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Immunosuppressant treatment for IgG4-related sclerosing cholangitis: A case report

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World Journal of Clinical Cases 2021年第1期9卷 267-273页

作者： Jong-Sun Kim won Ho choi Kyung-Ann Lee Hyun-Sook Kim Department of Internal Medicine Soonchunhyang University Seoul HospitalSeoul 04401South Korea

BACKGROUND Immunoglobulin G4-related disease(IgG4-RD)is a multi-system fibroinflammatory disorder that can involve any organ,including the salivary glands,pancreas,and biliary *** of immunoglobulin G4-related sclerosing cholangitis(IgG4-SC)is similar to that for IgG4-RD,but progression is irreversible in some *** present a case of IgG4-SC in which an immuno-suppressant induced marked clinical and radiologic *** SUMMARY A 63-year-old male presented with a prominent itching sensation and wholebody *** showed obstructive-pattern jaundice,an elevated IgG4 level,and infiltration of a large number of IgG4-positive cells in the ampulla of *** imaging findings of intrahepatic duct(IHD)and common bile duct dilation,an elevated serum IgG4 level,and characteristic histological findings led to diagnosis of IgG4-SC that compatible with the 2019 ACR/EULAR classification *** planned to treat the patient with high-dose glucocorticoid(GC),followed by cyclophosphamide pulse *** treatment with high-dose GC and an immunosuppressant,imaging studies showed that IHD dilatation had completely *** Prompt diagnosis and appropriate treatment of IgG4-SC are *** there is a risk of relapse of IgG4-SC,the GC dose should be gradually reduced,and a maintenance immunosuppressant should be given.

关键词： Immunoglobulin G4-related disease Immunoglobulin G4-related sclerosing cholangitis Glucocorticoid Immunosuppressant Case report ACR/EULAR classification criteria

Comparison of juvenile growth of wild and hatchery-raised olive flounders Paralichthys olivaceus as examined by otolith microstructure

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Aquaculture and Fisheries 2020年第1期5卷 52-57页

作者： Juri Yoo Tae won Lee Keun-Hyung choi Department of Oceanography and Ocean Environmental Sciences Chungnam National UniversityDaejeon34134South Korea

Fish stocking is a common practice for restocking wild populations of fishes,and the growth conditions of hatchery-raised fishes are a major key for successful ***,there are few studies that compare the growth of hatchery-reared juvenile fishes with wild *** compared the growth conditions of hatchery flounders,Paralichthys olivaceus,at two fish farms in Korea with that of natural *** of the relationships of growth parameters including total length-weight,otolith-total length,and weight/length ratio relative to otolith length indicated that the growth was similar between the wild and the reared fishes at the two fish *** results suggest that the fishes grown at farming facilities should have a similar probability of recruitment as wild juveniles.

关键词： Olive flounder Paralichthys olivaceus Fish growth Otolith Fish stocking

Anemia after gastrectomy for early gastric cancer:Long-term follow-up observational study

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World Journal of Gastroenterology 2012年第42期18卷 6114-6119页

作者： Chul-Hyun Lim Sang Woo Kim won Chul Kim Jin Soo Kim Yu Kyung Cho Jae Myung Park In seok Lee Myung-Gyu choi Kyo-Young Song Hae Myung Jeon Cho-Hyun Park Department of Internal Medicine The Catholic University of Korea College of MedicineSeoul 137-701South Korea Department of Surgery The Catholic University of Korea College of MedicineSeoul 137-701South Korea

AIM:To identify the incidence and etiology of anemia after gastrectomy in patients with long-term follow-up after gastrectomy for early gastric ***:The medical records of those patients with early gastric adenocarcinoma who underwent curative gastrectomy between January 2006 and October 2007 were *** with anemia in the preoperative workup,cancer recurrence,undergoing systemic chemotherapy,with other medical conditions that can cause anemia,or treated during follow up with red cell transfusions or supplements for anemia were *** was defined by World Health Organization criteria(Hb 100 fL) with vitamin B 12 *** profile of anemia over 48 mo of follow-up was ***:One hundred sixty-one patients with gastrectomy for early gastric cancer were *** incidence of anemia was 24.5% at 3 mo after surgery and increased up to 37.1% at 48 mo after *** incidence of iron deficiency anemia increased during the follow up and became the major cause of anemia at 48 mo after *** of chronic disease and megaloblastic anemia were *** incidence of anemia in female patients was significantly higher than in male patients at 12(40.0% vs 22.0%,P = 0.033),24(45.0% vs 25.0%,P = 0.023),36(55.0% vs 28.0%,P = 0.004),and 48 mo(52.0% vs 31.0%,P = 0.022) after *** with total gastrectomy showed significantly higher incidence of anemia than patients with subtotal gastrectomy at 48 mo after surgery(60.7% vs 31.3%,P = 0.008).The incidence of iron deficiency was significantly higher in female patients than in male patients at 6(35.4% vs 13.3%,P = 0.002),12(45.8% vs 16.8%,P

关键词： Gastrectomy Stomach neoplasms Anemia Iron deficiency Vitamin B 12 deficiency

Highly Concentrated,Conductive,Defect-free Graphene Ink for Screen-Printed Sensor Application

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Nano-Micro Letters 2021年第6期13卷 17-30页

作者： Dong seok Kim Jae-Min Jeong Hong Jun Park Yeong Kyun Kim Kyoung G.Lee Bong Gill choi Department of Chemical Engineering Kangwon National UniversitySamcheokGangwon-do 25913Republic of Korea Resources Utilization Research Center Korea Institute of Geoscience and Mineral ResourcesDaejeon 34132Republic of Korea Center for Nano Bio Development National Nanofab CenterDaejeon 34141Republic of Korea

Conductive inks based on graphene materials have received significant attention for the fabrication of a wide range of printed and flexible ***,the application of graphene fillers is limited by their restricted mass production and the low concentration of their *** this study,a highly concentrated and conductive ink based on defect-free graphene was developed by a scalable fluid dynamics process.A high shear exfoliation and mixing process enabled the production of graphene at a high concentration of 47.5 mg mL^(−1)for graphene *** screen-printed graphene conductor exhibits a high electrical conductivity of 1.49×10^(4)S m^(−1)and maintains high conductivity under mechanical bending,compressing,and fatigue *** on the as-prepared graphene ink,a printed electrochemical sodium ion(Na^(+))sensor that shows high potentiometric sensing performance was ***,by integrating a wireless electronic module,a prototype Na^(+)-sensing watch is demonstrated for the real-time monitoring of the sodium ion concentration in human sweat during the indoor exercise of a *** scalable and efficient procedure for the preparation of graphene ink presented in this work is very promising for the low-cost,reproducible,and large-scale printing of flexible and wearable electronic devices.

关键词： Graphene ink Fluid dynamics Screen printing Ion sensor Real-time monitoring

Formation of spherical alloy microparticles in a porous salt medium

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Journal of Materials Science & Technology 2020年第8期36卷 189-196页

作者： Hayk HNersisyan Suk Cheol Kwon Vladislav E.Ri Wan Bae Kim Woo seok choi Jong Hyeon Lee RASOM Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Graduate School of Materials Science and Engineering Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea

This study describes the development of a one-pot strategy to produce spherical alloy microparticles for advanced near-net-shape manufacturing processes, including additive manufacturing and powder injection molding. The Al Si12 eutectic alloy(ca. 12 wt% Si) system was chosen as the model with which the main experiments were carried out. The proposed process synergistically integrates a few common,low-cost processing techniques including the mixing of Al micrometer size particles with silicon and sodium chloride, heat-treating the mixture at temperatures of 650–810°C, and the dissolution of salt in water to produce spherical Al Si12 alloy particles without the need to rely on costly melting and atomizing techniques. This new process can use laow-cost source Al and Si powders as the raw materials to produce10–200 um-sized spherical particles of Al Si12. The Ansys-CFX computational fluid dynamics software was used to analyze the flow behavior of Al Si12 liquid droplets and particle size refinement in the narrow voids of the sample.

关键词： AlSi(12)alloy Morphology evaluation Particle distribution Simulation Solid-liquid transition Spheroidization

Direct Synthesis of Molybdenum Phosphide Nanorods on Silicon Using Graphene at the Heterointerface for Efficient Photoelectrochemical Water Reduction

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Nano-Micro Letters 2021年第5期13卷 135-150页

作者： Sang Eon Jun seokhoon choi Shinyoung choi Tae Hyung Lee Changyeon Kim Jin Wook Yang Woon‑Oh Choe In‑Hyuk Im Cheol‑Joo Kim Ho won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea

Transition metal phosphides(TMPs)and transition metal dichalcogenides(TMDs)have been widely investigated as photoelectrochemical(PEC)catalysts for hydrogen evolution reaction(HER).Using high-temperature processes to get crystallized compounds with large-area uniformity,it is still challenging to directly synthesize these catalysts on silicon photocathodes due to chemical incompatibility at the ***,a graphene interlayer is applied between p-Si and MoP nanorods to enable fully engineered interfaces without forming a metallic secondary compound that absorbs a parasitic light and provides an inefficient electron path for hydrogen ***,the graphene facilitates the photogenerated electrons to rapidly transfer by creating Mo-O-C covalent bondings and energetically favorable band *** a bridging role of graphene,numerous active sites and anti-reflectance of MoP nanorods lead to significantly improved PEC-HER performance with a high photocurrent density of 21.8 mA cm−2 at 0 V versus RHE and high ***,low dependence on pH and temperature is observed with MoP nanorods incorporated photocathodes,which is desirable for practical use as a part of PEC *** results indicate that the direct synthesis of TMPs and TMDs enabled by graphene interlayer is a new promising way to fabricate Si-based photocathodes with high-quality interfaces and superior HER performance.

关键词： Photoelectrochemical water splitting Silicon Molybdenum phosphide Hydrogen evolution Graphene

Clinicopathological significance of altered Notch signaling in extrahepatic cholangiocarcinoma and gallbladder carcinoma

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World Journal of Gastroenterology 2011年第35期17卷 4023-4030页

作者： Hyun Ah Yoon Myung Hwan Noh Byung Geun Kim Ji Sun Han Jin seok Jang seok Ryeol choi Jin Sook Jeong Jin Ho Chun Department of Gastroenterology Dong-A University Hospital3-1Dong dae shindongSeo-guBusan 602-715South Korea Department of Pathology Dong-A University Hospital3-1Dong dae shin-dongSeo-guBusan 602-715 South Korea Department of Preventive Medicine Inje University HospitalGae gum 2-dongBusanjinguBusan 614-735 South Korea

AIM:To investigate the role and clinicopathological significance of aberrant expression of Notch receptors and Delta-like ligand-4 (DLL4) in extrahepatic cholangiocarcinoma and gallbladder ***:One hundred and ten patients had surgically resected extrahepatic cholangiocarcinoma (CC) and gallbladder carcinoma specimens examined by immunohistochemistry of available paraffin *** was performed using anti-Notch receptors 1-4 and anti-DLL4 *** scored the immunopositivity of Notch receptors and DLL4 expression by percentage of positive tumor cells with cytoplasmic expression and intensity of *** nuclear localization was ***-logical parameters and survival data were compared with the expression of Notch receptors 1-4 and ***:Notch receptor proteins showed in the cytoplasm with or without nuclear expression in cancer cells,as well as showing weak cytoplasmic expression in non-neoplastic *** semiquantitative evaluation,positive immunostaining of Notch receptor 1 was detected in 96 cases (87.3%),Notch receptor 2 in 97 (88.2%),Notch receptor 3 in 97 (88.2%),Notch receptor 4 in 103 (93.6),and DLL4 in 84 (76.4%).In addition,coex- istent nuclear localization was noted [Notch receptor 1;18 cases (18.8%),Notch receptor 2;40 (41.2%),Notch receptor 3;32 (33.0%),Notch receptor 4;99 (96.1%),DLL4;48 (57.1%)].Notch receptor 1 expression was correlated with advanced tumor,node,metastasis (TNM) stage (P=0.043),Notch receptor 3 with advanced T stage (P=0.017),tendency to express in cases with nodal metastasis (P=0.065) and advanced TNM stage (P=0.052).DLL4 expression tended to be related to less histological differentiation (P=0.095).Coexistent nuclear localization of Notch receptor 3 was related to no nodal metastasis (P=0.027) and Notch receptor 4 with less histological differentiation (P=0.036),while DLL4 tended to be related inversely with T stage (P=0.053).Coexistent nuclear localizatio

关键词： Notch receptors Delta-like ligand-4 Cholangio-carcinoma Gallbladder carcinoma Immunohistochemistry

CO2/CH4 separation using inside coated thin film composite hollow fiber membranes prepared by interfacial polymerization

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Chinese Journal of Chemical Engineering 2017年第3期25卷 278-287页

作者： Eun-Sung Jo Xinghai An Pravin G.Ingole won-Kil choi Yeong-Sung Park Hyung-Keun Lee Korea Institute of Energy Research(KIER) 71-2 Jang-dongYuseong-guDaejeon 205343Republic of Korea Department of Environmental Engineering Daejeon UniversityDaejeonRepublic of Korea Department of Advanced Energy and Technology University of Science and Technology(UST)217 Gajeong-roYuseong-guDaejeon 305-350Republic of Korea

Carbon dioxide(CO_2) is greenhouse gas which originates primarily as a main combustion product of biogas and landfill gas. To separate this gas, an inside coated thin film composite(TFC) hollow fiber membrane was developed by interfacial polymerization between 1,3–cyclohexanebis–methylamine(CHMA) and trimesoyl chloride(TMC). ATR-FTIR, SEM and AFM were used to characterize the active thin layer formed inside the PSf hollow fiber. The separation behavior of the CHMA-TMC/PSf membrane was scrutinized by studying various effects like feed gas pressure and temperature. Furthermore, the influence of CHMA concentration and TMC concentration on membrane morphology and performance were investigated. As a result, it was found that mutually the CHMA concentration and TMC concentration play key roles in determining membrane morphology and performance. Moreover, the CHMA-TMC/PSf composite membrane showed good CO_2/CH_4 separation performance. For CO_2/CH_4 mixture gas(30/70 by volume) test, the membrane(PD1 prepared by CHMA 1.0% and TMC 0.5%) showed a CO_2 permeance of 25 GPU and the best CO_2/CH_4 selectivity of 28 at stage cut of 0.1. The high CO_2/CH_4 separation performance of CHMA-TMC/PSf thin film composite membrane was mostly accredited to the thin film thickness and the properties of binary amino groups.

关键词： Thin-film composite hollow fiber membrane Interfacial polymerization CHMA/TMC CO2/CH4 separation

Formation of unidirectional nanoporous structures in thickly anodized aluminum oxide layer

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中国有色金属学会会刊：英文版 2009年第4期19卷 1013-1017页

作者： Hyun-Chae NA Taek-Jin SUNG seok-Heon YOON Seung-Kyoun HYUN Mok-Soon KIM Young-Gi LEE Sang-Hyun SHIN seok-Moon choi Sung YI Division of Materials Science and Engineering Inha University Samsung Electro-Mechanics Co. Ltd.

A series of anodic aluminum oxide(AAO) was grown on the commercially pure 1050 aluminum sheet by controlling electrolyte temperature(2-15 ℃) and anodizing time(0.5-6 h),using a fixed applied current density of 3 A/dm2 in diluted sulfuric acid electrolyte.A crack-free thick AAO with the thickness of 105-120 μm and containing unidirectional nano sized pores(average pore diameter of 5-7 nm) is successfully achieved in the specimens anodized for 2 h,irrespective of electrolyte *** anodizing time reaches 6 h,very thick AAO with the thickness of 230-284 μm is grown,and average diameter of unidirectional pores is in the range of 6-24 *** higher values in both the AAO thickness and pore diameter are attained for the specimens anodized at higher temperatures of 10-15 ℃.A crack is observed to exist in the AAO after anodizing up to 4 h and more.A higher fraction(more than 9%) of the crack is shown in the specimens anodized at higher temperatures of 10-15 ℃ for 6 h and a considerable amount of giant cracks are contained.

关键词：阳极氧化铝纳米孔单向结构层电解液温度平均直径氧化时间硫酸电解液