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Neural Regeneration Research 2014年第23期9卷 2032-2035页

作者： Jong-Ho Cha Kyu-won kim SNU-Harvard Neuro Vascular Protection Research Center College of Pharmacy Seoul National University Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science and Technology and College of Medicine or College of PharmacySeoul National University

The central nervous system （CNS） contains the two most important organs, the brain and spinal cord, for the orchestration of the mental and physical activities of life. Because of its importance, the human body has evolved barrier systems to protect CNS tissue from the external environment. This barrier is a membrane composed of tightly apposed cells and is selectively permeable to specific molecules by way of membrane transporters.

关键词： EMT and immune cell trapping Standby CNS structure as novel mechanisms for limiting neuronal damage after CNS injury cell

Collagen fleece(Tachosil®)for treating testis torsion:A case report

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World Journal of Clinical Cases 2023年第18期11卷 4306-4312页

作者： ki Min kim Jae Heon kim Department of Urology Soonchunhayng University Seoul HospitalSeoul 04410South Korea

BACKGROUND Testicular torsion is an emergent disease in urology,and there has been discussion of the treatment of testicular *** decompression has been established as a critical treatment for testicular compartment syndrome(TCS),which occurs after detorsion in a patient who is diagnosed with testis *** now,testicular fasciotomy and incision of tunica albuginea with tunica vaginalis flap(TVF)graft have been suggested for decompression,and some studies about the efficacy of TVF were ***,this method is time consuming and needs meticulous technique,so other methods such as orchio-septopexy are *** objective of this clinical case report was to propose new surgical method using collagen fleece(Tachosil®)instead of tunica vagina *** SUMMARY A 5-year-old boy with scrotal pain visited our hospital 24 h after symptom *** history taking,physical examination,and scrotum ultrasonography,he was diagnosed with testis *** surgery was performed after *** the incision of scrotum and fasciotomy,we covered his tunica albuginea with collagen fleece called Tachosil®instead of covering with *** Short-term follow-up showed normal blood flow in testis without a *** is the first case report of using Tachosil®in testicular torsion surgery,and its advantages were already reported in other surgeries like Peyronie’s *** case suggests this new technique is an appropriate method because of its advantages including its cost-effective and time-saving *** main limitation is the short follow-up,so more studies are needed to provide a high level of evidence about its efficacy and safety.

关键词： Testicular torsion Testicular compartment syndrome Collagen fleece Tachosil® Case report

Efficacy of chemotherapy containing bevacizumab in patients with metastatic colorectal cancer according to programmed cell death ligand 1

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3521-3528页

作者： Shin Woo Kang Sung Hee Lim Min-Ji kim Jeeyun Lee Young Suk Park Ho Yeong Lim won ki Kang Seung Tae kim Division of Hematology Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Samsung Biomedical Research Institute Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Bevacizumab,an anti-vascular endothelial growth factor(VEGF)monoclonal antibody,inhibits angiogenesis and reduces tumor *** VEGF-C,lactate dehydrogenase,and inflammatory markers have been reported as predictive markers related to bevacizumab *** cell death ligand 1(PD-L1)could act upon VEGF receptor 2 to induce cancer cell angiogenesis and *** To investigate the efficacy of bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer(CRC)according to the expression of *** This analysis included CRC patients who received bevacizumab plus FOLFOX or FOLFIRI as first-line therapy between June 24,2014 and February 28,2022,at Samsung Medical Center(Seoul,South Korea).Analysis of patient data included evaluation of PD-L1 expression by the combined positive score(CPS).We analyzed the efficacy of bevacizumab according to PD-L1 expression status in patients with *** A total of 124 patients was included in this *** all patients were treated with bevacizumab plus FOLFIRI or FOLFOX as the first-line *** 77%of patients received FOLFOX,23%received FOLFIRI as backbone first-line *** numbers of patients with a PD-L1 CPS of 1 or more,5 or more,or 10 or more were 105(85%),64(52%),and 32(26%),*** results showed no significant difference in progression-free survival(PFS)and overall survival(OS)with bevacizumab treatment between patients with PDL1 CPS less than 1 and those with PD-L1 CPS of 1 or more(PD-L1<1%vs PD-L1≥1%;PFS:P=0.93,OS:P=0.33),between patients with PD-L1 CPS less than 5 and of 5 or more(PD-L1<5%vs PD-L1≥5%;PFS:P=0.409,OS:P=0.746),and between patients with PD-L1 CPS less than 10 and of 10 or more(PD-L1<10%vs PD-L1≥10%;PFS:P=0.529,OS:P=0.568).CONCLUSION Chemotherapy containing bevacizumab can be considered as first-line therapy in metastatic CRC irrespective of PD-L1 expression.

关键词： Bevacizumab Colorectal cancer Programmed cell death ligand 1 expression First-line chemotherapy Metastatic colorectal cancer

Comprehensive molecular analysis to predict the efficacy ofchemotherapy containing bevacizumab in patients with metastaticcolorectal cancer

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Oncology Research 2023年第6期31卷 855-866页

作者： SUNG HEE LIM HEE JIN CHO KYOUNG-MEE kim HO YEONG LIM won ki KANG JEEYUN LEE YOUNG SUK PARK HEE CHEOL kim SEUNG TAE kim Division of Hematology/Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSeoul06351Korea Precision Medicine Research Institute Samsung Medical CenterGangnam-guSeoul06351Korea Department of Biomedical Convergence Science and Technology Kyungpook National UniversityDaegu41566Korea Department of Pathology and Translational Genomics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul06351Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSeoul06351Korea

Background:Although bevacizumab is an important treatment for metastatic colorectal cancer(CRC),not allpatients with CRC benefit from it;in unselected patient populations,only modest survival benefits have been ***:We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identifybiomarkers for a response to bevacizumab-containing *** molecular analysis comprised whole-exomesequencing,ribonucleic acid sequencing,and a methylation array on patient ***:Genomic and molecularcharacterization was successfully conducted in 103 *** of 103 CRC samples were hypermutated,and none ofthe non-hypermutant tumors were microsatellite *** those 103 patients,89 had adenocarcinoma(ADC),15 were diagnosed with mucinous ADC,and six had signet-ring cell carcinoma(SRCC).Consensus molecular subtype(CMS)2 was unique to *** the four SRCCs,two were CMS1,one was CMS4,and the other was *** status was a significantly enriched factor in responders to bevacizumab *** growth factorreceptor(FGFR)1/2 signaling was upregulated in non-responders,whereas cell cycle,transfer ribonucleic acidprocessing,nucleotide excision repair,and oxidative phosphorylation pathways were enriched in ***,IGF1 was differentially expressed in non-responders(log2 fold change=−1.43,p=4.11×10^(−5),falsediscovery rate=0.098),and FLT1 was highly methylated in non-responders(p=7.55×10^(−3)).When the molecularpathways were reanalyzed separately according to the backbone chemotherapy(FOLFOX ***),thesignificance of the molecular pathways varied according to the backbone ***:This studysought a subset of CRC patients with a distinct clinical response to chemotherapy containing *** need to be validated in a large group of homogenous patient cohort and examined according to the differentchemotherapy backbones to create personalized therapeutic oppor

关键词： Bevacizumab Whole-exome sequencing Ribonucleic acid sequencing Methylation array Colorectal cancer

Management of antiviral drug resistance in chronic hepatitis B

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World Journal of Gastroenterology 2014年第33期20卷 11641-11649页

作者： ki Bae Bang Hong Joo kim Department of Internal Medicine Sungkyunkwan University Kangbuk Samsung Hospital Seoul 110-746 South Korea

Rescue antiviral treatment for patients with resistance to preexisting nucleos(t)ide analogues remains a clinical challenge. The correct choice of a first-line treatment of high potency and with a high genetic barrier to achieve sustained long-term suppression of viral replication provides the best chance of preventing treatment failure and the emergence of drug resistance. The management of treatment failure and drug resistance requires a precise and accurate clinical and virologic monitoring. Combination treatment with antiviral drugs that belong to different groups is associated with a lower chance of developing resistance to rescue drugs. To guarantee better control of viral replication in patients with drug resistance, the addition of another drug without a cross resistance profile should be given as early as possible, preferably at the time when genotypic resistance emerges. Long-term surveillance for treatment efficacy and possible emergence of drug resistance should be continued to prevent the emergence of multidrug-resistant strains.

关键词： Chronic hepatitis B Antiviral resistance Rescue treatment Multidrug resistance Cross resistance

High-efficiency technique based on dielectrophoresis for assembling metal,semiconductor,and polymer nanorods

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第5期12卷 368-373页

作者： Heng YUAN Kyu-jin kim won-seok KANG Byoung-ho KANG Se-hyuk YEOM Jae-ho kim Shin-won KANG School of Electrical Engineering and Computer Science Kyungpook National University 1370 Sankyuk-dong Bukgu Daegu 702-701 Korea) Department of Molecular Science and Technology Ajou University San s.Woncheon-dongYeongtong-guSuwon 443-749Korea School of Electronic Engineering College oflT Engineering Kyungpook National University 13 70 Sankyuk-dong Bukgu Daegu 702-701 Korea

This paper presents a high-efficiency technique based on dielectrophoresis (DEP) for assembling metal, semiconductor, and polymer nanorods, which are synthesized by electrochemical deposition (ECD). The assembly patterns of these nanorods (width: 20 nm; length: 7 μm) were designed using a finite element method (FEM) simulation tool. Further, these nanorods were used in our experiment after their assembly patterns were fabricated. The assembly yield was found to be approximately 70% at an AC voltage of 30 Vp-p and at frequencies of 20 and 30 kHz, and the DC voltage prevented the random alignment of the nanorods at the edge of the assembly pattern. Moreover, the above-mentioned nanorods, which had different permittivities, were found to have similar assembly yields. The proposed method can be improved and applied to nanostructure device fabrication.

关键词： Nanorod Assembly Dielectrophoresis (DEP) Finite element method (FEM) Electrochemical deposition (ECD) method

Optimal design of auxiliary-teeth to solve circulation current reduction of permanent magnet linear synchronous motor

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Journal of Central South University 2011年第3期18卷 690-696页

作者： JANG ki-bong kim Jee-hyun AN Ho-jin kim Gyu-tak School of Mechatronics Changwon National University

A discontinuity of magnetic circuits according to the end effect is generated in the permanent magnet linear synchronous motor （PMLSM）. Due to the unbalanced back electro-motive force （EMF） and impedance produced, unbalanced current is generated. The cireulatin8 current, which is caused by a decrease in the thrust, is generated by the unbalanced current. The optimal design of auxiliary-teeth at the end of the mover was carried out to solve the unbalance of phase by using design of experiment （DOE）, and compared with the basic model through finite element analysis （FEA）. As a result, the auxiliary-teeth model compensates for the decrease of thrust caused by the unbalanced phase. Also, this model is proven to reduce the detent force by the vibration and noise of the PMLSM and copper loss caused by the circulating current.

关键词： permanent magnet linear synchronous motor auxiliary-teeth circulation current end effect thrust reduction

Comparison of excyclotorsion following graded inferior oblique recession for primary versus secondary inferior oblique overaction

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1281-1286页

作者： Donghun Lee won Jae kim Myung Mi kim Department of Ophthalmology Catholic University of Daegu School of MedicineDaegu 42472Republic of Korea Department of Ophthalmology Yeungnam University Medical CenterDaegu 42415Republic of Korea Nune Eye Hospital Daegu 2179Republic of Korea

AIM:To compare the changes in excyclotorsion after inferior oblique(IO)recession in patients with primary and secondary inferior oblique overaction(IOOA).METHODS:We retrospectively analyzed the data obtained from patients with IOOA who underwent graded IO *** patients were followed up for at least 3 mo after *** photographs were taken preand postoperatively,and the sum of the angles of torsion in both eyes was used to analyze changes in *** were divided into two groups:those diagnosed with primary IOOA were enrolled in the 1’IOOA group,and those diagnosed with secondary IOOA caused by superior oblique palsy(SOP)were enrolled in the 2’IOOA *** before and after surgery were compared between the two ***:A total of 78 patients were enrolled in this study:34 eyes in the 1’IOOA group and 44 eyes in the 2’IOOA *** the 78 patients,torsional angle significantly decreased from 15.31°±7.40°to 12.11°±6.53°after IO recession(P<0.001).Mean preoperative torsional angle was larger in the 2’IOOA group than in the 1’IOOA group(P=0.03).In both groups,excyclotorsion significantly decreased after IO recession(P=0.001 and P<0.001,respectively);however,there was no significant difference in the amounts of changes in excyclotorsion between the two ***:Excyclotorsion is significantly larger in secondary IOOA than in primary IOOA,and a significant decrease in the torsional angle occurs after IO recession in both types of IOOA.

关键词： inferior oblique overaction inferior oblique recession ocular excyclotorsion strabismus

Protein and energy concentrations of meat meal and meat and bone meal fed to pigs based on in vitro assays

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Animal Nutrition 2021年第1期7卷 252-257页

作者： Hyunjun Choi Chang Sik won Beob Gyun kim Department of Animal Science and Technology Konkuk UniversitySeoul 05029Republic of Korea

The objective of this study was to develop equations for estimating ileal digestible crude protein(CP)and metabolizable energy(ME)contents of meat meal(MM)and meat and bone meal(MBM)as feed in-gredients for pigs based on in vitro *** ingredients were 4 sources of MM and 3 sources of *** and CP contents of the ingredients ranged from 3.8%to 33.1%and 46.8%to 82.9%(as-is basis),*** vitro ileal disappearance(IVID)of CP was determined and ileal digestible CP content was calculated by multiplying CP content by IVID of *** vitro total tract disappearance(IVTTD)of dry matter(DM)was determined and ME was calculated using gross energy,CP contents,and IVTTD of *** IVID of CP and IVTTD of DM ranged from 77.2%to 88.7%and from 82.7%to 92.4%,*** ileal digestible CP and ME contents ranged from 37.8%to 73.5%DM and 2,405 to 3,905 kcal/kg DM,*** contents were negatively correlated(P<0.001)with CP(r=-0.99),in vitro ileal digestible CP(r=-0.97),gross energy(r-1.00),in vitro digestible energy(r=-0.97),and adjusted ME(r=-0.97).The most fitting equations for ileal digestible CP and adjusted ME were:ileal digestible CP(%DM)=11.91-0.90×Ash(%DM)+0.74×IVID of CP(%)(R2=0.99)and adjusted ME(kcal/kg DM)=130.85-50.90×ash(%DM)+47.06×IVTTD of DM(%)(R2=0.99).To validate the accuracy of the prediction equations for ME,mean bias and linear bias were determined using a regression *** ME values of MM and MBM were in a good agreement with data obtained from animal ex-periments based on a statistically insignificant bias in the *** conclusion,ME concentrations of MM and MBM as swine feed ingredients can be calculated using ash concentration and in vitro disap-pearance of dry matter.

关键词： Animal offal Energy In vitro disappearance method Protein

Morbidity analysis of left hepatic trisectionectomy for hepatobiliary disease and live donor

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 362-369页

作者： Young-In Yoon Sung-Gyu Lee Deok-Bog Moon Shin Hwang ki-Hun kim Hui-Ju kim ki-Hoon Choi Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine388-1 Poongnap-dongSongpa-guSeoul 138-736Korea Department of Surgery Gold Coast University HospitalSouthportQLD 4215Australia

Background:Despite remarkable advances in surgical techniques and perioperative management,left hepatic trisectionectomy(LHT)remains a challenging procedure with a somewhat high postoperative morbidity rate compared with less-extensive *** study aimed to analyze the short-and long-term outcomes of LHT and identify factors associated with the postoperative morbidity of this technically demanding surgical ***:The medical records of 53 patients who underwent LHT between June 2005 and October 2019 at a single institution were retrospectively *** independent prognostic factor of postoperative morbidity was analyzed using the logistic regression ***:Hepatocellular carcinoma was the most common indication for surgery(n=21),followed by hilar cholangiocarcinoma(n=14),intrahepatic cholangiocarcinoma(n=10),and other pathologies(including colorectal liver metastasis,hepatolithiasis,gallbladder cancer,living donor,hemangioma,and multilocular biliary cyst;n=8).The rates of postoperative morbidities of Clavien-Dindo grade 3 or higher and 90-day mortality were 39.6% and 1.9%,*** 1-,3-,and 5-year overall survival rates were 81.1%,61.4%,and 44.6%,*** analysis revealed that preoperative jaundice[hazard ratio(HR)=6.15,95%confidence interval(CI):1.57-24.17,P=0.009]and operative time>420 min(HR=4.66,95%CI:1.27–17.17,P=0.021)were independent predictors of postoperative ***:The in-hospital mortality of LHT surgery can be minimalized by a reliable preoperative evaluation of liver function and selection of the dominant anatomic features of right posterior sector,active and appropriate preoperative management for obstructive cholangitis and compensatory hypertrophy of the future remnant posterior sector,and the experience of the surgeon.

关键词： Left hepatic trisectionectomy Major hepatectomy Liver neoplasms Survival rate Morbidity