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OSMR is a potential driver of inflammation in amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第11期19卷 2513-2521页

作者： wenzhi chen Shishi Jiang Shu Li cheng Li Renshi Xu Department of Neurology Jiangxi Provincial People’s HospitalXiangya Hospital Jiangxi Hospital of Central South UniversityThe Clinical College of Nanchang Medical CollegeThe First Affiliated Hospital of Nanchang Medical CollegeNanchangJiangxi ProvinceChina

Amyotrophic lateral sclerosis is a neurodegenerative disease,and the molecular mechanism underlying its pathology remains poorly ***,inflammation is known to play an important role in the development of this *** identify driver genes that affect the inflammatory response in amyotrophic lateral sclerosis,as well as potential treatment targets,it is crucial to analyze brain tissue samples from patients with both sporadic amyotrophic lateral sclerosis and C9orf72-related amyotrophic lateral ***,in this study we used a network-driven gene analysis tool,NetBID2.0,which is based on SJARACNe,a scalable algorithm for the reconstruction of accurate cellular networks,to experimentally analyze sequencing data from patients with sporadic amyotrophic lateral *** results showed that the OSMR gene is pathogenic in amyotrophic lateral sclerosis and participates in the progression of amyotrophic lateral sclerosis by mediating the neuroinflammatory ***,there were differences in OSMR activity and expression between patients with sporadic amyotrophic lateral sclerosis and those with C9orf72-related amyotrophic lateral *** findings suggest that OSMR may be a diagnostic and prognostic marker for amyotrophic lateral sclerosis.

关键词： amyotrophic lateral sclerosis driver neuroinflammation OSMR C9ORF72 neurodegenerative disease pathogenesis oxidative stress protein misfolding mitochondrial dysfunction

Formation Mechanism of the High-quality Upper Paleozoic Natural Gas Reservoirs in the Ordos Basin

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Acta Geologica Sinica(English Edition) 2005年第6期79卷 843-855页

作者： ZHAO wenzhi WANG Zecheng chen Menjin ZHENG Hongju Research Institute of Petroleum Exploration and Development Petrochina Beijing 100083

The upper Paleozoic natural gas reservoirs in the Ordos basin are generally characterized by a large gas-bearing area and low reserve abundance. On such a geological background, there still exist gas-enriched zones, with relatively high outputs, high reserve abundance and stably distributed gas layers. The gas-enriched layers with relatively high permeability （the lower limit permeability is 0.5×10^-3μm^2） are key factors for the enrichment and high output of natural gas. Based on core observation, analytic results of inclusions, and a great deal of drilling data, we proposed the following four mechanisms for the formation of high-quality reservoirs：（1） in the source area the parent rocks are mainly metamorphic rocks and granites, which are favorable to keeping primary porosity; （2） under the condition of low A/S （accommodation/sediment supply） ratios, sandstone complex formed due to multistage fluvial stacking and filling are coarse in grain size with a high degree of sorting, low content of mud and good physical properties; （3） early-stage recharge of hydrocarbons restricted compaction and cementation, and thus are favorable to preservation of primary pores; （4） microfractures caused by the activity of basement faults during the Yanshan Movement stage can not only improve the permeability of tight sandstones, but also afford vertical pathways for hydrocarbon gas migration.

关键词： lithology of parent rock A/S ratio recharge of hydrocarbons microfractures multistage fluvial complex upper Paleozoic Ordos Basin

Pathological mechanisms of amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第5期19卷 1036-1044页

作者： Yushu Hu wenzhi chen Caihui Wei Shishi Jiang Shu Li Xinxin Wang Renshi Xu Department of Clinical Medicine Nanchang UniversityNanchangJiangxi ProvinceChina Department of Neurology Jiangxi Provincial People’s HospitalNanchangJiangxi ProvinceChina Department of Neurology The First Affiliated Hospital of Nanchang Medical CollegeThe Clinical College of Nanchang Medical CollegeNanchangJiangxi ProvinceChina

Amyotrophic lateral sclerosis refers to a neurodegenerative disease involving the motor system,the cause of which remains unexplained despite several years of ***,the journey to understanding or treating amyotrophic lateral sclerosis is still a long *** to current research,amyotrophic lateral sclerosis is likely not due to a single factor but rather to a combination of mechanisms mediated by complex interactions between molecular and genetic *** progression of the disease involves multiple cellular processes and the interaction between different complex mechanisms makes it difficult to identify the causative factors of amyotrophic lateral ***,we review the most common amyotrophic lateral sclerosis-associated pathogenic genes and the pathways involved in amyotrophic lateral sclerosis,as well as summarize currently proposed potential mechanisms responsible for amyotrophic lateral sclerosis disease and their evidence for involvement in amyotrophic lateral *** addition,we discuss current emerging strategies for the treatment of amyotrophic lateral *** the emergence of these new therapies may help to further our understanding of the pathogenic mechanisms of the disease.

关键词： amyotrophic lateral sclerosis cellular pathways disease mechanisms motor neuron neurodegenerative disease

Simulation of phase transition process using lattice Boltzmann method

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Chinese Science Bulletin 2009年第24期54卷 4596-4603页

作者： ZENG JianBang LI LongJian LIAO Quan CUI wenzhi chen QingHua PAN LiangMing School of Power Engineering Chongqing University Chongqing 400030 China

A new lattice Boltzmann model based on SC model, is proposed to describe the liquid-vapor phase transitions. The new model is validated through the simulation of the one-component phase transition process. Compared with the simulation results of van der Waals gas and the Maxwell equal-area construction, the results of the new model have a better agreement with the analytical solutions than those of SC and Zhang models. Since the obtained temperature range and the maximum density ratio in this model are expanded, and the magnitude of maximum spurious current is only between those of SC and Zhang models, it is believed that this new model has better stability than SC and Zhang models. Consequently, the application scope of this new model is expanded compared with the existing phase transition models. According to the principle of the corresponding states in engineering thermodynamics, the simulations of ammonia and water phase transition process were implemented using this new model with different equations of state. Compared with the experimental data of ammonia and water, the results show that the Peng-Robinson is the best equation of state to describe the phase transition process of ammonia and water. Especially, the simulation results of ammonia with Peng-Robinson equation of state have an excellent agreement with its experimental data. Therefore these simulation results have a significant influence on the real engineering applications.

关键词：数值模拟相变过程格子玻尔兹曼方法格子Boltzmann模型工程热力学状态方程实验数据范德华气体

Study of Cell Behaviors on Anodized TiO_2 Nanotube Arrays with Coexisting Multi-Size Diameters

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Nano-Micro Letters 2016年第1期8卷 61-69页

作者： Yifan chen Jiahua Ni Hongliu Wu Ruopeng Zhang Changli Zhao wenzhi chen Feiqing Zhang Shaoxiang Zhang Xiaonong Zhang State Key Laboratory of Metal Matrix Composites School of Material Science and Engineering Shanghai Jiao Tong University Suzhou Origin Medical Technology Co. Ltd.

It has been revealed that the different morphologies of anodized TiO_2 nanotubes, especially nanotube diameters, triggered different cell behaviors. However, the influence of TiO_2 nanotubes with coexisting multi-size diameters on cell behaviors is seldom reported. In this work, coexisting four-diameter TiO_2 nanotube samples, namely,one single substrate with the integration of four different nanotube diameters(60, 150, 250, and 350 nm), were prepared by repeated anodization. The boundaries between two different diameter regions show well-organized structure without obvious difference in height. The adhesion behaviors of MC3T3-E1 cells on the coexisting fourdiameter TiO_2 nanotube arrays were investigated. The results exhibit a significant difference of cell density between smaller diameters(60 and 150 nm) and larger diameters(250 and 350 nm) within 24 h incubation with the coexistence of different diameters, which is totally different from that on the single-diameter TiO_2 nanotube arrays. The coexistence of four different diameters does not change greatly the cell morphologies compared with the singlediameter nanotubes. The findings in this work are expected to offer further understanding of the interaction between cells and materials.

关键词： Coexisting multi-size TiO2 nanotubes Repeated anodization MC3T3-E1 cells Cell adhesion behaviors Cell-material interaction

Structural and mechanical properties of nano-crystal TiN coatings

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Science China(Physics,Mechanics & Astronomy) 2004年第Z1期47卷 1-7页

作者： ZHANG chenhui PAN Guoshun LUO Jianbin LI wenzhi chen Darong State Key Laboratory of Tribology Tsinghua University Beijing 100084 China State Key Laboratory of Tribology Tsinghua University Beijing 100084 China State Key Laboratory of Tribology Tsinghua University Beijing 100084 China State Key Laboratory of Tribology Tsinghua University Beijing 100084 China State Key Laboratory of Tribology Tsinghua University Beijing 100084 China

The structural and mechanical properties of TiN coatings prepared by ion beam assisted deposition (IBAD) were studied. The coatings have a polycrystal structure with grain size of ～10 nm or less. The hardness of the coatings increases with increasing grain size of TiN crystallites. The coating with grain size of 10.3 nm even has a superhardness of 44.7GPa. The relationship between the hardness and the grain size in the nano-crystalline coatings was discussed on the basis of grain-boundary triple junctions.

关键词： TiN, nano-crystal, microstructure, hardness, grain-boundary triple junctions.

vCerberus:A DRTM System Based on Virtualization Technology

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Wuhan University Journal of Natural Sciences 2010年第3期15卷 185-189页

作者： chen wenzhi ZHANG Zhipeng YANG Jianhua HE Qinming College of Computer Science Zhejiang University Hangzhou 310012 Zhejiang China

This paper presents vCerberus, a novel hypervisor to provide trusted and isolated code execution within virtual domains vCerberus is considerably tiny, while allowing secure sensitive codes to be executed in an isolated circumstance from the virtual ddmain, and can be attested by a remote party in an efficient way. These properties will be guaranteed even if the guest operating system is malicious. This protects the secure sensitive codes against the malicious codes in the Guest OS, e.g., the kernel rootkits. We present an approach to dynamically measure and isolate the launch environment on the virtual machines based on the para-virtualization technology and a novel virtualization of trusted platform module （TPM）. Our performance experiment result shows that the overhead introduced by vCerberus is minimized; the performance of the launch environment in vCerberus is as competitive as the guest OS running on mainstream hypervisors.

关键词： trusted computing para-virtualization dynamic root of trust for measurement (DRTM) trusted platform module (TPM)

MILG:Realistic lip-sync video generation with audio-modulated image inpainting

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Visual Informatics 2024年第3期8卷 71-81页

作者： Han Bao Xuhong Zhang Qinying Wang Kangming Liang Zonghui Wang Shouling Ji wenzhi chen School of Software Technology Zhejiang UniversityHangzhouChina College of Computer Science Zhejiang UniversityHangzhouChina College of Engineering Zhejiang UniversityHangzhouChina

Existing lip synchronization(lip-sync)methods generate accurately synchronized mouths and faces in a generated ***,they still confront the problem of artifacts in regions of non-interest(RONI),e.g.,background and other parts of a face,which decreases the overall visual *** solve these problems,we innovatively introduce diverse image inpainting to lip-sync *** propose Modulated Inpainting Lip-sync GAN(MILG),an audio-constraint inpainting network to predict synchronous *** utilizes prior knowledge of RONI and audio sequences to predict lip shape instead of image generation,which can keep the RONI ***,we integrate modulated spatially probabilistic diversity normalization(MSPD Norm)in our inpainting network,which helps the network generate fine-grained diverse mouth movements guided by the continuous audio ***,to lower the training overhead,we modify the contrastive loss in lipsync to support small-batch-size and few-sample *** experiments demonstrate that our approach outperforms the existing state-of-the-art of image quality and authenticity while keeping lip-sync.

关键词： Lip-sync Image inpainting Face generation Modulated SPD normalization

Aloin ameliorates cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating gut microbiota

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Food Science and Human Wellness 2024年

作者： Jingqian Su Jianbin Xiao Siyuan chen Heng Zhao Xiaoni Zhang Zhihua Feng Kunsen chen Biyun Guan wenzhi chen Youqiang chen Duo chen Qi chen Fujian Key Laboratory of Innate Immune Biology， Biomedical Research Center of South China， College of Life Science， Fujian Normal University The Public Service Platform for Industrialization Development Technology of Marine Biological Medicine and Products of the State Oceanic Administration， Fujian Key Laboratory of Special Marine Bioresource Sustainable Utilization， Southern Institute of Oceanography， College of Life Science， Fujian Normal University

Most Aloe species are used as new food or functional food ingredient. Even though widely known for its health benefits， the anti-inflammatory effects and underlying mechanisms of Aloin (Alo)， an anthraquinone compound isolated from plant species of the genus Aloe， remain unidentified. Here， we investigated the protective effects of Alo against cecal ligation and puncture (CLP)-induced sepsis and microflora in mice. Alo significantly improved CLP-induced sepsis and the survival rate of septic mice， downregulated the expression of proinflammatory factors， and decreased the infiltration of inflammatory cells in tissues. Alo upregulated the proportion of peritoneal macrophages， reduced the number of peritoneal bacteria， decreased the content of short-chain fatty acids and bile acids in the abdominal cavity， and suppressed TLR-2/4/NF-κB/NLRP3/Caspase-1/3/8 signaling. Furthermore， Alo altered the composition of the microbiome and promoted the growth of Lactobacillus， which showed a stronger anti-inflammatory effect. Whole-genome analysis identified the genes Saa3， Il10， Fpr1， and Eif4a1 associated with the protective effects of Alo in mice with CLP-induced sepsis. Overall， our results provide novel insights into the therapeutic potential and mechanism of action of Alo in the treatment of sepsis.

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