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基于线粒体形态特征与UPLC-Triple-TOF-MS整合分析的人参/三七心肌保护物质辨析研究

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中国中药杂志 2024年第10期49卷 2766-2775页

作者：史雪敬陈彦羽蔡思怡邵青赵筱萍浙江中医药大学基础医学院浙江杭州310053 浙江大学药学院浙江杭州310058 浙江中医药大学中医药科学院浙江杭州310053

人参为补气强身之要药,三七具有散血定痛之功,常用于治疗心脉瘀阻所致的心肌缺血性疾病。线粒体功能障碍常伴随线粒体形态的异常改变,其可塑性和动态性在心血管疾病中至关重要。该研究将原代乳鼠心肌细胞缺氧培养4 h再复氧2 h,构建心肌... 详细信息

人参为补气强身之要药,三七具有散血定痛之功,常用于治疗心脉瘀阻所致的心肌缺血性疾病。线粒体功能障碍常伴随线粒体形态的异常改变,其可塑性和动态性在心血管疾病中至关重要。该研究将原代乳鼠心肌细胞缺氧培养4 h再复氧2 h,构建心肌细胞缺氧复氧损伤模型。采用荧光探针MitoTracker Deep Red标记心肌细胞线粒体,Hoechst 33342标记细胞核,使用高内涵荧光成像系统采集心肌细胞荧光图像,运用ImagePro Plus软件对图像自动批量处理并提取线粒体形态特征的量化参数,选取代表性参数用于评价线粒体形态功能改变进而筛选人参、三七有效组分;进一步整合UPLC-Triple-TOF-MS技术,筛选人参、三七有效成分。结果显示组分RS-2、RS-4、SQ-1、SQ-4可以同时显著提高线粒体3个形态参数值,增加线粒体长度、分支程度和面积,有效改善缺氧复氧损伤引起的心肌细胞线粒体形态改变。对有效组分的主要成分筛选发现20(R)-人参皂苷Rg_(3)、人参皂苷Re、七叶胆苷ⅩⅦ对心肌细胞线粒体保护作用最佳,进一步研究表明20(R)-人参皂苷Rg_(3)可能通过上调视神经萎缩蛋白1(optic atrophy 1,OPA1)和线粒体融合蛋白2(mitofusin 2,MFN2)表达,人参皂苷Re和七叶胆苷ⅩⅦ通过上调OPA1蛋白表达,促进线粒体膜融合,减轻线粒体损伤,从而发挥心肌细胞的保护作用。该研究为从人参、三七中发现创新药物提供了实验依据,也为中药心肌保护有效组分与有效成分的规模化筛选提供了新方法。

关键词：人参三七线粒体形态缺氧复氧活性成分心肌保护荧光成像

Amoeba-inspired magnetic microgel assembly assisted by engineered dextran-binding protein for vaccination against lifethreatening systemic infection

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Nano Research 2023年第1期16卷 938-950页

作者： Shuo Liu yan Zhao Linpei Guo Qilin yu Key Laboratory of Molecular Microbiology and Technology Ministry of EducationDepartment of MicrobiologyCollege of Life SciencesNankai UniversityTianjin 300071China Research Center for Infectious Diseases Nankai UniversityTianjin 300350China College of Environmental Science and Engineering Tianjin Key Laboratory of Environmental Remediation and Pollution ControlNankai UniversityTianjin 300350China Department of Urology The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical UniversityWuxi 214002China

Vaccination is critical for population protection from pathogenic ***,its efficiency is frequently compromised by a failure of antigen retention and ***,we designed a dextran-binding protein DexBP,which is composed of the carbohydrate-binding domains of Trichoderma reesei cellobiohydrolases Cel6A and Cel7A,together with the sequence of the fluorescent protein *** was further prepared by engineered Escherichia coli cells and grafted to magnetic *** magnetic nanoparticles were integrated with a dextran/poly(vinyl alcohol)framework and a reactive oxygen species-responsive linker,obtaining magnetic polymeric microgels for carrying pathogen *** to amoeba aggregation,the microgels self-assembled to form aggregates and further induced dendritic cell *** step-by-step assembly retained antigens at lymph nodes,promoted antigen presentation,stimulated humoral immunity,and protected the mice from lifethreatening systemic *** study developed a magnetic microgel-assembling platform for dynamically regulating immune response during protection of the body from dangerous infections.

关键词： magnetic nanoparticle engineered protein dextran microgel vaccination systemic infection

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基于等容瞬时单位线的水文模型研究

人民长江 2024年第6期55卷 92-97页

作者：闫宝伟唐仪伟刘昱古东霖孙明博华中科技大学土木与水利工程学院湖北武汉430074 华中科技大学数字流域科学与技术湖北省重点实验室湖北武汉430074 长江勘测规划设计研究有限责任公司湖北武汉430010

流域下垫面空间分布的不均匀性对径流的形成有较大影响,流域蓄水容量曲线解决了流域产流空间异质性的问题,但在采用瞬时单位线进行地表汇流计算时,又将其作为空间分布均匀的净雨处理,局部产流并没有实现局部的汇流。考虑汇流时间与蓄水... 详细信息

流域下垫面空间分布的不均匀性对径流的形成有较大影响,流域蓄水容量曲线解决了流域产流空间异质性的问题,但在采用瞬时单位线进行地表汇流计算时,又将其作为空间分布均匀的净雨处理,局部产流并没有实现局部的汇流。考虑汇流时间与蓄水容量的空间相关性,通过Copula函数构造二者的联合分布,以条件概率的形式反映不同蓄水容量处汇流时间的空间分布特征,进而以等蓄水容量为计算单元,提出了等容瞬时单位线的概念,相当于采用变单位线的方式计算单元产流量的地表径流,从而可以实现局部产汇流计算过程的统一。由此,创建了基于等容瞬时单位线的水文模型IIUHH,并根据Copula函数的类型构建了多种形式的IIUHH,最后选择清江上游作为案例进行验证。结果表明:Clayton型的IIUHH在研究区域表现更优,相比于新安江模型,Nash效率系数可以提高4%~12%,Kling-Gupta效率系数可以提高13%~27%,洪峰相对误差则可降低26%~36%,较大程度上提高了洪峰和洪水过程的模拟精度。研究成果可为流域高精度径流预报提供技术支撑。

关键词：等容瞬时单位线水文模型蓄水容量空间相关性新安江模型清江

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Traditional Chinese medicines derived natural inhibitors of ferroptosis on ischemic stroke

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Chinese Journal of Natural Medicines 2024年第8期22卷 746-755页

作者： WANG Yongliang LAN Xiaobing LIU Ning MA Lin DU Juan WEI Wei HAI Dongmei WU Jing yu Jianqiang LIU yue School of Pharmacy Ningxia Medical UniversityYinchuan 750000China Ningxia Key Laboratory of Drug Development and Generic Drug Research Ningxia Medical UniversityYinchuan 750000China Ningxia Characteristic Traditional Chinese Medicine Modern Engineering Research Center Ningxia Medical UniversityYinchuan 750000China College of Basic Medical Sciences Ningxia Medical UniversityYinchuan 750000China

Ischemic stroke(IS)is a globally prevalent cerebrovascular disorder resulting from cerebral vessel occlusion,leading to significant morbidity and *** intricate pathological mechanisms underlying IS complicate the development of effective therapeutic ***,a form of programmed cell death(PCD)characterized by iron overload and accumulation of lipid peroxidation products,has been increasingly recognized as a key contributor to IS *** Chinese medicines(TCMs)have long been utilized in the management of IS,prompting extensive research into their potential as sources of natural ferroptosis *** review investigates the critical role of ferroptosis in IS and provides a comprehensive analysis of current research on natural ferroptosis inhibitors identified in TCMs,aiming to lay a theoretical groundwork for the development of innovative anti-IS therapies.

关键词： Ischemic stroke Traditional Chinese medicines Natural inhibitors Ferroptosis

Clinical Management Guidelines for Intrahepatic Cholestasis of Pregnancy

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Maternal-Fetal Medicine 2024年第1期6卷 13-22页

作者： Obstetrics Group of the Gynecology and Obstetrics Branch of Chinese Medical Association Perinatal Medicine Branch of Chinese Medical Association Xinyang yu Huixia yang Hongbo Qi 不详 Medical University Chongqing 400016China Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Department of Obstetrics and Gynecology Women and Children's Hospital of Chongqing Medical UniversityChongqing 401147China

Intrahepatic cholestasis of pregnancy(ICP)is a significant gestational complication in late pregnancy,potentially leading to severe perinatal complications such as intrauterine fetal demise and preterm *** Obstetrics Group of the Gynecology and Obstetrics Branch and the Perinatal Medicine Branch of the Chinese Medical Association organized a panel of domestic experts to deliberate and propose recommendations based on domestic and international guidelines,recent evidence-based medical evidence about key clinical issues including risk factors,clinical manifestations,perinatal outcomes,diagnosis,severity grading,maternal and fetal monitoring,treatment methods,timing,and methods of pregnancy termination,and postpartum follow-up for ICP,with the aim to guide its clinical diagnosis,treatment,and management.

关键词： Cholestasis,Intrahepatic Bile Acids Stillbirth Preterm Birth Diagnostic and Therapeutic Guidelines(Theme)

Theoretical Performance Analysis of an Ejector Enhanced High-Temperature Heat Pump with Dual-Pressure Condensation and Evaporation

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Journal of Thermal Science 2022年第5期31卷 1367-1379页

作者： BAI Tao LIU Ye yan Gang yu Jianlin Department of Refrigeration and Cryogenic Engineering School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an710049China

In this paper,an ejector enhanced high-temperature heat pump with dual-pressure condensation and evaporation is proposed to improve the system *** analyses of the system operation characteristics are conducted using energetic and exergetic *** performance comparisons among the basic cycle,parallel compression cycle,and ejector enhanced cycle are conducted with six different refrigerants,including R245fa,R600a,R1234ze(Z),R1336mzz(Z),R1224yd(Z),and R1233zd(E).The results demonstrate that environmentally-friendly refrigerant R1234ze(Z)would be a promising alternative *** with the basic cycle and parallel compression cycle at selected operation conditions,29.5%and 12.6%improvements in COP,and 16.7%and 11.1%higher system exergy efficiency are achieved in the ejector enhanced cycle on *** volumetric heating capacity of the ejector enhanced cycle is increased by 15.7%–21.7%.The ejector enhanced cycle outperforms the other two cycles in high-temperature heat pump applications at the large temperature lift and temperature rise in the heat *** assessment offers an option to improve the energy utilization efficiency of the high-temperature heat pumps.

关键词： thermodynamics exergy high-temperature heat pump ejector dual-temperature condensation/evaporation

Smart industrial IoT empowered crowd sensing for safety monitoring in coal mine

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Digital Communications and Networks 2023年第2期9卷 296-305页

作者： Jing Zhang Qichen yan Xiaogang Zhu Keping yu Department of Computer Science and Technology Xi'an University of Science and TechnologyXi'an710054China Department of Information Science and Technology Northwest UniversityXi’an 710127China School of Public Policy and Administration Nanchang UniversityNanchangJiangxi330031China Graduate School of Science and Engineering Hosei UniversityTokyo184-8584Japan RIKEN Center for Advanced Intelligence Project RIKENTokyo103-0027Japan

The crowd sensing technology can realize the sensing and computing of people,machines,and environment in smart industrial IoT-based coal mine,which provides a solution for safety monitoring through distributed intelligence ***,due to the difficulty of neural network training to achieve global optimality and the fact that traditional LSTM methods do not consider the relationship between adjacent machines,the accuracy of human body position prediction and pressure value prediction is not *** solve these problems,this paper proposes a smart industrial IoT empowered crowd sensing for safety monitoring in coal ***,we propose a Particle Swarm Optimization-Elman Neural Network(PE)algorithm for the mobile human position ***,we propose an ADI-LSTM neural network prediction algorithm for pressure values of machines supports in underground *** them,our proposed PE algorithm has the lowest average cumulative prediction error,and the trajectory fit rate is improved by 24.1%,13.9%and 8.7%compared with Kalman filtering,Elman and Kalman plus Elman algorithms,***,compared with single-input ARIMA,RNN,LSTM,and GRU,the RMSE values of our proposed ADI-LSTM are reduced by 36.6%,52%,32%,and 13.7%,respectively;and the MAPE values are reduced by 0.0003%,0.9482%,1.1844%,and 0.3620%,respectively.

关键词： Crowd sensing Industrial Internet of things Safety monitoring Coal mine

基于3D打印的模块化点阵结构创意装设计研究

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北京服装学院学报（自然科学版） 2024年第2期44卷 23-29页

作者：赵雨张羽翔程琰孙梦琴危希曦西南大学蚕桑纺织与生物质科学学院重庆400715 福州大学厦门工艺美术学院福建厦门361024

为探索现代工业最新技术在创意装上的应用,以模块化及3D打印点阵结构为基础,提出了一种新的创意装设计思路及制造方法。首先建立了可多向扩展的单体模块几何设计框架及点阵结构连接单体的力学模型,分析它们的力学特性和设计制造可行性,... 详细信息

为探索现代工业最新技术在创意装上的应用,以模块化及3D打印点阵结构为基础,提出了一种新的创意装设计思路及制造方法。首先建立了可多向扩展的单体模块几何设计框架及点阵结构连接单体的力学模型,分析它们的力学特性和设计制造可行性,再通过创意装三维模型构建平面结构图方法及3D打印技术,实现了创意装的设计与制造。结果表明:提出的单体模块结构可在空间任意方向扩展,点阵结构连接单体再用聚乳酸(PLA)3D打印组装后可保持稳定的结构与承载能力,能保证创意装的再设计与多样性制造,为新一代服装设计从材料、设计到制造流程等方面提供了一种新的多学科交叉融合范式。

关键词：创意服装 3D打印单体模块点阵结构设计制造

Acute coronary syndrome in a patient with gastric cancer treated by immune checkpoint inhibitor: A case report

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Malignancy Spectrum 2024年第2期1卷 136-140页

作者： Bin Guan Lingyun Zhang Shan yu Department of Medical Oncology Jinshan HospitalFudan UniversityShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina Department of Medical Oncology Shanghai Geriatric Medical CenterShanghaiChina Department of Medical Oncology Zhongshan HospitalFudan UniversityShanghaiChina

Objective:To highlight the incidence and management of acute coronary syndrome(ACS)in patients with gastric cancer undergoing immune checkpoint inhibitor(ICI)therapy,emphasizing the need for early detection and intervention in this high-risk *** and methods:We presented a case of a 71-year-old male patient with poorly differentiated adenocarcinoma of the gastric antrum,clinical stage cT4N2M0,phase III,with no prior history of chronic diseases or cardiovascular risk *** patient was treated with a combination of ICI therapy(sintilimab)and chemotherapy using the albumin-bound paclitaxel combined with S1 *** therapy,he developed symptoms and diagnostic findings consistent with ACS,which was managed with percutaneous coronary ***:The patient's presentation with ACS during ICI therapy underscored the potential cardiovascular risks associated with cancer treatments,particularly in patients without traditional cardiovascular risk *** involved collaboration between oncologists and cardiologists,leading to successful coronary stenting and continuation of antitumor ***:ACS is a significant risk in patients with malignancies undergoing ICI therapy,even in those without prior cardiovascular *** recognition and management of ACS in this context are crucial to enable the continuation of cancer treatment and improve patient *** case underscores the importance of interdisciplinary collaboration in managing complex patients with concurrent cancer and cardiovascular disease.

关键词： gastric cancer acute coronary syndrome immune checkpoint inhibitor