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New stem cell autophagy surrogate diagnostic biomarkers in earlystage hepatocellular carcinoma in Egypt:A pilot study

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World Journal of Hepatology 2021年第12期13卷 2137-2149页

作者： Tarek Yosef wesam Ahmed ibrahim Marwa Matboli Amina Ahmed Swilam Sarah El-Nakeep Gastroenterology and Hepatology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Biochemistry Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Internal Medicine Health Affair DirectorateMinistry of Health and PopulationCairo 11591Egypt

BACKGROUND Stem cell autophagy disruption is responsible for the development of hepatocellular carcinoma(HCC).Many non-coding RNAs are linked to the activation and inhibition of certain *** SQSTM1 gene controls stem cell autophagy as shown in previous *** upregulation of SQSTM1 is associated with the inhibition of autophagy in cancerous stem cells in patients with *** To determine whether serum microRNA,hsa-miR-519d,is linked to SQSTM1 gene and whether they could be used as diagnostic biomarkers for early-stage *** In silico analysis was performed to determine the most correlated genes of autophagy with ***1 and hsa-miR-519d were validated through this pilot clinical *** study included 50 Egyptian participants,who were classified into three subgroups:Group 1 included 34 patients with early-stage HCC,Group 2 included 11 patients with chronic liver disease,and Group 3(control)included 5 healthy *** patients were subjected to full laboratory investigations,including viral markers and alpha-fetoprotein(AFP),abdominal ultrasound,and clinical assessment with the Child–Pugh score ***,the patients with HCC underwent triphasic computed tomography with contrast to diagnose and determine the tumor site,size,and *** real-time polymerase chain reaction was used to assess hsa-miR-519d-3p and SQSTM1 in the serum of all the study *** Hsa-miR-519d-3p was significantly upregulated in patients with HCC compared with those with chronic liver disease and healthy subjects with an area under the curve(AUC)of 0.939,with cutoff value 8.34,sensitivity of 91.2%,and specificity of 81.8%.SQSTM1 was upregulated with an AUC of 0.995,with cutoff value 7.89,sensitivity of 97.1%,and specificity of 100%.AFP significantly increased in patients with HCC with an AUC of 0.794,with cutoff value 7.30 ng/mL,sensitivity of 76.5%,and specificity of 72.7%.CONCLUSION This study is the first to show a direct re

关键词： Autophagy Hepatocellular carcinoma miRNA miR-519d Stem cell SQSTM1

N-butyl-2-cyanoacrylate, iso-amyl-2-cyanoacrylate and hypertonic glucose with 72% chromated glycerin in gastric varices

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World Journal of Gastrointestinal Endoscopy 2015年第4期7卷 411-416页

作者： Reda Elwakil Mohamed Fawzy Montasser Sara M Abdelhakam wesam a ibrahim Department of Tropical Medicine Faculty of MedicineAin Shams University Department of Internal Medicine Faculty of Medicine Ain Shams University

cyanoacrylate and a mixture of 72% chromated glycerinwith hypertonic glucose solution in management ofgastric ***： Ninety patients with gastric varicespresented to Endoscopy Unit of Ain Shams UniversityHospital were included. They were randomly allocatedinto three groups; each group included 30 patients treatedwith intravariceal sclerosant injections in biweeklysessions till complete obturation of gastric varices;Group I （n-butyl-2-cyanoacrylate; Histoacryl？）, GroupII （iso-amyl-2-cyanoacrylate; Amcrylate？） and GroupIII （mixture of 72% chromated glycerin; Scleremo？with glucose solution 25%）. All the procedures wereperformed electively without active bleeding. Recruitedpatients were followed up for 3 ***： 26% of Scleremo group had bleeding duringpuncture vs 3.3% in each of the other two groups withsignificant difference, （P 〈 0.05）. None of Scleremogroup had needle obstruction vs 13.3% in each of theother two groups with no significant difference, （P 〉0.05）. Rebleeding occurred in 13.3% of Histoacryl andAmcrylate groups vs 0% in Scleremo group with nosignificant difference. The in hospital mortality was 6.6%in both Histoacryl and Amcrylate groups, while it was0% in Scleremo group with no significant difference. Inthe first and second sessions, the amount of Scleremoneeded for obturation was significantly high, while the amount of Histoacryl was significantly low. Scleremo was the less costly of the two treatments. CONCLUSION： All used sclerosant substances showed efficacy and success in management of gastric varices with no significant differences except in total amount,cost and bleeding during puncture.

关键词： Gastric varices N-butyl-2-cyanoacrylate Iso-amyl-2-cyanoacrylate Hypertonic glucose solution 72% chromated glycerin

Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients

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World Journal of Hepatology 2016年第30期8卷 1279-1286页

作者： Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh wesam a ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud Department of Internal Medicine Hepatology and Gastroenterology Faculty of Medicine Ain Shams University Department of Tropical Medicine Faculty of Medicine Ain Shams University Department of Hepatobiliary Surgery Faculty of Medicine Ain Shams University Department of Community Environmental and Occupational Medicine Faculty of Medicine Ain Shams University Department of Internal Medicine Hepatology and Gastroenterology National Research Center Department of Neuropsychiatry Faculty of Medicine Ain Shams University

AIMTo evaluate the reversibility of minimal hepatic encephalopathy (MHE) following liver transplantation (LT) in Egyptian cirrhotic patients. METHODSThis prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty age- and sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A (TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score (PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTSBefore LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls (P P P P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score CONCLUSIONReversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score

关键词： Liver transplantation Model for end-stage liver disease score Psychometric tests Minimal hepatic encephalopathy Cirrhosis

Impact of biliary complications on quality of life in live-donor liver transplant recipients

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World Journal of Hepatology 2021年第10期13卷 1405-1416页

作者： Reginia Nabil Guirguis Ehab Hasan Nashaat Azza Emam Yassin wesam Ahmed ibrahim Shereen A Saleh Mohamed Bahaa Mahmoud El-Meteini Mohamed Fathy Hany Mansour Dabbous Iman Fawzy Montasser Manar Salah Ghada Abdelrahman Mohamed Department of Internal Medicine Gastroenterology and Hepatology UnitFaculty of MedicineAin Shams UniversityCairo 11591Egypt Department of General Surgery Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11591Egypt

BACKGROUND Despite significant advancements in liver transplantation(LT)surgical procedures and perioperative care,post-LT biliary complications(BCs)remain a significant source of morbidity,mortality,and graft *** addition,data are conflicting regarding the health-related quality of life(HRQoL)of LT ***,the success of LT should be considered in terms of both the survival and recovery of *** To assess the impact of BCs on the HRQoL of live-donor LT recipients(LDLT-Rs).METHODS We retrospectively analysed data for 25 LDLT-Rs who developed BCs post-LT between January 2011 and December 2016 at our *** Short Form 12 version 2(SF 12v2)health survey was used to assess their *** also included 25 LDLT-Rs without any post-LT complications as a control *** The scores for HRQoL of LDLT-Rs who developed BCs were significantly higher than the norm-based scores in the domains of physical functioning(P=0.003),role-physical(P<0.001),bodily pain(P=0.003),general health(P=0.004),social functioning(P=0.005),role-emotional(P<0.001),and mental health(P<0.001).No significant difference between the two groups regarding vitality was detected(P=1.000).The LDLT-Rs with BCs had significantly lower scores than LDLT-Rs without BCs in all HRQoL domains(P<0.001)and the mental(P<0.001)and physical(P=0.0002)component summary *** The development of BCs in LDLT-Rs causes a lower range of improvement in HRQoL.

关键词： Live-donor liver transplantation Quality of life The Short Form 12 version 2 Cirrhosis Biliary complications Mental health

Biliary complications in recipients of living donor liver transplantation:A single-centre study

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World Journal of Hepatology 2021年第12期13卷 2081-2103页

作者： Reginia Nabil Guirguis Ehab Hasan Nashaat Azza Emam Yassin wesam Ahmed ibrahim Shereen A Saleh Mohamed Bahaa Mahmoud El-Meteini Mohamed Fathy Hany Mansour Dabbous Iman Fawzy Montasser Manar Salah Ghada Abdelrahman Mohamed Gastroenterology and Hepatology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11591Egypt Department of General Surgery Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11591Egypt

BACKGROUND Biliary complications(BCs)after liver transplantation(LT)remain a considerable cause of morbidity,mortality,increased cost,and graft *** To investigate the impact of BCs on chronic graft rejection,graft failure and *** From 2011 to 2016,215 adult recipients underwent right-lobe living-donor liver transplantation(RT-LDLT)at our *** excluded 46 recipients who met the exclusion criteria,and 169 recipients were included in the final ***’and recipients’demographic data,clinical data,operative details and postoperative course information were *** also reviewed the management and outcomes of *** were followed for at least 12 mo post-LT until December 2017 or graft or patient *** The overall incidence rate of BCs including biliary leakage,biliary infection and biliary stricture was 57.4%.Twenty-seven(16%)patients experienced chronic graft *** failure developed in 20(11.8%)patients.A total of 28(16.6%)deaths occurred during *** were a risk factor for the occurrence of chronic graft rejection and failure;however,mortality was determined by recurrent hepatitis C virus *** Biliary complications after RT-LDLT represent an independent risk factor for chronic graft rejection and graft failure;nonetheless,effective management of these complications can improve patient and graft survival.

关键词： Biliary complications Living donor liver transplantation Retrospective analysis Bile leak Biliary stricture Risk factors Mortality Graft rejection

Hepatobiliary manifestations following two-stages elective laparoscopic restorative proctocolectomy for patients with ulcerative colitis:A prospective observational study

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World Journal of Gastrointestinal Surgery 2023年第2期15卷 234-248页

作者： Tamer A A M Habeeb Abdulzahra Hussain Mauro Podda Pasquale Cianci Bruce Ramshaw Khaled Safwat wesam M Amr Tamer Wasefy Alaa A Fiad Mohamed ibrahim Mansour Adel Mahmoud Moursi GamalOsman Anass Qasem Mohamed Fawzy Mohamed ibrahim Abo Alsaad Abd-Elfattah Kalmoush MohammedShaaban Nassar Fawzy M Mustafa Mahmoud Hassib Morsi Badawy Ahmed Hamdy Hamdi Elbelkasi Bassam Mousa Abd-Elrahman M Metwalli Walid A Mawla Mostafa M Elaidy Muhammad Ali Baghdadi Ahmed Raafat Department of General Surgery Faculty of MedicineZagazig UniversityZagazig 44759SharkiaEgypt Homerton University Hospital London E96SRUK Department of Surgical Science University of CagliariCagliari 2432Italy Department of Medical and Surgical Sciences Universitàdegli studi di FoggiaFoggia 546Italy MD CQInsights PBC Co-founder&CEOTennesseeTN 37010United States Department of Internal Medicine Zagazig UniversityZagazig 2355Egypt Department of Internal Medicine Suez UniversitySuez 235Egypt Department of General Surgery Faculty of Medicine-Merit UniversitySohag 82511Egypt Department of General Surgery Al-azhar UniversityCairo 285Egypt Department of Hepato-Bilio-Pancreatic(HBP)Surgery National Hepatology and Tropical Medicine Research InstituteCairo 285Egypt Department of General Surgery Mataryia Teaching HospitalCairo 285Egypt

BACKGROUND Hepatobiliary manifestations occur in ulcerative colitis(UC)*** effect of laparoscopic restorative proctocolectomy(LRP)with ileal pouch anal anastomosis(IPAA)on hepatobiliary manifestations is *** To evaluate hepatobiliary changes after two-stages elective laparoscopic restorative proctocolectomy for patients with *** Between June 2013 and June 2018,167 patients with hepatobiliary symptoms underwent two-stage elective LRP for UC in a prospective observational *** with UC and having at least one hepatobiliary manifestation who underwent LRP with IPAA were included in the *** patients were followed up for four years to assess the outcomes of hepatobiliary *** The patients'mean age was 36±8 years,and males predominated(67.1%).The most common hepatobiliary diagnostic method was liver biopsy(85.6%),followed by Magnetic resonance cholangiopancreatography(63.5%),Antineutrophil cytoplasmic antibodies(62.5%),abdominal ultrasonography(35.9%),and Endoscopic retrograde cholangiopancreatography(6%).The most common hepatobiliary symptom was Primary sclerosing cholangitis(PSC)(62.3%),followed by fatty liver(16.8%)and gallbladder stone(10.2%).66.4%of patients showed a stable course after *** or regressive courses occurred in 16.8%of *** was 6%,and recurrence or progression of symptoms required surgery for 15%.Most PSC patients(87.5%)had a stable course,and only 12.5%became ***-thirds(64.3%)of fatty liver patients showed a regressive course,while one-third(35.7%)showed a stable *** rates were 98.8%,97%,95.8%,and 94%at 12 mo,24 mo,36 mo,and at the end of the *** In patients with UC who had LRP,there is a positive impact on hepatobiliary *** caused an improvement in PSC and fatty liver *** most prevalent unchanged course was PSC,while the most common improvement was fatty liver disease.

关键词： Courses Hepatobiliary manifestations Primary sclerosing cholangitis Restorative proctocolectomy

High prevalence of chronic viral hepatitis B and C in Minnesota Somalis contributes to rising hepatocellular carcinoma incidence

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World Journal of Gastroenterology 2022年第35期28卷 5217-5229页

作者： Essa A Mohamed Nasra H Giama Abubaker O Abdalla Hassan M Shaleh Abdul M Oseini Hamdi A Ali Fowsiyo Ahmed wesam Taha Hager Ahmed Mohammed Jessica Cvinar ibrahim A Waaeys Hawa Ali Loretta K Allotey Abdiwahab O Ali Safra A Mohamed William S Harmsen Eimad M Ahmmad Numra A Bajwa Mohamud D Afgarshe Abdirashid M Shire Joyce E Balls-Berry Lewis R Roberts Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905United States Center for Clinical and Translational Science Mayo ClinicRochesterMN 55905United States School of Nursing University of MinnesotaMinneapolisMN 55455United States Division of Digestive Diseases Emory School of MedicineAtlantaGA 30322United States Department of Laboratory Medicine and Pathology Mayo ClinicRochesterMN 55905United States Department of Internal Medicine NewYork-Presbyterian QueensFlushingNY 11355United States Department of Pediatrics University of Nevada Las VegasLas VegasNV 89154United States Department of Quantitative Health Sciences Mayo ClinicRochesterMN 55905United States Department of Medicine Gargar Urgent Care and ClinicMinneapolisMN 55406United States Office of the Director Shire ScientificMinneapolisMN 55405United States Department of Neurology Washington University School of Medicine in St LouisSt LouisMO 63130United States Knight Alzheimer Disease Research Center Washington University School of MedicineSt LouisMO 63130United States

BACKGROUND Chronic hepatitis B virus(HBV)and hepatitis C virus(HCV)infections are known risk factors for liver disease,cirrhosis and hepatocellular carcinoma(HCC).There is substantial global variation in HBV and HCV prevalence resulting in variations in cirrhosis and *** previously reported high prevalence of HBV and HCV infections in Somali immigrants seen at an academic medical center in *** To determine the prevalence of chronic viral hepatitis in Somali immigrants in Minnesota through a community-based screening *** We conducted a prospective community-based participatory research study in the Somali community in Minnesota in partnership with community advisory boards,community clinics and local mosques between November 2010 and December 2015(data was analyzed in 2020).Serum was tested for hepatitis B surface antigen,hepatitis B core antibody,hepatitis B surface antibody and anti-HCV *** Of 779 participants,15.4%tested positive for chronic HBV infection,50.2%for prior exposure to HBV and 7.6%for chronic HCV *** age-adjusted frequencies in males and females for chronic HBV were 12.5%and 11.6%;for prior exposure to HBV were 44.8%and 41.3%;and for chronic HCV were 6.7%and 5.7%,*** participants developed incident HCC during follow *** Chronic HBV and HCV are major risk factors for liver disease and HCC among Somali immigrants,with prevalence of both infections substantially higher than in the general United States ***-based screening is essential for identifying and providing health education and linkage to care for diagnosed patients.

关键词： Viral hepatitis Liver disease Community engagement African Immigrant health