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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： Yu‑Ze Wang Yu‑Chang Wang Ting‑Ting Liu Quan‑Liang Zhao Chen‑Sha Li Mao‑Sheng cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

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Universal design of three-dimensional porous graphene-iron based promotors for kinetically rationalized lithium-sulfur chemistry

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Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： Hua Gao Yunfeng Zhang Menglei Wang Ruoxuan Yang Shuai Feng Xuan cao Yaping Zhang Zhongyuan Lu Yingze Song State Key Laboratory of Environment-Friendly Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and Engineering Henan University of Technology College of Chemistry and Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are widely deemed to be one of the most potential candidates for future secondary batteries because of their remarkable energy ***,notorious polysulfide shuttling and retarded sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally designed highly active electrocatalysts can facilitate polysulfide conversion,the universal and scalable synthesis strategies need to be ***,a universal synthetic strategy to construct a series of three-dimensional （3D） porous graphene-iron （3DGr-Fe） based electrocatalysts involving 3DGr-FeP,3DGr-Fe3C,and 3DGr-Fe3Se4is exploited for manipulating the Li-S redox *** has been observed that the implementation of a 3D porous Gr architecture leads to the well-designed conductive networks,while the uniformly dispersed iron nanoparticles introduce an abundance of active sites,fostering the lithium polysulfide conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3DGr-Fe based electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged Li-S pouch cell based on such a 3DGr-Fe electrocatalyst delivers superior capacity of 1060.71 mA h g-1and guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the design,synthesis,and mechanism of 3DGr-Fe based electrocatalysts with high activity toward efficient and durable Li-S batteries.

关键词： Redox reactions

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论综合性地图集对城市定位的客观表达

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城市勘测 2018年第1期 113-117页

作者：于江珮李海亭曹文涛武汉市测绘研究院湖北武汉430022

城市定位是城市发展的根基,准确的城市定位可以促进城市的快速发展。在综合地图集中,除了对交通、科教、文化和经济等诸多方面进行阐述以外,还会对城市定位进行深入挖掘,提炼城市优势,用地图语言对城市定位进行客观表达,从而构建地图集... 详细信息

城市定位是城市发展的根基,准确的城市定位可以促进城市的快速发展。在综合地图集中,除了对交通、科教、文化和经济等诸多方面进行阐述以外,还会对城市定位进行深入挖掘,提炼城市优势,用地图语言对城市定位进行客观表达,从而构建地图集的城市特色,建立城市自信。本文就是以《武汉市地图集》为例,分析城市定位在综合性地图集中挖掘和客观表达的方法。

关键词：武汉市地图集城市定位客观表达

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ADR-250型大孔径钻机在瓦斯抽采中的应用

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能源与节能 2016年第5期 69-70页

作者：曹文涛周玉军张连昆运城职业技术学院矿山工程系山西运城044000 河南工业和信息化职业学院资源环境系河南焦作454000

结合沙曲矿瓦斯易超限的实际,对裂隙带高位钻孔进行合理布置,采用ADR-250型大孔径钻机施工,并进行抽采。试验结果表明:钻孔高纯量抽采步距可达90 m,抽采效果明显,解决了瓦斯超限。

关键词： ADR-250型钻机大孔径瓦斯抽采钻孔布置

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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

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存量数据转换基础地理实体技术实现

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城市勘测 2021年第5期 24-30页

作者：曹文涛姚垚陈莎李海亭武汉市测绘研究院湖北武汉430022

2020年10月,全国国土测绘工作会议提出了新时期测绘工作“两服务、两支撑”的根本定位,明确要求重点以基础地理实体为突破口,加快推进体系化的新型基础测绘早日建成[1]。基础地理实体的生产路径一般分为存量测绘成果数据转换地理实体和... 详细信息

2020年10月,全国国土测绘工作会议提出了新时期测绘工作“两服务、两支撑”的根本定位,明确要求重点以基础地理实体为突破口,加快推进体系化的新型基础测绘早日建成[1]。基础地理实体的生产路径一般分为存量测绘成果数据转换地理实体和全息采集直接构建地理实体两种,本文聚焦前者,以存量大比例尺DLG(根据各地实际情况,通常采用1∶500~1∶2000比例尺DLG,以下简称为“DLG”)为基础,结合三调成果、宗地和自然幢、地理国情监测、建筑信息调查等数据成果,研究DLG转换为基础地理实体的关键技术与生产流程,并结合国家新型基础测绘建设武汉市试点生产实践,详细阐述存量数据转换基础地理实体的技术实现过程。

关键词：新型基础测绘存量数据转换基础地理实体

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耐高温高产酒精酵母菌的筛选鉴定及特性研究

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食品与发酵科技 2023年第1期59卷 83-89页

作者：曹云曹文涛王晓丹杨文娟刘云茂贵州大学酿酒与食品工程学院贵州贵阳550025 贵州轻工职业技术学院轻工化工系贵州贵阳550025 贵州大学贵州省发酵工程与生物制药重点实验室贵州贵阳550025

为了筛选耐高温产酒精酵母菌,以贵州省茅台镇酱香型酒厂的第四轮次酒醅为实验材料,采用平板划线分离法筛选出37株酵母菌,从37株酵母菌中通过热致死温度、TTC染色法获得1株耐高温且高产酒精的J18菌株,对其在最高发酵温度的耐乙醇、耐酸... 详细信息

为了筛选耐高温产酒精酵母菌,以贵州省茅台镇酱香型酒厂的第四轮次酒醅为实验材料,采用平板划线分离法筛选出37株酵母菌,从37株酵母菌中通过热致死温度、TTC染色法获得1株耐高温且高产酒精的J18菌株,对其在最高发酵温度的耐乙醇、耐酸、耐糖及发酵力进行了研究。结果表明:J18菌株的最高发酵温度为44℃,耐乙醇浓度18%vol,最适生长pH值为5.5;最适生长葡萄糖浓度为35%,最适发酵条件下发酵力为4.881 g/100 mL。对该菌株进行形态学鉴定和26S rDNA测序,确定该菌株为酿酒酵母(Saccharomyces cerevisiae)。

关键词：耐高温高产酒精酿酒酵母

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Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing cao Chenglin Cai Guangming Wang Min Zhou Luying Peng Yantao Fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

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响应面法优化解淀粉芽孢杆菌产中性蛋白酶发酵条件

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中国酿造 2017年第4期36卷 78-82页

作者：许曌昕曾辉曾德勇曹文涛王芙蓉席德州贵州大学酿酒与食品工程学院贵州贵阳550025 贵州盛世甲秀酒业有限公司贵州贵阳550004 贵州茅台(集团)生态农业产业发展有限公司贵州黔东南557500

在单因素试验的基础上,应用响应面法对解淀粉芽孢杆菌(Bacillus amyloliquefaciens)GZUB-7产中性蛋白酶的发酵条件进行优化,以达到提高菌株产中性蛋白酶酶活力的目的。结果表明,发酵培养基的最佳组分为葡萄糖用量50 g/L、豆粕粉40 g/L、... 详细信息

在单因素试验的基础上,应用响应面法对解淀粉芽孢杆菌(Bacillus amyloliquefaciens)GZUB-7产中性蛋白酶的发酵条件进行优化,以达到提高菌株产中性蛋白酶酶活力的目的。结果表明,发酵培养基的最佳组分为葡萄糖用量50 g/L、豆粕粉40 g/L、CaCl_2添加量0.44 g/L;最适发酵条件为发酵温度40℃、初始pH 7.0、接种量6.0%、发酵时间40 h,在此条件下,该菌株产中性蛋白酶酶活力达到192.7 U/mL。

关键词：解淀粉芽孢杆菌中性蛋白酶响应面法条件优化

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