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Novel Mobility Formula for Parallel Mechanisms Expressed with Mobility of General Link Group

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Chinese Journal of Mechanical Engineering 2013年第6期26卷 1082-1090页

作者： ZHANG Yitong lu wenjuan MU Dejun YANG Yandong ZHANG Lijie ZENG Daxing Key Laboratory of Parallel Robot and Mechatronic System Yanshan University Key Laboratory of Advanced Forging & Stamping Technology and Science Yanshan University

The determination of virtual constraints is always one of the key and difficult problems in traditional mobility calculation. To make mobility calculation simple, considering avoiding virtual constraints, some new formulae have been presented, however these formulae can hardly intuitively reflect general link group＇s restrictions on output member and its influences on independence of output parameters, which is premise to the judgment of the properties of mobility. Towards the problem to reveal the intrinsic relationship between the degree of freedom（DOF） of a mechanism, the link group, and the dimension of output parameters, also to avoid determination of virtual constraint, based on the new concepts of the ＂DOF of general link group＂ and ＂node parameters＂, a new formula in the calculation of the mobility of mechanisms is presented that is expressed with DOFs of the general link groups and rank of motion parameters of base point of the output link. It is named GOM（mobility of groups and output parameter） formula. On the basis of new concepts of＂effective parameters＂ and ＂invalid parameters＂, a rule is put forward for solving the DOF of mechanisms with invalid parameters by GOM formula, that is, the base point parameters are the subset of effective parameters of link group. Thereafter, several examples are enumerated and the results coincide with the prototype data, which proves the validity of the proposed formula. Meanwhile, it is obtained that the necessary and sufficient condition for the judgment of output parameters independence is that each of the DOF of the link group is not less than zero. The proposed formula which is simple in calculation provides theoretical basis for the judgment of independence of output parameters and provides references for type synthesis of novel parallel mechanisms with independence requirements of their output parameters.

关键词： parallel mechanism degree of freedom general link group output parameters

Cultivation of aerobic granular sludge in a conventional, continuous flow, completely mixed activated sludge system

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Frontiers of Environmental Science & Engineering 2015年第2期9卷 324-333页

作者： Xi CHEN Linjiang YUAN wenjuan lu Yuyou LI Pei LIU Kun NIE School of Environmental and Municipal Engineering Xi'an University of Architecture and Technology Xi'an 710055 China Department of Environmental Science Graduate School of Environmental Studies Tohoku University Sendai 980-8579 Japan

Aerobic granules were formed in a conven- tional, continuous flow, completely mixed activated sludge system （CMAS）. The reactor was inoculated with seed sludge containing few filaments and fed with synthetic municipal wastewater. The settling time of the sludge and the average dissolved oxygen （DO） of the reactor were 2 h and 4.2 mg. L 1, respectively. The reactor was agitated by a stirrer, with a speed of 250r·min^-1, to ensure good mixing . The granular sludge had good settleability, and the sludge volume index （SVI） was between 50 and 90 mL ·g ^-1. The laser particle analyzer showed the diameter of the granules to be between 0.18 and 1.25 mm. A scanning electron microscope （SEM） investigation revealed the predominance of sphere-like and rod-like bacteria, and only few filaments grew in the granules. The microbial community structure of the granules was also analyzed by polymerase chain reaction-denaturing gradient gel electro- phoresis （PCR-DGGE）. Sequencing analysis indicated the dominant species were α, β, and γ-Proteobacteria, Bacteroidetes, and Firmicutes. The data from the study suggested that aerobic granules could form, if provided with sufficient number of filaments and high shear force. It was also observed that a high height-to-diameter ratio of the reactor and short settling time were not essential for the formation of aerobic granular sludge.

关键词： aerobic granular sludge completely mixed activated sludge system (CMAS) continuous flow shear force filamentous bacteria polymerase chain reaction- denaturing gradient gel electrophoresis (PCR-DGGE)

A review of MXene-derived quantum dots:Synthesis,characterization,properties,and applications

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Particuology 2024年第8期91卷 50-71页

作者： Chunhe Zhou Kar Ban Tan wenjuan Han Li Wang Ming lu The Joint Laboratory of MXene Materials Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of EducationJilin Normal UniversityChangchunJilin 130103China Department of Chemistry Faculty of ScienceUniversiti Putra MalaysiaSerdangSelangor 43400Malaysia

Cutting MXene to a minimum size and forming the derived two-dimensional MXene quantum dots(MQDs),which possess a unique intrinsic layered geometry structure,restricts exciton due to their novel spatial *** gives rise to a broad spectrum of fascinating properties,rendering them for various ***,the correlation between composition,structure,and processing control of MQDs is investigated systematically,giving further insight into the intrinsic and extrinsic *** review also provides an opportunity to explore new compositions,modify the properties,and tailor MQDs into the guided architectural design before any prospective applications.

关键词： MXene Quantum dots Characterization Properties Applications

Fasudil hydrochloride differentiates bone marrow mesenchymal stem cells into neurons via notch signaling

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Neural Regeneration Research 2010年第11期5卷 814-819页

作者： Eryi Zhao Liudong Wang Quanqing Wen wenjuan Guan Jingjing lu Tao Peng Boai Zhang Yanjie Jia Department of Neurology First Affiliated Hospital Zhengzhou University Zhengzhou 450052 Henan Province China

BACKGROUND： Notch signaling regulates bone marrow mesenchymal stem cell （MSC） proliferation, differentiation, and apoptosis, Notch signaling and Rho kinase signaling exhibit a crosstalk phenomenon with JAK/STAT, and both participate in the neuronal dendritic spine development. Inhibition of RhoA/Rho kinase signaling may regulate MSC differentiation into neuronal-like cells. OBJECTIVE： To investigate the effect of Notch1 signaling on the differentiation of rat MSCs into neurons induced by fasudil hydrochloride （C14H17N3O2S-HCI）, a Rho kinase inhibitor, through a siRNA approach. DESIGN, TIME AND SETTING： An in vitro cytological experiment was performed in the Cell Laboratory of Henan Academy of Medical and Pharmaceutical Sciences between December 2007 and May 2009. MATERIALS： MSCs were obtained from Wistar rat femoral bone, fasudil hydrochloride was provided by -Tianjin Chase Sun Pharmaceutical Co., Ltd. Rn-notchl-siRNa, negative control siRNA （Cy3 label） and Rn-MAPK1 control siRNA were provided by QIAGEN, Coloqne, German. METHODS： The cultured MSCs were divided into non-transfected, transfected group （transfected with Rn-Notchl-siRNA）, positive control （transfected with Rn-MAPK-1 control siRNA）, and negative control （transfected with negative control siRNA） groups. Fasudil hydrochloride was applied to induce MSCs to differentiate into neurons. MAIN OUTCOME MEASURES： The fluorescence expression by the transfected MSCs was observed under an inverted fluorescence microscope; the expression of Notch1 mRNA, Hesl mRNA, and MAPK1 mRNA in MSCs was detected by reverse transcription polymerase chain reaction; the expression of Notch1 protein, nestin, neurofilament M, and glial fibrillary acidic protein was detected by immunocytochemistry. The viability of MSCs was detected by tetrazolium bromide assay. RESULTS： MSC fluorescence increased following a 72-hour siRNA transfection, with transfection efficiencies of up to （0.91 ± 0.04）; the Notch1 mRNA and Hesl mRNA expressed by tra

关键词： Notch Rho fasudil hydrochloride marrow mesenchymal stem cells neuronal-like cells transfection nerve stem cells neural regeneration

直丝弓矫治联合咬合重建治疗安氏Ⅱ类2分类伴重度磨耗疗效分析

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中国美容医学 2024年第4期33卷 139-143页

作者：王静庞淑婷路茜周建营冯艳芬卢文娟张倩沧州市人民医院口腔正畸科河北沧州061000 沧州市人民医院口腔内科河北沧州061000 沧州市人民医院口腔修复科河北沧州061000

目的:探讨传统直丝弓矫治技术结合修复咬合重建治疗内倾型深覆牙合伴重度磨耗患者的临床效果和影响因素。方法:选取2018年1月-2021年12月沧州市人民医院口腔科就诊的82例内倾型深覆牙合伴重度磨耗成年患者为研究对象,随机分为实验组和... 详细信息

目的:探讨传统直丝弓矫治技术结合修复咬合重建治疗内倾型深覆牙合伴重度磨耗患者的临床效果和影响因素。方法:选取2018年1月-2021年12月沧州市人民医院口腔科就诊的82例内倾型深覆牙合伴重度磨耗成年患者为研究对象,随机分为实验组和对照组,每组41例。实验组采用传统直丝弓矫治技术结合修复咬合重建治疗,对照组仅采用传统直丝弓矫治技术治疗。比较两组患者的正畸治疗时间、颞下颌关节功能、关节间隙、下面高等指标的变化,并分析影响治疗效果的相关因素。结果:实验组正畸治疗时间(12.6±1.8)个月,明显短于对照组的(18.4±2.1)个月(P<0.05),颞下颌关节功能评分、关节间隙、下面高等指标在治疗后均有显著改善,且优于对照组(均P<0.05);影响治疗效果的相关因素包括患者年龄、性别、牙合类型、牙周健康状况等(P<0.05)。结论:传统直丝弓矫治技术结合修复咬合重建治疗内倾型深覆牙合伴重度磨耗患者,能有效缩短正畸治疗时间,改善颞下颌关节功能,恢复咬合高度,提高患者的生活质量。患者的个体差异和牙周健康状况是影响治疗效果的重要因素,应根据具体情况制定个体化的治疗方案。

关键词：直丝弓咬合重建内倾型深覆牙合重度牙齿磨耗颞下颌关节功能

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Preparation of high-purity fluorite and nanoscale calcium carbonate from low-grade fluorite

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1198-1207页

作者： Qianqian lu Haisheng Han wenjuan Sun Xingfei Zhang Weiwei Wang Bilan Zhang Wensheng Chen Qin Zou School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Hunan Nonferrous Chenzhou Fluoride Chemical Co. Ltd.Chenzhou 423000China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030China Hunan Shizhuyuan Nonferrous Metal Co. Ltd.Chenzhou 423000China

Flotation separation of calcite from fluorite is a challenge on low-grade fluorite flotation that limits the recovery and purity of fluorite concentrate.A new acid leaching–flotation process for fluorite is proposed in this *** innovative process raised the fluor-ite’s grade to 97.26wt%while producing nanoscale calcium carbonate from its leachate,which contained plenty of calcium *** the production of nanoscale calcium carbonate,the impacts of concentration,temperature,and titration rate were *** modifying the process conditions and utilizing crystal conditioning agents,calcite-type and amorphous calcium carbonates with corresponding particle sizes of 1.823 and 1.511μm were *** influence of the impurity ions Mn^(2+),Mg^(2+),and Fe^(3+)was demonstrated to reduce the particle size of nanoscale calcium carbonate and make crystal shape easier to manage in the fluorite leach solution system compared with the calcium chloride *** combination of the acid leaching–flotation process and the nanoscale calcium carbonate preparation method improved the grade of fluorite while recovering calcite resources,thus presenting a novel idea for the effective and clean usage of low-quality fluorite resources with embedded microfine particles.

关键词： fluorite calcite nanoscale calcium carbonate waste recovery

OBE 理念下“数字集成电路设计”课程教学改革

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电气电子教学学报 2024年第3期46卷 37-40页

作者：赵强彭春雨郝礼才卢文娟蔺智挺吴秀龙安徽大学集成电路学院合肥230601

“数字集成电路设计”是微电子科学与工程专业重要的专业核心课。在课程中引入OBE教学理念,以学生毕业从事集成电路设计工作应达成的能力目标为导向,逆向设计课程教学方案。从课程理论讲授到工程项目案例教学,对学习目标达成情况进行跟... 详细信息

“数字集成电路设计”是微电子科学与工程专业重要的专业核心课。在课程中引入OBE教学理念,以学生毕业从事集成电路设计工作应达成的能力目标为导向,逆向设计课程教学方案。从课程理论讲授到工程项目案例教学,对学习目标达成情况进行跟踪并针对教学活动和目标持续改进,形成面向能力目标的教学效果评价体系。帮助学生独立解决科学与工程问题,锻炼了学生的工程实践能力和创新能力。

关键词：案例教学 OBE教学理念数字集成电路

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“数字集成电路设计”教学方法研究与探索

电气电子教学学报 2024年第1期46卷 177-179页

作者：郝礼才彭春雨卢文娟赵强蔺智挺吴秀龙安徽大学集成电路学院合肥230601

当前安徽大学“数字集成电路设计”课程的开展存在诸多问题(如教学方法单一,验证性实验内容相对简单,实验课程考核机制单一等),因此教学方法亟须改进。针对课程的现状,立足于教学模式、教学内容和考核方式三个方面进行改革和探索,积极... 详细信息

当前安徽大学“数字集成电路设计”课程的开展存在诸多问题(如教学方法单一,验证性实验内容相对简单,实验课程考核机制单一等),因此教学方法亟须改进。针对课程的现状,立足于教学模式、教学内容和考核方式三个方面进行改革和探索,积极探索“新工科”背景下数字集成电路设计的教学新方法,提出采用线上线下混合式教学方式,激发学生的学习兴趣,致力于提高学生的主观能动性和创新能力。

关键词：数字集成电路设计线上线下混合式教学创新能力

Ionic liquid-based in situ dynamically self-assembled cationic lipid nanocomplexes(CLNs)for enhanced intranasal siRNA delivery

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Chinese Chemical Letters 2024年第7期35卷 367-371页

作者： luyu Zhang Zirong Dong Shuai Yu Guangyue Li Weiwen Kong wenjuan Liu Haisheng He Yi lu Wei Wu Jianping Qi Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China School of Pharmacy Shandong Academy of SciencesQilu University of TechnologyJi'nan 250353China College of Chemical Engineering North China University of Science and TechnologyTangshan 063210China

This research aims to develop a non-invasive strategy for small interfering RNA(siRNA)nasal delivery based on ionic liquids(ILs)and cationic lipid(2,3-dioleoyloxy-propyl)-trimethylammonium-chloride(DOTAP).Other than the classical role of penetration enhancer,ILs also acted as superior solvents to simultaneously load siRNA and DOTAP,forming siRNA-DOTAP-ILs(siRNA-DILs)*** nasal mucosa penetration,DOTAP and ILs components self-assembled into cationic lipid nanocomplexes to load siRNA for enhanced in situ *** siRNA-DILs demonstrated resistance against RNase,significant mucosa penetration,prolonged nasal retention,and satisfying gene-silencing efficacy at lower ***,DILs were also able to deliver KCa3.1-targeted siRNA effectively for the treatment of allergic rhinitis in rat model by nasal ***,DILs have great potentials to deliver biological macromolecules across nasal mucosa by in situ dynamic self-assembly.

关键词： Ionic liquids Cationic lipids Lipid nanoparticles siRNA Allergic rhinitis