgd. Chinese W. M. China Tianjin Inst. of Acute Abdom. Dis. Nankai District Tianjin 300100 China

ＴｈｅｒａｐｙｏｆａｃｕｔｅｓｅｖｅｒｅｐａｎｃｒｅａｔｉｔｉｓａｗａｉｔｓｆｕｒｔｈｅｒｉｍｐｒｏｖｅｍｅｎｔＷＵＸｉａｎＺｈｏｎｇＳｕｂｊｅｃｔｈｅａｄｉｎｇｓｐａｎｃｒｅａｔｉｔｉｓ／ｔｈｅｒａｐｙ；ｐａｎｃ... 详细信息

ＴｈｅｒａｐｙｏｆａｃｕｔｅｓｅｖｅｒｅｐａｎｃｒｅａｔｉｔｉｓａｗａｉｔｓｆｕｒｔｈｅｒｉｍｐｒｏｖｅｍｅｎｔＷＵＸｉａｎＺｈｏｎｇＳｕｂｊｅｃｔｈｅａｄｉｎｇｓｐａｎｃｒｅａｔｉｔｉｓ／ｔｈｅｒａｐｙ；ｐａｎｃｒｅａｔｉｔｉｓ／ｄｒｕｇｔｈｅｒ...

关键词： pancreatitis/therapy pancreatitis/drug therapy pancreatitis/mortality pancreatitis/complication TCMWM therapy

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Recent progress in sulfonyl fluoride synthesis via the radical sulfur dioxide insertion and fluorination strategy

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Science China Chemistry 2024年

作者： Haozhen Zhang Wangchuan Xiao Fanhong wu Xiaoyu Ma Chao liu School of Chemical and Environmental Engineering Shanghai Institute of Technology Shanghai-Sanming Engineering Research Center of Green Fluoropharmaceutical Technology Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of Sciences Chinese Academy of Sciences

Sulfonyl fluoride compounds, as the key components for sulfur(VI) fluoride exchange(SuFEx) reaction, are characterized by their high chemical stability yet can be selectively activated under specific conditions to enable efficient chemical bonding and connections. This unique capability has garnered significant interest across various domains. Many strategies have been developed for the synthesis of sulfonyl fluoride compounds. This review focuses on the latest advancements in synthesizing these compounds using the radical sulfur dioxide insertion and fluorination(RSIF) strategy, underscoring the versatility and efficacy of the RSIF strategy in constructing sulfonyl fluoride compounds.

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Artificial intelligence strengthenes cervical cancer screening–present and future

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Cancer Biology & Medicine 2024年第10期 864-879页

作者： Tong wu Eric Lucas Fanghui Zhao Partha Basu Youlin Qiao School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College Early Detection Prevention & Infections Branch International Agency for Research on Cancer (WHO) Department of Cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Cervical cancer is a severe threat to women's health. The majority of cervical cancer cases occur in developing countries. The WHO has proposed screening 70% of women with high-performance tests between 35 and 45 years of age by 2030 to accelerate the elimination of cervical cancer. Due to an inadequate health infrastructure and organized screening strategy, most low-and middleincome countries are still far from achieving this goal. As part of the efforts to increase performance of cervical cancer screening, it is necessary to investigate the most accurate, efficient, and effective methods and strategies. Artificial intelligence(AI) is rapidly expanding its application in cancer screening and diagnosis and deep learning algorithms have offered human-like interpretation capabilities on various medical images. AI will soon have a more significant role in improving the implementation of cervical cancer screening, management, and follow-up. This review aims to report the state of AI with respect to cervical cancer screening. We discuss the primary AI applications and development of AI technology for image recognition applied to detection of abnormal cytology and cervical neoplastic diseases, as well as the challenges that we anticipate in the future.

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课程思政视域下初中英语阅读教学实践研究

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教育理论与实践 2024年第17期44卷 58-61页

作者：吴丽红石丁宇山西省太原市教研科研中心山西省实验中学山西太原030002

课程思政视域下初中英语阅读教学是以立德树人为教育的根本目标,由教师进行文本的分析和解读,通过学习理解、应用实践和迁移创新的教学实践活动,引导学生深度探究语篇中蕴含的育人价值。在阅读教学过程中教师致力于传授知识、培养能力... 详细信息

课程思政视域下初中英语阅读教学是以立德树人为教育的根本目标,由教师进行文本的分析和解读,通过学习理解、应用实践和迁移创新的教学实践活动,引导学生深度探究语篇中蕴含的育人价值。在阅读教学过程中教师致力于传授知识、培养能力与引领价值,进而提升学生的英语核心素养,增强育人效果。教师应提升对课程思政的认识,整合教学内容,挖掘并利用课程中的思政元素,拓展多模态语篇阅读;采用创新的教学方法,提升课程育人效果;完善育人评价方式,提高课程育人的品质,推进初中英语阅读课程思政的有效落实。

关键词：课程思政初中英语阅读教学思政元素语篇阅读

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Long-term functional maintenance of primary hepatocytes in vitro using macroporous hydrogels engineered through liquid-liquid phase separation

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Nano Research 2024年第3期17卷 1725-1736页

作者： Yang Sun Sheng Yin Jian Cui zhongxia Wang Yueying Han Ding Ma Shuo Wang Junhua wu Yi Cao Chunping Jiang Xiaosong Gu Jinan Microecological Biomedicine Shandong Laboratory Jinan 250021China Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State MicrostructureKey Laboratory of Intelligent Optical Sensing and ManipulationMinistry of EducationDepartment of PhysicsNanjing UniversityNanjing 210093China Department of Hepatobiliary Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210093China National Institute of Healthcare Data Science at Nanjing University Nanjing UniversityNanjing 210093China

Preserving the functionality of hepatocytes in vitro poses a significant challenge in liver tissue engineering and bioartificial liver,as these cells rapidly lose their metabolic and functional characteristics after *** by the macroporous structures found in native liver tissues,here we develop synthetic hydrogel scaffolds that closely mimic the liver’s structural organization through the phase separation between polyethylene glycol(PEG)and *** hydrogels exhibit interconnected macroporous structures and appropriate mechanical properties,providing an optimal microenvironment conducive to hepatocyte adhesion and the formation of sizable *** to two-dimensional hepatocyte cultures,enhanced functionalities of hepatocytes cultured in our macroporous hydrogels were observed for 14 days,as evidenced by quantitative reverse-transcription–polymerase chain reactions(qRT-PCR),immunofluorescence,and enzyme linked immunosorbent assay(EliSA)*** sequencing data further confirmed the establishment of cell–cell interactions among hepatocytes when cultured in our ***,these hepatocytes maintained a protein expression lineage that closely resembled freshly isolated hepatocytes,particularly in the Notch and tumor necrosis factor(TNF)signaling *** results suggest that the macroporous hydrogels are attractive scaffolds for liver tissue engineering.

关键词： liver tissue engineering phase separation hepatocytes macroporous hydrogel

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“帽子效应”与产业链韧性

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中国软科学 2024年第9期 44-55页

作者：孙成李瑷蔚吴金希清华大学社会科学学院北京100084 清华大学地球系统科学系北京100084

专精特新企业是中小企业中的明星企业,他们之间的合作创新对于增强产业链韧性、提升产业集群竞争力有着重要意义。近年中国的专精特新“小巨人”企业认定政策对于中小企业自身的技术创新起到了正向激励作用,然而这种认定政策对于企业之... 详细信息

专精特新企业是中小企业中的明星企业,他们之间的合作创新对于增强产业链韧性、提升产业集群竞争力有着重要意义。近年中国的专精特新“小巨人”企业认定政策对于中小企业自身的技术创新起到了正向激励作用,然而这种认定政策对于企业之间的合作产生了多大效果呢?鲜有研究涉及该领域。运用PSM-DID模型,考察专精特新“小巨人”企业认定政策如何影响中小企业的合作创新。研究发现:专精特新“小巨人”企业认定能够显著提升中小企业合作创新能力,其作用机制在于“帽子”显著提升了资金效应、人才效应与市场效应。同时还发现,这种提升效应在知识产权保护水平较高地区和市场化程度较高地区中更明显。在理论上,研究结果揭示了专精特新企业“帽子效应”对区域合作创新的作用机理,丰富了区域创新理论和产业能力理论。在实践上,建议政府继续提升专精特新“帽子”含金量、鼓励中小企业合作创新,进一步加强区域经济市场化水平、优化知识产权保护制度。

关键词：专精特新“小巨人”企业认定政策产业链韧性中小企业合作创新双重差分模型

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城市更新规划的框架体系与内在逻辑研究——以广深为例

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城市规划 2024年第10期48卷 64-73页

作者：姚之浩田莉吴军王嘉苏州科技大学建筑与城市规划学院中国城市规划学会清华大学建筑学院城市规划系清华大学建筑学院土地利用与住房政策研究中心清华大学自然资源部智慧人居环境与空间规划治理技术创新中心中国城市规划学会规划实施分会广州市城市规划勘测设计研究院有限公司广州市城市规划勘测设计研究院有限公司区域规划设计所深圳市城市规划设计研究院股份有限公司城市更新规划研究中心中国城市规划学会城市更新分会

基于土地发展权配置的视角,以广深城市更新实践为例,提出了国土空间规划体系背景下城市更新规划的编制与管控内在逻辑、空间层次和内容框架。进而从城市更新背景、土地发展权配置方式两方面解释了城市更新规划编制与管控模式的差异。研... 详细信息

基于土地发展权配置的视角,以广深城市更新实践为例,提出了国土空间规划体系背景下城市更新规划的编制与管控内在逻辑、空间层次和内容框架。进而从城市更新背景、土地发展权配置方式两方面解释了城市更新规划编制与管控模式的差异。研究发现,城市更新中的“政府—市场”关系、土地增值收益分配机制和实施主体选择决定了更新规划的框架体系和编制逻辑。广州城市更新由政府深度主导土地增值收益分配,更新规划管控要素广泛,强调更新专项规划的统筹引领和要素层级传导;深圳城市更新在政府统筹下坚持市场化运作,在规划管控等方面向市场分权。分析广深两地城市更新规划管控体系及更新绩效的差异,应深入理解更新规划背后的“技术—政策—实施”逻辑。

关键词：城市更新规划规划框架体系规划编制逻辑 “政府—市场”关系土地发展权配置

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冲击载荷下蓄液结构动响应及防护机理的研究进展

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爆炸与冲击 2024年第5期44卷 15-47页

作者：赵杰侯海量吴晓伟李永清李典姜安邦海军工程大学舰船与海洋学院湖北武汉430033 海军研究院北京100161

工程实际中,飞机油箱、船舶液舱、油液储罐等各类蓄液结构可能面临炸药爆炸冲击波、弹丸侵彻等冲击载荷的威胁。在冲击载荷作用下,蓄液结构的动响应受载荷特性、结构形式、充液方式等多种因素影响,相应的结构防护机理涉及多相介质的流... 详细信息

工程实际中,飞机油箱、船舶液舱、油液储罐等各类蓄液结构可能面临炸药爆炸冲击波、弹丸侵彻等冲击载荷的威胁。在冲击载荷作用下,蓄液结构的动响应受载荷特性、结构形式、充液方式等多种因素影响,相应的结构防护机理涉及多相介质的流固耦合、波在不同介质中的传播、液体介质的空化、结构动态力学特性等多个科学问题。针对冲击载荷下蓄液结构的动响应及防护机理,总结了工程领域中典型的蓄液结构形式,分析了各类蓄液结构在爆炸冲击波、弹体侵彻及其联合作用等载荷下的结构动响应过程、结构破坏模式、载荷耗散过程、能量转化与吸收过程,总结了蓄液结构的冲击动响应特性,归纳了蓄液结构对各类冲击载荷的防护机理,从结构构型、结构动响应、理论研究方法、抗冲击防护技术等方面对蓄液结构抗冲击防护研究进行了展望。

关键词：冲击载荷蓄液结构动响应特性防护机理防护技术

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