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Prolonged overall survival in gastric cancer patients after adoptive immunotherapy

World Journal of Gastroenterology 2015年第9期21卷 2777-2785页

作者： Guo-Qing Zhang Hong Zhao Jian-Yu wu Jin-Yu Li Xiang Yan Gang Wang Liang-Liang wu xiao-Gang Zhang Yi Shao Yu Wang Shun-Chang Jiao Department of Clinical Oncology Chinese PLA General Hospital Laboratory of Tumor Research Center Chinese PLA General Hospital Beijing Immunotech Applied Science Limited

AIM:To assess the efficacy of immunotherapy with expanded activated autologous lymphocytes(EAALs) in gastric ***:An observational study was designed to retrospectively analyze the clinical data of 84 gastric cancer patients,of whom 42 were treated by EAAL immunotherapy plus conventional treatment and another 42 only received conventional treatment(control group).EAALs were obtained by proliferation of peripheral blood mononuclear cells from patients followed by phenotype *** data including age,gender,clinical stage,chemotherapeutic regimens,hospitalization,surgical,radiotherapy,and survival data were collected along with EAAL therapy details and side *** were followed and the relationship between treatment and overall survival(OS) data obtained for the immunotherapy and control groups were compared *** safety of EAAL immunotherapy was also ***:After in vitro culture and proliferation,the percentages of CD3+,CD3+CD8+,CD8+CD27+,CD8+CD28+,and CD3+CD16+/CD56+cells increased remarkably(P < 0.05),while the percentages of CD3+CD4+,CD4+CD25+,and CD3-CD16+/CD56+(natural killer cells) were overtly decreased(P < 0.05); no significant change was observed in CD4+CD25+CD127- cells(P =0.448).Interestingly,OS in the immunotherapy group was significantly higher than that in the control group,with 27.0 and 13.9 mo obtained for the two groups,respectively(P =0.028,HR =0.573,95%CI:0.347-0.945).These findings indicated a 42.7% decrease in the risk of *** addition,we found that clinical stage and application of EAAL immunotherapy wereindependent prognostic factors for gastric cancer ***,the OS in stage Ⅲc and Ⅳ patients that had received surgery was prolonged after EAAL immunotherapy(P < 0.05).Importantly,in vitro induction and proliferation of EAAL were easy and biologically ***:Overall,EAAL adoptive immunotherapy might prolong the OS in gastric cancer patients.

关键词： Adoptive immunotherapy Gastric cancer Expanded act

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基于周期混合信号和时滞项的非对称双稳系统的随机共振

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高校应用数学学报（A辑） 2010年第2期25卷 127-133页

作者：董小娟西安电子科技大学理学院陕西西安710071

研究了具有周期混合信号的带时滞项和non-Gaussian噪声项的非对称双稳系统的随机共振.首先应用统一色噪声理论近似了non-Gaussian噪声项,然后用小时滞近似理论简化了时滞项,进而根据两态理论得到了系统的输出信噪比的表达式.并讨论了系... 详细信息

研究了具有周期混合信号的带时滞项和non-Gaussian噪声项的非对称双稳系统的随机共振.首先应用统一色噪声理论近似了non-Gaussian噪声项,然后用小时滞近似理论简化了时滞项,进而根据两态理论得到了系统的输出信噪比的表达式.并讨论了系统的非对称性r,时滞量τ和噪声相关时间τ_0对信噪比的影响,发现信噪比曲线上出现了随机多振现象,这种现象与不考虑时滞影响时系统中的随机共振现象是不同的.且数值模拟表明,系统的非对称性r,时滞量τ和周期混合信号的影响使得信噪比曲线上出现了多个峰值.

关键词：时滞反馈信噪比非对称双稳系统混合信号

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Modulating the threshold voltage of oxide nanowire field-effect transistors by a Ga^＋ ion beam

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Nano Research 2014年第11期7卷 1691-1698页

作者： Wenqing Li Lei Liao Xiangheng xiao Xinyue Zhao Zhigao Dai Shishang Guo Wei wu Ying Shi Jinxia Xu Feng Ren Changzhong Jiang Department of Physics and Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education Wuhan UniversityWuhan 430072 China

In this paper, we report a method to change the threshold voltage of SnO2 and In2O3 nanowire transistors by Ga^＋ ion irradiation. Unlike the results in earlier reports, the threshold voltages of SnO2 and In2O3 nanowire field-effect transistors （FETs） shift in the negative gate voltage direction after Ga^＋ ion irradiation. Smaller threshold voltages, achieved by Ga^＋ ion irradiation, are required for high-performance and low-voltage operation. The threshold voltage shift can be attributed to the degradation of surface defects caused by Ga＋ ion irradiation. After irradiation, the current on/off ratio declines slightly, but is still close to -106. The results indicate that Ga^＋ ion beam irradiation plays a vital role in improving the performance of oxide nanowire FETs.

关键词： nanowire field-effect transistor ion irradiation threshold voltage

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美国联邦土地收支管理法律制度及启示

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中国土地科学 2010年第8期24卷 77-80,F0003,20页

作者：操小娟武汉大学政治与公共管理学院湖北武汉430072

研究目的:分析美国联邦政府在土地收支管理方面的法律制度,探求对中国土地出让收支管理的借鉴。研究方法:文献分析法和归纳法。研究结果:美国联邦土地收支管理的法律规定是在公共预算观念下的制度选择。研究结论:美国在预算观念、体制... 详细信息

研究目的:分析美国联邦政府在土地收支管理方面的法律制度,探求对中国土地出让收支管理的借鉴。研究方法:文献分析法和归纳法。研究结果:美国联邦土地收支管理的法律规定是在公共预算观念下的制度选择。研究结论:美国在预算观念、体制设置、制度安排、监督和责任机制等方面,对中国土地出让收支管理法律制度的构建具有借鉴意义。

关键词：土地法学土地收支管理法律制度比较美国联邦土地

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Toxic influence of chronic oral administration of paraquat on nigrostriatal dopaminergic neurons in C57BL/6 mice

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Chinese Medical Journal 2009年第19期122卷 2366-2371页

作者： REN Jin-peng ZHAO Yu-wu SUN xiao-jiang Department of Neurology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 China

Background Paraquat （PQ; 1,1＇-dimethyl-4,4＇-bipyridinium）, a widely used herbicide, has been repeatedly suggested as a potential etiologic factor for the development of Parkinson＇s disease （PD）, owing to its structural similarity to the known dopaminergic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine （MPTP）. This study aimed to observe the influence of paraquat on nigrostriatal dopaminergic neurons in C57BL/6 mice. Methods A total of 24 male C57BL/6 mice were assigned randomly to 3 groups： control group （treated by saline）, PQ treated group, and MPTP treated group. Mice in PQ treated group were taken orally with PQ （10 mg/kg） daily for four months. Locomotor activity was measured. Level of dopamine （DA） and its metabolites levels in the striatum were measured by high-performance liquid chromatography with an electrochemical detector （HPLC-ECD）, and tyrosine hydroxylase （TH） positive neurons were detected by using immunohistochemistry. At the same time, the activities of superoxide dismutase （SOD） and glutathione peroxidase （GSH-PX）, and the content of malondialdehyde （MDA） in substantia nigra were measured by spectrophotometry, mRNA expression of dopamine transporter （DAT） in dopaminergic neurons of substantia nigra was also determined by reverse transcription （RT）-PCR technique. Results Locomotor activities were significantly impaired in the PQ treated group. Level of DA and its metabolites levels in the striatum were declined. The activities of SOD and GSH-PX were decreased, and the content of MDA was increased in PQ treated mice compared with that in control group. Numbers of TH positive neurons and the mRNA expression of DAT in substantia nigra of mice were also decreased after PQ taken orally for four months. Conclusions The present study suggests that chronic oral administration of PQ could trigger dopaminergic neuron degeneration. Oxidative stress could be involved in the pathogenic mechanism of PD induced by PQ.

关键词： Parkinson's disease," paraquat oxidative stress," tyrosine hydroxylase dopamine transporter

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内标在LC-MS法生物样品分析中的相关问题探讨

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中国新药杂志 2018年第2期27卷 138-141页

作者：杜晓琳黄娟刘小娟雍小兰中国人民解放军成都军区总医院临床药学科成都610083

内标在LC-MS法生物样品定量分析时被广泛使用,它可以补偿检测过程中待测物在样品准备、色谱分离和信号响应等方面的损失或变化,使定量结果更加准确。选择一个合适的化合物做内标十分关键。采用内标法需关注诸多问题,如选择类似物还是稳... 详细信息

内标在LC-MS法生物样品定量分析时被广泛使用,它可以补偿检测过程中待测物在样品准备、色谱分离和信号响应等方面的损失或变化,使定量结果更加准确。选择一个合适的化合物做内标十分关键。采用内标法需关注诸多问题,如选择类似物还是稳定同位素内标,使用稳定同位素内标需要注意什么,内标浓度如何确定及如何评价未知浓度样品内标响应的变异。本文将对这些问题进行初步探讨。

关键词：生物分析 LC-MS 内标

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Dissociation Dynamics of Energy-Selected Ions using Threshold Photoelectron-Photoion Coincidence Velocity Imaging

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Chinese Journal of Chemical Physics 2019年第1期32卷 11-22,I0001页

作者： Xiang-kun wu xiao-feng Tang xiao-guo Zhou Shi-lin Liu Hefei National Laboratory for Physical Sciences at the Microscale iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Department of Chemical Physics University of Science and Technology of China Hefei 230026 China Laboratory of Atmospheric Physico-Chemistry Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences Hefei 230031 China

Threshold photoelectron-photoion coincidence (TPEPICO) is a powerful method to prepare and analyze internal energy- or state-selected ions. Here, we review the state-of-the-art TPEPICO imaging technique combining with tunable vacuum ultraviolet (VUV) synchrotron radiation and its recent applications at Hefei Light Source (HLS), especially on the fundamental data measurement and the dissociation dynamics of ions. By applying the double velocity map imaging for both electrons and ions in coincidence, the collection efficiency of the charged particles, the electron energy resolution and the resolving power of the released kinetic energy in dissociation have been greatly improved. The kinetic energy and the angular distributions of fragment ions dissociated from parent ions with definitive internal energy or state have been acquired directly from TPEPICO images. Some dissociation mechanisms involving non-adiabatic quantum effects, like conical intersection and internal conversion, have been revealed. Moreover, the mass-selected threshold photoelectron spectroscopy (MS-TPES) shows tremendous advantages in isomer-specific analysis of complex systems.

关键词： Photodissociation Photoionizaiton Coincidence Velocity imaging

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法治视野下市县“多规合一”问题探讨

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华中科技大学学报（社会科学版） 2016年第5期30卷 59-67页

作者：操小娟武汉大学政治与公共管理学院湖北武汉430072

"多规合一"是我国当前党和国家深入推进新型城镇化的重点工作。规划是政府行政权力的行使,只有在法治的框架下运行,才能促进法治国家目标的实现。虽然规划在起源上具有法治基础,但是由于规划所涉及的主体多,还需要依据法治要求正确处理... 详细信息

"多规合一"是我国当前党和国家深入推进新型城镇化的重点工作。规划是政府行政权力的行使,只有在法治的框架下运行,才能促进法治国家目标的实现。虽然规划在起源上具有法治基础,但是由于规划所涉及的主体多,还需要依据法治要求正确处理地方人民政府与其职能部门、本级人民代表大会、上级人民政府和公众之间的关系。当前市县"多规合一"试点在法治建设方面比较薄弱,需要在规划立法、规划执行、司法审查等方面加强制度建设。

关键词：法治多规合一行政权控制

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Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2023年第1期18卷 226-232页

作者： Lin Wang Bi-Qiang Zhou Ying-Hong Li Qian-Qian Jiang Wei-Hong Cong Ke-Ji Chen xiao-Min Wen Zheng-Zhi wu The First Affiliated Hospital of Shenzhen University Shenzhen Second People’s HospitalShenzhen Institute of GeriatricsShenzhenGuangdong ProvinceChina The First Affiliated Hospital of Shenzhen University Shenzhen Second People’s HospitalShenzhenGuangdong ProvinceChina China Academy of Chinese Medical Sciences Xiyuan HospitalBeijingChina School of Chinese Medicine Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Previous studies have shown that berberine has neuroprotective effects against Alzheimer’s disease,including antagonizing tau phosphorylation,and inhibiting acetylcholinesterase activity and neural cell ***,its low bioavailability and adverse reactions with conventional administration limit its clinical *** this study,we prepared berberine nanoliposomes using liposomes characterized by low toxicity,high entrapment efficiency,and biodegradability,and modified them with ***-modified berberine nanoliposomes had uniform particle size and high entrapment *** used the lactoferrin-modified berberine nanoliposomes to treat a mouse model of Alzheimer’s disease established by injection of amyloid-beta 1-42 into the lateral ***-modified berberine nanoliposomes inhibited acetylcholinesterase activity and apoptosis in the hippocampus,reduced tau over-phosphorylation in the cerebral cortex,and improved mouse *** findings suggest that modification with lactoferrin can enhance the neuroprotective effects of berberine nanoliposomes in Alzheimer’s disease.

关键词： acetylcholinesterase Alzheimer’s disease apoptosis berberine brain targeting lactoferrin nanoliposomes neuroprotective effects Tau phosphorylation

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新时期民间文学类“非遗”的传播策略分析——以江苏省国家级“非遗”项目为例

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艺术百家 2014年第A01期30卷 39-44页

作者：谢小娟南京博物院民族民俗研究所江苏南京210016

文章以江苏省国家级非物质文化遗产项目1为例,分析了各级地方政府和博物馆在民间文学类非遗传播中的作用和角色定位、应把握的原则,阐述了旅游与民间文学类非遗传播的关系与影响,具体分析了每条传播策略的优缺点,并指出了需要注意的问... 详细信息

文章以江苏省国家级非物质文化遗产项目1为例,分析了各级地方政府和博物馆在民间文学类非遗传播中的作用和角色定位、应把握的原则,阐述了旅游与民间文学类非遗传播的关系与影响,具体分析了每条传播策略的优缺点,并指出了需要注意的问题和今后应努力的方向。

关键词：文化建设民间文学非物质文化遗产文化传播中华传统文化

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