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In situ measurement of ECM rheology and microheterogeneity in embedded and overlaid 3D pancreatic tumor stroma co-cultures via passive particle tracking

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 26-34页

作者： Dustin P.Jones william hanna Gwendolyn M.Cramer Jonathan P.Celli Department of Physics University of Massachusetts Boston Boston MA 02215USA

Tumor growth is regulated by a diverse set of extraellular infuences,including paracrine crosstalk with stromal partners,and biophysical interactions with surrounding cells and *** elucidating the role of physical force and the mechanical properties of the extracellular matrix(ECM)itself as regulators of tumor growth and invasion have been greatly catalyzed by the use of in ritro three-dimensional(3D)tumor *** systems provide the ability to systematically isolate,manipulate,and evaluate impact of stromal components and extracellular mechanics in a platform that is both conducive to imaging and biologically ***,recognizing that mechanoregulatory crosstalk is bi-directional and fully utilizing these models requires complementary methods for in situ measurements of the local mechanical ***,in 3D tumor/fbroblast co-culture models of pancreatic canocer,a discase characterized by its prominent stromal involvement,we evaluate the use of particle-tracking microrhoology to probe dynamic mechanical *** videos of fuorescently labeled polystyrene micro-spheres embedded in ollagen I ECM,we measure spatiotemporal changes in the Brownian motion of probes to report local ECM shear modulus and *** approach reveals st ffening of collagen in fibroblast co-cultures relative to cultures with cancer cells only,which exhibit degraded ECM with heterogeneous *** further show that these effects are dependent on culture geometry with contrast ing behavior for embedded and overlay *** addition to potential application to screening stroma targeted therapeutics,this work also provides insight into how the compoition and plating geometry impact the mechanical propertios of 3D cell cultures that are increasingly widey used in cancer biology.

关键词： Microrheology 3D tumor models matrix remodeling mechanobiology stromal depletion

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Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee william J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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Effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

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Tungsten 2025年第1期7卷 195-213页

作者： Zhi-Peng Zhu Dian Jia william Yi Wang Jun-Lei Yin Xing-Yu Gao Shu-Feng Yang Hai-Feng Song Jin-Shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

关键词： First-principles calculations Phase stability TCP phases Thermodynamic properties W–Re alloy

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Estimation of actual carbon dioxide removal in burned forests using satellite data:A case study in South Korea

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Journal of Mountain Science 2023年第4期20卷 1051-1060页

作者： hanna LEE Gihong KIM Institute for Disaster Prevention Gangneung-Wonju National UniversityGangneung25457South Korea Department of Civil Engineering Gangneung-Wonju National UniversityGangneung25457South Korea

With the increasing impact of climate change,carbon emissions and removals have become major *** are major carbon pools,and forest fires are an essential part of the carbon *** study introduces a model for estimating the detailed actual CO_(2)removal in burned forests using burn severity and tree *** CO_(2)removal was estimated from empirical yield tables without using the standard carbon removal provided by the national *** primary CO_(2)calculation method followed the guidelines of the International Panel on Climate *** burn severity was mapped using Sentinel-2 multispectral instrument data,and the survivability of each forest type was estimated according to burn *** survivability was applied to the pre-fire CO_(2)removal of each forest to estimate post-fire CO_(2)*** our case study,the burned forest area was 1,034 ha,and the CO_(2)removal before the fire was 8,615.3t/*** the fire,removal decreased by 81.2%to 1,618.4 t/*** particular,the decrease in coniferous forests was high,more than 86%.The lack of survivability data on burned trees was a major limitation of our *** accumulating field monitoring data of post-fire forests will be necessary for future research and could serve as a reference for devising immediate countermeasures against forest fires.

关键词： Forest fire CO_(2)removal Carbon emission Tree survivability Remote sensing Satellite data

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Heat of absorption of CO_2 in aqueous N,N-diethylethanolamine+ N-methyl-1,3-propanediamine solutions at 313 K

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Chinese Journal of Chemical Engineering 2019年第3期27卷 628-633页

作者： Katarzyna Sobala hanna Kierzkowska-Pawlak Lodz University of Technology Faculty of Process and Environmental Engineering

Differential heat of absorption of CO_2 in aqueous solutions of N,N-diethylethanolamine(DEEA) and activated DEEA solutions up to a total concentration of 2 mol·L^(-1) was measured as a function of CO_2 loading at 313.15 K using a reaction calorimeter. In order to analyze the performance of N-methyl-1,3-propanediamine(MAPA)as an activator, DEEA blended solutions containing 0.05, 0.1 and 0.2 mol·L^(-1) MAPA were studied. The heat of CO_2 absorption in single DEEA solutions was unaffected by changing the DEEA concentration in the range of(0.5–2) mol·L^(-1). On the other hand, increasing the concentration of MAPA in aqueous amine mixtures of(DEEA + MAPA) raised the heat of absorption.

关键词： CO2 capture Differential heat of absorption N,N-diethylethanolamine N-methyl-1,3-propanediamine Amine blends

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Oscillating-grid turbulence at large strokes: Revisiting the equation of Hopfinger and Toly

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Journal of Hydrodynamics 2016年第3期28卷 473-481页

作者： wan hanna melini wan mohtar Department of Civil and Structural Engineering Faculty Engineering and Built Environment Universiti Kebangsaan Malaysia Bandar BaruBangi 43600 Selangor Malaysia

A quasi-isotropic, quasi-homogeneous turbulence generated by an oscillating-grid, spatially decays according to power law of u ∝ Z-nM , where u is the root mean square （rms） horizontal velocity, Z is the vertical distance from the grid and nu = 1. However, the findings of Nokes and Yi indicate that as the stroke of oscillation increases, the power law n u= 1 and does not follow the established decay law equation of Hopfinger. This paper investigates the characteristics of the turbulence that are generated using larger strokes S/M = 1.6 and 2 and compares with that obtained using a S/M = 0.8, which is the stroke used when the equation was developed. Measurements of the grid-generated turbulence in a water tank were taken using particle image velocimetry （PIV）. The results showed that the homogeneity occurred at distance beyond 2.5 mesh spacings away from the grid midplane, independent of the stroke and the frequency of oscillation. Within this region, the turbulent kinetic energy distribution was quasi-homogeneous, and the secondary mean flow is negligible. The statistical characteristics of the measured turbulence confirmed that although nu decreases as stroke increases, the grid-turbulence generated at S/M = 1.6 and 2 obeys the universal decay law.

关键词： oscillating-grid turbulence large strokes decay power law

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Strong internal resonance in a nonlinear, asymmetric microbeam resonator

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Microsystems & Nanoengineering 2021年第1期7卷 117-131页

作者： Keivan Asadi Junghoon Yeom hanna Cho Department of Mechanical and Aerospace Engineering The Ohio State UniversityColumbusOH 43210USA Department of Mechanical Engineering Michigan State UniversityEast LansingMI 48824USA

Exploiting nonlinear characteristics in micro/nanosystems has been a subject of increasing interest in the last *** others,vigorous intermodal coupling through internal resonance(IR)has drawn much attention because it can suggest new strategies to steer energy within a micro/nanomechanical ***,a challenge in utilizing IR in practical applications is imposing the required frequency commensurability between vibrational modes of a nonlinear micro/***,we experimentally and analytically investigate the 1:2 and 2:1 IR in a clamped–clamped beam resonator to provide insights into the detailed mechanism of *** is demonstrated that the intermodal coupling between the second and third flexural modes in an asymmetric structure(e.g.,nonprismatic beam)provides an optimal condition to easily implement a strong IR with high energy transfer to the internally resonated *** this case,the quadratic coupling between these flexural modes,originating from the stretching effect,is the dominant nonlinear mechanism over other types of geometric *** design strategies proposed in this paper can be integrated into a typical micro/nanoelectromechanical system(M/NEMS)via a simple modification of the geometric parameters of resonators,and thus,we expect this study to stimulate further research and boost paradigm-shifting applications exploring the various benefits of IR in micro/nanosystems.

关键词： nonlinear asymmetric clamped

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Nanomechanical Characterization of Bone Quality Depending on Tissue Age via Bimodal Atomic Force Microscopy

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Nanomanufacturing and Metrology 2023年第4期6卷 24-34页

作者： Jinha Kwon hanna Cho Department of Mechanical and Aerospace Engineering The Ohio State UniversityColumbusOH 43210USA

Characterization of bone quality during the healing process is crucial for successful implantation procedures and patient *** this study,a bone implant specimen that underwent a 4-week healing period was *** atomic force microscopy(AFM)was employed to simultaneously obtain the morphology and elastic modulus maps of the newly formed and pre-existing bone regions within the *** indicate that the new bone matrix possessed lower miner-alization levels and presented larger,uneven mineral grains,exhibiting the attributes of a woven *** the other hand,the old bone matrix exhibited a more uniform and mineralized structure,which is characteristic of lamellar *** new bone had a lower overall elastic modulus than the old *** AFM further confrmed that the new bone displayed three regions comprising unmineralized,partially mineralized,and fully matured sections,which indicate a turbulent change in its ***,the old bone exhibited two sections comprising partially mineralized and matured bone parts,which denote the fnal phase of *** study provides valuable insights into the morphological and nanome-chanical diferences between the old and new bone matrixes and presents a novel approach to investigate bone quality at diferent phases of the bone-healing process.

关键词： Bone quality Atomic force microscopy Bimodal AFM Nanomechanical characterization Bone tissue age Woven bone Lamellar bone

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Impact of rotavirus vaccine implementation on Israeli children:a comparison between pre-and post-vaccination era

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World Journal of Pediatrics 2022年第6期18卷 417-425页

作者： Hussein Zaitoon Shaden hanna Ellen Bamberger Department of Pediatrics Bnai Zion Medical CenterThe Ruth and Bruce Rappaport Faculty of MedicineTechnion-Israel Institute of Technology47 Golomb St.31048HaifaIsrael The Ruth and Bruce Rappaport Faculty of Medicine Technion-Israel Institute of TechnologyHaifaIsrael

Background Worldwide rotavirus vaccination has resulted in a substantial decrease in rotavirus-induced severe gastroenteritis and related hospitalizations among ***,the characterization of patients warranting hospitalization needs to be further *** purpose of the study is to compare the clinical and laboratory features of children hospitalized with acute rotavirus infection before and after the introduction of routine *** This is a retrospective observational *** were pediatric patients who presented to the Bnai Zion Medical Center pediatric emergency department and were diagnosed with rotavirus acute gastroenteritis between 2017 and *** During the pre-vaccination period(2007–2009),114 infants and young children(median age:14 months,range:1–72 months;59 male,55 female)were hospitalized for rotavirus-induced acute gastroenteritis with a rate of 11.71 positive rotavirus tests per 1000 emergency room *** the post-vaccination period(2012–2019),168 infants and young children(median age:17 months,range:0–84 months;90 male,78 female)were hospitalized with a rate of 4.18 positive rotavirus tests per 1000 emergency room *** were no statistical differences between the two groups in gender,breast-feeding rates and sibling(s).The proportion of cases with moderate-to-severe dehydration was higher in the post-vaccination children than in the pre-vaccination *** Rates of rotavirus-attributed acute gastroenteritis hospitalizations declined from the pre-to the post-vaccination *** rates of dehydration were found in the post-vaccination *** surveillance is warranted to better understand the implications of the vaccine.

关键词： Acute gastroenteritis Booster dose Hospitalization Rotavirus Vaccination

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