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Exosome secretion from hypoxic cancer cells reshapes the tumor microenvironment and mediates drug resistance

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cancer Drug Resistance 2022年第3期5卷 577-594页

作者： Kenneth K.W.To william c.s.cho school of Pharmacy Faculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of clinical Oncology Queen Elizabeth HospitalHong Kong SARChina

Hypoxia is a common phenomenon in solid tumors as the poorly organized tumor vasculature cannot fulfill the increasing oxygen demand of rapidly expanding *** hypoxia,tumor cells reshape their microenvironment to sustain survival,promote metastasis,and develop resistance to *** are extracellular vesicles secreted by most eukaryotic cells,including tumor *** are enriched with a selective collection of nucleic acids and proteins from the originating cells to mediate cell-to-cell *** evidence suggests that exosomes derived from tumor cells play critical roles in modulating the tumor microenvironment(TME).Hypoxia is known to stimulate the secretion of exosomes from tumor cells,thereby promoting intercellular communication of hypoxic tumors with the surrounding stromal ***-mediated signaling pathways under hypoxic conditions have been reported to cause angiogenesis,invasion,metastasis,drug resistance,and immune ***,the programmed cell death ligand-1(PD-L1)has been reported to reside as a transmembrane protein in tumor *** PD-L1 was shown to suppress T cell effector function in the TME and cause drug resistance to immune checkpoint *** review provides an update about the pivotal role of tumor-derived exosomes in drug resistance to chemotherapy and immunotherapy,particularly under hypoxic *** strategies that target the exosomes in the hypoxic TME to enhance the antitumor efficacy are discussed.

关键词： Hypoxia drug resistance exosome tumor microenvironment immunotherapy non-coding RNA

MicroRNAs: Mechanisms, Functions and Progress

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Genomics, Proteomics & Bioinformatics 2012年第5期10卷 237-238页

作者： Tongbin Li william c.s.cho *** Research Group LC SciencesHoustonTX 77054USA Department of clinical Oncology Queen Elizabeth HospitalHong Kong SARChina

In 1993 when Ambros and co-workers [1] discovered that a mysterious caenorhabditis elegans gene, lin-4, does not encode a protein, but acts in the form of a small RNA and represses the expression of its target gene, lin-14, through base-pairing with its 3＇ untranslated region （3tUTR）, nobody would imagine that 20 years later, this category of small RNAs - now widely known as microR- NAs （or miRNAs）, has ～2000 known members in the human genome （and counting）, and that miRNA-mediated gene regulation is deeply involved in virtually all important biological processes in animals and plants.

关键词： caenorhabditis elegans biological processes gene regulation human genome target gene small RNA form of

A systematic review of herbal medicines for the treatment of cancer cachexia in animal models

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2019年第1期20卷 9-22页

作者： Bongki PARK sooseong YOU william c.s.cho Jun-Yong choI Myeong soo LEE Liver and Immunology Research center Oriental College Daejeon University clinical Medicine Division Korea Institute of Oriental Medicine Department of clinical Oncology Queen Elizabeth Hospital Department of Korean Internal Medicine School of Korean Medicine Pusan National University

Objective: The aim of this study is to summarize preclinical studies on herbal medicines used to treat cancer cachexia and its underlying mechanisms. Methods: We searched four representing databases, including Pub Med, EMBAsE, the Allied and complementary Medicine Database, and the Web of science up to December 2016. Randomized animal studies were included if the effects of any herbal medicine were tested on cancer cachexia. The methodological quality was evaluated by the collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental studies(cAMARADE) checklist. Results: A total of fourteen herbal medicines and their compounds were identified, including coptidis Rhizoma, berberine, Bing De Ling, curcumin, Qing-shu-Yi-Qi-Tang, scutellaria baicalensis, Hochuekkito, Rikkunshito, hesperidin, atractylodin, sipjeondaebo-tang, sosiho-tang, Anemarrhena Rhizoma, and Phellodendri cortex. All the herbal medicines, except curcumin, have been shown to ameliorate the symptoms of cancer cachexia through anti-inflammation, regulation of the neuroendocrine pathway, and modulation of the ubiquitin proteasome system or protein synthesis. conclusions: This study showed that herbal medicines might be a useful approach for treating cancer cachexia. However, more detailed experimental studies on the molecular mechanisms and active compounds are needed.

关键词： cancer cachexia Herbal medicine Traditional East Asian medicine systematic review

Disease Biomarkers for Precision Medicine:challenges and Future Opportunities

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Genomics, Proteomics & Bioinformatics 2017年第2期15卷 57-58页

作者： Edwin Wang william c.s.cho s.c.cesar Wong siqi Liu center for Health Genomics and Informatics University of Calgary Cumming School of Medicine Department of clinical Oncology Queen Elizabeth Hospital Department of Health Technology and Informatics Faculty of Health and Social Sciences Hong Kong Polytechnic University cAs Key Laboratory of Genome sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences

Most of the human diseases are complex diseases,which could be caused by many genetic *** means that for a given phenotype(i.e.,a complex disease),there are multiple potential genes which could be genomically or epigenetically changed(i.e.,mutations,copy number variations,epigenetic modifications,and so on).Therefore,it is understandable that different individuals who share the same phenotype/diseases may have different causal genes and thus,may have different drug *** example,mutated genes are rarely common between the cancer patients of the same cancer type[1];furthermore,for a given drug,only 10%-30% of the patients

关键词： data Disease Biomarkers for Precision Medicine:challenges and Future Opportunities

Thematic Trends in complementary and Alternative Medicine Applied in cancer-Related symptoms

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Journal of Data and Information science 2018年第2期3卷 1-19页

作者： Jose A.Moral-Munoz Manuel Arroyo-Morales Barbara F.Piper Antonio I.cuesta-Vargas Lourdes Díaz-Rodríguez william c.s.cho Enrique Herrera-Viedma Manuel J.cobo Dept. Nursing and Physiotherapy University of Cádiz Cádiz Spai Institute of Research and Innovation in Biomedical sciences of the Province of cádiz （INiBIcA） University of Cádiz Cádiz Spain 3Dept. Physical Therapy University of Granada Granada Spain 4Dept. Nursing School of Health and Human Services National University San Diego CA US 5school clinical science Queensland University of Technology Brisbane QLD Australi 6Instituto Biosanitario （IBs） University of Granada Granada Spai 7Hospital Authority Hong Kong Chin 8Dept. computer science and Artificial Intelligence University of Granada Granada Spai 9Dept. of computer science and Engineering University of Cádiz Cádiz Spai

Purpose： The main goal of this study is to discover the scientific evolution of cancer-Related symptoms in complementary and Alternative Medicine research area, analyzing the articles indexed in the Web of science database from 1980 to ***/Methodology/Approach： A co-word science mapping analysis is performed under a longitudinal framework（1980 to 2013）. The documental corpus is divided into two subperiods,1980–2008 and 2009–2013. Thus, the performance and impact rates, and conceptual evolution of the research field are ***： According to the results, the co-word analysis allows us to identify 12 main thematic areas in this emerging research field： anxiety, survivors and palliative care,meditation, treatment, symptoms and cancer types, postmenopause, cancer pain, low back pain, herbal medicine, children, depression and insomnia, inflammation mediators, and lymphedema. The different research lines are identified according to the main thematic areas,centered fundamentally on anxiety and suffering prevention. The scientific community can use this information to identify where the interest is focused and make decisions in different *** limitation： several limitations can be addressed： 1） some of the complementary and Alternative Medicine therapies may not have been included; 2） only the documents indexed in Web of science are analyzed; and 3） the thematic areas detected could change if another dataset was *** implications： The results obtained in the present study could be considered as an evidence-based framework in which future studies could be ***/value： currently, there are no studies that show the thematic evolution of this research area.

关键词： cancer-related symptoms complementary and Alternative Medicine Bibliometrics science mapping analysis Thematic evolution H-index

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage Mark L.Dell’Acqua Brian M.cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Proteomics Technologies and challenges

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Genomics, Proteomics & Bioinformatics 2007年第2期5卷 77-85页

作者： william c.s. cho Department of clinical Oncology Queen Elizabeth Hospital

Proteomics is the study of proteins and their interactions in a cell. With the completion of the Human Genome Project, the emphasis is shifting to the protein compliment of the human organism. Because proteome reflects more accurately on the dynamic state of a cell, tissue, or organism, much is expected from proteomics to yield better disease markers for diagnosis and therapy monitoring. The advent of proteomics technologies for global detection and quantitation of proteins creates new opportunities and challenges for those seeking to gain greater understanding of diseases. High-throughput proteomics technologies combining with advanced bioinformatics are extensively used to identify molecular signatures of diseases based on protein pathways and signaling cascades. Mass spectrometry plays a vital role in proteomics and has become an indispensable tool for molecular and cellular biology. While the potential is great, many challenges and issues remain to be solved, such as mining low abundant proteins and integration of proteomics with genomics and metabolomics data. Nevertheless, proteomics is the foundation for constructing and extracting useful knowledge to biomedical research. In this review, a snapshot of contemporary issues in proteomics technologies is discussed.

关键词： proteomics mass spectrometry, protein chip

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee william J.Mack Department of Integrative Anatomical sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents

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Food science and Human Wellness 2024年第5期13卷 2353-2362页

作者： Ammad Ahmad Farooqi Iqra Mobeen Rukset Attar Khalida I.Noel Baojun Xu william c.cho Institute of Biomedical and Genetic Engineering(IBGE) Islamabad 44000Pakistan Khursheed Rasheed Hospital Lahore Lahore 53720Pakistan Department of Obstetrics and Gynecology Yeditepe UniversityAtaşehir 34755Turkey Human Anatomy Department College of MedicineAl-Mustansiriyah UniversityBaghdad 10036Iraq Food science and Technology Program Department of Life SciencesBNU-HKBU United International CollegeZhuhai 519087China Department of clinical Oncology Queen Elizabeth HospitalHong Kong G514TFChina

High-throughput technologies in combination with modern exciting advancements in mass spectrometry-based proteomics and data analysis pipelines have empowered comprehensive characterization of disease phenotypes and their mechanistic regulation by dietary agents and bioactive molecules at unprecedented dimensionality and ***-ordinary breakthroughs in the field of nutrigenomics have leveraged our understanding altogether to a new level of *** researchers have extensively analyzed health promoting and pharmacologically significant properties of garlic(Allium sativum).Importantly,garlic and its biologically active chemicals targeted oncogenic signaling *** this mini-review we have attempted to summarize how garlic and its bioactive constituents regulated signal transduction cascades in cell culture studies and tumor-bearing mice.

关键词： cancer Nutrigenomics signaling Apoptosis Allium sativum