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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao Ren Cheng Xu Chengkuo lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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Cambrian Reefs in the Western North China Platform,Wuhai,Inner Mongolia

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Acta Geologica Sinica(English Edition) 2016年第6期90卷 1946-1954页

作者： lee Jeong-hyun KIM Byeong-Jun LIANG Kun PARK Tae-Yoon S. CHOH Suk-Joo lee Dong-Jin woo Jusun Department of Geology and Earth Environmental Sciences Chungnam National University Department of Geoenvironmental Sciences Kongju National University Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences Division of Polar Earth-System Sciences Korea Polar Research Institute Department of Earth and Environmental Sciences Korea University Department of Earth and Environmental Sciences Andong National University

Mid to late Cambrian thrombolites and maze-like maceriate reefs from the western North China Platform, Wuhai, Inner Mongolia, northwestern China, occur in the middle of a succession dominated by thin-bedded lime mudstone-shale/marlstone alternations, and are laterally surrounded by limestone conglomerate and/or grainstone. Thrombolite, characterized by meter-scale lenticular mounds composed of millimeter- to centimeter-scale mesoclots and wackestone matrix, occurs in the lower middle part of the sequence. Thrombolite mesoclots are composed of microstromatolites with alternating dark gray and light gray micritic laminae. The maze-like maceriate reefs occur in the middle to the upper part of the sequence, commonly forming lenticular mounds up to 1 m thick. They are characterized by centimeter- to decimeter-scale branched maze-like structures, whose biogenic portions （maceria） are selectively dolomitized. The maceriae are composed of poorly preserved microstromatolites and siliceous sponges. Inter-macerial sediments consist of lime mud and scattered bioclasts. These Wuhai reefs are generally similar to but older than various other Cambrian reefs previously reported from the Shandong region, northeastern China.

关键词： organosedimentary petrology reefal carbonate microbialite siliceous sponge Cambrian Series 3: Guzhangian North China Platform

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Simplified fistula dilation technique and modified stent deployment maneuver for EUS-guided hepaticogastrostomy

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World Journal of Gastroenterology 2014年第17期20卷 5051-5059页

作者： woo hyun Paik Do hyun Park Jun-Ho Choi Joon Hyuk Choi Sang Soo lee Dong Wan Seo Sung Koo lee Myung-Hwan Kim Jung Bok lee Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 138-736South Korea Department of Internal Medicine Inje University Ilsan Paik HospitalKoyang 411-706South Korea Department of Clinical Epidemiology and Biostatics University of Ulsan College of MedicineAsan Medical CenterSeoul 138-736South Korea

AIM: To evaluate the success rates, procedural time and adverse event rates of the modified methods in endoscopic ultrasonography-guided hepaticogastrostomy (EUS-HGS).

关键词： Endoscopic ultrasonography Biliary drainage Hepaticogastrostomy Treatment outcome Adverse event

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Development of tenofovir disoproxil fumarate resistance after complete viral suppression in a patient with treatment-na?ve chronic hepatitis B: A case report and review of the literature

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World Journal of Gastroenterology 2018年第17期24卷 1919-1924页

作者： woo Hee Cho hyun Jae lee Ki Bae Bang Seok Bae Kim Il Han Song Department of Internal Medicine Dankook University College of MedicineCheonan 31116South Korea

Tenofovir disoproxil fumarate(TDF) is a potent nucleo-tide analogue that is recommended as first-line therapy for patients with chronic hepatitis B. The results of a longitudinal study of TDF treatment demonstrated no development of resistance. We observed one treatment-na?ve chronic hepatitis B(CHB) patient who developed TDF resistance after complete viral suppression during long-term TDF treatment. A 37-year-old HBe Ag-positive man received TDF 300 mg/d for 43 mo. The hepatitis B virus(HBV) DNA titer was 8 log_(10) copies/m L at baseline and became undetectable at 16 mo after treatment. However, the HBV DNA titer rebounded to 7.5 log_(10) copies/m L at 43 mo after treatment. We performed full sequencing to find mutation sites associated with virologic breakthrough. The results showed 9 mutation sites, most of which had not been well-known as mutation sites. We changed the therapy from tenofovir to entecavir with a regimen of 0.5 mg once daily. After 4 mo, the HBV DNA titer decreased to 267 copies/m L, and the liver enzyme levels were normalized.

关键词： Chronic hepatitis B Tenofovir Resistance Mutation

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Effect of light scattering on the performance of a direct absorption solar collector

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Frontiers in Energy 2018年第1期12卷 169-177页

作者： Kwang hyun WON Bong Jae lee Department of Mechanical Engineering Korea Advanced Institute ofScience and Technology Daejeon 34141 South Korea

Recently, a solar thermal collector often employs nanoparticle suspension to absorb the solar radiation directly by a working fluid as well as to enhance its thermal performance. The collector efficiency of a direct absorption solar collector （DASC） is very sensitive to optical properties of the working fluid, such as absorption and scattering coefficients. Most of the existing studies have neglected particle scattering by assuming that the size of nanoparticle suspension is much smaller than the wavelength of solar radiation （i.e., Rayleigh scattering is applicable）. If the nanoparticle suspension is made of metal, however, the scattering cross-section of metallic nanoparticles could be comparable to their absorption cross-section depending on the particle size, especially when the localized surface plasmon （LSP） is excited. Therefore, for the DASC utilizing a plasmonic nanofluid supporting the LSP, light scattering from metallic particle suspension must be taken into account in the thermal analysis. The present study investigates the scattering effect on the thermal performance of the DASC employing plasmonic nanofluid as a working fluid. In the analysis, the Monte Carlo method is employed to numerically solve the radiative transfer equation considering the volume scatter- ing inside the nanofluid. It is found that the light scattering can improve the collector performance if the scattering coefficient of nanofluid is carefully engineered depending on its value of the absorption coefficient.

关键词： direct absorption solar collector plasmonicnanofluid light scattering

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Groundwater contamination and natural attenuation capacity at a petroleum spilled facility in Korea

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Journal of Environmental Sciences 2011年第10期23卷 1650-1659页

作者： hyun-Mi Choi Jin-Yong lee Department of Geology Kangwon National University

As a remedial option, the natural attenuation capacity of a petroleum contaminated groundwater at a military facility was examined. Hydrogeological conditions, such as high water level, permeable uppermost layer and frequent heavy rainfall, were favorable to natural attenuation at this site. The changes in the concentrations of electron acceptors and donors, as well as the relevant hydrochemical conditions, indicated the occurrence of aerobic respiration, denitrification, iron reduction, manganese reduction and sulfate reduction. The calculated BTEX expressed biodegradation capacity ranged between 20.52 and 33.67 mg/L, which appeared effective for the reduction of the contaminants levels. The contribution of each electron accepting process to the total biodegradation was in the order： denitrification 〉 iron reduction 〉 sulfate reduction 〉 aerobic respiration 〉 manganese reduction. The BTEX and benzene point attenuation rates were 0.0058-0.0064 and 0.0005-0.0032 day-1, respectively, and the remediation time was 0.7-1.2 and 2.5-30 years, respectively. The BTEX and benzene bulk attenuation rates were 8.69 × 10^-4 and 1.05 × 10^-3 day-l, respectively, and the remediation times for BTEX and benzene were 7.2 and 17.5 years, respectively. However, most of the natural attenuation occurring in this site can be attributed to dilution and dispersion. Consequently, the biodegradation and natural attenuation capacities were good enough to lower the contaminants levels, but their rates appeared to be insufficient to reach the remediation goal within a reasonable time frame. Therefore, some active remedial measures would be required.

关键词： petroleum contaminated site BTEX electron acceptor expressed biodegradation capacity natural attenuation

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Bacterial peptide deformylase inhibitor PMT analogs inhibit cancer cell growth by interacting with human peptide deformylase

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Chinese Science Bulletin 2014年第32期59卷 4274-4282页

作者： Won-Je Kim woo Sung Son Kyoung-Seok Ryu Seung-Kyu lee Kwang-hyun Choi Jong-Sun lee Bong-Jin lee College of Pharmacy Seoul National University Seoul 151-742Korea College of Pharmacy CHA University SeongnamGyeonggi-do 487-010 Korea Division of Magnetic Resonance Korea Basic Science InstituteOchang Campus Seoul Chungcheongbuk-Do 363-883 Korea Promeditech Ltd Seoul National University Seoul 151-742Korea

Potent inhibitors of human peptide deformylase(HsPDF)were screened using known PMT analog inhibitors of bacterial peptide ***-three species of PMT analogs that are non-peptidyl bacterial PDF inhibitors like actinonin were selected using virtual screening *** species out of 43 that could bind to HsPDF were selected and their antitumor activities were *** them,four species(PMT-172,PMT-173,PMT-199,and PMT-201)showed excellent growth inhibition of cancer cell in the MTT ***-PMT binding was confirmed through a1H-CPMG-T2filter NMR experiment leading to a significant change in peak intensity for PMT-172 and *** results suggest that PMT analogs could possibly interact with HsPDF and be a novel anticancer drug candidate.

关键词：相互作用抑制剂类似物 PMT 癌细胞类肽细胞生长细菌

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Creep and tensile properties of press molding joined GMT-sheets

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 170-174页

作者： Jin-woo KIM Dong-Gi lee Center for NDE Iowa State University Department of Mechatronics Engineering Chosun University

GMT-sheet is used in automobile bumper with high rigidity and strength, and its joining strength is influenced by lap length, one of the joined molding conditions. Fracture strength was calculated by dividing fracture load with cross-sectional area. Total five repeated measurements were made to obtain the average value. Tensile test was conducted at room temperature for 10 specimens. In addition, the effect of compression ratio on creep and tensile performance during lap joined molding was discussed. With increasing lap length, the lap joining efficiency of GMT-sheet was increased. However, higher compression ratio reduced the joining efficiency. Creep test on GMT-sheet showed abrupt fracture without tertiary creep. This can be explained by the weak thermal resistance of the resin. If GMT-sheet was exposed to high temperature for a long time, it was easily failed by external force.

关键词： GMT-sheet randomly oriented composite unidirectional oriented composite compression ratio lap joint

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Photo-Induced Electron Spin Polarization in a Narrow Band Gap Semiconductor Nanostructure

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Chinese Physics Letters 2012年第11期29卷 186-190页

作者： A.John Peter Chang woo lee Department of Chemical Engineering and Green Energy Center College of EngineeringKyung Hee University1 SeochunGihungYonginGyeonggi 446-701S.Korea

Photo-induced spin dependent electron transmission through a narrow gap InSb/InGa_(x)Sb_(1-x) semiconductor symmetric well is theoretically studied using transfer matrix *** transparency of electron transmission is calculated as a function of electron energy for different concentrations of *** spin-polarized photon assisted resonant tunnelling in the heterostructure due to Dresselhaus and Rashba spin-orbit coupling induced splitting of the resonant level and compressed spin-polarization are *** results show that Dresselhaus spin-orbit coupling is dominant for the photon effect and the computed polarization efficiency increases with the photon effect and the gallium concentration.

关键词： polarization resonant photon

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Contrast in Fluid M etallogeny between the Tianmashan Au-S Deposit and the Datuanshan Cu Deposit in Tongling,Anhui Province

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Acta Geologica Sinica(English Edition) 2003年第1期77卷 116-124页

作者： lee hyun Koo Depatment of Geology Chungnam National University 220 Kungdong Yuseong Ku Taejon 305-764 Republic of Korea

A comprehensive contrast of ore-forming geological background and ore-forming fluid features, especially fluid ore-forming processes, has been performed between the Tianmashan and the Datuanshan ore deposits in Tongling, Anhui Province. The major reasons for the formation of the stratabound skarn Au-S ore deposit in Tianmashan and the stratabound skarn Cu ore deposit in Datuanshan are analyzed in accordance with this contrast. The magmatic pluton in Tianmashan is rich in Au and poor in Cu, but that in Datuanshan is rich in Cu and Au. The wallrock strata in Tianmashan contain Au-bearing pyrite layers with some organic substance but those in Datuanshan contain no such layers. Moreover, the ore-forming fluids in Tianmashan are dominantly magmatic ones at the oxide and sulfide stages, but those with high content of Cu in Datuanshan are mainly groundwater fluids. In addition, differences in compositional evolution and physicochemical condition variation of the ore-forming fluids result in gradual dispersion

关键词： fluid inclusion fluid ore-forming process contrast in fluid metallogeny Au-S ore deposit Cu ore deposit magmatic fluid groundwater fluid Tongling Anhui Province

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