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Induction of Apoptosis in Lung Cancer Cells by TRAIL and L-leucyl-L-leucine Methyl Ester

Journal of Cancer Therapy 2011年第3期2卷 418-430页

作者： X. Sarah Sun Laura Bandura-Morgan wolfgang zacharias 不详

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor superfamily that induces apoptosis in many tumor cells. Previous studies suggested that TRAIL treatment might also cause release of lysosomal cathepsin proteases to the cytosol, thus further promoting apoptosis. L-leucyl-L-leucine methyl ester (LeuLeuOMe) is a lysosome-destabilizing agent that may cause release of cathepsins into the cytosol and ensuing apoptosis. We hypothesized that a combination of TRAIL and LeuLeuOMe may synergistically promote apoptosis in lung cancer cells. The human epidermoid lung carcinoma cell line Calu-1 (TRAIL-resistant) and human large cell lung carcinoma cell line NCI-H460 (TRAIL-sensitive) were assayed for sensitivity to TRAIL and LeuLeuOMe, given alone or in different combination doses. Each agent alone induced a dose-dependent cytotoxicity, with substantially different efficacies of the two agents for the two cell types. When both agents were combined, synergistic cytotoxicity was achieved even in the TRAIL-resistant cells. TRAIL-induced cytotoxicity was completely inhibited by pan-caspase inhibitor z-VAD-fmk, but not by cysteine protease inhibitor E-64d. Conversely, E-64d totally blocked LeuLeuOMe-induced cytotoxicity. TRAIL caused mitochondrial damage, while enlarged lysosomes and lysosomal rupture were observed in LeuLeuOMe-treated cells. Our data suggest that, while TRAIL and LeuLeuOMe cause apoptosis through pathways that differ in their involvement of lysosomal cysteine proteases, mitochondrial and lysosomal desta-bilization have converging pro-apoptotic effects. Thus, the synergy of TRAIL and LeuLeuOMe may be used therapeutically to promote apoptosis in lung cancers, even those with intrinsic or acquired resistance to TRAIL.

关键词： Apoptosis Lung Cancer Lysosome Mitochondria TRAIL

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Induction of Apoptosis in Lung Cancer Cells by TRAIL and L-Leucyl-L-Leucine Methyl Ester

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Journal of Cancer Therapy（癌症治疗） 2011年第3期

作者： X. Sarah Sun Laura Bandura-Morgan wolfgang zacharias

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Relativistic gravitational collapse by thermal mass

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Communications in Theoretical Physics 2021年第1期73卷 68-70页

作者： zacharias Roupas Centre for Theoretical Physics The British University in EgyptSherouk City 11837CairoEgypt

Gravity and thermal energy are universal phenomena which compete over the stabilization of astrophysical *** former induces an inward pressure driving collapse and the latter a stabilizing outward pressure generated by random motion and energy *** a contracting self-gravitating system is heated up one may wonder why is gravitational collapse not halted in all cases at a sufficient high temperature establishing either a gravo-thermal equilibrium or ***,based on the equivalence between mass and energy,we show that there always exists a temperature threshold beyond which the gravitation of thermal energy overcomes its stabilizing pressure and the system collapses under the weight of its own heat.

关键词： gravothermal instability supernova relativistic thermodynamics

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The habitation Model Trend Calculation(MTC):A new effective tool for predictive modeling in archaeology

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Geo-Spatial Information Science 2019年第4期22卷 314-331,I0008页

作者： George Malaperdas Nikolaos zacharias Department of History Archaeology and Cultural Resources ManagementUniversity of PeloponneseKalamataGreece

The aim of this paper is to create and present a new archaeological predictive model via GIS,incorporating what archaeologists consider the most important criterion absent of similar past models,that of critical *** new model suggested in this paper is named habitation Model Trend Calculation(MTC)and is not only integrates the archaeological questions with a critical view,but it can be easily adjusted,according to the conditions or the questions concerning the archaeological ***,it uses new topographical and geomorphological indexes such as Topographical Index(TPI),Hillslope and Landform Classification that give a new sense of the topographical and geomorphological characteristics of the examined area;therefore this model is a more powerful tool compared to older models that did not use new topographical and geomorphological *** success of the created model is checked as a case study in the region of Messenia,Greece during the Mycenaean *** region of Messenia is considered as one of the most important Mycenaean regions of Greece due to the great number and the importance of Mycenaean sites *** the present paper,140 habitation sites were divided into four hierarchical categories(centers,large villages,villages,and farms)based on the extent and the plurality of the tholos tombs that exist in the broader region and according to the hierarchical categorization used by the archaeologists who have studied the *** new predictive model presented in this work can assist in solving a series of criticisms that have been expressed in the previous studies regarding such ***,in the case of Mycenaean Messenia,the model shows excellent results in relation to the habitats of the time.

关键词： GIS Mycenaean Messenia predictive model archaeology habitation Model Trend Calculation(MTC) analytical hierarchy process(AHP) spatial analysis

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SCHEDULING IN THE SERVICE INDUSTRIES:AN OVERVIEW

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Journal of Systems Science and Systems Engineering 2015年第1期24卷 1-48页

作者： Michael Pinedo Christos zacharias Ning Zhu Stern Business School New York University School of Business Administration University of Miami College of Economics and Management Tianjin University

Scheduling plays an important role in many different service industries. In this paper we provide an overview of some of the more important scheduling problems that appear in the various service industries. We focus on the formulations of such problems as well as on the techniques used for solving those problems. We consider five areas of scheduling in service industries, namely （i） project scheduling, （ii） workforce scheduling, （iii） timetabling, reservations, and appointments, （iv） transportation scheduling, and （v） scheduling in entertainment. The first two areas are fairly general and have applications in many different service industries. The third, fourth and fifth areas are more related to some very specific service industries, namely the hospitality and health care industries, the transportation industries （of passengers as well as of cargo）, and the entertainment industries. In our conclusion section we discuss the similarities and the differences between the problem formulations and solution techniques used in the various different industries and we also discuss the design of the decision support systems that have been developed for scheduling in the service industries.

关键词： Artificial intelligence Decision support systems Problem solving

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Assessment of potential impacts to surface and subsurface water bodies due to longwall mining

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International Journal of Mining Science and Technology 2017年第1期27卷 57-64页

作者： Christopher Newman zacharias Agioutantis Gabriel Boede Jimenez Leon Department of Mining Engineering University of KentuckyLexingtonKY 40506USA

Ground movements due to longwall mining operations have the potential to damage the hydrological balance within as well as outside the mine permit area in the form of increased surface ponding and changes to hydrogeological properties. Recently, the Office of Surface Mining, Reclamation and Enforcement(OSMRE) in the USA, has completed a public comment period on a newly proposed rule for the protection of streams and groundwater from adverse impacts of surface and underground mining operations(80 FR 44435). With increased community and regulatory focus on mining operations and their potential to adversely affect streams and groundwater, now there is a greater need for better prediction of the possible effects mining has on both surface and subsurface bodies of water. With mining induced stress and strain within the overburden correlated to changes in the hydrogeological properties of rock and soil, this paper investigates the evaluation of the hydrogeological system within the vicinity of an underground mining operation based on strain values calculated through a surface deformation prediction model. Through accurate modeling of the pre- and post-mining hydrogeological system, industry personnel can better depict mining induced effects on surface and subsurface bodies of water aiding in the optimization of underground extraction sequences while maintaining the integrity of water resources.

关键词： Streams Aquifers Ground strain Coal mining

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Anharmonic electron-phonon coupling in ultrasoft and locally disordered perovskites

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npj Computational Materials 2023年第1期9卷 744-756页

作者： Marios zacharias George Volonakis Feliciano Giustino Jacky Even Univ Rennes INSA RennesCNRSInstitut FOTON-UMR 6082F-35000 RennesFrance Univ Rennes ENSCRINSA RennesCNRSISCR-UMR 6226F-35000 RennesFrance Oden Institute for Computational Engineering and Sciences The University of Texas at AustinAustinTX 78712USA Department of Physics The University of Texas at AustinAustinTX 78712USA

Anharmonicity and local disorder(polymorphism)are ubiquitous in perovskite physics,inducing various phenomena observed in scattering and spectroscopy *** of these phenomena still lack interpretation from first principles since,hitherto,no approach is available to account for anharmonicity and disorder in electron–phonon ***,relying on the special displacement method,we develop a unified treatment of both and demonstrate that electron–phonon coupling is strongly influenced when we employ polymorphous perovskite *** uncover that polymorphism in halide perovskites leads to vibrational dynamics far from the ideal noninteracting phonon picture and drives the gradual change in their band gap around phase transition *** also clarify that combined band gap corrections arising from disorder,spin-orbit coupling,exchange–correlation functionals of high accuracy,and electron–phonon coupling are all *** findings agree with experiments,suggesting that polymorphism is the key to address pending questions on perovskites’technological applications.

关键词： perovskite phonon harmonic

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Manipulation of Crawling Growth for the Formation of Sub-millimeter Long ZnO Nanowalls

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Journal of Materials Science & Technology 2008年第4期24卷 589-593页

作者： H.J.FAN M.zacharias Department of Earth Sciences University of Cambridge U.K. Faculty of Applied Science Albert-Ludwigs-University Freiburg Germany Formerly at： Max Planck Institute of Microstructure Physics Halle Germany

Vapor-phase growth of ZnO nanowires based on gold catalyst is usually accompanied with lateral crawling growth on the substrate surface. We present results from our systematic experiments where the growth temperature and catalyst size are controlled. The data corroborate that it is possible to obtain clean vertical nanowire arrays while avoiding the crawling growth. 0% the other hand, crawling growth can be manipulated to obtain root-interconnected nanowire arrays, which could be useful for certain applications. Our results also imply that the previously suggested growth mechanism for the wire-on-wall hybridstructure might be incorrect. Finally, we show the formation of sub-millimeter long, straight ZnO nanowalls by combining a gold-catalyzed epitaxial growth of vertical nanowires and their mergence due to a confined crawling growth. These unconventional nanostructures might have unique electric or optical transport properties.

关键词： Nanowire Nanowall ZnO Crawling growth

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Application of cone beam computed tomography in facial imaging science

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上海口腔医学 2012年第2期21卷 220-231页

作者： zacharias Fourie Janalt Damstra Department of Orthodontics University Medical Center GroningenUniversity of Groningen

Facial imaging is used to study the facial shapeand its developmental changes over *** isimportant to diagnose acquired malformations,to studynormal and abnormal growth and to differentiatebetween the results of treatment and normal growth,and to validate facial *** two mainmethods to study and record facial imaging are bymeans of cephalometry and anthropometry[1].Cephalometrics is the scientific study of themeasurements of the

关键词：口腔医学临床分析患者症状

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Beyond Mendelian Inheritance:Genetic Buffering and Phenotype Variability

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Phenomics 2022年第2期2卷 79-87页

作者： Andrea Rossi zacharias Kontarakis Genome Engineering and Model Development Lab(GEMD) IUF-Leibniz Research Institute for Environmental Medicine40225 DüsseldorfGermany Genome Engineering and Measurement Laboratory(GEML) Eidgenössische Technische Hochschule(ETH)ZurichZurichSwitzerland Functional Genomics Center Zurich of ETH Zurich University of Zurich8093 ZurichSwitzerland

Understanding the way genes work amongst individuals and across generations to shape form and function is a common theme for many genetic *** recent advances in genetics,genome engineering and DNA sequencing reinforced the notion that genes are not the only players that determine a *** to physiological or pathological fluctuations in gene expression,even genetically identical cells can behave and manifest different phenotypes under the same ***,we discuss mechanisms that can influence or even disrupt the axis between genotype and phenotype;the role of modifier genes,the general concept of genetic redundancy,genetic compensation,the recently described transcriptional adaptation,environmental stressors,and phenotypic *** furthermore highlight the usage of induced pluripotent stem cells(iPSCs),the generation of isogenic lines through genome engineering,and sequencing technologies can help extract new genetic and epigenetic mechanisms from what is hitherto considered‘noise’.

关键词： Genetic compensation Transcriptional adaptation Modifiers Phenotypes Phenotypic plasticity

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