The role of human rhinovirus in immunology, COPD, and corresponding treatments

作     者：William J. ROBERTS Georgianna G. SERGAKIS Li ZUO 

作者机构：Department of Biological Sciences Oakland University Rochester MI 48309 USAA Respiratory Therapy Division School of Health and Rehabilitation Sciences Davis Heart and Lung Research Institute The Ohio State University College of Medicine The Ohio State University Wexner Medical Center Columbus OH 43210 USA 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2013年第8卷第4期

页      面：377-386页

核心收录：

学科分类：071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 09[农学] 0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 090603[农学-临床兽医学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1001[医学-基础医学(可授医学、理学学位)] 0817[工学-化学工程与技术] 0906[农学-兽医学] 0836[工学-生物工程] 0713[理学-生态学] 

基　　金：supported by grants of OU General Fund G110 Research Excellence Fund of Biomedical Research and OSUMC Fund 013000 

主　　题：human rhinovirus common cold immunology COPD 

摘      要：The common cold is most often a result of human rhinovirus （HRV） infection. Common cold symptoms including rhinorrhea and nasal obstruction frequently occur during HRV infection of the upper respiratory tract. Conversely, HRV may also infect the epithelial cells of the lower respiratory tract. Symptom severity associated with HRV infection ranges from mild to potentially serious depending on a person＇s susceptibility and preexisting condition, such as chronic obstructive pulmonary disease. An over active host immune response is believed to be the primary contributor to HRV pathogenesis. Enhanced activity of various host cell cytokines and granulocytes mediate specific cellular pathways inducing many of the symptoms associated with HRV infection. There are over 100 serotypes of HRV which can be further categorized based on the specific characteristics of each type. The two main categories of HRV consist of the major and minor groups. The unique host cell receptor is the distinguishing factor between these two groups. Yet, these viruses may also differ in mechanism of infection and replication. Due to the high frequency of hospital and clinical visits and the corresponding economic burden, novel therapies are of interest. Several different treatment options varying from herbal remedies to anti-viral drugs have been studied. However, the vast number of HRV serotypes complicates the progress of developing a universal treatment for attenuating HRV infection.