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Current natural products with antihypertensive activity

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Chinese Journal of Natural Medicines 2015年第10期13卷 721-729页

作者： BAI Ren-Ren wu xiao-ming XU Jin-Yi School of Medicine Emory University Department of Medicinal Chemistry China Pharmaceutical University State Key Laboratory of Natural Medicines China Pharmaceutical University

Natural products have been an important source of new drugs, which also played a dominant role in the discovery and research of new drugs for the treatment of hypertension. This review article reviews the recent progress in the research and development of natural lead compounds with antihypertensive activity, including alkaloids, diterpenes, coumarins, flavonoids, and peptides. We summarized their structures, sources, as well as the antihypertensive mechanisms. These information provides instructive reference for the following structural modifications and optimization.

关键词： Natural products Antihypertensive activity Lead compounds Action mechanism

Epidemic Spread in Networks Induced by Deactivation Mechanism

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Communications in Theoretical Physics 2008年第5期49卷 1357-1360页

作者： YU xiao-Ling wu xiao ZHANG Duan-ming LI Zhi-Hao LIANG Fang WANG xiao-Yu Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

We have studied the topology and epidemic spreading behaviors on the networks in which deactivation mechanism and long-rang connection are coexisted. By means of numerical simulation, we find that the clustering coefficient C and the Pearson correlation coefficient r decrease with increasing long-range connection μ and the topological state of the network changes into that of BA model at the end （when μ = 1）. For the Susceptible-Infect-Susceptible model of epidemics, the epidemic threshold can reach maximum value at μ = 0.4 and presents two different variable states around μ= 0.4.

关键词： epidemic threshold deactivation mechanism long-rang connection

Blast-Resistance Inheritance of Space-Induced Rice Lines and Their Genomic Polymorphism by Microsatellite Markers

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Agricultural Sciences in China 2009年第4期8卷 387-393页

作者： xiao wu-ming YANG Qi-yun CHEN Zhi-qiang WANG Hui GUO Tao LIU Yong-zhu ZHU xiao-yuan Plant Protection Research Institute Guangdong Academy of Agricultural Sciences Guangzhou 510640 P.R.China College of Agriculture South China Agricultural University Guangzhou 510642 P.R.China

To understand the resistance inheritance basis of space-induced rice lines to blast, and to probe mutants＇ genomic DNA polymorphism compared with ground control by microsatellite markers, three space-induced lines were crossed with a highly susceptible variety LTH, and their F1 and F2 populations were inoculated by two representative blast isolates with broad pathogenicity to analyze their resistance inheritance basis. Meanwhile three mutant lines and the ground control were analyzed by 225 rice SSR （simple sequence repeat） primer pairs selected throughout the 12 chromosomes of whole rice genome, to scan the mutagenesis in genome of the mutant lines. The results indicated the blast-resistant genes harbored in these mutant lines were dominant. It was demonstrated that the resistance of mutant H1 to isolate GD0193 and GD3286 was controlled by a single gene, respectively; while mutants H2 and H3 were controlled by two pairs of major genes against isolate GD3286 and H2 showed complicated genetic mechanism to isolate GD0193. H3＇s resistance to isolate GD0193 was verified to be controlled by a single gene. According to the results of SSR analysis, three mutant lines showed different mutant rates as compared with the ground control, and the mutant rates also varied. Resistance genes can be induced from rice by space mutation, and different genomic variations were detected in blast-resistant lines.

关键词： blast space mutation inheritance analysis microsatellite DNAs polymorphism

Small intestinal submucosa improves islet survival and function during in vitro culture

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World Journal of Gastroenterology 2005年第46期11卷 7378-7383页

作者： xiao-Hui Tian wu-Jun Xue xiao-ming Ding Xin-Lu Pang Yan Teng Pu-Xun Tian Xin-Shun Feng Center of Renal Transplantation The First Hospital of Xi'an Jiaotong UniversityXi'an 710061 Shaanxi Province China

AIM： To evaluate the recovery and function of isolated rat pancreatic islets during in vitro culture with small intestinal submucosa （SIS）. METHODS： Pancreatic islets were isolated from Wistar rats by standard surgical procurement followed by intraductal collagenase distension, mechanical dissociation and Euroficoll purification. Purified islets were cultured in plates coated with multilayer SIS （SIS-treated group） or without multilayer SIS （standard cultured group） for 7 and 14 d in standard islet culture media of RPMI 1640. After isolation and culture, islets from both experimental groups were stained with dithizone and counted. Recovery of islets was determined by the ratio of counts after the culture to the yield of islets immediately following islet isolation. Viability of islets after the culture was assessed by the glucose challenge best with low （2.7 mmol/L） and high glucose （16.7 mmol/L） solution supplemented with 50 mmol/L 3-isobutyl-1- methylxanthine （IBMX） solution. Apoptosis of islet cells after the culture was measured by relative quantification of histone-complexed DNA fragments using ELISA. RESULTS： After 7 or 14 d of in vitro tissue culture, the recovery of islets in SIS-treated group was significantly higher than that cultured in plates without SIS coating. The recovery of islets in SIS-treated group was about twice more than that of in the control group. In SIS treated group, there was no significant difference in the recovery of islets between short- and long-term periods of culture （95.8±1.0% vs 90.8±1.5%, P〉0.05）. When incubated with high glucose （16.7 mmol/L） solution, insulin secretion in SIS-treated group showed a higher increase than that in control group after 14 d of culture （20.7±1.1 mU/L vs 11.8±1.1 mU/L, P〈0.05）. When islets were placed in high glucose solution containing IBMX, stimulated insulin secretion was higher in SlS-treated group than in control group. Calculated stimulation index of SlS-treated group was about 23 times of

关键词： Islet culture Islet survival Islet function Small intestinal submucosa

Improvement of the Injection and Transport Characteristics of Electrons in Organic Light-Emitting Diodes by Utilizing a NaC1 N-Doped Layer

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Chinese Physics Letters 2014年第4期31卷 178-181页

作者： xiao Zhi-Hui wu xiao-ming HUA Yu-Lin WANG Li BI Wen-Tao BAI Juan-Juan MU Xue YIN Shou-Gen School of Materials Science and Engineering Tianjin University of Technology Tianjin 300384Key Laboratory of Display Materials and Photoelectric Devices .Ministry of Education Tianjin 300384 Tianjin Key Laboratory of Photoelectric Materials and Devices Tianjin 300384

The injection and transport characteristics of electrons are enhanced by using sodium chloride （NaC1） as an n-type dopant doped into a 4, 7-diphnenyl-1, lO-phe-nanthroline （Bphen） electron-transporting layer, which improves the performance of organic light-emitting diodes （OLEDs）. Meanwhile, a NaCl-doped Bphen layer can effectively influence electrical characteristics of the devices, and significantly improve the current and power efficiency. The turn-on voltage and the operation voltage of the optimal device are decreased drastically from 6.5 V and 10.8 V to 3.3 V and 5 V, respectively, compared with those of the reference device. The maximum current efficiency and power efficiency of the optimal device are 7.0 cd/A and 4.4 Im/W at the current density of 16.70 mA/cm~, which are about I. 7 and 4 times higher than those of the reference device, respectively. Moreover, the enhancement of the injection and transport ability for electrons is attributed not only to the reduced energy barrier between A1 cathode and Bphen, but also to the increased mobility of electrons by the doping effect of NaCl. Therefore, both the electron injection and transport ability are enhanced, which improve the carrier balance in OLEDs and lead to the better device efficiency.

关键词： Layer Improvement performance

A Community Health Service Architecture Based on the Internet of Things on Health-Care

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Chinese Journal of Biomedical Engineering(English Edition) 2016年第3期25卷 114-120页

作者： wu Zhao LIU Lei-hong HUANG Yue-shan wu xiao-ming Department of Biomedical Engineering South China University of Technology

In order to assure a real-time medical care for the elders who live alone or have a chronic disease and also to improve the responsiveness and quality of the community hospital, a community health service architecture was designed according to the Internet of Things on Health-Care. The users' body physiological and sports information can be collected intelligently by the health sensors at home and then the health information can be transmitted to the community health-care center through networks after information processing. The community doctors can provide a medical service on kinds of video, voice or email according to the users' process notes, test data and symptoms. Of course, doctors also can communicate and share their opinions with other specialist who is online. The key technology of this system is Internet of Things on Health-Care, which system can get users' health information actively and then make out intelligent decisions promptly and finally provide a more personal health service.

关键词： internet of things on health-care community health remote medical health surveillance

High Performance Polymer Field-Effect Transistors Based on Thermally Crosslinked Poly(3-hexylthiophene)

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Chinese Physics Letters 2011年第11期28卷 264-267页

作者： JIANG Chun-Xia YANG xiao-Yan ZHAO Kai wu xiao-ming YANG Li-Ying CHENG xiao-Man WEI Jun YIN Shou-Gen Key Laboratory of Display Materials and Photoelectric Devices(Ministry of Education) Tianjin University of TechnologyTianjin 300384 Institute of Material Physics and Tianjin Key Laboratory for Photoelectric Materials and DevicesTianjin University of TechnologyTianjin 300384 Singapore Institute of Manufacturing Technology 71 Nanyang DriveSingapore

The performance of polymer field-effect transistors is improved by thermal crosslinking of poly(3-hexylthiophene),using ditert butyl peroxide as the *** device performance depends on the crosslinker concentration *** obtain an optimal on/off ratio of 105 and the saturate field-effect mobility of 0.34 cm2V−1s−1,by using a suitable ratios of ditert butyl peroxide,0.5 wt%of poly(3-hexylthiophene).The microstructure images show that the crosslinked poly(3-hexylthiophene)active layers simultaneously possess appropriate crystallinity and smooth ***,crosslinking of poly(3-hexylthiophene)prevents the transistors from large threshold voltage shifts under ambient bias-stressing,showing an advantage in encouraging device environmental and operating stability.

关键词： stability morphology thiophene

A Comparison of Complete Genome Sequences of a Rabies Virus Chinese Isolate SH06 with the Vaccine Strains

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Virologica Sinica 2009年第6期24卷 529-536页

作者： Sheng-li MENG Ge-Lin XU Jie wu xiao-ming YANG Jia-Xin YAN Center of Rabies Diagnosis Wuhan Institute of Biological Products Wuhan 430060 China

In this study, we determined the complete nucleotide and deduced amino acid sequence of a primary isolate of rabies virus (SH06) obtained from the brain of a rabid dog. The overall length of the genome was 11 924 nucleotides. Comparison of the genomic sequence showed the homology of SH06 at nucleotide level with full-length genomes of reference vaccine strains ranged from 82.2% with the PV strain to 86.9% with the CTN strain. A full-length genome-based phylogenetic analysis was performed with sequences available from GenBank. Phylogenetic analysis of the complete genome sequences indicated that the SH06 exhibited the highest homology with rabies street virus BD06 and CTN vaccine strain originated from China.

关键词： Rabies virus Complete genome sequence Phylogenetic analysis

Pyramiding of Pi46 and Pita to improve blast resistance and to evaluate the resistance effect of the two R genes

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Journal of Integrative Agriculture 2016年第10期15卷 2290-2298页

作者： xiao wu-ming LUO Li-xin WANG Hui GUO Tao LIU Yong-zhu ZHOU Ji-yong ZHU xiao-yuan YANG Qi-yun CHEN Zhi-qiang National Engineering Research Center of Plant Space Breeding South China Agricultural University Plant Protection Research Institute Guangdong Academy of Agricultural Sciences/Guangdong Provincial Key Laboratory of High Technology for Plant Protection

Utilization of R（resistance） genes to develop resistant cultivars is an effective strategy to combat against rice blast disease. In this study, R genes Pi46 and Pita in a resistant accession H4 were introgressed into an elite restorer line Hang-Hui-179（HH179） using the marker-assisted backcross breeding（MABB） procedure. As a result, three improved lines（e.g., R1791 carrying Pi46 alone, R1792 carrying Pita alone and R1793 carrying both Pi46 and Pita） were developed. The three improved lines had significant genetic similarities with the recurrent parent HH179. Thus, they and HH179 could be recognized as near isogenic lines（NILs）. The resistance spectrum of the three improved lines, which was tested at seedling stage, reached 91.1, 64.7 and 97.1%, respectively. This was markedly broader than that of HH179（23.5%）. Interestingly, R1793 showed resistance to panicle blast but neither R1791 nor R1792 exhibited resistance at two natural blast nurseries. The results implied that the stacking of Pi46 and Pita resulted in enhanced resistance, which was unachievable by either R gene alone. Further comparison indicated that the three improved lines were similar to HH179 in multiple agronomic traits; including plant height, tillers per plant, panicle length, spikelet fertility, and 1 000-grain weight. Thus, the three improved lines with different R genes can be used as new sources of resistance for developing variety. There is a complementary effect between the two R genes Pi46 and Pita.

关键词： rice blast resistance gene improvement marker-assisted selection