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Recent clinical trials and optical control as a potential strategy to develop microtubule-targeting drugs in colorectal cancer management

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World Journal of Gastroenterology 2024年第13期30卷 1780-1790页

作者： Katsuhiro Kita allen Burdowski Department of Biology St.Francis CollegeBrooklynNY 11201United States

Colorectal cancer(CRC)has remained the second and the third leading cause of cancer-related death worldwide and in the United States,*** significant improvement in overall survival has been achieved,death in adult populations under the age of 55 appears to have increased in the past *** new classes of therapeutic strategies such as immunotherapy have emerged,their application is very limited in CRC so ***(MT)inhibitors such as taxanes,are not generally successful in *** may be some way to make MT inhibitors work effectively in *** potential advantage that we can take to treat CRC may be the combination of optical techniques coupled to an endoscope or other fiber optics-based devices.A combination of optical devices and photo-activatable drugs may allow us to locally target advanced CRC cells with highly potent MT-targeting *** this Editorial review,we would like to discuss the potential of optogenetic approaches in CRC management.

关键词： Colorectal cancer Chemotherapy Microtubule Combretastatin Photopharmacology

Physiology of medicinal and aromatic plants under drought stress

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The Crop Journal 2024年第2期12卷 330-339页

作者： Zohreh Emami Bistgani allen V.Barker Masoud Hashemi Isfahan Agricultural and Natural Resources Research and Education Center Agricultural Research Education and Extension Organization(AREEO)Isfahan 81748-35117Iran Stockbridge School of Agriculture University of MassachusettsAmherstMA 01002USA

Drought poses a significant challenge,restricting the productivity of medicinal and aromatic *** strain induced by drought can impede vital processes like respiration and photosynthesis,affecting various aspects of plants’growth and *** response to this adversity,medicinal plants employ mechanisms such as morphological and structural adjustments,modulation of drought-resistant genes,and augmented synthesis of secondary metabolites and osmotic regulatory substances to alleviate the *** water scarcity can lead to leaf wilting and may ultimately result in plant *** cultivation and management of medicinal plants under stress conditions often differ from those of other *** is because the main goal with medicinal plants is not only to increase the yield of the above-ground parts but also to enhance the production of active ingredients such as essential *** elucidate these mechanisms of drought resistance in medicinal and aromatic plants,the current review provides a summary of recent literature encompassing studies on the morphology,physiology,and biochemistry of medicinal and aromatic plants under drought conditions.

关键词： Drought stress Medicinal and aromatic plants Phytochemistry Physiology

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货币政策中的透明度及责任制

金融科学（中国金融学院学报） 1998年第3期 106-110页

作者： william a allen 于海中国光大银行总行

关于货币政策的基础结构问题,就是以什么样的程序制定货币政策,促使各个机构间责任的分配,以带来最佳的货币政策。人们曾大量讨论过这个问题,这个讨论尚未结束。七十年代的通货膨胀及其负面影响引起了这些讨论。人们希望能建立一种制... 详细信息

关于货币政策的基础结构问题,就是以什么样的程序制定货币政策,促使各个机构间责任的分配,以带来最佳的货币政策。人们曾大量讨论过这个问题,这个讨论尚未结束。七十年代的通货膨胀及其负面影响引起了这些讨论。人们希望能建立一种制度结构从而尽量减少通货膨胀复发而造成的风险。下面以英国为例阐明问题。通过1945年以来的通货膨胀率(以零售衡量)和长期英国政府债券收益,我们可以看到60年代中期以前英国没有明显的通货膨胀上升趋势,60年代后期到70年代前期通货膨胀不断加剧,并在1975年达到顶值25％。至此以后通货膨胀一直处在下降趋势,尽管有时中断。

关键词：货币政策透明度责任制中央银行货币信用

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微塑料和纳米塑料威胁青藏高原环境

Science Bulletin 2024年第5期69卷 589-592页

作者：张玉兰康世昌罗犀 Tanuj Shukla 高坛光 Deonie allen Steve allen Melanie Bergmann State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Earth and Environmental Sciences Lanzhou UniversityLanzhou 730000China School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham 200003UK Ocean Frontiers Institute Dalhousie UniversityHalifax B3H 4R2Canada Alfred-Wegener-Institut Helmholtz-Zentrum für Polar-und Meeresforschung Bremerhaven D-27515Germany University of Chinese Academy of Sciences Beijing 100049China

Plastic pollution is a planetary level threat which affects Earth’s environment and *** the poles to deep ocean basins,the growth of plastic waste has already exceeded its *** projected increase of plastic production and waste generation over the coming years makes the situation even more *** after stagnation in 2020 due to the COVID-19 pandemic,the global plastic production has also increased from 335 to 391 million metric tons(Mt)between 2016 and 2021(Fig.S1 online);yet currently post-consumer recycled and bio-based/attributed plastics only accounts~9%of the world’s plastic production[1].Statistically.

关键词：微塑料 attributed plastics

Low phase noise K-band signal generation using polarization diverse single-soliton integrated microcombs

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Photonics Research 2024年第6期12卷 1175-1185页

作者： ALWALEED ALDHAFEERI HSIAO-HSUAN CHIN TRISTAN MELTON DONG IL LEE allen CHU WENTING WANG MINGBIN YU PATRICK GUO-QIANG LO DIM-LEE KWONG CHEE WEI WONG Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCalifornia 90095USA Institute of Microelectronics A*STARSingapore 117865Singapore State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technologyand Shanghai Industrial Technology Research InstituteShanghai 200050China

Frequency microcombs with microwave and millimeter-wave repetition rates provide a compact solution for coherent communication and information *** implementation of these microcombs using a CMOS-compatible platform further paves the way for large-scale photonic integration and ***,we demonstrate free-running soliton microcombs with K-band repetition rates with very low phase noise over a 4 GHz pump detuning range reaching−117(−123)dBc/Hz at 10 kHz offset for a 19.7(10)GHz carrier without active pump stabilization,exceeding commercial electronic microwave oscillators at frequency offsets above 40 *** minimum laser noise to soliton microwave signal transduction factor observed is−*** noise performance is achieved using a hybridized dual-mode for soliton generation to achieve passive thermal stabilization and minimal soliton spectrum shift from prior Raman scattering and dispersive wave *** further examine the locking of the repetition rate to an external ultrastable photonic oscillator to illustrate the feasibility of phase noise suppression below the thermorefractive noise limits of microresonator frequency combs.

关键词： pump polarization millimeter

美国目前对膳食纤维的定义以及对纤维作出推荐的科学依据

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美国目前对膳食纤维的定义以及对纤维作出推荐的科学依据

Exploring the Reasons for Selfie-Taking and Selfie-Posting on Social Media with Its Effect on Psychological and Social Lives:A Study among Indian Youths

第三届营养与保健食品专业会议

作者： Joanne R.Lupton Regents william W.allen Ph.D. Endowed Chair in Nutrition Texas A&M University Professor Endowed Chair in Nutrition Texas A&M University

讨论的内容1)定义“膳食纤维”的准备工作2)纤维定义小组进行定义的过程3)已经提出的定义4)加拿大和美国目前对纤维摄入量的推荐

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International Journal of Mental Health Promotion 2024年第5期26卷 389-398页

作者： Divya P.Vijayan Tokani Ghuhato Eslavath Rajkumar allen Joshua George Romate John John Abraham Department of Psychology Central University of KarnatakaKalaburagi585367India Department of Liberal Arts Indian Institute of Technology BhilaiChhattisgarh491002India Liberal Arts&Sciences Indian Institute of Management RanchiJharkhand834001India Department of Family Medicine/Geriatrics St.John’s National Academy of Health SciencesBangalore560034India

‘Selfie’taking was introduced to the common people by smartphones and has become a common practice across the globe in no *** technological advancement and the popularity of smartphones,selfie-taking has grown rapidly within a short *** light of the new trend set by the generation,this study aimed to explore reasons for selfie-taking and selfie-posting on social media and their effects on the social and psychological lives of young adults.A purposive sampling method was adopted to select 20 Indian citizens,between 18 and 24 *** data were collected through semi-structured interviews and analysed using thematic ***-taking and posting on social media give positive feelings,and it acts as a mood modifier dependent mostly on the favourability and feedback about the post which in turn affects emotions and self-satisfaction.

关键词： Selfie social media social networking sites obsessive selfie-taking Indian youth

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关于通货膨胀目标选择

广西金融研究 1998年第7期 49-51页

作者：于海 william a allen 中国光大银行总行

通货膨胀目标选择是90年代发展起来的一种货币政策工具.许多国家都已经宣布他们正在以某种形式运用通货膨胀目标.通货膨胀目标选择与控制通货膨胀的其他方法有何区别?不同之处在于货币政策制定过程中决策的具体步骤以及向公众解释这些... 详细信息

通货膨胀目标选择是90年代发展起来的一种货币政策工具.许多国家都已经宣布他们正在以某种形式运用通货膨胀目标.通货膨胀目标选择与控制通货膨胀的其他方法有何区别?不同之处在于货币政策制定过程中决策的具体步骤以及向公众解释这些决策的方式.货币政策的目标决策的正确制定有赖于明确的目标.在确定货币政策时一个需要解决的主要问题就是需要达到的目的是什么.一个普遍的认同是维持价格稳定应是货币政策的恰当目标.对价格稳定目标的共识是基于这样一个认识,即所有经济政策的最终目标都是促进经济繁荣.于是问题就归结为货币政策如何才能最有效地为该最终目标服务.

关键词：通货膨胀目标选择货币政策

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