Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

作     者：Shang Lyu Zhifei Dong Xiaoxiao Xu Ho-Pan Bei Ho-Yin Yuen Chung-Wai James Cheung Man-Sang Wong Yong He Xin Zhao 

作者机构：Department of Biomedical EngineeringThe Hong Kong Polytechnic UniversityHung HomHong Kong SARPR China Faculty of ScienceUniversity of WaterlooWaterlooOntarioCanada State Key Laboratory of Fluid Power and Mechatronic SystemsSchool of Mechanical EngineeringZhejiang UniversityHangzhouPR China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第27卷第9期

页      面：303-326页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 

基　　金：supported by the grant from the Guangdong Basic and Applied Basic Research Foundation(2020B1515130002) Collaborative Research with World-leading Research Groups from The Hong Kong Polytechnic University(P0039523) National Excellent Young Scientists Fund(Hong Kong and Macao),National Natural Science Foundation of China(No.82122002) National Natural Science Foundation of China(No.U1909218) the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.T2121004) 

主　　题：Microneedles Microfabrication Wound healing Tissue regeneration Drug delivery 

摘      要：Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading capacity. Although microneedles are initially designed to penetrate stratum corneum of skin for transdermal drug delivery, they, recently, have been used to promote wound healing and regeneration of diverse tissues and organs and the results are promising. Despite there are reviews about microneedles, few of them focus on wound healing and tissue regeneration. Here, we review the recent advances of microneedles in this field. We first give an overview of microneedle system in terms of its potential cargos (e.g., small molecules, macromolecules, nucleic acids, nanoparticles, extracellular vesicle, cells), structural designs (e.g., multidrug structures, adhesive structures), material selection, and drug release mechanisms. Then we briefly summarize different microneedle fabrication methods, including their advantages and limitations. We finally summarize the recent progress of microneedle-assisted wound healing and tissue regeneration (e.g., skin, cardiac, bone, tendon, ocular, vascular, oral, hair, spinal cord, and uterine tissues). We expect that our article would serve as a guideline for readers to design their microneedle systems according to different applications, including material selection, drug selection, and structure design, for achieving better healing and regeneration efficacy.