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NETosis,complement,and coagulation:a triangular relationship

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Cellular & Molecular Immunology 2019年第1期16卷 19-27页

作者： Cynthia M.de Bont wilbert C.Boelens Ger j.M.Pruijn Department of Biomolecular Chemistry Institute for Molecules and Materials(IMM)Radboud UniversityNijmegenThe Netherlands

NETosis is a regulated form of neutrophil cell death that contributes to the host defense against pathogens and was linked to various diseases soon after its first description in *** NETosis,neutrophils release neutrophil extracellular traps(NETs),which can capture and kill bacteria and other pathogens to prevent them from *** substantial progress has been made in our understanding of NETosis,the precise mechanism underlying NETosis is still a matter of *** continues to elucidate the molecular pathways involved in *** recent years,interactions with the complement and coagulation systems have become increasingly *** complement proteins can stimulate NET formation,and NETs,in turn,can serve as a platform for complement *** addition,NETs can act as a scaffold for thrombus formation during *** crosstalk between the coagulation and complement systems has been previously described,NETosis appears to be a third important player in this consortium to protect the host against *** review summarizes our current knowledge on the mutual interactions between NETosis,the complement system and the coagulation system,with an emerging description of their complex triangular relationship.

关键词： coagulation complement NETosis neutrophils thrombosis

Polymeric foams for flexible and highly sensitive low-pressure capacitive sensors

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npj Flexible Electronics 2019年第1期3卷 72-77页

作者： Mickaël Pruvost wilbert j.Smit Cécile Monteux Philippe Poulin Annie Colin Chimie Biologie Innovation ESPCI ParisCNRSPSL University75005 ParisFrance Sciences et Ingénierie de la Matière Molle ESPCI ParisCNRSPSL University75005 ParisFrance Centre de Recherche Paul Pascal CNRSUniversitéde Bordeaux115 Avenue Schweitzer33600 PessacFrance

Flexible low-pressure sensors(<10 kPa)are required in areas as diverse as blood-pressure monitoring,human–computer interactions,robotics,and object *** applications,it is essential that these sensors combine flexibil... 详细信息

Flexible low-pressure sensors(ject *** applications,it is essential that these sensors combine flexibility,high sensitivity,robustness,and low production *** works involve surface micro-patterning,electronic amplification(OFET),and ***,these solutions are limited as they involve complex processes,large bias voltages,large energy consumption,or are sensitive to ***,we report a major advance to solve the challenge of scalable,efficient and robust *** present an unconventional capacitive sensor based on composite foam materials filled with conductive carbon black *** to the elastic buckling of the foam pores,the sensitivity exceeds 35 kPa^(−1) for pressure<0.2 *** performances are one order of magnitude higher than the ones previously *** materials are low-cost,easy to prepare,and display high capacitance values,which are easy to measure using low-cost *** materials pave the road for the implementation of e-skin in commercialized applications.

关键词： computer filled buckling

Illumina Sequencing Technology as a Method of Identifying T-DNA Insertion Loci in Activation- Tagged Arabidopsis thaliana Plants

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Molecular Plant 2012年第4期5卷 948-950页

作者： joanna K. Polko Mohamed-Ramzi Temanni Martijn van Zanten wilbert van Workum Sven Iburg Ronald Pierik Laurentius A.C.j. Voesenek Anton j.M. Peeters Plant Ecophysiology Institute of Environmental Biology Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands ServiceXS BV Plesmanlaan ld 2333 BZ Leiden The Netherlands Department of Cell Biology and Molecular Genetics Maryland Pathogen Research Institute (MPRI) 3128 Biosciences Research Bldg University of Maryland College Park MD 20742 USA Molecular Plant Physiology Institute of Environmental Biology Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands

Dear Editor, Forward genetic screens are commonly used as unbiased tools to isolate genes responsible for a phenotype of interest. In Arabidopsis thaliana, especially T-DNA activation tagging pop- ulations are frequently employed. These populations are gener- ated using vectors containing multiple copies of the constitutive 35S promoters derived from cau and often result in isolation i flower mosaic virus （35S CaMV） of dominant gain-of-function alleles （Weigel et al., 2000; Nakazawa et al., 2003）. This allows the study of members of large gene families that are often func- tionally redundant and, therefore, hard to identify in loss-of- function screens. Moreover, due to the dominant nature,

关键词： T-DNA 激活标签拟南芥测序技术插入位点 35S启动子识别中国农业大学

附评论五则:评《脑神经科学与教育研究》之三一项能推论教学远程因果关系的科学研究

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上海教育科研 2008年第7期 11-11页

作者： wilbert mckeachie 钟曼怡(译) 美国密西根大学美国心理学会心理学教授不详

《脑神经科学与教育：中英语文教学研究》研究报告的设计、规模和涉及范围都非常突出，特点如下：1．由一支非常强大的跨学科研究队伍来主持，包括教育家、认知心理学家、语言学家、神经学家、儿科医生、放射学家和统计学家等等；这个... 详细信息

《脑神经科学与教育：中英语文教学研究》研究报告的设计、规模和涉及范围都非常突出，特点如下：1．由一支非常强大的跨学科研究队伍来主持，包括教育家、认知心理学家、语言学家、神经学家、儿科医生、放射学家和统计学家等等；这个队伍分成四个相互联系的小组来设计课题，并且进行实验、分析和资料解释。

关键词：语文教学研究科学研究因果关系远程推论设计课题神经科学涉及范围

A meta-analysis of 1-year outcomes of transcatheter versus surgical aortic valve replacement in low-risk patients with severe aortic stenosis

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journal of Geriatric Cardiology 2020年第1期17卷 43-50,I0008-I0010页

作者： Aaqib H Malik Syed Zaid Hasan Ahmad joshua Goldberg Tanya Dutta Cenap Undemir Martin Cohen wilbert S Aronow Steven L Lansman Department of Medicine Westchester Medical Center and New York Medical CollegeValhallaNYUSA Department of Cardiology Westchester Medical Center and New York Medical CollegeValhallaNYUSA Section of Cardiothoracic Surgery Department of SurgeryWestchester Medical CenterValhallaNew YorkUSA

Background Transcatheter aortic valve replacement(TAVR)for the treatment symptomatic severe aortic stenosis(AS)is indicated in patients with intermediate or higher surgical *** trials showed TAVR,and surgical aortic valve replacement(SAVR)perform similarly at 1-year for the composite outcomes of mortality,stroke and *** performed a comprehensive meta-analysis to compare individual outcomes at 1-year for TAVR compared to SAVR in low-risk *** Pub Med,Embase,and Cochrane central were searched for all the randomized controlled trials(RCTs)that reported 1-year comparative outcomes of TAVR and surgical aortic valve replacement(SAVR).Our conclusions are based upon the random-effects model using Der Simonian-Laird *** Data from 4 trials and 2887 randomized patients showed that TAVR had lower rates of all-cause mortality,cardiovascular mortality,and atrial fibrillation compared to SAVR at 1-year follow-up(P<0.05 for all).Also,TAVR was also associated with a significantly higher risk of permanent pacemaker implantation and moderate-severe paravalvular leak(P<0.05).Conclusions The latest randomised trial data demonstrates that in short-term,TAVR is safe and effective in reducing all-cause mortality or *** follow-up of RCTs is needed to determine the durability of clinical benefits in TAVR over SAVR in low-risk patients.

关键词： Aortic stenosis Low surgical risk Meta-analysis Transcatheter aortic valve replacement

Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma

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World journal of Gastroenterology 2009年第28期15卷 3493-3497页

作者： jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie Mj Roelofs T Wobbes Ben jM Witteman Adriaan CITL Tan Martijn GH van Oijen jan BMj jansen wilbert HM Peters Department of Gastroenterolog Radboud University Nijmegen Medical Center PO Box 9106500 HB Nijmegen The Netherlands Department of Surgery Radboud UniversityNijmegen Medical Center PO Box 9101 6500 HB NijmegenThe Netherlands Department of Gastroenterology Hospital Gelderse Vallei PO Box 9025 6710 HN Ede The Netherlands Department of Gastroenterology Canisius Wilhelmina Hospital Weg door Jonkerbos 100 6532 SZ Nijmegen The Netherlands

AIM： TO determine whether -1195 A→G and/or -765 G→C polymorphisms in Cyclooxygenase-2 CCOX-2） may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population. METHODS： Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area. DNA was isolated from whole blood and used for genotyping. PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis. Odds ratios （OR） and 95% confidence intervals （CI） were estimated. RESULTS： The distribution of the -1195A→G polymorphism was significantly different in esophageal cancer patients compared to controls. The -1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma （OR = 3.85, 95% CI： 1.45-10.3） compared with the -1195AA genotype as a reference. The -765 G→C genotype distribution was not different between the two groups. The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls （OR = 3.45, 95% CI： 1.24-9.58; with AG/AG as a reference）. The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical significance. CONCLUSION： Presence of the COX-2 -1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma.

关键词： Adenocarcinoma Cyclooxygenase-2 Esophagus Genetic polymorphism Squamous cellcarcinoma

MLT Diurnal tide long term variations

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MLT Diurnal tide long term variations