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遗传性血管性水肿诊治的“院内多学科会诊协作网联动线上线下全程管理”模式的初探

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中华预防医学杂志 2024年第3期58卷 406-413页

作者：姚我吴定钱沈颖沈磊李燕葛柳雅张松照陈炯汪慧英浙江大学医学院附属第二医院变态反应科杭州310009 浙江大学医学院附属第二医院急诊科杭州310009 浙江大学医学院附属第二医院皮肤科杭州310009 浙江大学医学院附属第二医院耳鼻咽喉科杭州310009 浙江大学医学院附属第二医院消化内科杭州310009 浙江大学医学院附属第二医院门诊护理部杭州310009 浙江大学医学院附属第二医院检验科杭州310009 宁波大学农产品质量安全危害因子与风险防控国家重点实验室宁波315211

遗传性血管性水肿(hereditary angioedema,HAE)是一种常染色体显性遗传的罕见病,患病率约为50 000分之一,以反复发作、不可预测的皮肤或黏膜下水肿为临床特征,累及咽喉部可导致潜在的致命风险。其疾病的罕见性、临床表现的多样性,造成... 详细信息

遗传性血管性水肿(hereditary angioedema,HAE)是一种常染色体显性遗传的罕见病,患病率约为50 000分之一,以反复发作、不可预测的皮肤或黏膜下水肿为临床特征,累及咽喉部可导致潜在的致命风险。其疾病的罕见性、临床表现的多样性,造成医务人员认识不足,导致临床的误诊误治。因此,提高医务人员对HAE的认识非常重要。本院建立以院内多学科会诊(multi-disciplinary treatment,MDT)团队、省内协作网联动、线上线下患者管理和媒体宣教交互的管理模式(“院内MDT协作网联动线上线下全程管理”),通过这种模式的推广,显著提高了浙江省HAE患者的精准诊断,缩短了诊断时间,显著降低了患者的严重喉头水肿发作急救,同时为HAE的临床诊治提供参考。

关键词：遗传性血管性水肿管理模式临床路径 C1酯酶抑制物

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新型甲型H1N1流感孕妇的临床表现

中华结核和呼吸杂志 2010年第6期33卷 447-448页

作者：姚我吴琦冯靖天津医科大学总医院呼吸科 300052

2009年4月第1例新型甲型H1N1流感（简称甲型流感）病例确诊[1].这种起源于墨西哥的病毒已传播到美国、加拿大及中国等100多个国家.孕妇是甲型流感发生并发症的高危人群[2],孕妇患重症甲型流感病例和需住院治疗的风险是其他人群的4倍[3]... 详细信息

2009年4月第1例新型甲型H1N1流感（简称甲型流感）病例确诊[1].这种起源于墨西哥的病毒已传播到美国、加拿大及中国等100多个国家.孕妇是甲型流感发生并发症的高危人群[2],孕妇患重症甲型流感病例和需住院治疗的风险是其他人群的4倍[3].现将孕妇甲型流感病例的临床特点、诊治现状及预防等综述如下.

关键词：甲型H1N1流感孕妇临床表现甲型流感高危人群 2009年临床特点住院治疗

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Chinese Medical Journal 2010年第17期123卷 2392-2399页

作者： FENG Jing Ambrose An-Po Chiang WU Qi CHEN Bao-yuan CUI Lin-yang LIANG Dong-chun ZHANG Ze-li yao wo Department of Respiratory Disease Tianjin Medical University General Hospital Tianjin 300052 China Division of Pulmonary and Critical Care Medicine Duke University Medical Center Durham NC 27710 USA Tianjin Neurology Research Institute Tianjin 300052 China Tianjin Medical University Endocrinology Research Institute Tianjin 300052 China

Background Sleep disturbance is common in patients with emphysema. This study aimed to develop a novel model of sleep-related hypoxemia （SRH） in emphysema （SRHIE） with rats, and to explore the inflammatory status of SRHIE in lung, liver, pancreas, carotid artery and whole *** Seventy-five male Wistar rats were assigned to 5 groups with 15 per group according to the exposure conditions. The protocols varied with the degree of hypoxia exposure and severity of pre-existing emphysema caused by cigarette smoke exposure：（1） SRH control （SRHCtrl） group, sham smoke exposure （smoke exposure, exposed to smoke of 15 cigarettes twice everyday, 16 weeks） and SRH exposure （12.5% O2, 3 hours, SRH exposure, divide total hypoxia time （1.5 hours or 3 hours） into 4 periods evenly （22.5 minutes or 45 minutes） and distribute these hypoxia periods evenly into physiological sleep time of rats identified by electroencephalogram, week 9 to week 16）; （2） Emphysema control （ECtrl） group, smoke exposure and sham SRH exposure （21% O2, 3 hours）; （3） Short SRH in emphysema （SRHShort） group, smoke exposure and short SRH exposure （12.5% O2, 1.5 hours）; （4） Mild SRH in emphysema （SRHMild） group,smoke exposure and mild SRH exposure （15% O2, 3 hours）; （5） Standard SRH in emphysema （SRHStand） group, smoke exposure and SRH exposure （12.5% O2, 3 hours）. ECtrl, SRHShort, SRHMild and SRHStand groups were groups with emphysematous rats. Two days before the end of exposure, 5 rats in each group were randomly selected for arterial blood gas analysis. In the rest 10 rats in each group, we obtained blood samples and bronchoalveolar lavage fluid （BALF）for routine tests. We also obtained tissue blocks of lung, liver, pancreas, and right carotid artery for pathologic scoring and measurements of liver oxidative stress （measuring hepatic oxidative stress enzymes, superoxide dismutase （SOD） activity, catalase （CAT） activity and malondialdehyde （MDA） concentration）.Results Emphysematous groups had higher me

关键词： sleep-related hypoxemia emphysema inflammation oxidative stress bronchoalveolar lavage fluid superoxide dismutase catalase malondialdehyde

Allergen Sensitization Patterns to Aeroallergens in Allergies Involving Respiratory System,Eye,Skin and Combination:A Cross-Sectional Survey

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Allergen Sensitization Patterns to Aeroallergens in Allergie...

第八次全国中西医结合变态反应学术会议暨首届深圳市中西医结合变态反应学术会议暨第十届深圳呼吸论坛

作者： Huiying Wang Lanfang Tang Ling Wu wo yao Ran Diao Xiuzhen Zhao Dai Yu Xuyan Yang Department of Allergy the Second Affiliated Hospital of Zhejiang University School of Medicine Department of Respirology the Children' s HospitalZhejiang University College of Medicine Department of Pediatrics the Chinese Traditional Medicine HospitalHangzhouChina Department of Clinic Laboratory the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Rheumatology and Clinical Immunology the Second Affiliated Hospital of Zhejiang University School of Medicine

Aim:To investigate sensitization pattern of inhalant allergens in allergies involving respiratory system,skin,eye and ***:A cross-sectional study was conducted from July 2009 to August2012 in allergic centers from three hospitals in Zhejiang *** prick test data of patients diagnosed with rhinitis,conjunctivitis,atopic cough,asthma and atopic dermatitis were collected for ***:Of total 3643 patients,2247(64.9%) had at least one positive skin *** with atopic dermatitis had the highest prevalence of sensitization rate at about 80%,followed by patients of allergic rhinitis and allergic asthma,and patients of allergic conjunctivitis or atopic cough had the lowest sensitization rate of *** have the highest prevalence of skin reaction in the total population with 56.3%for ***,55.5%for *** and 34.6%for Blomia tropicalis,followed by 8.5%for cat,8.2%for cockroach,7.0%for dog,5.9%for mould,2.5%for mugwort,2.2%for timothy grass,1.8%for ragweed,1.5%for ***-allergen sensitization is the most common phenomenon which took 68%in all groups of *** had highest skin reaction index,followed by ***,mould,and timothy *** sensitization with *** and ***,and triple sensitization with ***,*** and Blomia tropicalis are the main patterns of ***:Different allergic diseases showed different sensitization pattern of inhalant allergens with different sensitization prevalence and *** single diseases involved different systems showed different sensitization prevalence and patterns of inhalant *** diseases involving more systems has more numbers of sensitized allergens and stronger sensitized reaction presented as skin reaction *** allergen sensitization plays more important role in skin allergy than respiratory mucous allergy,and comorbid diseases had more stronger skin *** dust mites a

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成人先天性小肠旋转不良长期误诊1例

中国当代医药 2015年第30期22卷 171-173页

作者：姚我潘文胜浙江大学医学院附属第二医院普内科杭州310009 浙江大学医学院附属第二医院消化内科杭州310009

目的探讨成人先天性小肠旋转不良的临床特点、诊治方法及误诊原因。方法报道本院1例成人先天性小肠旋转不良的诊治过程,并复习相关文献。结果本例患者为女性,60岁,因长期腹部不适就诊,收入我院后经小肠CT、胃肠造影及肠系膜动脉B超确诊... 详细信息

目的探讨成人先天性小肠旋转不良的临床特点、诊治方法及误诊原因。方法报道本院1例成人先天性小肠旋转不良的诊治过程,并复习相关文献。结果本例患者为女性,60岁,因长期腹部不适就诊,收入我院后经小肠CT、胃肠造影及肠系膜动脉B超确诊为成人先天性小肠旋转不良,确诊后因患者并无肠梗阻征象,暂内科保守治疗。结论当遇到成人患者长期消化道症状久治不愈时,需考虑先天性小肠旋转不良的可能。消化道造影、腹部CT及B超等影像学检查是明确诊断的重要手段,确诊本病并存在肠梗阻时,需行手术治疗。

关键词：先天性小肠旋转不良成人误诊上消化道造影

Defect engineering of W^(6+)-doped NiO for high-performance black smart windows

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Nano Research 2024年第4期17卷 3043-3052页

作者： Yingjun Xiao Xiang Zhang Dukang Yan Jianbo Deng Mingjun Chen Hulin Zhang Wenhai Sun Jiupeng Zhao yao Li School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China Center for Composite Materials and Structure Harbin Institute of TechnologyHarbin 150001China

In this report,W^(6+)doping as a defect engineering strategy has been proposed to improve the electrochromic properties of NiO *** research was conducted to explore the electrochromic properties and the modified mechanism of W-doped NiO *** to the pure NiO,W-doped NiO film exhibits improved electrochromic properties with significant optical modulation(61.56%at 550 nm),fast switching speed(4.42 s/1.40 s for coloring/bleaching),high coloration efficiency(45.41 cm^(2)·C-1)and outstanding cycling stability(no significant attenuation after 2000 cycles)in Li-based *** functional theory(DFT)calculations combined with the experimental results indicate that the improved electrochromic properties were due to enhanced the electronic conductivity and ion conductivity after the introduction of W^(6+).The charge capacity of W-doped NiO has also been improved,and it can function with wo_(3) to achieve a high performance black electrochromic smart window(ECSW)by balancing *** work could advance the fundamental understanding of defect engineering as an effective strategy to boost the electrochromic properties of NiO anodic material,manifesting a significant development as a candidate counter electrode in high-performance black smart windows.

关键词： NiO defect engineering charge balance black electrochromic windows

Efficient hydrogenolysis of fructose to 1,2-propanediol over bifunctional Ru-wo_(x)-MgO_(y) catalysts under mild reaction conditions via enhancing the chemoselective cleavage of C-C bonds

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Journal of Energy Chemistry 2024年第5期92卷 311-321页

作者： Shuang Luo Tie Shu Min Mao Haijie Yu Yuxin Zheng Daqian Ding Lingmei Liu Kexin yao Jianjian Wang School of Chemistry and Chemical Engineering State Key Laboratory of Coal Mine Disaster Dynamics and ControlInstitute of Advanced Interdisciplinary StudiesMulti-scale Porous Materials CenterChongqing UniversityChongqing 401331China Key Laboratory for Efficient Conversion and Circular Economy of Coal Chemical Engineering CollegeInner Mongolia University of TechnologyHohhot 010051Inner MongoliaChina

Selective conversion of fructose to 1,2-propanediol(1,2-PDO)is considered as a sustainable and cost-effective alternative to petroleum-based processes,however,this approach still faces challenges associated with low efficiency and harsh reaction ***,we have successfully synthesized a novel bifunctional Ru-wo_(x)-MgO_(y) catalyst through a facile'one-pot'solvothermal ***,this catalyst exhibits exceptional catalytic performances in the conversion of fructose to 1,2-PDO under mild reaction *** yield of 1,2-PDO is up to 56.2%at 140°C for 4 h under an ultra-low hydrogen pressure of only 0.2 MPa,surpassing the reported results in recent literature(below 51%).Comprehensive characterizations and density functional theory(DFT)calculations reveal that the presence of oxygen vacancies in the Ru-wo_(x)-MgO_(y) catalyst,serving as active acidic sites,facilitates the chemoselective cleavage of C-C bonds in fructose,which leads to the generation of active intermediates and ultimately resulted in the high yield of 1,2-PDO.

关键词： Biomass Fructose 1,2-Propanediol Retroaldol condensation Heterogenous catalysis

Morphological disruption and visual tuning alterations in the primary visual cortex in glaucoma(DBA/2J)mice

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Neural Regeneration Research 2024年第1期19卷 220-225页

作者： Yin Yang Zhaoxi Yang Maoxia Lv Ang Jia Junjun Li Baitao Liao Jing’an Chen Zhengzheng Wu Yi Shi Yang Xia Dezhong yao Ke Chen Department of Ophthalmology Sichuan Provincial People’s HospitalMedical SchoolUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for NeuroInformationSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Research Unit of NeuroInformation Chinese Academy of Medical SciencesChengduSichuan ProvinceChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical CollegeBeijingChina Health Management Center Sichuan Provincial Key Laboratory for Human Disease Gene StudySichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuan ProvinceChina School of Electrical Engineering Zhengzhou UniversityZhengzhouHenan ProvinceChina

Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the ***,it is not yet clear how the primary visual cortex(V1)is altered in *** study used DBA/2J mice as a model for spontaneous secondary *** aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J *** conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band *** morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue ***-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were *** with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial *** r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J *** findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual *** findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse *** study might offer some innovative perspectives regarding the treatment of glaucoma.

关键词： DBA/2J degeneration gamma band oscillations glaucoma primary visual cortex(V1) retina single-unit recording tuning curve

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慢性阻塞性肺疾病的睡眠相关低氧

国际呼吸杂志 2009年第23期29卷 1461-1464页

作者：冯靖姚我 AmbroseAn—Po Chiang 吴琦陈宝元天津医科大学总医院呼吸科 300052 杜勒姆美国杜克大学医学中心呼吸与危重监护科 27710

慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）患者的夜间低氧问题从50年以前就认识到了。在许多COPD患者的多导睡眠监测研究中，研究者发现患者的睡眠潜伏期延长，总睡眠时间减少，慢波睡眠减少，快速动眼睡眠减... 详细信息

慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）患者的夜间低氧问题从50年以前就认识到了。在许多COPD患者的多导睡眠监测研究中，研究者发现患者的睡眠潜伏期延长，总睡眠时间减少，慢波睡眠减少，快速动眼睡眠减少，还有一个最为重要的问题就是睡眠相关低氧（SRH）。本文主要对COPD患者SRH的定义、原因、患病率、严重程度、意义以及治疗等相关问题作一综述。

关键词：肺疾病慢性阻塞性睡眠低氧