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The role of human rhinovirus in immunology, COPD, and corresponding treatments

Frontiers in Biology 2013年第4期8卷 377-386页

作者： william j. roberts Georgianna G. SERGAKIS Li ZUO Department of Biological Sciences Oakland University Rochester MI 48309 USAA Respiratory Therapy Division School of Health and Rehabilitation Sciences Davis Heart and Lung Research Institute The Ohio State University College of Medicine The Ohio State University Wexner Medical Center Columbus OH 43210 USA

The common cold is most often a result of human rhinovirus （HRV） infection. Common cold symptoms including rhinorrhea and nasal obstruction frequently occur during HRV infection of the upper respiratory tract. Conversely, HRV may also infect the epithelial cells of the lower respiratory tract. Symptom severity associated with HRV infection ranges from mild to potentially serious depending on a person＇s susceptibility and preexisting condition, such as chronic obstructive pulmonary disease. An over active host immune response is believed to be the primary contributor to HRV pathogenesis. Enhanced activity of various host cell cytokines and granulocytes mediate specific cellular pathways inducing many of the symptoms associated with HRV infection. There are over 100 serotypes of HRV which can be further categorized based on the specific characteristics of each type. The two main categories of HRV consist of the maj.r and minor groups. The unique host cell receptor is the distinguishing factor between these two groups. Yet, these viruses may also differ in mechanism of infection and replication. Due to the high frequency of hospital and clinical visits and the corresponding economic burden, novel therapies are of interest. Several different treatment options varying from herbal remedies to anti-viral drugs have been studied. However, the vast number of HRV serotypes complicates the progress of developing a universal treatment for attenuating HRV infection.

关键词： human rhinovirus common cold immunology COPD

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Ischemic and hypoxic preconditioning protect cardiac muscles via intracellular ROS signaling

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Frontiers in Biology 2013年第3期8卷 305-311页

作者： Li ZUO william j. roberts Rosa C. TOLOMELLO Adam T. GOINS Molecular Physiology and Biophysics Laboratory Department of Biological Sciences Oakland University Rochester MI 48326 USA

Oxidative stress can cause extensive damage to cardiac tissue under reperfusion conditions. However, preconditioning the myocardium may diminish these negative effects and alleviate reperfusion inj.ry. There are a variety of preconditioning therapies, such as ischemic preconditioning （IPC） and hypoxie preconditioning （HPC）, each targeting specific channels, receptors, and/or intracellular molecules. Ischemic preconditioning involves brief periods of ischemia followed by brief periods of reperfusion, thus strengthening the cardiac resistance for a longer period of ischemia. IPC involves complex mechanisms, some of which are still not completely understood today. Nevertheless, many studies have already established models of IPC. In addition, similar to IPC, HPC has also been recognized as preventing reperfusion inj.ry. Reactive oxygen species （ROS） are known mediators of IPC and HPC. Particularly, mitochondria-generated ROS initiate activity of several beneficial preconditioning pathways. The role of ROS is paradoxical; low levels of ROS are key factors in signaling IPC/HPC, but high levels of ROS can contribute to increased oxidative stress on cardiomyocytes. Therefore, it is important to determine the molecular mechanism of IPC and HPC to avoid excessive accumulation of ROS to prevent cardiac inj.ry. In this review, we will outline IPC and HPC, explaining the putative role of ROS in both pathways. We will also discuss preconditioning efficacy in certain conditions such as exercise and how the aging myocardium responds to preconditioning therapies.

关键词： hypoxia ischemia-reperfusion ROS cardiomyocyte preconditioning

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Etiology and management of urethral calculi:A systematic review of contemporary series

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Asian j.urnal of Urology 2024年第1期11卷 10-18页

作者： Andrew Morton Arsalan Tariq Nigel Dunglison Rachel Esler Matthew j.roberts Faculty of Medicine The University of QueenslandBrisbaneQueenslandAustralia Department of Urology Ipswich HospitalQueenslandAustralia Department of Urology Royal Brisbane and Women's HospitalQueenslandAustralia The University of Queensland Centre for Clinical Research HerstonAustralia

Obj.ctive:To conduct a systematic literature review on urethral calculi in a contemporary cohort describing etiology,investigation,and management ***:A systematic search of MEDLINE and Cochrane Central Register of Controlled Trials(CENTRAL)databases was ***,including case reports and case series on urethral calculi published between j.nuary 2000 and December 2019,were ***-text manuscripts were reviewed for clinical parameters including symptomatology,etiology,medical history,investigations,treatment,and *** were collated and analyzed with univariate ***:Seventy-four publications met inclusion criteria,reporting on 95 *** symptoms(41.1%),pain(40.0%),and acute urinary retention(32.6%)were common presenting *** calculi were most often initially investigated using plain X-ray(63.2%),with almost all radio-opaque(98.3%).Urethral calculi were frequently associated with coexistent bladder or upper urinary tract calculi(16.8%)and underlying urethral pathology(53.7%)including diverticulum(33.7%)or stricture(13.7%).Urethral calculi were most commonly managed with external urethrolithotomy(31.6%),retrograde manipulation(22.1%),and endoscopic in situ lithotripsy(17.9%).Conclusion:This unique systematic review of urethral calculi provided a summary of clinical features and treatment trends with a suggested treatment *** in contemporary urological practice should be according to calculus size,shape,anatomical location,and presence of urethral pathology.

关键词： Urinary calculi Urethra Urethral calculi Management algorithm

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The risk of prostate cancer on incidental finding of an avid prostate uptake on 2-deoxy-2-[^(18)F]fluoro-D-glucose positron emission tomography/computed tomography for non-prostate cancer-related pathology:A single centre retrospective study

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Asian j.urnal of Urology 2024年第1期11卷 33-41页

作者： Anthony Franklin Troy Gianduzzo Boon Kua David Wong Louise McEwan j.mes Walters Rachel Esler Matthew j.roberts Geoff Coughlina j.hn W.Yaxley Department of Urology The Wesley HospitalBrisbaneQLDAustralia Wesley Medical Research BrisbaneQLDAustralia School of Medicine The University of QueenslandBrisbaneQLDAustralia Department of Radiology Wesley Medical ImagingBrisbaneQLDAustralia Department of Urology Royal Brisbane and Women's HospitalBrisbaneQLDAustralia

Obj.ctive:To review the risk of prostate cancer(PCa)in men with incidentally reported increased intraprostatic uptake at 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography(18F-FDG PET/CT)ordered at Department of Urology,The Wesley Hospital,Brisbane,QLD,Australia for non-PCa related ***:Retrospective analysis of consecutive men between August 2014 and August 2019 presenting to a single institution for 18F-FDG PET/CT for non-prostate related conditions was *** were classified as benign,indeterminate,or malignant depending of the results of prostate-specific antigen(PSA),PSA velocity,biopsy histopathology,and three-Tesla(3 T)multiparametric MRI(mpMRI)Prostate Imaging Reporting and Data System score,or gallium-68-prostate-specific membrane antigen(68Ga-PSMA)PET/CT ***:Three percent(273/9122)of men demonstrated 18F-FDG avidity within the ***-five percent(231/273)were further investigated,including with PSA tests(227/231,98.3%),3 T mpMRI(68/231,29.4%),68Ga-PSMA PET/CT(33/231,14.3%),and prostate biopsy(57/231,24.7%).Results were considered benign in 130/231(56.3%),indeterminate in 31/231(13.4%),and malignant in 70/231(30.3%).PCa was identified in 51/57(89.5%)of the men who proceeded to biopsy,including 26/27(96.3%)men with Prostate Imaging Reporting and Data System scores 4-5 mpMRI and six men with a positive 68Ga-PSMA PET/*** most common Gleason score on biopsy was greater than or equal to 4+5(14/51,27.5%).68Ga-PSMA PET/CT was concordant with the 18F-FDG findings in 26/33(78.8%).All 13 men with a positive concordant 18F-FDG,3 T mpMRI,and 68Ga-PSMA PET/CT had PCa on *** was no statistically significant difference in the 18F-FDG maximum standardized uptake value between the benign or malignant groups(5.7 vs.6.1;p=0.580).Conclusion:In this study,after an incidental finding of an avid intraprostatic lesion on 18F-FDG PET/CT,70 of the 231 cases(30.3%;0.8%of the entire cohort)had results c

关键词： Prostatecancer Positionemission tomography Multiparametric magneticresonance imaging Prostatebiopsy

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Hepatic vein reconstruction during hepatectomy:A feasible and underused technique

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 421-427页

作者： Manish Ahuj. Kunal j.shi Chris Coldham Paulo Muiesan Bobby Dasari Manuel Abradelo Ravi Marudanayagam Darius Mirza j.hn Isaac David Bartlett Nikolaos A Chatzizacharias Robert P Sutcliffe Keith j.roberts Department of HPB and Liver Transplant Surgery University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Immunology and Immunotherapy University of BirminghamBirminghamUK

Complete surgical resection(R0)of liver tumors,primary or metastatic,remains the main obj.ctive in management of primary and metastatic liver tumors[1].Tumors invading to the proximity of the hepatic venous outflow pose a peculiar challenge to achieve R0 resections,because this location may render a tumor *** median survival of patients with liver tumor without surgery is less than 12 months[2].Even with surgery,post-hepatectomy liver failure and subsequently increased mortality are the main problems associated with complex resection[3].Moreover,when the vein is affected,vein resection and subsequent reconstruction are *** resection is a standard practice in liver resection and transplantation[4],for example,hepatic vein reconstruction during a living-donor liver transplant,porto-mesenteric axis reconstruction during resection of advanced pancreatic cancer and caval reconstruction during resection of retroperitoneal ***,novel techniques like total hepatic vascular exclusion(HVE)[5],veno-venous bypass[6]and ex vivo hepatic resection[7,8]have facilitated curative resections of tumors close to one or more maj.r hepatic veins.

关键词： hepatectomy surgery mortality

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Management of distal cholangiocarcinoma with arterial involvement: Systematic review and case series on the role of neoadj.vant therapy

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World j.urnal of Gastrointestinal Surgery 2024年第8期16卷 2689-2701页

作者： Lewis A Hall Duncan Loader Santiago Gouveia Marta Burak j.mes Halle-Smith Peter Labib Moath Alarabiyat Ravi Marudanayagam Bobby V Dasari Keith j.roberts Syed S Raza Michail Papamichail David C Bartlett Robert P Sutcliffe Nikolaos A Chatzizacharias Department of Hepatopancreatobiliary Surgery and Liver Transplantation University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom College of Medical and Dental Sciences University of BirminghamBirmingham B152TTUnited Kingdom Institute of Clinical Sciences University of BirminghamBirmingham B152TTUnited Kingdom

BACKGROUND The use of neoadj.vant therapy(NAT)in distal cholangiocarcinoma(dCCA)with regional arterial or extensive venous involvement,is not widely accepted and evidence is *** To synthesise evidence on NAT for dCCA and present the experience of a highvolume tertiary-centre managing dCCA with arterial *** A systematic review was performed according to PRISMA guidance to identify all studies reporting outcomes of patients with dCCA who received *** patients from 2017 to 2022 who were referred for NAT for dCCA at our centre were retrospectively collected from a prospectively maintained *** characteristics,NAT type,progression to surgery and oncological outcomes were *** Twelve studies were *** definition of“unresectable”locally advanced dCCA was *** studies reported outcomes for 9 patients who received NAT for dCCA with extensive vascular involvement.R0 resection rate ranged between 0 and 100%but without survival benefit in most *** studies considered either NAT in resectable dCCA or inclusive with extrahepatic *** presented case series includes 9 patients(median age 67,IQR 56-74 years,male:female 5:4)referred for NAT for borderline resectable or locally advanced *** patients progressed to surgery and 2 were *** patient died at 14 months with evidence of recurrence at 6 months and the other died at 51 months following recurrence 6 months *** Evidence for benefit of NAT is *** on criteria for uniform definition of resectability for dCCA is *** propose using the established National-Comprehensive-Cancer-Network®criteria for pancreatic ductal adenocarcinoma.

关键词： Cholangiocarcinoma Neoadj.vant therapy Arterial involvement Locally advanced Systematic review

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The Geology of the Everglades and Adj.cent Areas Har/DVD

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2007年

作者： Petuch, Edward j. roberts, Charles

ISBN: (数字)9781420045598

ISBN: (纸本)9781420045581

Painting a complete picture of the history of the Everglades, The Geology of the Everglades and Adj.cent Areas brings together theperspectives of various geoscientists to provides an overview of the geology, paleontology, and paleoceanography of the Everglades region. It emphasizes the upper 300 m of the geologic framework of the area and gi

关键词： Geology

来源：畅想之星图书光盘版（南... 评论

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"Miles wide and miles deep"-Exploring the depth and breadth of geoscience during the first ten years of Geoscience Frontiers

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Geoscience Frontiers 2019年第3期10卷 1219-1221页

作者： Christopher j. Spencer Nick M.W.roberts Damian Nance The Institute of Geoscience Research (TIGeR) School of Earth and Planetary Sciences Curtin University NERC Isotope Geosciences Laboratory British Geological Survey Department of Geological Sciences Ohio University Department of Geology and Geophysics Yale University

When early explorers first crossed the Platte River in what is now Nebraska (USA), it was said the river was “a mile wide and an inch deep”(Mokler, 1923;Smith, 1971). This phrase was used to describe not only the difficulty in crossing the river but also in navigating its length. The trouble with a river being too wide is the risk that it won’t provide the depth necessary to be useful. The same thing can be said of multidisciplinary scientific j.urnals. While a j.urnal can claim to be multidisciplinary, there is a risk of it being so broad that its articles can only engage the reader at a superficial level. Nothing could be further from the truth with Geoscience Frontiers. Over the past ten years, this j.urnal has successfully navigated the wide breadth of geoscience while providing a level of depth and detail that rivals discipline-specific j.urnals.

关键词： engage its was can past be is now

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ESTIMATE ACCURACY OF NONLINEAR COEFFICIENTS OF SQUEEZEFILM DAMPER USING STATE VARIABLE FILTER METHOD

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Chinese j.urnal of Mechanical Engineering 1998年第3期11卷 13-19页

作者： Zhang, Youyun roberts, j.B. Xian j.aotong Univ Xian China

The estimate model for a nonlinear system of squeeze film damper (SFD) is *** method of state variable filter (SVF) is used to estimate the coefficients of *** factors which are critical to the estimate accuracy are ... 详细信息

关键词： Nonlinear coefficient Squeeze film State variable filter Parameter estimate

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Transcriptional Control of SET DOMAIN GROUP 8 and CAROTENOID ISOMERASE during Arabidopsis Development

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Molecular Plant 2010年第1期3卷 174-191页

作者： Christopher I. Cazzonelli Andrea C. roberts Melanie E. Carmody Barry j. Pogson Australian Research Council Centre of Excellence in Plant Energy Biology Research School of Biology The Australian National University Canberra ACT0200 Australia

Carotenoids are pigments required for photosynthesis, photoprotection and the production of carotenoid- derived hormones such as ABA and strigolactones. The carotenoid biosynthetic pathway bifurcates after lycopene to produce epsilon- and beta-carotenoids and this branch is critical for determining carotenoid composition. Here, we show how the branch point can be regulated by the chromatin-modifying histone methyltransferase, Set Domain Group 8 （SDG8） targeting the carotenoid isomerase （CRTISO）. SDG8 is required to maintain permissive expression of CRTISO during seedling development, in leaves, shoot apex, and some floral organs. The CRTISO and SDG8 promoters show overlapping tissue-specific patterns of reporter gene activity. Interestingly, CRTISO showed atypical reporter gene expression in terms of greater variability between different lines compared to the Cauliflower Mosaic Virus 35S promoter （CaMV35s） and ~LCY promoters, potentially due to chromosomal position effects. Regulation of the CRTISO promoter was dependent in part upon the presence or absence of SDG8. Knockouts of SDG8 （carotenoid and chloroplast regulation （ccrl）） and CRTISO （ccr2） result in altered carotenoid composition and this could be restored in ccr2 using the CaMV35s or CRTISO promoters. In contrast, varying degrees of GUS expression and carotenoid complementation by CRTISO overexpression using CaMV35S or CRTISO promoters in the ccrl background demonstrated that both the CRTISO promoter and open reading frame are necessary for SDG8-mediated expression of CRTISO.

关键词： Photosynthesis secondary metabolism--terpenoids, isoprenoids, and carotenoids chloroplast biology epigenetics gene expression gene regulation.

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