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Si-wu-tang attenuates liver fibrosis via regulating lncRNA H19-dependent pathways involving cytoskeleton remodeling and ECM deposition

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Chinese Journal of Natural Medicines 2024年第1期22卷 31-46页

作者： QU Jiaorong XUE Xiaoyong WANG Zhixing MA Zhi JIA Kexin LI Fanghong ZHANG Yinhao wu Ruiyu ZHOU Fei ZHAO Piwen LI Xiaojiaoyang School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China

Liver fibrosis is a dynamic wound-healing response characterized by the agglutination of the extracellular matrix(ECM).Si-wu-tang(SWT),a traditional Chinese medicine(TCM)formula,is known for treating gynecological diseases and liver *** previous studies demonstrated that long non-coding RNA H19(H19)was markedly upregulated in fibrotic livers while its deficiency markedly reversed ***,the mechanisms by which SWT influences H19 remain ***,we established a bile duct ligation(BDL)-induced liver fibrosis model to evaluate the hepatoprotective effects of SWT on various cells in the *** results showed that SWT markedly improved ECM deposition and bile duct reactions in the ***,SWT relieved liver fibrosis by regulating the transcription of genes involved in the cytoskeleton remodeling,primarily in hepatic stellate cells(HSCs),and influencing cytoskeleton-related angiogenesis and hepatocellular *** modulation collectively led to reduced ECM *** extensive bioinformatics analyses,we determined that H19 acted as a miRNA sponge and mainly inhibited miR-200,miR-211,and let7b,thereby regulating the above cellular regulatory ***,SWT reversed H19-related miRNAs and signaling pathways,diminishing ECM deposition and liver ***,these protective effects of SWT were diminished with the overexpression of H19 in *** conclusion,our study elucidates the underlying mechanisms of SWT from the perspective of H19-related signal networks and proposes a potential SWT-based therapeutic strategy for the treatment of liver fibrosis.

关键词： Liver fibrosis LncRNA H19 Si-wu-tang miRNAs Cytoskeleton ECM deposition

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EXPONENTIAL DECAY FOR A NONLINEAR VISCOELASTIC EQUATION WITH SINGULAR KERNELS

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Acta Mathematica Scientia 2012年第6期32卷 2237-2246页

作者： Shun-tang wu General Education Center National Taipei University of Technology Taipei 106~ China

The nonlinear viscoelastic wave equation ｜μt｜^pμtt-△μ-μutt＋∫^t0g（t-s）△μ（s）ds＋｜μ｜^pU=0,in a bounded domain with initial conditions and Dirichlet boundary conditions is consid- ered. We prove that, for a class of kernels 9 which is singular at zero, the exponential decay rate of the solution energy. The result is obtained by introducing an appropriate Lyapounov functional and using energy method similar to the work of Tatar in 2009. This work improves earlier results.

关键词： viscoelastic wave equation kernel exponential decay memory term singular kernel

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BLOW-UP OF SOLUTION FOR A VISCOELASTIC WAVE EQUATION WITH DELAY

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Acta Mathematica Scientia 2019年第1期39卷 329-338页

作者： Shun-tang wu General Education Center National Taipei University of Technology

In this paper, we consider the following viscoelastic wave equation with delay|u_t|~ρu_(tt)-△u-△u_(tt)+∫_0~t g(t-8)△u(8)d8 + μ_1 u_t(x,t) + μ_2 u_t(x,t-τ) = b|u|^(p-2) u in a bounded domain. Under appropriate conditions on μ1, μ2, the kernel function g, the nonlinear source and the initial data, there are solutions that blow up in finite time.

关键词： blow up nonlinear source wave equation delay viscoelastic

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Crystalline Size Effects on Texture Coefficient,Electrical and Optical Properties of Sputter-deposited Ga-doped ZnO Thin Films

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Journal of Materials Science & Technology 2015年第2期31卷 175-181页

作者： Yaqin Wang wu tang Lan Zhang State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University

C-axis oriented Ga-doped ZnO(GZO) films with various thicknesses were deposited on glass substrate by radio frequency(RF) magnetron sputtering. The dependence of crystal structure,electrical,and optical properties of the GZO films on crystalline size were systematically studied. The results showed that the texture coefficient of (002) peak (TC(002)) decreases with increasing crystalline size. The Hall mobility m was reciprocal to electron effective mass and the fitted relaxation time s was 0.11±0.01 ms. With the increase of average crystalline size,the resistivity increased slightly,which is caused by the competition of (002) and(101) plane,introducing in some defects and leading to carrier density reduction. The optical band gap was in the range from 3.454 to 3.319 eV with increasing crystalline size from 26.96 to 30.88 nm,showing a negative relationship. The dependence of optical band gap (Eopg) on the crystalline size(R) can be qualitatively explained by a quantum confinement effect. The relationship between Eopg and R of GZO films suggests that tuning up optical properties for desired applications can be achieved by controlling the crystalline size.

关键词： Ga-doped ZnO film Crystalline size Texture coeffic

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Study on adhesion and electro-optical properties of ITO films on flexible PET substrate

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Rare Metals 2006年第z2期25卷 65-68页

作者： tang wu WENG Xiaolong wu Yutao DENG Longjiang State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 610054China

High-quality ITO films on flexible PET substrate were prepared by RF magnetron sputtering at low deposition temperature with different Ar gas sputtering *** and electro-optical properties of ITO films were investigated as a function of Ar partial *** sputtering conditions provide very uniform ITO films with high transparency(>85%in 400-760 nm spectra)and low electrical resistivity(1.408×10^(-3)-1.956×10^(-3)Ω·cm).Scratch test experiments indicate that there is a good adhesion property between ITO films and PET substrate,the critical characteristic load increases from 16.5 to 23.2 N with increasing Ar sputtering pressure from 0.2 to 1.4 Pa.

关键词： ITO films adhesion resistivity

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Properties of Resistivity, Reflection and Absorption Related to Structure of ITO Films

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Journal of Materials Science & Technology 2012年第4期28卷 325-328页

作者： Yipeng Chao wu tang Xuehui Wang State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technologyof ChinaChengdu 610054China

Indium tin oxide （ITO） films were fabricated on polyethylene terephthalate （PET） substrate at room temperature using dc magnetron sputtering technique with different sputtering powers. The structural, electrical and optical properties were investigated by X-ray diffraction （XRD）, Hall effect, reflection and transmission, respectively. XRD patterns show gradual enhancement of crystalline quality with increasing sputtering power. Significant improvement of Hall mobility due to the reduction of defects was observed though the carrier density varied slightly. Simultaneously, the mean transmission in visible light range decreased severely with increasing sputtering power. Slight move toward shorter-wavelength side of absorption peak was due to the variation of plasma wavelength. The reflection increase of near-infrared light originated from the decrease of resistivity. Finally, band gap was obtained using Tauc＇s relation and it was consistent with Burstein-Moss shift.

关键词： Crystalline quality Hall mobility Absorption

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Precipitation and stability of reversed austenite in 9Ni steel

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International Journal of Minerals,Metallurgy and Materials 2010年第5期17卷 587-595页

作者： Yue-hui Yang Qing-wu Cai Di tang Hui-bin wu Research Institute of Metallurgical Engineering University of Science and Technology Beijing Beijing 100083 China

A new method was used to analyze the factors affecting the precipitation of reversed austenite during tempering. The samples were kept at various tempering temperatures for 10 min and their length changes were recorded. Then, the precipitation of reversed austenite which led to the length reduction was shown by thermal expansion curves. The results show that the effects of process parameters on the precipitation of reversed austenite can be determined more accurately by this method than by X-ray diffraction. When the quenching and tempering process is adopted, both the lower quenching temperature and higher tempering temperature can promote the precipitation of reversed austenite during tempering; and when the quenching, lamellarizing, and tempering process is used, intercritical quenching is considered beneficial to the precipitation of reversed austenite in the subsequent tempering because of Ni segregation during holding at the intercritical temperature.

关键词： cryogenic equipment low carbon steel reversed austenite precipitation stability thermal expansion measurement

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Influence of isothermal bainitic processing on the mechanical properties and microstructure characterization of TRIP steel

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Journal of University of Science and Technology Beijing 2008年第5期15卷 574-579页

作者： Haitao Jiang Hubin wu Di tang Qiang Liu National Engineering Research Center for Advanced Rolling Technology University of Science and Technology Beijing Beijing 100083 China

The mechanical properties of transformation induced plasticity （TRIP） steel are strongly affected by the conditions of iso-thermal bainitic processing. The multiphase microstructure of TRIP steel under different conditions of isothermal bainitic processing was investigated using OM,SEM,XRD and TEM. The volume fraction of retained austenite and the carbon content in austenite were determined quantitatively using X-ray diffraction patterns. The relationship between mechanical properties and isothermal bainitic processing parameters was investigated. The stability of retained austenite was analyzed by the volume fraction of retained austenite and the carbon content in retained austenite. The experimental results show that the multiphase microstructure consists of ferrite,bainite and metastable retained *** obtain good mechanical properties,the optimal conditions of isothermal bainitic temperature and holding time are 410-430°C and 180-240 s,respectively. After isothermal bainitic processing under the optimal conditions,the corresponding volume fraction of retained austenite is 5vol%-15vol%,which can provide enough retained austenite and plastic stability for austenite with high carbon content.

关键词： transformation induced plasticity steel isothermal bainitic processing mechanical properties microstructure

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The Electrical Characterization and NIR Absorption of ITO Film under Different Sputtering Time

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稀有金属材料与工程 2012年第S1期41卷 306-308页

作者： Chao Yipeng tang wu Wang Xuehui Univ Elect Sci & Technol China State Key Lab Elect Thin Films & Integrated Devic Chengdu 610054 Peoples R China

Indium-tin-oxide(ITO)films with different sputtering time have been prepared by dc magnetron sputtering method on PET substrate at room *** film structure,thickness,electrical and optical properties are investigated through XRD,SEM,van der Pauw method and FTIR,*** XRD results indicate that all the films are amorphous *** the increase of sputtering time,resistivity and transmittance decrease *** the absorption gets stronger,especially in near-infrared light *** Drude model the plasma frequency is calculated and the calculation result is pretty consistent with films deposited at 60 and 90 min.

关键词： ITO films Drude model near-infrared absorption

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Tectonic Evolution and Key Geological Issues of the ProtoSouth China Sea

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Acta Geologica Sinica(English Edition) 2021年第1期95卷 77-90页

作者： TIAN Zhiwen tang wu WANG Pujun ZHAO Zhigang SUN Xiaomeng tang Huafeng Key Laboratory of Mineral Resources Evaluation in Northeast Asia Ministry of Land and ResourcesChangchun 130061China College of Earth Sciences Jilin UniversityChangchun 130061China CNOOC Research Institute Co. Ltd.Beijing 100028China

There are numerous controversies surrounding the tectonic properties and evolution of the Proto-South China Sea(PSCS).By combining data from previously published works with our geological and paleontological observations of the South China Sea(SCS),we propose that the PSCS should be analyzed within two separate contexts:its paleogeographic location and the history of its oceanic *** respect to its paleogeographic location,the tectonic properties of the PSCS vary widely from the Triassic to the mid-Late *** the Triassic,the Paleo-Tethys and the Paleo-Pacific Oceans were the major causes of tectonic changes in the SCS,while the PCSC may have been a remnant sea residing upon Tethys or Paleo-Pacific oceanic *** the Jurassic,the Meso-Tethys and the Paleo-Pacific oceans joined,creating a PSCS back-arc basin consisting of Meso-Tethys and/or Paleo-Pacific oceanic *** the Early Cretaceous to the midLate Cretaceous,the Paleo-Pacific Ocean was the main tectonic body affecting the SCS;the PSCS may have been a marginal sea or a back-arc basin with Paleo-Pacific oceanic *** respect to its oceanic crust,due to the subduction and retreat of the Paleo-Pacific plate in Southeast Asia at the end of the Late Cretaceous,the SCS probably produced new oceanic crust,which allowed the PSCS to formally *** this time,the PSCS was most likely a combination of a new marginal sea and a remnant sea;its oceanic crust,which eventually subducted and became extinct,consisted of both new oceanic crust and remnant oceanic crust from the Paleo-Pacific *** the present day,the remnant PSCS oceanic crust is located in the southwestern Nansha Trough.

关键词： tectonic evolution paleogeographic location new oceanic crust Proto-South China Sea

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