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利多卡因联合舒芬太尼静脉自控镇痛对结直肠癌根治术后疼痛和肠道功能恢复的影响

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现代肿瘤医学 2024年第7期32卷 1311-1315页

作者：吴玉敏张森兵阎文军张文洁屈松田斌甘肃中医药大学第一临床医学院甘肃兰州730000 甘肃省人民医院麻醉科甘肃兰州730000 宁夏医科大学宁夏银川750004

目的:本研究旨在探索利多卡因联合舒芬太尼静脉自控镇痛(patient controlled intravenous analgesia,PCIA)对腹腔镜结直肠癌根治术患者术后镇痛效果和肠道功能恢复的影响。方法:将135例拟行全身麻醉下腹腔镜结直肠癌根治术患者随机分为... 详细信息

目的:本研究旨在探索利多卡因联合舒芬太尼静脉自控镇痛(patient controlled intravenous analgesia,PCIA)对腹腔镜结直肠癌根治术患者术后镇痛效果和肠道功能恢复的影响。方法:将135例拟行全身麻醉下腹腔镜结直肠癌根治术患者随机分为舒芬太尼组(S组,n=68)和利多卡因联合舒芬太尼组(LS组,n=67),术后的疼痛管理使用PCIA装置。S组(PCIA:舒芬太尼2.0μg/kg+昂丹司琼16 mg+0.9%盐水配至300 mL),LS组(PCIA:利多卡因48 mg/kg+舒芬太尼2.0μg/kg+昂丹司琼16 mg+0.9%盐水配至300 mL)。主要结果是术后6 h、12 h、24 h、36 h、48 h的VAS疼痛评分。次要结果包括术后48 h内PCIA有效按压次数和补救镇痛发生率;术后首次排气和排便时间;恢复质量(QoR-15)评分;术后住院时间;术后48 h内恶心呕吐(postoperative nausea and vomiting,PONV)的发生率;局麻药中毒不良事件的发生率。结果:LS组患者在术后6 h、12 h、24 h、36 h、48 h的VAS疼痛评分均显著低于S组(P0.05)。LS组患者术后首次排气和排便时间均显著早于S组(P0.05);术后第一天和术后第二天,LS组患者的QoR-15评分均显著高于S组(P<0.05)。LS组患者术后住院时间较S组显著缩短(P<0.05)。LS组患者PONV的发生率显著低于S组(P<0.05)。LS组患者未出现局麻药中毒不良事件。结论:利多卡因联合舒芬太尼PCIA能为腹腔镜结直肠癌根治术患者提供更有效的术后镇痛,加快肠道功能恢复。

关键词：利多卡因结直肠癌疼痛恢复质量

国审玉米新品种‘MC278’的选育、不同生态区特性及其栽培技术

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中国农学通报 2022年第15期38卷 17-21页

作者：王晓光瞿文洁刘春阁吴鹏王荣焕冯培煜陕红史桂清冷燕成广雷北京市农林科学院玉米研究所玉米DNA指纹及分子育种北京市重点实验室北京100097 北京顺鑫农科种业科技有限公司北京100097 四川农业大学生态农业研究所成都611130 中国农业科学院农业环境与可持续发展研究所北京100081

针对不同生态区水热资源紧缺,风灾倒伏频发、产量低、品质差等问题,以‘京X005’为母本、‘京27’为父本进行杂交培育成玉米新品种‘MC278’。该品种在吉林、河北等地接种表明,对小斑病、弯孢病、矮花叶病、丝黑穗病、茎腐病的抗性较强... 详细信息

针对不同生态区水热资源紧缺,风灾倒伏频发、产量低、品质差等问题,以‘京X005’为母本、‘京27’为父本进行杂交培育成玉米新品种‘MC278’。该品种在吉林、河北等地接种表明,对小斑病、弯孢病、矮花叶病、丝黑穗病、茎腐病的抗性较强,易感染大斑病,中抗吉林地区玉米螟。在北京、内蒙等地不同年度的区试中,‘MC278’籽粒产量显著高于‘郑单958’(CK),产量最高达16166 kg/hm^(2),平均产量增幅达8.3%;‘MC278’的粗蛋白质、粗淀粉、赖氨酸含量显著高于‘郑单958’。2019年河北、山西、内蒙等地生产中,产量均高于12804 kg/hm^(2),产量最高达14283 kg/hm^(2);‘MC278’配套适宜播期、密度、水肥和病虫害防治等田间管理措施及收获技术。2019年通过国家审定(国审玉20190030),种植区域包括安徽、山西、山东等15个省级区域。

关键词： MC278 选育不同生态区特征特性栽培技术

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天然化合物治疗肝癌作用机制研究进展

甘肃中医药大学学报 2024年第1期41卷 116-121页

作者：屈延张文杰田淑菊陈芳芳李静王鹏韩飞李翻红甘肃省第二人民医院肝病科甘肃兰州730030

查阅近年来国内外相关文献,对胡椒碱、姜黄素、橄榄油刺激醛、葱提取物、蛇床子提取物、胡桃楸提取物等天然化合物治疗肝癌的作用机制研究进行概述。指出天然化合物主要通过抑制癌细胞转移、诱导癌细胞凋亡、抑制癌细胞血管生成、降低... 详细信息

查阅近年来国内外相关文献,对胡椒碱、姜黄素、橄榄油刺激醛、葱提取物、蛇床子提取物、胡桃楸提取物等天然化合物治疗肝癌的作用机制研究进行概述。指出天然化合物主要通过抑制癌细胞转移、诱导癌细胞凋亡、抑制癌细胞血管生成、降低癌细胞耐药性等多种途径发挥其抗肿瘤作用。虽然目前有关天然化合物治疗肝癌的相关研究逐渐增多,但是多为基础性研究,关于其临床应用的安全性和疗效仍不明确,今后需要更多的临床应用性研究加以验证。

关键词：肝癌天然化合物作用机制综述

Microarray microRNA profiling of urinary exosomes in a 5XFAD mouse model of Alzheimer’s disease

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Animal Models and Experimental Medicine 2021年第3期4卷 233-242页

作者： Zhiqi Song Yajin qu Yanfeng Xu Ling Zhang Li Zhou Yunlin Han wenjie Zhao Pin Yu Yu Zhang Xianglei Li Chuan Qin Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of HealthBeijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina

Background:Alzheimer's disease(AD)is an incurable and irreversible neurodegen-erative disease,without a clear ***,identification of candidates before amyloid-βplaque(Aβ)deposition proceeds is of major significance for earlier intervention in ***:To explore the potential noninvasive earlier biomarkers of AD in a 5XFAD mouse model,microRNAs(miRNAs)from urinary exosomes in 1-month-old pre-Aβaccumulation 5XFAD mice models and their littermate controls were profiled by mi-croarray *** differentially expressed miRNAs were further analyzed via droplet digital PCR(ddPCR).Results:Microarray analysis demonstrated that 48 differentially expressed miRNAs(18 upregulated and 30 downregulated),of which six miRNAs-miR-196b-5p,miR-339-3p,miR-34a-5p,miR-376b-3p,miR-677-5p,and miR-721-were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ***:Urinary exosomal miRNAs showing differences in expression prior to Aβ-plaque deposition were *** exosomal miRNAs represent potential noninvasive biomarkers that may be used to prevent AD in clinical applications.

关键词： 5XFAD mouse model Alzheimer's disease biomarkers microarray miRNA urinary exosome

Analysis of Chilling-Tolerance in Sweet Sorghum of Different Genotypes

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IMP & HIRFL Annual Report 2017年第1期 131-132页

作者： Liu Ruiyuan Dong Xicun Jin wenjie qu Ying 不详

The objective of this study was to investigate the chilling tolerance of sweet sorghum seedlings of different genotypes,to screen suitable evaluation indicators of chilling-tolerance,and to establish the mathematical evaluation model on cold tolerance,which would provide a theoretical basis for discovery and promotion of chilling tolerant germplasm,breeding of new chilling-tolerant varieties and evaluation on chilling tolerance of a large number of sweet sorghum *** superoxide dismutase(SOD)activity,peroxidase(POD)activity,catalase(CAT)activity,proline(Pro)content and the soluble sugar content in leaves of six sweet sorghum cultivars were measured as physiological indices for evaluating the chilling *** was found that the responses of these physiological indices to low temperature treatments were quite different among sweet sorghum cultivars.

关键词： cultivar breeding indices

Comparison of the RNA editing sites of chloroplast protein-coding genes in early-maturity mutant induced by carbon-ion beam in Sweet Sorghum

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Comparison of the RNA editing sites of chloroplast protein-c...

Rapid Synthesis and In Vitro Antibacterial Effects of Silver Nanoparticles Mediated by Using Polygonum cuspidatum Extract

2018全国植物生物学大会

作者： Ruiyuan Liu Ying qu wenjie Jin Wenjian Li Xicun Dong Department of Biophysics Institute of Modern PhysicsChinese Academy of Sciences

RNA editing is an important post-transcriptional process for converting nucleotide sequence of RNA from cytidine(C) to uridine(U) at specific *** it has been systematically studied in many plants,little is known about the change of RNA editing events in plants mutants induced by ***-ion beam irradiation is one of the effective methods to generate mutants in ***,using prediction and experimental determination,we compared and identified the RNA editing sites of chloroplast protein-coding genes in early-maturity mutant(KFJT-1) induced by carbonion beam in sweet sorghum and its wild type(KFJT-CK).A total of 21 and 19 editing sites were identified in the KFJT-CK and KFJT-1 chloroplast,*** KFJT-1 and KFJT-CK,all of the editing sites were C-to-U conversations,which mainly occurred in the second position,and bias to the U

关键词： RNA editing Sweet sorghum Carbon-ion beam irradiation Chloroplast genome

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Rapid Synthesis and In Vitro Antibacterial Effects of Silver...

眼调节对葡萄膜巩膜房水外流途径影响的形态学观察

第十四届全国中药和天然药物学术研讨会

作者： wenjie Sun Ding qu Yan Chen Jing Zhou Congyan Liu Jiangsu Provincial Academy of Chinese Medicine

＜正＞The well-designed silver nanopartides（AgNPs）are of particular interest and gradually become a primary strategy to prevent pathogenic bacteria for wound treatment,medical device sterilization,oral health protec...

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眼科新进展 2020年第11期40卷 1019-1023页

作者：江文捷曲超三六三医院四川省成都市610041 西南医科大学临床医学院四川省泸州市646100 四川省医学科学院四川省人民医院眼科四川省成都市610072

目的通过形态学观察探讨眼调节对葡萄膜巩膜房水外流途径的影响。方法14只健康日本大耳白兔,10只(20眼)用于荧光显微镜观察,4只(8眼)用于光镜观察,按用药方法不同各分为调节状态组和非调节状态组。所有白兔双眼分别采用5 g·L^-1硝酸毛... 详细信息

目的通过形态学观察探讨眼调节对葡萄膜巩膜房水外流途径的影响。方法14只健康日本大耳白兔,10只(20眼)用于荧光显微镜观察,4只(8眼)用于光镜观察,按用药方法不同各分为调节状态组和非调节状态组。所有白兔双眼分别采用5 g·L^-1硝酸毛果芸香碱滴眼液和10 g·L^-1盐酸环喷托酯滴眼液模拟眼调节态和非调节态,测量滴眼前及末次滴眼后30 min的眼压,于滴眼后30 min将5μL异硫氰酸荧光素标记牛血清白蛋白(FITC-BSA)注入前房,于前房注射后0.5 h、1.5 h、2.5 h、3.5 h、4.5 h各处死2只白兔,摘取双眼作冰冻切片,于荧光显微镜下观察调节态和非调节态葡萄膜巩膜途径的房水荧光强度及其分布形态;于滴眼后30 min处死4只白兔,摘取双眼通过HE染色和抗平滑肌抗体染色在普通光镜下观察兔眼睫状肌形态、肌间隙。结果调节状态组基线眼压(19.13±1.75)mmHg(1 kPa=7.5 mmHg),毛果芸香碱模拟眼调节后眼压下降,滴眼后眼压为(16.56±1.67)mmHg,差异有统计学意义(t=9.37,P=0.00)。调节状态组睫状体、脉络膜上腔和前巩膜荧光强度较非调节状态组均显著减弱(均为P0.05)。光镜观察见非调节状态组放射肌区域有明显肌间隙,而在调节状态组未发现此间隙。结论眼调节可通过收缩睫状肌从而减少房水从葡萄膜巩膜房水外流道排出。

关键词：眼调节葡萄膜巩膜通途径形态学

Switchable chiral mirror based on PIN diodes

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光子学研究:英文版 2023年第7期11卷 1154-1161页

作者： ZHIBIAO ZHU ZHE QIN HE WANG LIXIN JIANG YONGFENG LI wenjie WANG HONGYA CHEN JIAFU WANG YONGQIANG PANG SHAOBO qu Shaanxi Key Laboratory of Artificially-Structured Functional Materials and Devices Air Force Engineering UniversityXi’an 710051China School of Electronic Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

Chiral mirrors can produce spin selective absorption for left-handed circularly polarized(LCP) or right-handed circularly polarized(RCP) waves. However, the previously proposed chiral mirror only absorbs the designated circularly polarized(CP) wave in the microwave frequency band, lacking versatility in practical ***, we propose a switchable chiral mirror based on a pair of PIN diodes. The switchable chiral mirror has four working states, switching from the handedness-preserving mirror to the LCP mirror, RCP mirror, and perfect absorber. The basis of these advances is to change the chirality of two-dimensional(2D) chiral metamaterials and the circular conversion dichroism related to it, which is the first report in the microwave frequency *** current distributions shed light on how switchable chiral mirrors work by handedness-selective excitation of reflective and absorbing electric dipole modes. Energy loss distributions verify the working mechanism. The thickness of the switchable chiral mirror is one-tenth of the working wavelength, which is suitable for integrated manufacturing. The measurement results are in good agreement with the simulation results.

关键词： mechanism mirror chiral