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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Tomato Ovary-to-Fruit Transition is Characterized by a Spatial Shift of mRNAs for Cell Wall Invertase and its Inhibitor with the Encoded Proteins Localized to Sieve Elements

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molecular Plant 2015年第2期8卷 315-328页

作者： william m. Palmer School of Environmental and Life Sciences The University of Newcastle NSW 2308 Callaghan Australia Australia-China Research Centre for Crop Improvement The University of Newcastle NSW 2308 Callaghan Australia Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 300 Fenglin Road Shanghai 200032 China These authors contributed equally to the article. Present address: College of Life Sciences. Central China Normal University Wuhan 430079 China

Central to understanding fruit development is to elucidate the processes mediating a successful transition from pre-pollination ovaries to newly set fruit, a key step in establishing fruit yield potential. In tomato, cell wall invertase （CWIN） LIN5 and its inhibitor INH1 are essential for fruit growth. However, the molecular and cellular basis by which they exert their roles in ovary-to-fruit transition remains unknown. To address this issue, we conducted a study focusing on ovaries and fruitlets at 2 days before and 2 days after anthesis, respectively. In situ hybridization analyses revealed that LIN5 and INH1 exhibited a dispersed expression in ovaries compared with their phloem-specific expression in fruitlets. Remarkably, LIN5 and INH1 proteins were immunologically co-localized to cell walls of sieve elements （SEs） in ovaries immediately prior to anthesis and in young fruitlets, but were undetectable in provascular bundles of younger ovaries. A burst in CWlN activity occurred during ovary-to-fruit transition. Interestingly, the ovaries, but not the fruit- lets, exhibited high expression of a defective invertase, SldeCWIN1, an ortholog of which is known to enhance inhibition of INH on CWlN activity in tobacco. Imaging of a fluorescent symplasmic tracer indicated an apoplasmic phloem unloading pathway operated in ovaries, contrary to the previously observed symplasmic unloading pathway in fruit pericarp. These new data indicate that （1） a phloem-specific patterning of the CWIN and INH mRNAs is induced during ovary-to-fruit transition, and （2） LIN5 protein functions specifically in walls of SEs and increases its activity during ovary-to-fruit transition, probably to facilitate phloem unloading and to generate a glucose signal positively regulating cell division, hence fruit set.

关键词： fruit set invertase invertase inhibitor phloem unloading sugar signaling

The Aerosol-monsoon Climate System of Asia:A New Paradigm

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Journal of meteorological Research 2016年第1期30卷 1-11页

作者： william K.m.Lau Earth Science Interdisciplinary Center University of MarylandCollege Park

This commentary is based on a series of recent lectures on aerosol-monsoon interactions I gave at the Beijing Normal University in August 2015. A main theme of the lectures is on a new paradigm of ＂An Aerosol-monsoon-Climate-System＂, which posits that aerosol, like rainfall, cloud, and wind, is an integral component of the monsoon climate system, influencing monsoon weather and climate on m1 timescales. Here, salient issues discussed in my lectures and my personal perspective regarding interactions between atmospheric dynamics and aerosols from both natural and anthropogenic sources are summarized. my hope is that under this new paradigm, we can break down traditional disciplinary barriers, advance a deeper understanding of weather and climate in monsoon regions, as well as entrain a new generation of geoscientists to strive for a sustainable future for one of the most complex and challenging human-natural climate sub-system of the earth.

关键词： aerosol monsoon climate system interaction new paradigm

Assessment of mercury(II) bioavailability using a bioluminescent bacterial biosensor: Practical and theoretical challenges

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Journal of Environmental Sciences 2010年第8期22卷 1137-1143页

作者： Paulo R G Barrocas william m Landing Robert J m Hudson Department of Sanitation and Environmental Health National School of Public Health Oswaldo Cruz Foundation Department of Oceanography Florida State University. Tallahassee Department of Natural Resources and Environmental Sciences University of Illinois

Critical methodological challenges in the microbial biosensor approach to assessing Hg（II） bioavailability were evaluated from the perspective of analytical chemists. The main challenge stems from the fact that the chemical speciation of Hg（II） in natural waters exerts a major control on its bioavailability, yet its natural complexation equilibria are extensively altered during conventional bioassays. New data, obtained using a bioluminescent Hg（II）-biosensor, that illustrate these challenges are presented and potential solutions proposed.

关键词： mercury bioavailability biosensor chemical speciation bioluminescent

Predictive value of hypo-osmotic swelling test to identifyviable non-motile sperm

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Asian Journal of Andrology 2003年第3期5卷 209-212页

作者： william m.Buckett University of Liverpool and the Reproductive medicine Unit Liverpool Women's Hospital Liverpool UK

Aim: To determine the predictive value of the hypo-osmotic swelling (HOS) test to identify viable, non-motile sperm. methods: Semen samples from 20 men with severe asthenozoospermia underwent traditional seminal analysis, eosin-nigrosin (EN) staining and the HOS test. A further EN stain was then performed on a HOS pre-treated aliquot and a total of 2000 further sperm examined. Results: The median sperm density was 5.1 million/mL (IQR 4.3-13.1) and the median motility was 3.0 % (IQR 0-7). Seven samples showed complete asthenozoospermia. Initial EN staining showed 59 % viability (range 48-69) despite the poor standard parameters and 47 % (range 33-61) in the complete asthenozoospermia subgroup. The HOS test showed 49.9 % reacted overall (range 40-59) and 41.7 % (range 22-61) in the complete asthenozoospermia subgroup. The combined HOS/EN stain showed the positive predictive value of the HOS test to identify viable sperm was 84.2 % overall and 79.7 % in the complete asthenozoospermia subgroup. Conclusion: The HOS test can effectively predict sperm viability in patients with severe and complete asthenozoospermia.

关键词： azoospermia sperm spermmotility hypo-osmotic swelling (HOS) test sperm viability predictive value

Reproductive biology of an old endemic murid rodent of Australia, the Spinifex hopping mouse, Notomys alexis:adaptations for life in the arid zone

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Integrative Zoology 2011年第4期6卷 321-333页

作者： william G.BREED Chris m.LEIGH Discipline of Anatomy and Pathology University of AdelaideAdelaideAustralia

The Spinifex hopping mouse(Notomys alexis Thomas,1922)is an arid adapted Australo–Papuan old endemic rodent that undergoes boom and bust population *** this communication,we review our findings on the timing of reproduction and the potential reproductive rate of this *** investigate the first question,the reproductive condition of adult females,and occurrence of immatures,in a population on a cattle station in central Australia was determined and,for the second,data from a laboratory colony compared to those previously published on closely related species in other *** findings show that,at least in the population at the times that monitoring was performed,reproductive activity was only taking place in spring and early summer,whereas the laboratory study indicates that females have a similar gestation length and litter size to those of most close relatives occurring in other *** have extremely small testes and store relatively few *** findings suggest that Notomys alexis might show some seasonality of reproduction at least in this region of central Australia and that this species does not have a higher reproductive rate than that of related species in other,more predictable,environments.

关键词： arid environment hopping mouse reproduction

Industry mix and Curvilinear Spillovers from FDI in China

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2013年第4期8卷 535-551页

作者： william m. Tracy Lally School of management and Technology Rensselaer Polytechnic Institute Troy NY 12309 USA

This paper uses industry and province specific Chinese industrial data to demonstrate a potential causal link between two strands of the FDI literature. The first strand suggests that the impact of spillovers from inward FDI is less robust in middle-income economies than in either high-income or low-income economies. The second strand suggests diminishing returns of inward FDI on horizontal labor productivity in low-technology industries but not in high-technology industries. This paper suggests a link between these two phenomena. Specifically, if both FDI intensity and industry mix vary with the level of economic development, then an industry-dependent relationship between inward FDI and horizontal spillovers could cause middle-income economies to derive fewer benefits from inward FDI than either high- or low-income economies. This paper also verifies the curvilinear relationship between FDI in low-technology industries and horizontal labor productivity without relying on problematic FDI from Hong Kong, Taiwan and macao.

关键词： foreign direct investment curvilinear China spillovers

L13a-dependent translational control in macrophages imits the pathogenesis of colitis

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Cellular & molecular Immunology 2016年第6期13卷 816-827页

作者： Darshana Poddar Ravinder Kaur william m Baldwin III Barsanjit mazumder Center for Gene Regulation in Health and Disease Department of Biology Geology and Environmental Sciences Cleveland State University Cleveland OH USA Department of Immunology Cleveland Clinic Lemer College of Medicine Cleveland OH USA

Sustained inflammation from infiltrated immune cells plays a pivotal role in the pathogenesis of ulcerative colitis （UC）. Previously, we established the role of ribosomal protein L13a in the regulation of an inflammation-responsive post-transcriptional operon in myeloid cells. However, the role of this protein as a molecular cue to control the severity of colitis is not known. Here, we examined whether L13a-dependent translational control in macrophages could serve as an endogenous defense against colitis. The administration of dextran sodium sulfate induced experimental colitis in myeloid-specific L13a-knockout （KO） and control mice. Pathological scoring and injury to the colon mucosa evaluated the severity of colitis. The steady-state levels of several pro-inflammatory cytokines and chemokines were determined through ELISA and polyribosome profile analysis. Rapid weight loss, severe rectal bleeding, shortening of the colon, and significantly reduced survival rate were observed in the KO mice. Histopathological analysis of the colons of KO mice showed a severe disruption of epithelial crypts with immune cell infiltrates. Elevated levels of several inflammatory cytokines and chemokines and abrogation of their naturally imposed translational silencing were observed in the colons of the KO mice. Higher serum levels of several pro-inflammatory cytokines and the release of gut bacteria and endotoxins into the blood streams of KO mice were detected, suggesting the amplification of the inflammatory response to septicemia. Taken together, these results reveal an essential role for L13a in the endogenous protection against UC and demonstrate the potential for new therapeutic opportunities through the deliberate promotion of this mechanism.

关键词： inflammation L13a, macrophages, translational control ulcerative colitis

Prophylactic PEG placement in head and neck cancer:How many feeding tubes are unused (and unnecessary)?

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World Journal of Gastroenterology 2011年第8期17卷 1004-1008页

作者： mohammad F madhoun matt m Blankenship Derek m Blankenship Greg A Krempl william m Tierney Section of Gastroenterology Department of Internal Medicine University of Oklahoma Health Sciences Center Department of Biostatistics Institute for Health Care Research and ImprovementBaylor Health care System Department of Otorhinolaryngology University of Oklahoma Health Sciences Center

AIm:To determine the rate of use and non-use of prophylactic percutaneous endoscopic gastrostomy(PEG) tubes among patients with head and neck cancer(HNC) ***:All patients with HNC undergoing PEG between January 01,2004 and June 30,2006 were ***(or their next-of-kin) were surveyed by phone and all available medical records and cancer registry data were *** PEG was def ined as placement in the absence of dysphagia and prior to radiation or *** patient with a prophylactic PEG was assessed for cancer diagnosis,type of therapy,PEG use,and complications related to ***:One hundred and three patients had PEG tubes placed for *** four patients(33%) could not be contacted for *** the 23(22.3%) patients with prophylactic PEG tubes,11/23(47.8%) either never used the PEG or used it for less than 2 *** association with PEG use vs non-use was observed for cancer diagnosis,stage,or specific cancer ***-use or limited use was observed in 3/6(50%) treated with radiation alone vs 8/17(47.1%) treated with chemoradiation(P = 1.0),and 3 of 10(30%) treated with surgery vs 8 of 13(62%) not treated with surgery(P = 0.21).minor complications were reported in 5/23(21.7%).One(4.3%) major complication was ***:There is a high rate of unnecessary PEG placement when done prophylactically in patients with head and neck cancer.

关键词： Head and neck cancer Percutaneous gastrostomy tube Prophylactic