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Towards a respondent-preferred k_i-anonymity model

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Frontiers of Information Technology & Electronic Engineering 2015年第9期16卷 720-731页

作者： Kok-Seng wong Myung ho KIM School of Computer Science and Engineering Soongsil University School of Software Soongsil University

Recently, privacy concerns about data collection have received an increasing amount of attention. In data collection process, a data collector （an agency） assumed that all respondents would be comfortable with submitting their data if the published data was anonymous. We believe that this assumption is not realistic because the increase in privacy concerns causes some re- spondents to refuse participation or to submit inaccurate data to such agencies. If respondents submit inaccurate data, then the usefulness of the results from analysis of the collected data cannot be guaranteed. Furthermore, we note that the level of anonymity （i.e., k-anonymity） guaranteed by an agency cannot be verified by respondents since they generally do not have access to all of the data that is released. Therefore, we introduce the notion of ki-anonymity, where ki is the level of anonymity preferred by each respondent i. Instead of placing full trust in an agency, our solution increases respondent confidence by allowing each to decide the preferred level of protection. As such, our protocol ensures that respondents achieve their preferred kranonymity during data collection and guarantees that the collected records are genuine and useful for data analysis.

关键词： Anonymous data collection Respondent-preferred privacy protection k-anonymity

Solitary extraovarian primary peritoneal carcinoma with direct invasion into the liver,diaphragm and lung without peritoneal dissemination or distant metastasis

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 322-325页

作者： Billy ho Hung Cheung wong hoi She Siu Lun ho Albert Chi Yan Chan Chung Mau Lo Tan To Cheung Department of Surgery The University of Hong KongHong KongChina Department of Pathology The University of Hong KongHong KongChina

To the Editor:Extraovarian primary peritoneal carcinoma(EOPPC)is an uncommon malignancy with many similarities to epithelial ovarian carcinoma in histological,clinical,and etiological aspects[1].This phenomenon is explained by their common embryonal origin,in which both develop from the coelomic epithelium in the early embryological *** their similarities,the incidence of EOPPC is significantly lower than that of epithelial ovarian carcinoma(6.78 cases per million vs.120.5 cases per million)[1].

关键词： peritoneal invasion metastasis

On eco-planning for an eco-demonstration park (EDP) and sustainability-Case study of the Luhua EDP in the Chongming Island of Shanghai,China

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Frontiers of Environmental Science & Engineering 2008年第2期2卷 178-186页

作者： Xiangrong WANG Yi YONG Shixiong WANG Hao ZHANG Hing hon ho Pingjian WANG Shoubing WANG Weizhen CHEN Research Center for Urban Eco-Planning&Design Fudan UniversityShanghai 200433China Department of Biology State University of New York at New PaltzNew York 12561USA

Thebackground,concept,connotation,principles,andmethodsofeco-planningforanEco-Demonstration Park(EDP)and sustainability were examined based on a case study of the Luhua EDP in the Chongming Island of Shanghai,China,which is an important part of Shanghai Eco-city planning and construction in the 21st *** analyzing natural,social and economic conditions,calculating population using the land capacity eco-model,eco-function zoning,and eco-construction,an innovative eco-industrial structure and technical chain were formulated.A comprehensive eco-planning scheme for the EDP was proposed,including planning and management strategies for subsystems of efficient industry,good quality human settlement,high standard eco-construction and eco-tourism as well as effective environmental protection and attractive *** EDP should be an area with coordinated and sustainable economic,social and environmental ***-planning for the EDP should be a very important part of eco-city planning and *** paper aims to set up a theoretical framework and practical basis for eco-planning and promoting harmony between human and nature.

关键词： eco-demonstration park(EDP) eco-planning eco-model Luhua Chongming Island Shanghai

Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

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Bioactive Materials 2023年第9期27卷 303-326页

作者： Shang Lyu Zhifei Dong Xiaoxiao Xu ho-Pan Bei ho-Yin Yuen Chung-Wai James Cheung Man-Sang wong Yong He Xin Zhao Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHung HomHong Kong SARPR China Faculty of Science University of WaterlooWaterlooOntarioCanada State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhouPR China

Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading capacity. Although microneedles are initially designed to penetrate stratum corneum of skin for transdermal drug delivery, they, recently, have been used to promote wound healing and regeneration of diverse tissues and organs and the results are promising. Despite there are reviews about microneedles, few of them focus on wound healing and tissue regeneration. Here, we review the recent advances of microneedles in this field. We first give an overview of microneedle system in terms of its potential cargos (e.g., small molecules, macromolecules, nucleic acids, nanoparticles, extracellular vesicle, cells), structural designs (e.g., multidrug structures, adhesive structures), material selection, and drug release mechanisms. Then we briefly summarize different microneedle fabrication methods, including their advantages and limitations. We finally summarize the recent progress of microneedle-assisted wound healing and tissue regeneration (e.g., skin, cardiac, bone, tendon, ocular, vascular, oral, hair, spinal cord, and uterine tissues). We expect that our article would serve as a guideline for readers to design their microneedle systems according to different applications, including material selection, drug selection, and structure design, for achieving better healing and regeneration efficacy.

关键词： Microneedles Microfabrication Wound healing Tissue regeneration Drug delivery

NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation

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Cellular & Molecular Immunology 2016年第4期13卷 535-550页

作者： Delong Jiao Chun-Kwok wong Huai-Na Qiu Jie Dong Zhe Cai Man Chu Kam-Lun hon Miranda Sin-Man Tsang Christopher Wai-Kei Lam Department of Chemical Pathology The Chinese University of Hong Kong Prince of Wales Hospital Shatin NT Hong Kong China Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Hong Kong China Department of Paediatrics The Chinese University of Hong Kong Prince of Wales Hospital Shatin NT Hong Kong China State Key Laboratory of Quality Research in Chinese Medicine Macao institute for Applied Research in Medicine and Health Macao University of Science and Technology Taipa Macao People's Republic of China

The skin of patients with atopic dermatitis （AD） has a unique predisposition for colonization by Staphylococcus aureus （S. aureus）, which contributes to the inflammation and grim prognosis of AD. Although the mechanism underlying the S. aureus-induced exacerbation of AD remains unclear, recent studies have found a pivotal role for pattern recognition receptors in regulating the inflammatory responses in S. aureus infection. In the present study, we used a typical mouse model of AD-like skin inflammation and found that S. aureus-associated nucleotide-binding oligomerization domain-containing protein 2 （NOD2） and toll-like receptor 2 （TLR2） ligands exacerbated AD-like symptoms, which were further deteriorated by the in vivo expansion of basophils and eosinophils. Subsequent histological analyses revealed that dermal fibroblasts were pervasive in the AD-like skin lesions, Co-culture of human dermal fibroblasts with basophils and eosinophils resulted in a vigorous cytokine/chemokine response to the NOD2/TLR2 ligands and the enhanced expression of intercellular adhesion molecule-1 on the dermal fibroblasts. Basophils and eosinophils were primarily responsible for the AD-related cytokine/chemokine expression in the co-cultures. Direct intercellular contact was necessary for the crosstalk between basophils and dermal fibroblasts, while soluble mediators were sufficient to mediate the eosinophil-fibroblast interactions. Moreover, the intracellular p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and nuclear factor-kappa B signaling pathways were essential for NOD2/TLR2 ligand-mediated activation of basophils, eosinophils, and dermal fibroblasts in AD-related inflammation. This study provides the evidence of NOD2/TLR2-mediated exacerbation of AD through activation of innate immune cells and therefore sheds light on a novel mechanistic pathway bv which S. aureus contributes to the DathoDhvsiology of AD.

关键词： atopic dermatitis basophils, eosinophils NOD2 TLR2

Performance of the hybrid growth sequencing batch reactor(HG-SBR) for biodegradation of phenol under various toxicity conditions

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Journal of Environmental Sciences 2019年第1期31卷 64-72页

作者： NikAthirah Yusoff Soon-An Ong Li-Ngee ho Yee-Shian wong Farah Naemah Mohd Saad WanFadhilah Khalik Sin-Li Lee School of Environmental Engineering University Malaysia Perlis School of Materials Engineering University Malaysia Perlis

Hybrid growth microorganisms in sequencing batch reactors have proven effective for treating the toxic compound phenol, but the toxicity effect under different toxicity conditions has rarely been discussed. Therefore, the performance of the HG-SBR under toxic, acute and chronic organic loading can provide the overall operating conditions of the system. Toxic organic loading(TOL) was monitored during the first 7 hr while introducing50 mg/L phenol to the system. The system was adversely affected with the sudden introduction of phenol to the virgin activated sludge, which caused a low degradation rate and high dissolved oxygen consumption during TOL. Acute organic loading(AOL) had significant effects at high phenol concentrations(600, 800 1000 mg/L). The specific oxygen uptake rate(SOUR) gradually decreased to 4.9 mg O_2/(g MLVSS·hr) at 1000 mg/L of phenol compared to 12.74 mg O_2/(g MLVSS·hr) for 200 mg/L of phenol. The HG-SBR was further monitored during chronic organic loading(COL) over 67 days. The effects of organic loading were more apparent at 800 mg/L and 1000 mg/L phenol concentrations, as the removal range was between 22%–30% and 18%–46% respectively, which indicated the severe effects of COL.

关键词： Toxic organic loading Acute organic loading Chronic organic loading Phenol Sequencing batch reactor

Post-fontan circulation hepatocellular carcinoma:Open and laparoscopic hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 90-93页

作者： Karin KY ho wong hoi She Simon HY Tsang Kevin S Lo Tan To Cheung Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Anaesthesiology Queen Mary Hospital102 Pok Fu Lam RoadHong KongChina

To the Editor:Fontan-associated liver disease shows increasing incidence as advances in pediatric cardiology have prolonged life expectancy in patients with single ventricle congenital heart defects[1].Their unique physiology and procedure-related sequelae present an increasingly relevant challenge in hepatic *** hereby reported a series of patients suffering from hepatocellular carcinoma(HCC)who successfully underwent open and laparoscopic hepatectomy.

关键词： hepatocellular hepatectomy surgery

Lithographic patterning of ferromagnetic FePt nanoparticles from a single-source bimetallic precursor containing hemiphasmidic structure for magnetic data recording media

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Science China Materials 2019年第4期62卷 566-576页

作者： Zhengong Meng Cheuk-Lam ho hon-Fai wong Zhen-Qiang Yu Nianyong Zhu Guijun Li Chi-Wah Leung Wai-Yeung wong College of Chemistry and Environmental Engineering Shenzhen University Institute of Molecular Functional Materials and Department of Chemistry Hong Kong Baptist University HKBU Institute of Research and Continuing Education Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Applied Physics The Hong Kong Polytechnic University

Patterning of L10 FePt nanoparticles(NPs) with high coercivity offers a promising route to develop bit-patterned media(BPM) for the next generation magnetic data recording system, but the synthesis of monodisperse FePt NPs and mass production of their nanopatterns has been a longstanding challenge. Here, highly efficient nanoimprint lithography was applied for large-scale universal patterning, which was achieved by imprinting the solution of a single-source bimetallic precursor. The rigid coplanar metallic cores and the surrounding flexible tails in the bimetallic complex permit the spontaneous molecular arrangements to form the highly ordered negative morphology replicated from the soft ***-situ pyrolysis study was then investigated by one-pot pyrolysis of the precursor under an Ar/H2 atmosphere, and the resultant NPs were fully characterized to identify the phase,morphology and magnetic properties. Finally, highly-ordered patterns on certain substrates were preserved perfectly after pyrolysis and could be potentially utilized in magnetic data recording media.

关键词： FePt nanoparticles single-source bimetallic precursors one-pot pyrolysis lithographic patterning magnetic data recording media

Optically invariant InGaN nanowire light-emitting diodes on flexible substrates under mechanical manipulation

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npj Flexible Electronics 2019年第1期3卷 120-125页

作者： Mohsen Asad Renjie Wang Yong-ho Ra Pranav Gavirneni Zetian Mi William S.wong Department of Electrical and Computer Engineering University of WaterlooWaterlooON N2L 3G1Canada Waterloo Institute for Nanotechnology University of WaterlooWaterlooON N2L 3G1Canada Department of Electrical and Computer Engineering McGill UniversityMontrealQC H3A 0E9Canada Department of Electrical and Computer Engineering University of MichiganAnn ArborMI 48109USA

The integration of GaN-based light-emitting diodes(LEDs)onto flexible platforms provides opportunities for conformal lighting,wearable electronics,and bendable *** this technology may enhance the functionality of the light source,the development of flexible GaN LEDs suffers from performance degradation,when mechanical bending is applied during operation.A unique approach to eliminate the degradation employs dot-in-wire structures,using cylindrical light-emitting heterostructures that protrude above the flexible platform,separating the active light-emitting region from the bending ***,we demonstrate the optical enhancement of nanowire light emitters by changing the geometric orientation within a 1×1 mm^(2) array of nanowires on a flexible platform through bending of the substrate *** flexible structures were achieved by transferring GaN nanowire LEDs from sapphire substrates onto flexible polyethylene terephthalate(PET)using a“paste-and-cut”integration *** I–V characteristics of the nanowire LEDs showed negligible change after integration onto the PET,with a turn-on voltage of 2.5 V and a forward current of 400μA at 4 V.A significant advantage for the nanowire devices on PET was demonstrated by tilting the LEDs through substrate bending that increased the electroluminescence(EL)intensity,while the I–V characteristics and the EL peak position remained *** finite-element analysis and three-dimensional finite-difference time-domain modeling,it was determined that tilting the protruding devices changed the effective distance between the structures,enhancing their electromagnetic coupling to increase light output without affecting the electrical properties or peak emission wavelength of the LEDs.

关键词： diodes sapphire light