Nanomechanical Characterization of Bone Quality Depending on Tissue Age via Bimodal Atomic Force Microscopy

作     者：Jinha Kwon Hanna Cho Jinha Kwon;Hanna Cho

作者机构：Department of Mechanical and Aerospace EngineeringThe Ohio State UniversityColumbusOH 43210USA 

出 版 物：《Nanomanufacturing and Metrology》 (纳米制造与计量（英文）)

年 卷 期：2023年第6卷第4期

页      面：24-34页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by OSU Material Research Seed Grant and NSF-CMMI-2227527 

主　　题：Bone quality Atomic force microscopy Bimodal AFM Nanomechanical characterization Bone tissue age Woven bone Lamellar bone 

摘      要：Characterization of bone quality during the healing process is crucial for successful implantation procedures and patient *** this study,a bone implant specimen that underwent a 4-week healing period was *** atomic force microscopy(AFM)was employed to simultaneously obtain the morphology and elastic modulus maps of the newly formed and pre-existing bone regions within the *** indicate that the new bone matrix possessed lower miner-alization levels and presented larger,uneven mineral grains,exhibiting the attributes of a woven *** the other hand,the old bone matrix exhibited a more uniform and mineralized structure,which is characteristic of lamellar *** new bone had a lower overall elastic modulus than the old *** AFM further confrmed that the new bone displayed three regions comprising unmineralized,partially mineralized,and fully matured sections,which indicate a turbulent change in its ***,the old bone exhibited two sections comprising partially mineralized and matured bone parts,which denote the fnal phase of *** study provides valuable insights into the morphological and nanome-chanical diferences between the old and new bone matrixes and presents a novel approach to investigate bone quality at diferent phases of the bone-healing process.