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Lipid transport to avian oocytes and to the developing embryo

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The Journal of Biomedical Research 2016年第3期30卷 174-180页

作者： wolfgang J.Schneider Department of Medical Biochemistry Max F.Perutz LaboratoriesMedical University and Biocenter Vienna

Studies of receptor-mediated lipoprotein metabolic pathways in avian species have revealed that physiological intricacies of specific cell types are highly analogous to those in mammals. A prime example for the power of com- parative studies across different animal kingdoms, elucidated in the chicken, is that the expression of different lipo- protein receptors in somatic cells and oocytes are the key to oocyte growth. In avian species, yolk precursor transport from the hen＇s liver to rapidly growing oocytes and the subsequent transfer of yolk nutrients via the yolk sac to the developing embryo are highly efficient processes. Oocytes grow from a diameter of 5 mm to 2.5-3 cm in only 7 days, and the yolk sac transfers nutrients from the yolk stored in the mature oocyte to the embryo within just 2 weeks. The underlying key transport mechanism is receptor-mediated endocytosis of macromolecules, i.e., of hepatically synthesized yolk precursors for oocyte growth, and of mature yolk components for embryo nutrition, respectively. Recently, the receptors involved, as well as the role of lipoprotein synthesis in the yolk sac have been identified. As outlined here, lipoprotein degradation/resynthesis cycles and the expression of lipoprotein receptors are not only coordinated with the establishment of the tbllicular architecture embedding the oocyte, but also with the generation of the yolk sac vasculature essential for nutrient transfer to the embryo.

关键词： chicken embryo oocyte yolk sac lipoprotein receptors vascularization

Next generation in vitro primary hepatic cell test systems—their suitability as an alternative to in vivo testing?

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Hepatobiliary Surgery and Nutrition 2020年第1期9卷 103-105页

作者： Ali Kermanizadeh wolfgang Moritz Heriot Watt University School of Engineering and Physical SciencesEdinburghUK InSphero SchlierenSwitzerland

To date traditional toxicity testing has relied heavily on in-life animal studies that are expensive and restrictive with regards to very important ethical implications. In addition, these studies often yield data that are not relevant to human exposures or biological responses due to intra-species variations, necessitating the requirement for further testing or candidate (drug) abandonment in late development stages. There is increasing global pressure from regulatory agencies, the general public, and the scientific community to develop in vitro alternatives for toxicity testing that can be utilized for mechanistic dose response hazard identification prior to embarking on small well designed and absolutely necessary in vivo studies.

关键词： testing vivo absolutely

Hidden in the parts:How the cell-type perspective reveals novel insights into plant-microbe interactions

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Molecular Plant 2023年第9期16卷 1359-1362页

作者： Christian Froschel wolfgang Droge-Laser Pharmaceutical Biology Julius-von-Sachs-InstituteJulius-Maximilians-Universitat WurzburgJulius-von-Sachs Platz 297082 WurzburgGermany Present address:Botany ll Julius-von-Sachs-lnstituteJulius-Maximilians-Universitat WurzburgJulius-von-Sachs Platz 397082 WurzburgGermany

The origin of multicellularity is considered an evolutionary milestone,as cellular differentiation and cooperation have allowed the emergence of specialized and unique *** crucial biological processes involve only a few cells,making it difficult to detect specific transcriptional signatures in classical bulk tissue *** information often remains hidden in the sum of thousands of cells,and thus localized studies are *** plant responses to microbes are well known to occur highly localized(Emonet et al.,2021),approaches to describe their impact at a cellular level have been established only very *** single-cell transcriptomics,Verbon et al.,2023 addressed this topic and disclosed heterogeneous responses of root cells when colonized by the beneficial bacterium Pseudomonas *** on Arabidopsis,we here compare this study with some groundbreaking methodological advances and provides perspectives on upcoming endeavors(Figure 1).

关键词： Figure insight specialized

Modification Management for Construction Processes

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Tsinghua Science and Technology 2008年第S1期13卷 185-191页

作者： wolfgang Huhnt Sven Richter Felix Enge Institute of Civil Engineering Berlin Institute of Technology

This paper presents an approach to handle different types of subsequent modifications in construction processes. It is focused on a formalized approach with the objective that effects of subsequent modifications are detected automatically. The approach presented in this paper makes use of an existing modeling technique specifically focused on construction processes. The modeling techniques result in a process description where all technological interdependencies between construction activities are considered and where consistency between the sequence of activities and the history of components is guaran-teed. This modeling technique is expanded by an existing concept for handling versions and dependencies between objects. The integration of these different concepts makes it possible to track effects of relevant types of subsequent modifications in construction processes on a formalized basis. Effects of subsequent modifications are detected by algorithms, different versions can be compared by algorithms and different versions are stored so that subsequent modifications are documented. The innovation of the approach presented is the completeness. Effects of different relevant types of subsequent modifications in construction processes are tracked on a formalized basis.

关键词： construction processes process modeling subsequent modifications

Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917

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World Journal of Gastroenterology 2016年第23期22卷 5415-5421页

作者： Elina Manzhalii Daniel Hornuss wolfgang Stremmel Department of Propedeutics of Internal Medicine 2 Bogomolets National Medical University Department of Gastroenterology University Hospital of Heidelberg

AIM: To evaluate the effect of oral Escherichia coli (E. coli) Nissle application on the outcome of intestinal-borne ***: In a randomized, controlled, non-blinded prospective clinical trial 82 patients with intestinal-borne facial dermatoses characterized by an erythematous papular-pustular rash were screened. At the initiation visit 37 patients entered the experimental arm and 20 patients constituted the control arm. All 57 patients were treated with a vegetarian diet and conventional topical therapy of the dermatoses with ointments containing tetracycline, steroids and retinoids. In the experimental arm patients received a one month therapy with oral E. coli Nissle at a maintenance dose of 2 capsules daily. The experimental group was compared to a non-treatment group only receiving the diet and topical therapy. The primary outcome parameter was improvement of the dermatoses, secondary parameters included life quality and adverse events. In addition the immunological reaction profile (IgA, interleucin-8 and interferon-α) was determined. Furthermore the changes of stool consistency and the microbiota composition over the time of intervention were ***: Eighty-nine percent of the patients with acne, papular-pustular rosacea and seborrhoic dermatitis responded to E. coli Nissle therapy with significant amelioration or complete recovery in contrast to 56% in the control arm (P 107 CFU/g stool) was observed in 79% and 63%

关键词： Intestinal-borne dermatoses Escherichia coli Nissle 1917 Immunological response IgA Interleukin-8 Interferon-α Gut microbiota

Jure Piskur (1960—2014)

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Journal of Genetics and Genomics 2015年第5期42卷 275-277页

作者： Birgitte Munch-Petersen Zoran Gojkovic wolfgang Knecht Department of Science Systems and Models Roskilde University The Department of Applied Yeast Research Carlsberg Laboratory Department of Biology Molecular Cell Biology & Lund Protein Production Platform Lund University

Following a short struggle against an aggressive cancer, Prof. Jure Piskur （Fig. 1 ）, a professor of molecular genetics at Lund University （LU）, Sweden, and the University of Nova Gorica （UNG）, Slovenia, died in his home in Lund on 18 May 2014. He leaves behind his lifelong partner and wife, Judita Gartner, and their sons, Jan and Jure.

关键词： Jure Piskur ICAP

A Computational Model of Concept Generalization in Cross-Modal Reference

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Tsinghua Science and Technology 2011年第2期16卷 113-120页

作者： Patrick McCrae wolfgang Menzel Maosong SUN CINACS Graduate Research Group Department of Informatics Hamburg University 22527 Hamburg Germany Natural Language Systems Group Department of Informatics Hamburg University 22527 Hamburg Germany Department of Computer Science Tsinghua University Beijing 100084 China

Cross-modal interactions between visual understanding and linguistic processing substantially contribute to the remarkable robustness of human language *** argue that the formation of cross-modal referential links is a prerequisite for the occurrence of cross-modal interactions between vision and *** this paper we examine a computational model for a cross-modal reference formation with respect to its robustness against conceptual underspecification in the visual *** investigation is motivated by the fact that natural systems are well capable of establishing a cross-modal reference between modalities with different degrees of conceptual *** the investigated model,conceptually underspecified context information continues to drive the syntactic disambiguation of verb-centered syntactic ambiguities as long as the visual context contains the situation arity information of the visual scene.

关键词： vision-language interaction cross-modal reference syntactic disambiguation

Nonlinear Reduced DNN Models for State Estimation

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Communications in Computational Physics 2022年第6期32卷 1-40页

作者： wolfgang Dahmen Min Wang Zhu Wang Department of Mathematics University of South CarolinaColumbiaSC 29208USA Department of Mathematics Duke UniversityDurhamNC 27708USA

We propose in this paper a data driven state estimation scheme for generating nonlinear reduced models for parametric families of PDEs, directly providingdata-to-state maps, represented in terms of Deep Neural Networks. A major constituentis a sensor-induced decomposition of a model-compliant Hilbert space warranting approximation in problem relevant metrics. It plays a similar role as in a ParametricBackground Data Weak framework for state estimators based on Reduced Basis concepts. Extensive numerical tests shed light on several optimization strategies that areto improve robustness and performance of such estimators.

关键词： State estimation in model-compliant norms deep neural networks sensor coordinates reduced bases ResNet structures network expansion

A possible important CO_2 sink by the global water cycle

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Chinese Science Bulletin 2008年第3期53卷 402-407页

作者： LIU ZaiHua wolfgang DREYBRODT WANG HaiJing The State Key Laboratory of Environmental Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China Karst Dynamics Laboratory Ministry of Land and Resources Guilin 541004 China Institute of Experimental Physics University of Bremen Bremen 28334 Germany School of Geographical Sciences Southwest University Chongqing 400715 China

The locations,magnitudes,variations and mechanisms responsible for the global CO2 sink are uncer-tain and under ***,we show,based on theoretical calculations and evidences from field monitoring results,that there is a possible important CO2 sink(as DIC-dissolved inorganic carbon)by the global water *** sink constitutes up to 0.8013 Pg C/a(or 10.1% of the total anthropogenic CO2 emission,or 28.6% of the missing CO2 sink),and is formed by the CO2 absorption of water and subsequent enhanced consumption by carbonate dissolution and aquatic plant *** the sink,0.5188 Pg C/a goes to sea via precipitation over sea(0.2748 Pg C/a)and continental rivers(0.244 Pg C/a),0.158 Pg C/a is released to the atmosphere again,and 0.1245 Pg C/a is stored in the continental aquatic ***,the net sink could be 0.6433 Pg C/*** sink may increase with the global-warming-intensified global water cycle,the increase in CO2 and carbonate dust in atmosphere,and reforestation/afforestation,the latter increasing soil CO2,and thus the concentration of the DIC in water.

关键词：二氧化碳全球水循环碳酸盐分解水生植物光合作用