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Chemical Research in Chinese Universities 2001年第4期17卷 407-414页

作者： wu wei-dong MA Ling-tai ZHANG Li-he National Laboratory of Natural and Biomimetic Drugs School ofPharmaceutical SciencesPeking UniversityBeijing 100083P.R.China

The syntheses of 5-substituted-3-[( 2’ R, 4’ R)-4 ’ -hydroxy-2 ’ -hydroxymethyltetra-hydrofuran-4’ -yl]D-1 ,2, 4-oxadiazoles and their epimers were accomplished with the aid of th construction of 1,2, 4-oxadiazoles by condensation of O-acylated cyanohydrins with hydroxylamine via intramolecular transacylation and subsequent cyclization.

关键词： Nucleoside analogue 1,2,4-Oxadiazole Transacylation

Design, Synthesis and Application of Multifunctional Chiral Aminophosphine Catalyst for Asymmetric Intermolecular Cross Rauhut-Currier Reaction

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Chinese Journal of Chemistry 2022年第17期40卷 2061-2066页

作者： wu-wei dong Kui Tian Xiu-Qin dong Chun-Jiang Wang Engineering Research Center of Organosilicon Compounds&Materials Ministry of EducationCollege of Chemistry and Molecular SciencesWuhan UniversityWuhanHubei430072 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai230021 China Suzhou Institute of wuhan University SuzhouJiangsu215123 China

A series of structurally novel multifunctional chiral aminophosphine catalysts were developed through a concise synthetic strategy from easily available starting *** highly enantioselective intermolecular cross Rauhut-Currier reactions of vinyl ketones with 3-acyl acrylates and 2-ene-1,4-diones catalyzed by(S,S)-5a were well realized,generating a wide range of the structurally important chiral multicarbonyl products in good to excellent yields with high stereocontrol(up to 97%yield,99%ee).In addition,a series of 31P NMR experiments were carried out to further investigate the catalytic process.

关键词： Asymmetric catalysis Chiral aminophosphine Intermolecular cross Rauhut-Currier reaction Chiral multicarbonyl molecules Enantioselectivity

Comparative Ligandomic Analysis of Human Lung Epithelial Cells Exposed to PM2.5

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Biomedical and Environmental Sciences 2020年第3期33卷 165-173页

作者： TIAN Hong Akhalesh SHAKYA WANG Feng wu wei dong LI wei School of Public Health Xinxiang Medical UniversityXinxiang 453003HenanChina Bascom Palmer Eye Institute Department of OphthalmologyUniversity of Miami School of MedicineMiami 33136FloridaUSA Department of Genomic Medicine UT MD Anderson Cancer CenterHouston 77054TXUSA

Objective To investigate whether exposure to particulate matter of diameter equal to or less than 2.5μm(PM2.5)alters the response of lung epithelial cells to extrinsic regulation by globally profiling cell surface ligands and quantifying their binding *** Human A549 lung epithelial cells(LECs)were treated with or without *** profiling was applied to these cells for the global identification of LEC-binding ligands with simultaneous quantification of binding *** comparisons of the entire ligandome profiles systematically identified ligands with increased or decreased binding to PM2.5-treated *** We found 143 ligands with increased binding to PM2.5-treated LECs and 404 ligands with decreased *** other ligands showed no change in binding *** example,apolipoprotein E(ApoE),Notch2,and growth arrest-specific 6(Gas6)represent ligands with increased,decreased,or unchanged binding activity,*** ApoE and Gas6 are phagocytosis ligands,suggesting that phagocytic receptors on LECs after stimulation with PM2.5 were differentially upregulated by *** These results suggest that the newly-developed ligandomics is a valuable approach to globally profile the response of LECs to PM2.5 in terms of regulating the expression of cell surface receptors,as quantified by ligand binding *** quantitative ligandome profiling will provide indepth understanding of the LEC molecular response on the cell surface to particulate matter air pollution.

关键词： PM2.5 Ligandomics Lung epithelial cell Comparative ligandomics Ligand

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生物炭表面NO吸附特性的量子化学研究

原子与分子物理学报 2025年第5期42卷 7-16页

作者：朱世遥薛婕雯张雨轩陈斌武卫东上海理工大学上海200093 上海工程技术大学城市轨道交通学院上海201620 上海交通大学机械与动力工程学院上海200240

生物炭表面具有丰富的官能团,通过化学吸附可以与一氧化氮(NO)分子形成稳定化学键,廉价易得且环境适应性强,具有广阔的应用前景.然而,当前对生物炭表面NO吸附特性的研究大多仍停留在宏观层面,缺乏深入的微观机制解析.本文基于密度泛函理... 详细信息

生物炭表面具有丰富的官能团,通过化学吸附可以与一氧化氮(NO)分子形成稳定化学键,廉价易得且环境适应性强,具有广阔的应用前景.然而,当前对生物炭表面NO吸附特性的研究大多仍停留在宏观层面,缺乏深入的微观机制解析.本文基于密度泛函理论,深入研究了生物炭表面一氧化氮(NO)的吸附转化路径,从分子层面揭示了生物炭对NO的吸附特性.研究结果显示,N-down型吸附构型的能量普遍低于O-down型吸附构型,是较为可能的吸附构型,并且含氧原子的官能团在NO的吸附和氨(NH_(3))的形成过程中扮演着关键角色.此外,通过对N-down型构型的进一步分析发现,在与活性位点结合后,NO将优先取代羟基,最终在生物质焦炭表面转化为NH_(3).同时,基于变分过渡态理论(CVT)计算了反应速率,发现NO优先反应的途径将受到不同区域内反应速率的限制.本文通过量子化学方法深入揭示了生物炭表面NO吸附特性的微观机制,为优化生物炭在NO治理中的应用提供了理论支持.

关键词：吸附生物炭密度泛函理论

Urine Metabonomic Analysis of Interventions Effect of Soy Isoflavones on Rats Exposed to Di-(2-ethylhexyl) Phthalate

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Biomedical and Environmental Sciences 2020年第2期33卷 77-88页

作者： dong Xin Wen YAO San Qiao wu Hao Yu ZHANG Yun Bo WANG Cheng NA Xiao Lin wu wei dong Department of Environmental and Occupational Health School of Public HealthXinxiang Medical UniversityXinxiang 453003HenanChina Department of Environmental Hygiene Public Health CollegeHarbin Medical UniversityHarbin 150086HeilongjiangChina

Objective Di-(2-ethylhexyl) phthalate(DEHP) is a ubiquitous environmental *** an endocrine disruptor,it seriously threatens human health and ecological environmental *** study examines the impact of intervention with soybean isoflavones(SIF) on DEHP-induced toxicity using a metabonomics *** Rats were randomly divided into control(H),SIF-treated(A,86 mg/kg body weight),DEHP-treated(B,68 mg/kg),and SIF plus DEHP-treated(D) *** were given SIF and DEHP daily through diet and gavage,*** 30 d of treatment,rat urine was tested using UPLC/MS with multivariate *** changes were also evaluated using biochemical *** Metabolomics analyses revealed that p-cresol glucuronide,methyl hippuric acid,N1-methyl-2-pyridone-5-carboxamide,lysophosphatidycholine [18:2(9 Z,12 Z)] {lyso PC [18:2(9 Z,12 Z)]},lyso PC(16:0),xanthosine,undecanedioic acid,and N6-acetyl-l-lysine were present at significantly different levels in control and treatment *** SIF supplementation partially protects rats from DEHP-induced metabolic abnormalities by regulating fatty acid metabolism,antioxidant defense system,amino acid metabolism,and is also involved in the protection of mitochondria.

关键词： Di-(2-ethylhexyl) phthalate Soy isoflavones Metabonomics UPLC-QTOF-MS/MS Urine

A Potential Hydrogen-Storage Media:C_(2)H_(4) and C_(5)H_(5) Molecules Doped with Rare Earth Atoms

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Chinese Physics Letters 2012年第12期29卷 152-155页

作者： LEI Hong-Wen ZHANG Hong GONG Min wu wei-dong Institution of Atomic and Molecular Physics Sichuan UniversityChengdu 610065 College of Physical Science and Technology Sichuan UniversityChengdu 610065 Science and Technology on Plasma Physics Laboratory Research Center of Laser FusionChina Academy of Engineering PhysicsMianyang 621900

Using first-principles calculations,we predict that a single C_(2)H_(4) or C_(5)H_(5) molecule can form a stable complex with two rare earth metals such as La,Eu,and *** La_(2)C_(2)H4 complex then absorbs up to sixteen hydrogen molecules,reaching a gravimetric storage capacity of 9.5wt%by adding a rare-earth metal atom,The results show that Eu-4f electrons have little impact on the hydrogen *** nature of bonding between Eu and H_(2) is due to the hybridization of Eu-5d with the H-1s orbital.

关键词： rare earth Rare

Long-term Di-(2-ethylhexyl) phthalate Exposure Disturbs the Lipid Metabolism Profiles and Hepatic Enzymes in Male Rats:A UPLC-MS-based Serum Metabolomics Analysis

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Biomedical and Environmental Sciences 2021年第11期34卷 920-925页

作者： dong Xin Wen wu wei dong YAO San Qiao ZHANG Yun Bo WANG Cheng wu Hao Yu NA Xiao Lin Department of Environmental and Occupational Health School of Public HealthXinxiang Medical UniversityXinxiang 453003HenanChina Department of Environmental Hygiene Public Health CollegeHarbin Medical UniversityHarbin 150086HeilongjiangChina

In recent years,many investigations have indicated that environmental endocrine disruptors(EEDs)may accelerate the development of obesity[1].One kind of EEDs,di-(2-ethylhexyl)phthalate(DEHP),is ubiquitous in natural e... 详细信息

关键词： Lipid Metab Serum

Simulation of Light Intensification Induced by Defects of Polished Fused Silica

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Chinese Physics Letters 2011年第1期28卷 109-111页

作者： WANG Feng-Rui LIU Hong-Jie HUANG Jin ZHOU Xin-Da JIANG Xiao-dong wu wei-dong ZHENG Wan-Guo JU Xin Research Center of Laser Fusion China Academy of Engineering Physics Mianyang 621900 Department of Physics University of Science and Technology Beijing Beijing 100083

Light intensity distribution in the vicinity of inclusions and etched cracks in polished fused silica at wavelength scale are simulated by using the finite-difference time-domain algorithm. Light intensity enhancement factor as functions of diameter and refractive index of inclusions are investigated, more than 10 times that of incident beam is obtained in the simulation. We model the etched crack in close proximity to a real structure, which is characterized by AFM. We find that the peak light intensity of the crack is a function of its cross sectional breadth depth ratio, providing good hints for the effective processing of fused silica samples to improve the damage threshold.

关键词： Computational physics Condensed matter: electrical magnetic and optical Condensed matter: structural mechanical & thermal

Effects of AMP579 and adenosine on L-type Ca2+current in isolated rat ventricular myocytes

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Acta Pharmacologica Sinica 2005年第5期26卷 559-562页

作者： Xiong WANG~1,Bo-wei wu,dong-mei wuDepartment of Physiology Shanxi Medical University,Taiyuan 030001,China Department of Physiology Shanxi Medical University Taiyuan China

Aim:To compare the effects of AMP579 and adenosine on L-type Ca2+current(ICa-L)in rat ventricular myocytes and explore the mechanism by which AMP579acts on ***:ICaLwas recorded by patch-clamp technique in ***:Adenosine(10nmol/L to 50μmol/L)showed no effect onbasal ICaL,but it inhibited the ICaLinduced by isoproterenol 10 nmol/L in a concen-tration-dependent manner with the IC50of 13.06 μmol/*** to adenosine,AMP579 also showed an inhibitory effect on the ICaLinduced by ***579 and adenosine(both in 10 μmol/L)suppressed isoproterenol-inducedICaLby 11.1% and 5.2%, *** addition,AMP579 had a direct inhibitoryeffect on basal ICaLin a concentration-dependent manner with IC50(1.17 μmol/L).PD 116948(30μmol/L),an adenosine A1receptor blocker,showed no action on theinhibitory effect of AMP579 on basal ***,GF109203X(0.4μmol/L),aspecial protein kinase C(PKC)blocker,could abolish the inhibitory effect of AMP579on basal I*** the inhibitory effect of AMP579 on basal ICaLwas inducedthrough activating PKC,but not linked to adenosine ***:AMP579 shows a stronger inhibitory effect than adenosine on the ICaLinducedby ***579 also has a strong inhibitory effect on basal ICaLin ratventricular *** of PKC is involved in the inhibitory effect ofAMP579 on basal ICaLat downstream-mechanism.

关键词： AMP579 adenosine heart ventricles cardiac myocytes L-type calcium channels patch-clamp techniques

Effects of Laser Parameters on Fast Electron Generation in a Multihole Array Target

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Chinese Physics Letters 2011年第3期28卷 128-131页

作者： JI Yan-Ling DUAN Tao JIANG Gang wu wei-dong TANG Yong-Jian Research Center of Laser Fusion China Academy of Engineering PhysicsPO Box 919-987Mianyang 621900 Laboratory for Extreme Conditions Matter Properties Southwest University of Science and TechnologyMianyang 621010 Institute of Atomic and Molecular Physics Sichuan UniversityChengdu 610065

The effects of laser parameters on the production of fast electrons from laser-multihole array target interaction are investigated theoretically via two-dimensional particle-in-cell *** results show that the fast electron temperature is scaled by I^(1/2)(λ)^(2)with I and(λ)being the laser intensity and *** the laser intensity reaches 2.14×10^(20)***^(-2),a typical bi-Maxwellian energy distribution is *** slope temperature of the low-energy component fits the linear scaling T_(h)~I^(1/2)*** high-energy component has an increased slope temperature comparable to ponderomotive potential scaling *** addition,the electron temperature rises linearly with the pulse duration,T_(h)~△_(t).The divergence angle of the fast electrons increases with laser intensity and pulse duration,but is independent of laser wavelength.

关键词： laser pulse scaling