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Enhanced CO_(2)electroreduction to ethylene via strong metal-support interaction

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Green Energy & Environment 2022年第4期7卷 792-798页

作者： Mengen Chu Chunjun Chen yahui wu Xupeng Yan Shuaiqiang Jia Ruting Feng Haihong wu Mingyuan He Buxing Han Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai200062China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Colloid and Interface and ThermodynamicsCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing100190China

The CuO/CeO_(2) composites with strong metal-support interaction were synthesised,which can efficiently electroreduct CO_(2)to C(2)H_(4).The Faradaic efficiency(FE)of C_(2)H_(4) could reach 50.5%with a current density of 18 mA cm^(-2).The strong metal-support interaction could not only enhance the adsorption and activation of CO_(2),but also can stablize the CuO.

关键词： Carbon dioxide reduction Ethyene Electrocatalyst Copper-ceria interaction

GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine

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Acta Pharmaceutica Sinica B 2022年第1期12卷 424-436页

作者： Lei Luo Yiming Qi Hong Zhong Shinan Jiang Hu Zhang Hao Cai yahui wu Zhongwei Gu Qiyong Gong Kui Luo Huaxi MR Research Center(HMRRC) Department of RadiologyFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China College of Pharmaceutical Sciences Southwest UniversityChongqing 400716China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengdu 610041China Amgen Bioprocessing Centre Keck Graduate InstituteClaremontCA 91711USA

Precisely delivering combinational therapeutic agents has become a crucial challenge for anti-tumor treatment. In this study, a novel redox-responsive polymeric prodrug(molecular weight,MW: 93.5 k Da) was produced by reversible addition-fragmentation chain transfer(RAFT) polymerization. The amphiphilic block polymer-doxorubicin(DOX) prodrug was employed to deliver a hydrophobic photosensitizer(PS), chlorin e6(Ce6), and the as-prepared nanoscale system [NPs(Ce6)] was investigated as a chemo-photodynamic anti-cancer agent. The glutathione(GSH)-cleavable disulfide bond was inserted into the backbone of the polymer for biodegradation inside tumor cells, and DOX conjugated onto the polymer with a disulfide bond was successfully released intracellularly. NPs(Ce6) released DOX and Ce6 with their original molecular structures and degraded into segments with low MWs of 41.2 k Da in the presence of GSH. NPs(Ce6) showed a chemo-photodynamic therapeutic effect to kill 4 T1 murine breast cancer cells, which was confirmed from a collapsed cell morphology, a lifted level in the intracellular reactive oxygen species, a reduced viability and induced apoptosis. Moreover, ex vivo fluorescence images indicated that NPs(Ce6) retained in the tumor, and exhibited a remarkable in vivo anticancer efficacy. The combinational therapy showed a significantly increased tumor growth inhibition(TGI,58.53%). Therefore, the redox-responsive, amphiphilic block polymeric prodrug could have a great potential as a chemo-photodynamic anti-cancer agent.

关键词： Stimuli responsiveness Polymeric prodrug Photodynamic therapy Combinational therapy Nanomedicine

Non-Uniform Pitch Helical Resonators for Dual-Passband Filter Design

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Wireless Engineering and Technology 2022年第2期13卷 19-31页

作者： yahui wu Ruwan Gajaweera Jeremy Everard Department of Research and Development Anhui Tatfook Technology Co. Ltd. Shenzhen China Department of Electronic Engineering University of York York UK

This paper presents a study of a non-uniform pitch helical resonator (NPHR) structure and the coupling mechanisms to design dual-passband filters. The previous research analyzes NPHR as a type of step impedance resonator (SIR), however, it does not give analytical equations or prediction for the dual-resonance characteristics of the NPHR structure discussed in this paper. Consequently, a circuit model is proposed to analyze the dual-resonance characteristics of NPHRs. Analytical equations are derived, showing that the frequency ratio of a dual-band NPHR can be determined by the ratio of turns. EM simulation and experimental results have shown good agreement with the circuit analysis. The derived analytical equations from circuit model can be used for fast design of NPHRs. A step-width aperture is proposed to independently control the coupling coefficients at the each band of NPHRs. A third order dual-passband filter has been designed and fabricated. The filter has 3.3% and 3% fractional bandwidths at 789 MHz and 2402 MHz, respectively. The designed prototype filter shows that NPHRs can be utilized to realize compact filters with dual-band characteristics. The filter design can be extended from engineering perspective for application in wireless communication systems.

关键词： Helical Filter Dual-Band Circuit Model Step-Width Aperture

Dendritic nanomedicine enhances chemoimmunotherapy by disturbing metabolism of cancer-associated fibroblasts for deep penetration and activating function of immune cells

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3680-3696页

作者： Yunkun Li Xiaoding Shen Haitao Ding Yuxin Zhang Dayi Pan Liping Su yahui wu Zaixiang Fang Jie Zhoua Qiyong Gong Kui Luo Department of Radiology Huaxi MR Research Center(HMRRC)Frontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Functional and Molecular Imaging Key Laboratory of Sichuan Province and Research Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610041China Department of Radiology West China Xiamen Hospital of Sichuan UniversityXiamen 361021China

Inefficient drug penetration hurdled by the stroma in the tumor tissue leads to a diminished therapeutic effect for drugs and a reduced infiltration level of immune ***,we constructed a PEGylated dendritic epirubicin(Epi)prodrug(Epi-P4D)to regulate the metabolism of cancer-associated fibroblasts(CAFs),thus enhancing Epi penetration into both multicellular tumor spheroids(MTSs)and tumor tissues in mouse colon cancer(CT26),mouse breast cancer(4T1)and human breast cancer(MDA-MB-231)*** cytotoxicity against CT26 MTSs and remarkable antitumor efficacy of Epi-P4D were ascribed to reduced fibronectin,α-SMA,and collagen ***,thinning of the tumor tissue stroma and efficient eradication of tumor cells promoted the immunogenic cell death effect for dendritic cell(DC)maturation and subsequent immune activation,including elevating the CD4^(+)T cell population,reducing CD4^(+)and CD8^(+)T cell hyperactivation and exhaustion,and amplifying the natural killer(NK)cell proportion and effectively activating *** a result,this dendritic nanomedicine thinned the stroma of tumor tissues to enhance drug penetration and facilitate immune cell infiltration for elevated antitumor efficacy.

关键词： Dendritic prodrug Enhanced penetration Metabolic intervention Cancer-associated fibroblasts Immunogenic cell death Chemotherapy Immunotherapy Immune microenvironment reconstitution

Construction of Comprehensive Development Index and Analysis on the Development Trend of Solar Energy Industry

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Engineering（科研） 2018年第8期10卷 477-485页

作者： Linlin Jia Xuehua Zhang yahui wu Institute of Economics in Tianjin Polytechnic University Tianjin China

As a strategic emerging industry, solar energy industry has been wished to ease the energy crisis and stimulate economic growth. In order to judge the development of the industry objectively, this paper constructs the index system of China’s solar energy industrial development from three dimensions of micro enterprise, medium industry and macroeconomic. This paper simultaneously takes 27 specific indicators, 54 listed companies and 10206 data from 2010 to 2016 as an example to calculate the industrial development index. The result reveals that with the implementation of the support policies playing a positive role in the development of China’s solar energy industry, the solar industry has steadily improved. Solar energy industry in our country is under the support of national support policies and its technological innovation capability is relatively active. However, the moderate investment and financing activities and inadequate enterprise operational capacity, to some extent, alleviate the development of the solar energy industry. The above shows that the solar energy industrial development index and its evaluation methods can help people to accurately grasp the development trend of the solar energy industry and accurately identify the development of advantages and disadvantages.

关键词： Solar Energy Industry Development Index Comprehensive Index Method Analytic Hierarchy Process

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基于反双曲正切函数的跟踪微分器设计与应用

系统工程与电子技术 2020年第12期42卷 2875-2883页

作者：鲁力王洁袁成人吴亚晖空军工程大学防空反导学院陕西西安710051 海军工程大学研究生院湖北武汉430033 空军预警学院黄陂士官学校湖北武汉430345

通过引入反双曲函数与终端吸引子函数,构造了一种新型跟踪微分器。反双曲正切函数在平衡点较近处优异的线性特性可以保证系统收敛的平滑性,远离平衡点处的非线性特性能保证收敛的快速性。通过引入终端吸引子函数,降低了高频信号引起的抖... 详细信息

通过引入反双曲函数与终端吸引子函数,构造了一种新型跟踪微分器。反双曲正切函数在平衡点较近处优异的线性特性可以保证系统收敛的平滑性,远离平衡点处的非线性特性能保证收敛的快速性。通过引入终端吸引子函数,降低了高频信号引起的抖振,增强了噪声抑制能力。通过扫频测试总结得出了参数整定规则后,与典型的跟踪微分器进行对比仿真,测试了所设计新型跟踪微分器的性能。最后,在控制器设计时,基于所提出的新型跟踪微分器构造了干扰观测器。通过仿真对比,证明所构造的干扰观测器实现了对模型不确定项的有效估计。

关键词：跟踪微分器反双曲正切函数终端吸引子函数干扰观测器

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基于改进NSGA-Ⅲ的文本空间树聚类算法

华中科技大学学报（自然科学版） 2020年第5期48卷 86-92页

作者：马武彬王锐吴亚辉邓苏国防科技大学信息系统工程重点实验室湖南长沙410073

构建倒排文本空间索引树(IR)分裂聚类多目标模型,对非支配排序遗传算法(NSGA-Ⅲ)的求解过程进行改进,提出一种基于先验初始种群策略的非支配排序遗传算法(PIPS-NSGA-Ⅲ),使其更适应于倒排文本空间对象分裂聚类问题的求解.通过PIPS-NSGA... 详细信息

构建倒排文本空间索引树(IR)分裂聚类多目标模型,对非支配排序遗传算法(NSGA-Ⅲ)的求解过程进行改进,提出一种基于先验初始种群策略的非支配排序遗传算法(PIPS-NSGA-Ⅲ),使其更适应于倒排文本空间对象分裂聚类问题的求解.通过PIPS-NSGA-Ⅲ算法寻求对象最小包围矩形(MBR)之间的重叠与覆盖面积、对象群间平均距离以及语义相似度等目标的最优前端解.通过对比PIPS-NSGA-Ⅲ,NSGA-Ⅱ,NSGA-Ⅲ和SPEA-Ⅱ进化多目标算法,从对象分类时间、效率、查询时间和准确度等多个方面来评估算法的优劣.实验结果表明:PIPS-NSGA-Ⅲ算法对文本空间对象聚类分裂具有较高的效率;相对于简化传统R树(STR树)与R树空间索引结构,基于改进NSGA-Ⅲ文本空间索引的平均查询时间减少24.8%,平均准确度提高3.75%.

关键词：倒排文本空间索引遗传算法非支配排序先验初始种群策略多目标优化

签证制度与入境游客流:基于引力模型的实证研究

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旅游科学 2017年第5期31卷 17-31页

作者：王亚辉吴云超湖南文理学院资源环境与旅游学院湖南常德415000

推动入境旅游市场规模成长是当前旅游领域的重大国家战略之一。在已有的文献中,研究者普遍认为签证制度便利化是促进中国入境旅游市场成长的一个重要推动力,但多数研究者只是笼统地论证了签证制度对中国入境旅游具有正向影响,而忽略了... 详细信息

推动入境旅游市场规模成长是当前旅游领域的重大国家战略之一。在已有的文献中,研究者普遍认为签证制度便利化是促进中国入境旅游市场成长的一个重要推动力,但多数研究者只是笼统地论证了签证制度对中国入境旅游具有正向影响,而忽略了签证制度的不同细分类型分别对中国入境旅游市场规模的净效应。首先,本文剖析了中国签证制度的演变历程及各个阶段的典型签证制度的变革及其影响。其次,构建了引力模型,运用多元回归分析法以美国、俄罗斯等28个中国主要入境客源国(地区)2000年~2013年的面板数据为基础进行实证研究,结果表明:港澳台居民往来大陆通行证持有者免签制度对中国入境游客流的效应显著小于APEC商务旅行卡持有者免签制度;APEC商务旅行卡持有者免签制度对中国入境游客流的效应显著小于在中国境内停留时间不超过30日的普通签证制度。最后,提出了扩大APEC商务旅行卡持有者免签的适应人群等建议。

关键词：入境游客流签证制度引力模型多元回归分析法

疫情防控视角下社会治理共同体的表现与优化路径

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探求 2020年第4期 98-103页

作者：吴亚慧中共佛山市委党校广东佛山528300

突如其来的新冠肺炎疫情是对我国治理体系和治理能力的一次大考,取得疫情防控阶段性胜利,集中展示了我国应对重大风险挑战的制度威力和强大力量。上至提供政治保证的党委领导、落实主体责任的政府负责,下至筑牢安全防线的社会协同、凝... 详细信息

突如其来的新冠肺炎疫情是对我国治理体系和治理能力的一次大考,取得疫情防控阶段性胜利,集中展示了我国应对重大风险挑战的制度威力和强大力量。上至提供政治保证的党委领导、落实主体责任的政府负责,下至筑牢安全防线的社会协同、凝聚强大合力的公众参与,都切实发挥“联防联控”“群防群治”治理模式的巨大效力。以此为契机,进一步深入贯彻党的十九届四中全会精神,通过规范共同体的公共价值导向、界定共同体的主体参与维度、创造共同体的联动治理环境等举措,推进社会治理共同体的科学构建与优化,搭建起更加全面的重大疫情防控体制机制,不断提升社会治理效能。

关键词：社会治理共同体疫情防控主体参与优化