Current natural products with antihypertensive activity

作     者：BAI Ren-Ren WU Xiao-Ming XU Jin-Yi 

作者机构：School of Medicine Emory University Department of Medicinal Chemistry China Pharmaceutical University State Key Laboratory of Natural Medicines China Pharmaceutical University 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2015年第13卷第10期

页      面：721-729页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81302635) 

主　　题：Natural products Antihypertensive activity Lead compounds Action mechanism 

摘      要：Natural products have been an important source of new drugs, which also played a dominant role in the discovery and research of new drugs for the treatment of hypertension. This review article reviews the recent progress in the research and development of natural lead compounds with antihypertensive activity, including alkaloids, diterpenes, coumarins, flavonoids, and peptides. We summarized their structures, sources, as well as the antihypertensive mechanisms. These information provides instructive reference for the following structural modifications and optimization.