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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily Lee william j.mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity:their action in Alzheimer's disease prevention

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Neural Regeneration Research 2023年第12期18卷 2675-2676页

作者： Rayudu Gopalakrishna Andrew Oh Narayan R.Bhat william j.mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neuroscience Medical University of South CarolinaCharlestonSCUSA

Recently,we have found that various intracellular cyclic adenosine monophosphate(cAMP)-e leva ting agents,both pharmacological(dibutyryl-cAMP,forskolin,and rolipram)and physiological(pituitary adenylate cyclase-activa... 详细信息

关键词： action prevention Cyclic

Nogo-A receptor internalization by cyclic adenosine monophosphate in overcoming axonal growth inhibitors after stroke

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Neural Regeneration Research 2022年第1期17卷 91-92页

作者： Rayudu Gopalakrishna Charlotte Lin Mark S.Kindy william j.mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Pharmaceutical Sciences College of PharmacyUniversity of South FloridaTampaFLUSA

Currently,there are no clinically proven drugs for recovery from stroke and other neuronal injuries such as traumatic brain injury and spinal cord *** therapy requires axonal regeneration,which is inhibited by diverse axonal growth inhibitors,such as Nogo-A,myelin-associated glycoprotein(MAG),oligodendrocyte myelin glycoprotein(OMgp),and chondroitin sulfate proteoglycans(CSPGs)(Chaudhry and Filbin,2007;Carmichael,2010;Schwab and Strittmatter,2014).

关键词： axonal injuries inhibited

Cell signaling associated with internalization of 67 kDa laminin receptor (67LR) by soluble laminin and its implication for protection against neurodegenerative diseases

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Neural Regeneration Research 2019年第9期14卷 1513-1514页

作者： Rayudu Gopalakrishna Narayan R.Bhat Sarah Zhou william j.mack Department of Integrative Anatomical Sciences Keck School of MedicineLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineLos AngelesCAUSA Department of Neuroscience Medical University of South CarolinaCharlestonSCUSA

Various isoforms of laminins are present in the basement membranes complexed with other structural *** the central nervous system(CNS),they are primarily localized to the basement membranes of blood vessels and reactive *** amounts of various laminin isoforms are also associated with neuronal cell bodies and axons,which are referred to as“neuronal”laminins(Yamamoto et al.,1988).They exist in a soluble form,free from other basement membrane *** either produce these soluble laminins or acquire them from astroglial *** stimulates neuritogenesis and confers neuroprotection in vitro,but their exact role of these neuronal soluble laminins in the CNS is yet unknown.

关键词： Various isoforms basement membranes confers neuroprotection

Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products

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Neural Regeneration Research 2016年第4期11卷 545-546页

作者： Tiffany K.Fan Usha Gundimeda william j.mack Rayudu Gopalakrishna department of cell and neurobiology keck school of medicineuniversity of southern californiaLos AngelesCAUSA department of neurological surgery keck school of medicineuniversity of southern californiaLos AngelesCAUSA

Neuronal injuries such as stroke,traumatic brain injury,and spinal cord injury are leading causes of major disability and *** therapy for these neuronal injuries requires the promotion of axonal regeneration from the ... 详细信息

关键词： EGCG Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products

Two-stage corrective operation for the treatment of pes cavovarus in patients with spina bifida

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World journal of Orthopedics 2024年第7期15卷 618-626页

作者： Anthony mack Padgett Ezan Kothari Michael j Conklin Department of Orthopedics Indiana UniversityIndianapolisIN 46202United States Department of Orthopaedic Surgery University of Alabama at BirminghamBirminghamAL 35233United States Department of Orthopedic Surgery Children’s of AlabamaBirminghamAL 35233United States

BACKGROUND Pes cavovarus has an estimated incidence of 8%-17%in patients with spina bifida(SB).The majority of the current literature on surgical treatment of cavovarus feet in children and adolescents includes a variety of *** are currently no case series describing a treatment algorithm for deformity correction in this specific patient *** authors of this study present the results of a retrospective case series performed to assess the radiographic outcomes of two-stage corrective surgery in patients with *** Retrospective chart review was performed on patients with SB with a diagnosis of pes cavovarus at a freestanding children’s hospital who underwent surgical correction of the *** were excluded for lack of two-stage corrective operation,nonambulatory status,lack of at least six months follow-up,and age>18 years at the time of *** resulted in a cohort of 19 *** analysis was performed on 11 feet that had a complete series of preoperative and postoperative weightbearing *** and postoperative radiographic outcome measurements were compared using a two-sample *** Significant changes between the preoperative and postoperative measurements were seen in Meary’s angle,the anteroposterior talo-first metatarsal(AP TMT1)angle,and the talonavicular *** values of Meary’s angle were 17.9±13.1 preoperatively and 4.7±10.3 postoperatively(P=0.016).Mean AP TMT1 angle was 20.6±15.1 preoperatively and 9.3±5.5 postoperatively(P=0.011).Mean talonavicular coverage values were-10.3±9.6 preoperatively and-3.8±10.1 postoperatively(P=0.025).CONCLUSION The two-stage corrective procedure demonstrated efficacy in correcting cavovarus deformity in patients with *** should strongly consider employing the staged surgical algorithm presented in this manuscript for management of these patients.

关键词： Cavovarus Spina bifida Osteotomy Plantar release Radiographs Pediatrics

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby john Emma Griffin john Thornton jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-jehani Sunil A Sheth Victor S Lopez Rivera james E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami jin Soo Lee ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong juan F Arenillas Mario Martinez-Galdamez jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon john Alex Brehm Marios Psychogios william j mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters johnny Wong Mohamed Teleb jeremy Payne Hiroki Fukuda Kosuke Miyake junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid

机体如何感受慢性痒:感觉神经元利用经典免疫信号通路介导慢性痒的分子机制

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中国疼痛医学杂志 2017年第12期23卷 897-899页

作者： oetjen lk mack mr feng j 王志红(译) 苏州大学不详

哺乳动物进化出的神经生理性反射(如咳嗽和抓挠),用来排除入侵的病原体和有害的环境刺激。这类机体反应与慢性炎性疾病相关,包括哮喘和特性应皮炎(AD)。然而,人们对炎症通路如何介导躯体感觉(如痒觉)的机制仍然知之甚少。本研究结果显示... 详细信息

哺乳动物进化出的神经生理性反射(如咳嗽和抓挠),用来排除入侵的病原体和有害的环境刺激。这类机体反应与慢性炎性疾病相关,包括哮喘和特性应皮炎(AD)。然而,人们对炎症通路如何介导躯体感觉(如痒觉)的机制仍然知之甚少。本研究结果显示Th2型细胞因子直接激活小鼠和人类的感觉神经元。慢性痒依赖于神经元IL-4Rα和jAK1信号。临床上,用jAK抑制剂治疗慢性顽固性瘙痒的病人效果显著,而其他免疫抑制治疗无效。因此,经典免疫信号机制可作为神经系统内的新型治疗靶点。综之,这项研究揭示一个进化保守的范式,即感觉神经系统采用经典的免疫信号通路来影响哺乳动物的行为。

关键词：神经元 IL jAK 信号通路

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聚合物提高水驱效率

国外油田工程 1998年第7期14卷 5-6页

作者： j.E.Smith j.C.mack A.B.Nicol 王勇郭森胜利油田设计院胜利油田大明集团

在开始注水项目时，向水中添加聚合物可以避免高渗透率的变化和不利的流度比。在怀俄明东北部的保德河盆地，油气生产单位从注水开始时便对AdonRoadUnitMinnelusa油藏实施聚合物强化注水驱油，以此改善大的渗透率变化和不利的流度比，... 详细信息

在开始注水项目时，向水中添加聚合物可以避免高渗透率的变化和不利的流度比。在怀俄明东北部的保德河盆地，油气生产单位从注水开始时便对AdonRoadUnitMinnelusa油藏实施聚合物强化注水驱油，以此改善大的渗透率变化和不利的流度比，从而获得了超出预想的效果。聚合物和胶凝项目提高了原油采收率并减少了水处理量。从1996年1月，在32．2％的孔隙体积（PV）总注水后，总采收率为原始原油地质储量（OOIP）的39．5％，相比之下，在累积注水相同的情况下，Minnelusa单纯注水的OOIP为27％。最终采收率已明显超过了原始的模拟预测。

关键词：油藏开发水驱效率聚合物

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聚合物提高水驱效率

石油石化节能 1998年第7期 5-6页

作者： j.E.Smith j.C.mack A.B.Nicol 王勇郭森胜利油田大明集团胜利油田设计院

关键词：聚合物水驱原油采收率