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康复管理在肝胆胰术患者中的运用效果及手术部位感染预防作用

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中华实验外科杂志 2024年第9期41卷 2050-2050页

作者：马骞郭庆平孙衍李翀程雯婕渠海长治医学院附属和济医院手术室长治046011 长治医学院附属和济医院内分泌科长治046011 长治医学院附属和济医院肝胆外科长治046011

本研究旨在观察康复管理在肝胆胰术患者中的运用效果及手术部位感染预防作用. 一、资料与方法 1.一般资料:选择于长治医学院附属和济医院住院进行肝胆胰手术治疗患者144例,2022年1月至2023年5月病例入组,所有患者分组方式为随机数字表法... 详细信息

本研究旨在观察康复管理在肝胆胰术患者中的运用效果及手术部位感染预防作用. 一、资料与方法 1.一般资料:选择于长治医学院附属和济医院住院进行肝胆胰手术治疗患者144例,2022年1月至2023年5月病例入组,所有患者分组方式为随机数字表法,72例为常规干预组,给予患者常规干预,72例为康复管理组,在常规管理干预基础上给予患者康复管理措施,记录两组肛门排气时间、术后下床时间、肠鸣音恢复时间、住院时间、手术部位感染发生率,干预前、后给予患者数字疼痛评分法(numerical rating scale,NRS)评价切口疼痛程度.

关键词：手术部位感染康复管理分组方式肛门排气时间肝胆胰手术切口疼痛常规干预长治医学院

RNA Sequencing Analysis Reveals Transcriptomic Variations in Tobacco (Nicotiana tabacum) Leaves Affected by Climate,Soil,and Tillage Factors

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RNA Sequencing Analysis Reveals Transcriptomic Variations in...

Application of icariin in the preparation of drugs for the treatment of low-androgen infertility in epididymis

中国烟草学会2015年年会

作者： Bo Lei Kun Lu Fuzhang Ding Kai Zhang Yi Chen Huina Zhao Lin Zhang Zhu Ren Cunmin qu Wenjing Guo Jing Wang wenjie Pan Key Laboratory of Molecular Genetics China National Tobacco CorporationGuizhou Academy of Tobacco Science Engineering Research Center of South Upland Agriculture College of Agronomy and BiotechnologySouthwest University

The growth and development of plants are sensitive to their surroundings. Although numerous studies have analyzed plant transcriptomic variation, few have quantified the effect of combinations of factors or identified factor-specific effects. In this study, we performed RNA sequencing(RNA-seq) analysis on tobacco leaves derived from 10 treatment combinations of three groups of ecological factors, i.e., climate factors(CFs), soil factors(SFs), and tillage factors(TFs). We detected 4980, 2916, and 1605 differentially expressed genes(DEGs) that were affected by CFs, SFs, and TFs, which included 2703, 768, and 507 specific and 703 common DEGs(simultaneously regulated by CFs, SFs, and TFs), respectively. GO and KEGG enrichment analyses showed that genes involved in abiotic stress responses and secondary metabolic pathways were overrepresented in the common and CF-specific DEGs. In addition, we noted enrichment in CF-specific DEGs related to the circadian rhythm, SF-specific DEGs involved in mineral nutrient absorption and transport, and SF- and TF-specific DEGs associated with photosynthesis. Based on these results, we propose a model that explains how plants adapt to various ecological factors at the transcriptomic level. Additionally, the identified DEGs lay the foundation for future investigations of stress resistance, circadian rhythm and photosynthesis in tobacco.

关键词： climate factors soil factors tillage factors tobacco leaves transcriptome RNA-seq

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Application of icariin in the preparation of drugs for the t...

Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome

中国药理学会第十一届全国基础与临床生殖药理学术研讨会暨生殖药理新技术与新方法培训班

作者： Shuwu Xie Lijuan qu Ruihua Zhong Guoting Li Yingying Lu Yang Cao wenjie Yang Jieyun Zhou Zhao Li Xiangjie Guo Can Cao Yan Zhu Department of Reproductive Pharmacology NHC Key Lab of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research) Fudan University Department of Clinical Laboratory Shanghai Eighth People's Hospital Obstetrics and Gynecology Hospital of Fudan University Yueyang Hospital of Integrated Traditional Chinese and Western Medicine

Background and introduction: In recent years, more and more attention has been paid to male infertility and its treatment. Due to environmental pollution, long-term lack of trace elements, bad living habits, long-term high mental stress, excessive smoking, alcohol consumption, abuse of hormones, sexually transmitted diseases and other factors, the reproductive capacity of modern human beings, especially men, is declining significantly. According to statistics, 10%-20% of married couples are infertile, of which male-induced infertility accounts for 40%-70%, and has an increasing trend year by year. Male reproductive health has become a major problem affecting human reproduction and survival. It is necessary to carry out the etiology and treatment of male infertility. Fewer and weaker sperms are common in male infertility. At present, testosterone, clomiphene and chorionic gonadotropin are the main drugs for male infertility patients in western medicine clinic. The overall efficacy has its limitations. Traditional Chinese medicine paysattention to holistic concept and syndrome differentiation and treatment, and has certain advantages and characteristics in the treatment of male infertility. Among them, Kidney-Tonifying and spermatogenesis herbs can improve the function of hypothalamus-pituitary-testicular gonadal axis, promote the secretion and release of hypothalamus gonadotropin, so as to improve pituitary luteinizing hormone and follicle stimulating spur. The synthesis, secretion and release of growth hormone promote testicular androgen synthesis, and finally promote testicular spermatogenesis and epididymal sperm maturation, and finally improve the treatment of male infertility. Systematic meta-analysis has shown that Chinese herbal medicine for tonifying kidney is superior to western medicine in improving the total efficiency of oligoasthenospermia and sperm density, motility and viability, and has fewer adverse reactions and is safe and reliable in clinical prac

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Genomics, Proteomics & Bioinformatics 2019年第3期17卷 229-247页

作者： Zhenglin Du Liang Ma Hongzhu qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100101China BIG Data Center Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese ***,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in *** the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano *** this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and *** order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural *** the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han ***,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and ***,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree *** together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine.

关键词： De novo assembly Reference genome Variation map Phenotype association Large population

A Possible 250s X-Ray quasi-periodicity in the Fast Blue Optical Transient AT2018cow

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Research in Astronomy and Astrophysics 2022年第12期22卷 299-310页

作者： wenjie Zhang Xinwen Shu Jin-Hong Chen Luming Sun Rong-Feng Shen Lian Tao Chun Chen Ning Jiang Liming Dou Ying Qin Xue-Guang Zhang Liang Zhang Jinlu qu Tinggui Wang Department of Physics Anhui Normal UniversityWuhu 241002China School of Physics and Astronomy Sun Yat-Sen UniversityZhuhai 519082China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of ScienceBeijing 100049China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China Department of Astronomy Guangzhou UniversityGuangzhou 510006China School of Physics and Technology Nanjing Normal UniversityNanjing 210023China

The fast blue optical transients(FBOTs)are a new population of extragalactic transients of unclear physical origin.A variety of mechanisms has been proposed including failed supernova explosion,shock interaction with a dense medium,young magnetar,accretion onto a compact object and stellar tidal disruption event,but none is *** we report the discovery of a possible X-ray quasi-periodicity signal with a period of~250 s(at a significance level of 99.76%)in the brightest FBOT AT2018cow through the analysis of XMM-Newton/PN *** signal is independently detected at the same frequency in the average power density spectrum from data taken from the Swift telescope,with observations covering from 6 to 37 days after the optical discovery,though the significance level is lower(94.26%).This suggests that the quasi-periodic oscillation(QPO)frequency may be stable over at least 1.1×10^(4)*** the~250 s QPO to be a scaled-down analog of that typically seen in stellar mass black holes,a black hole mass of~103–10^(5)solar masses could be *** overall X-ray luminosity evolution could be modeled with a stellar tidal disruption by a black hole of~10^(4)solar masses,providing a viable mechanism to produce *** findings suggest that other bright FBOTs may also harbor intermediate-mass black holes.

关键词： black hole physics X-rays:individual(AT2018cow) X-rays:bursts

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青光眼视神经损伤机制的研究进展

医学综述 2017年第22期23卷 4495-4500页

作者：江文捷曲超西南医科大学四川泸州646000 四川省医学科学院.四川省人民医院眼科成都610072

青光眼是目前继白内障后全球第2位致盲性眼病,总人群发病率为1%,严重威胁着人类的视觉健康。关于青光眼视神经损伤的发病机制,近年来各国学者在该领域做了大量的研究,许多学说都证实其最终的共同通路是视网膜神经节细胞的凋亡,然而每一... 详细信息

青光眼是目前继白内障后全球第2位致盲性眼病,总人群发病率为1%,严重威胁着人类的视觉健康。关于青光眼视神经损伤的发病机制,近年来各国学者在该领域做了大量的研究,许多学说都证实其最终的共同通路是视网膜神经节细胞的凋亡,然而每一种学说都不能完全解释青光眼视神经损害的具体机制。到目前为止,其确切机制尚未阐明,因此,有必要进行更深入的研究,在合理的理论框架下,探索特异性阻断视网膜神经节细胞凋亡的新方法,从而更有效地保护视功能。

关键词：青光眼视神经损伤视网膜神经节细胞凋亡

水相中有机化学品和卤素自由基反应速率常数的定量结构-活性关系模型

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环境化学 2022年第2期41卷 663-672页

作者：张坤赵健辰金文杰曲蛟张亚南国家环境保护湿地生态与植被恢复重点实验室东北师范大学环境学院长春130117

卤素自由基尤其是氯自由基在污水中难降解污染物的降解以及表层海水中环境微污染物的降解过程中发挥重要作用,能够影响污染物的环境持久性与毒性风险。在污水及表层海水中存在着多种多样的有机污染物,单纯依靠实验手段测定它们和氯自由... 详细信息

卤素自由基尤其是氯自由基在污水中难降解污染物的降解以及表层海水中环境微污染物的降解过程中发挥重要作用,能够影响污染物的环境持久性与毒性风险。在污水及表层海水中存在着多种多样的有机污染物,单纯依靠实验手段测定它们和氯自由基的反应速率常数费时费力并且成本较高。因此本研究通过发展氯自由基与有机污染物的反应速率常数的QSAR模型来实现反应速率常数的定量预测。本研究搜集了28种有机化合物与Cl^(·)的反应速率常数以及18种有机化合物与Cl_(2)^(·−)的反应速率常数的实测值,采用多元线性回归(MLR)分别建立了QSAR模型。lgk_(Cl⋅)=11.133−7.236×Dv−0.087×VE3sign_RG+0.569×GATS5e−0.158×H-051。lgk_(Cl⋅)的QSAR模型的校正决定系数(R^(2)_(adj,tr))为0.810,均方根误差(RMSE_(train))为0.34,去一法交叉验证系数(Q^(2)_(LOO))为0.716,外部验证系数Q^(2)_(ext)=0.793;lgkC_(l2⋅)-=3.657+0.374×RDF010s−0.037×ATSC5s+0.073×L/Bw。lgkC_(l2⋅)-QSAR模型R^(2)_(adj,tr)为0.902,RMSE_(train)为0.29,Q^(2)_(LOO)为0.839,Q^(2)_(ext)为0.629。表明两个模型具有较高的拟合优度、稳健性和预测能力。应用域表征结果显示所选择的模型具有较好的代表性,所有化合物均在应用域范围内。所构建的模型可以实现含羟基,羰基,羧基等多种官能团有机化合物k_(Cl⋅)及kC_(l2⋅-)的定量预测。

关键词：氯自由基反应速率常数多元线性回归定量结构活性关系模型

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基于动态执行的基带固件函数安全性分析

中国海洋大学学报（自然科学版） 2022年第1期52卷 65-70页

作者：曲海鹏于芮孙磊吕文杰中国海洋大学信息科学与工程学院山东青岛266100

移动通信设备中的基带固件运行于独立的计算环境,其漏洞既可危及设备安全,又无法通过设备主操作系统的安全机制进行防护,因此其安全性备受攻防研究者的关注。实验中发现,得到的基带固件由于函数重写、调试信息剥离等原因,现有对比工具... 详细信息

移动通信设备中的基带固件运行于独立的计算环境,其漏洞既可危及设备安全,又无法通过设备主操作系统的安全机制进行防护,因此其安全性备受攻防研究者的关注。实验中发现,得到的基带固件由于函数重写、调试信息剥离等原因,现有对比工具难以准确识别其危险函数,进而无法进行后续的漏洞发掘工作。本文提出一种基于动态执行的函数安全性分析方法DEx。根据预处理过程得到的基带固件的函数信息和段内容,在交叉编译和虚拟机环境下对基带固件函数实现动态执行。基于运行过程中产生的语义特征,设计优先级排序以对函数的安全性进行分析,识别得到内存拷贝函数。基于DEx方法构造了dyndiff工具,与基于二进制代码相似性方法的主流工具BinDiff对比,dyndiff的危险函数识别率是BinDiff的5.5倍。最后,阐述了本文工作在后续漏洞挖掘工作中的应用。

关键词：基带固件动态执行语义特征安全性分析危险函数

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A Novel Method to against quantum Noises in quantum Teleportation

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Journal of quantum Computing 2020年第1期2卷 33-55页

作者： Shengyao Wu wenjie Liu Zhiguo qu School of Computer&Software Nanjing University of Information Science and TechnologyNanjing210044China Jiangsu Engineering Center of Network Monitoring Nanjing University of Information Science and TechnologyNanjing210044China Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science&TechnologyNanjing210044China

In order to improve the anti-noise performance of quantum teleportation,this paper proposes a novel dynamic quantum anti-noise scheme based on the quantum teleportation which transmits single qubit state using Bell *** that quantum noise only acts on the transmitted qubit,i.e.,the entangled state that Alice and Bob share in advance is affected by the noise,thus affecting the final transmission *** this paper,a method for dynamically adjusting the shared entangled state according to the noise environment is *** calculating the maximum fidelity of the output state to determine the shared entangled state,which makes the quantum teleportation be affected by the noise as little as *** paper calculates the fidelity of teleportation under four kinds of channel noise(amplitude damping,phase damping,bit flip and depolarizing noise).The results show that the scheme has a suppression effect on phase damping,bit flip and depolarizing noise under certain *** the noise intensity is larger,the optimized efficiency is better.

关键词： quantum noise quantum teleportation entangled channel fidelity