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七氟烷联合异丙酚麻醉对行腹腔镜胆囊切除术患者应激反应及认知功能的影响

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首都食品与医药 2024年第9期31卷 63-65页

作者：詹文华冯昕江西省九江市第一人民医院江西九江332005 江西省九江市中医医院江西九江332099

目的探讨七氟烷联合异丙酚麻醉对行腹腔镜胆囊切除术(LC)患者应激反应及认知功能的影响.方法选择2021年1月-2023年7月在九江市第一人民医院拟行LC治疗的84例患者,按随机数字表法分为联合组与单一组,每组各42例.单一组使用异丙酚麻醉,联... 详细信息

目的探讨七氟烷联合异丙酚麻醉对行腹腔镜胆囊切除术(LC)患者应激反应及认知功能的影响.方法选择2021年1月-2023年7月在九江市第一人民医院拟行LC治疗的84例患者,按随机数字表法分为联合组与单一组,每组各42例.单一组使用异丙酚麻醉,联合组使用七氟烷联合异丙酚麻醉.对比两组苏醒质量、应激反应、认知功能及躁动、不良反应.结果联合组睁眼时间、自主呼吸恢复时间、拔管时间及语言应答时间较单一组短(P0.05).结论七氟烷联合异丙酚麻醉应用于LC术中可减轻应激反应及对认知功能造成的损伤,减少躁动发生,改善苏醒质量,安全性较高.

关键词：腹腔镜胆囊切除术七氟烷应激反应异丙酚认知功能麻醉

Aptamer-functionalized nanoplatforms overcoming temozolomide resistance in synergistic chemo/photothermal therapy through alleviating tumor hypoxia

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Nano Research 2023年第7期16卷 9859-9872页

作者： Yun Zeng Linfei Zhao Ke Li Jingwen Ma Dan Chen Changhu Liu wenhua zhan Yonghua zhan School of Life Science and Technology Xidian University and Engineering Research Center of Molecular and Neuro ImagingMinistry of EducationXi’an 710126China Department of Radiation Oncology General Hospital of Ningxia Medical UniversityYinchuan 750004China International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment and Xi’an Key Laboratory of Intelligent Sensing and Regulation of trans-Scale Life Information School of Life Science and TechnologyXidian UniversityXi’an 710126China Xi’an Key Laboratory for Prevention and Treatment of Common Aging Diseases Translational and Research Centre for Prevention and Therapy of Chronic DiseaseInstitute of Basic and Translational MedicineXi’an Medical UniversityXi’an 710021China Radiology Department CT and MRI RoomNinth Hospital of Xi’anXi’an 710054China

Tumor hypoxia is intimately associated with gliomas,which represents a significant threat to human health and are resistant to the first-line chemotherapeutic drug temozolomide(TMZ)due to *** this work,to overcome TMZ resistance in orthotopic gliomas,aptamer-functionalized liposomes are manufactured to encapsulate TMZ and photothermal agent IR780,and can cross the blood-brain barrier and actively target *** is possible to employ liposomes for both fluorescence and photoacoustic imaging simultaneously due to their stability and excellent photothermal conversion *** chemo/photothermal synergistic therapeutic effect of liposomes on gliomas is demonstrated by their abilities to target orthotopic gliomas,alleviate tumor hypoxia and consequently reverse resistance of glioma cells to TMZ,thereby extending the survival time of tumor-bearing mice,making the nanoplatforms and their synergistic chemo/photothermal therapy as a potential clinical treatment for gliomas.

关键词： aptamers blood-brain barrier gliomas liposomes photothermal therapy

EGFR-mutant non-small cell lung cancer patients harboring CDK4 amplification show favorable response to afatinib:Two case reports

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Chinese Medical Journal 2024年第12期137卷 1465-1467页

作者： Shuting zhan Bo Cheng Xiwen Liu Jianfu Li Ge Bai Qi Cai Huiting Wang Yang Xiang Chunyan Li Jianxing He wenhua Liang Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical University&Guangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhouGuangdong 510120China National Center for Respiratory Medicine State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseasesGuangzhou Institute of Respiratory Health&The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China Southern Medical University GuangzhouGuangdong 510120China Department of Respiratory and Critical Care Medicine The Tenth Affiliated Hospital of Southern Medical UniversityDongguanGuangdong 523108China

To the Editor:Epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)show significant efficacy in patients with advanced-stage non-small cell lung cancer(NSCLC)with sensitive EGFR mutations and significantly prolong the survival of these ***,drug resistance emerges in most *** studies indicated that cyclin-dependent kinase 4/6(CDK4/6)gene amplification was one of the resistance mechanisms of the EGFR-TKI osimertinib,weakening its *** options for EGFR-mutant NSCLC patients with CDK4 amplification are limited to add CDK4 inhibitors.

关键词： CDK4 NSCLC EGFR

Evaluation of para-aortic nodal dissection for locoregionally advanced gastric cancer with 1-3 involved para-aortic nodes

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Chinese Medical Journal 2014年第3期127卷 435-441页

作者： zhang Changhua He Yulong Roderich E.Schwarz David D.Smith Wang Liang Liu Fakeng zhan wenhua Department of Gastrointestinopancreatic Surgery the First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Gastric Cancer Center of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Surgery University of Texas Southwestern Medical Center Dallas TX 75235 USA Division of Biostatistics City of Hope National Medical Center Duarte CA 91010 USA

Background Prophylactic para-aortic nodal dissection （PAND） has no proven benefits for potentially curable advanced gastric ***,the value of therapeutic PAND for involved para-aortic nodes （PANs） in patients with locally advanced gastric cancers has not been determined *** Between 1998 and 2010,157 gastric cancer patients with 1-3 involved PANs underwent extended D2 （D2＋） lymphadenectomy plus PAND （PAND group,n=69） or extended D2 lymphadenectomy alone （non-PAND group,n=88）.The clinicopathologic features and prognostic data were compared between the two groups.A propensity score-adjusted analysis was used for a balanced *** The rate of PAN metastasis was 40.6％（28/69） in the PAND *** 5-year survival rate was significantly higher in the PAND group than in the non-PAND group （43.7％ vs.31.8％,P=-0.044）.Compared to the non-PAND group,the death hazard ratios in the PAND group were 0.45 （95％ CI 0.274-0.739; P=0.002） and 0.536 （95％ CI 0.328-0.861; P=-0.0097） by multivariate analysis without and with propensity score adjustment *** rate at 5 years was 39.1％ in the PAND group and 43.2％ in the non-PAND group （P=0.628）.Conclusion Extended D2 lymphadenectomy plus PAND is associated with superior outcomes for advanced gastric cancer patients with 1-3 involved PANs.

关键词： gastric cancer lymphadenectomy para-aortic node prognosis

LMR和LMR/LDH对原发韦氏环弥漫大B 细胞淋巴瘤预后的影响

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肿瘤防治研究 2022年第2期49卷 110-115页

作者：刘琦郭鹏詹文华宁夏医科大学研究生学院银川750004 宁夏医科大学总医院放疗科银川750004

目的探讨外周血LMR和LMR/LDH在原发韦氏环弥漫性大B细胞淋巴瘤(DLBCL)患者预后中的预测价值。方法收集71例原发韦氏环DLBCL患者临床资料,采用ROC曲线确定患者治疗前外周血LMR、LMR/LDH的最佳临界值,卡方检验分析LMR高低组和LMR/LDH高低... 详细信息

目的探讨外周血LMR和LMR/LDH在原发韦氏环弥漫性大B细胞淋巴瘤(DLBCL)患者预后中的预测价值。方法收集71例原发韦氏环DLBCL患者临床资料,采用ROC曲线确定患者治疗前外周血LMR、LMR/LDH的最佳临界值,卡方检验分析LMR高低组和LMR/LDH高低组构成比和率。生存率的比较采用Kaplan-Meier法,单因素分析用Log rank法检验,多因素分析用Cox风险回归模型。结果 LMR和LMR/LDH临界值分别为2.97和1.56。高LMR组患者的预后明显优于低LMR组(P<0.001);高LMR/LDH组患者的预后明显优于低LMR/LDH组(P<0.001)。单因素分析显示年龄、B症状、临床分期、治疗疗效、IPI评分、LDH水平、LMR及LMR/LDH是影响早期韦氏环DLBCL患者预后的重要因素;多因素分析显示LMR/LDH、年龄、临床分期是其独立预后因素。结论治疗前LMR和LMR/LDH在韦氏环DLBCL患者预后中可能具有一定的预测价值。

关键词：弥漫性大B细胞淋巴瘤韦氏环淋巴细胞/单核细胞乳酸脱氢酶预后

一种基于邻域保持的数值天气预报数据降维可信度评估准则

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太阳能学报 2022年第6期43卷 106-114页

作者：郝颖车建峰冬雷王丽婕战文华郭洪武北京信息科技大学自动化学院北京100192 中国电力科学研究院有限公司北京100192 中山市北京理工大学研究院中山528437 国网内蒙古东部电力有限公司赤峰供电公司赤峰024000

针对以风电、光伏发电为代表的新能源发电功率预测中数值天气预报(NWP)数据降维问题,应用不同特征选择和特征转换算法进行降维后,提出一种基于邻域保持的NWP降维可信度评估准则。该评估准则基于数据降维投影过程中样本点邻域变化,不考... 详细信息

针对以风电、光伏发电为代表的新能源发电功率预测中数值天气预报(NWP)数据降维问题,应用不同特征选择和特征转换算法进行降维后,提出一种基于邻域保持的NWP降维可信度评估准则。该评估准则基于数据降维投影过程中样本点邻域变化,不考虑降维算法本身的降维原理及目标函数,可对不同降维算法在NWP数据降维中的可信度进行有效评估。研究结果可为其他研究提供选取NWP降维算法提供参考。

关键词：数值天气预报数据降维邻域保持降维可信度评估准则

从循证医学的角度认识消化道肿瘤新辅助治疗的现状

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中国实用外科杂志 2005年第5期25卷 259-260页

作者：詹文华中山大学附属第一医院广州510080

据世界卫生组织统计,1999年全球共有800万的肿瘤新病例发生,其中消化道肿瘤(结直肠、胃和食管癌肿)占肿瘤病人总数的24%,死亡数占25%.早期消化道肿瘤可以完全治愈,但这种可能性随肿瘤向晚期进展而呈线性下降.为了改善进展期消化道肿瘤... 详细信息

据世界卫生组织统计,1999年全球共有800万的肿瘤新病例发生,其中消化道肿瘤(结直肠、胃和食管癌肿)占肿瘤病人总数的24%,死亡数占25%.早期消化道肿瘤可以完全治愈,但这种可能性随肿瘤向晚期进展而呈线性下降.为了改善进展期消化道肿瘤的治疗效果,多年来,内、外科同道均投入大量的研究和实践.外科界的努力主要在于设法完全切除原发肿瘤,同时进行系统的淋巴结清扫.为了取得更好的根治效果,不少作者推荐扩大手术范围.但是,即使手术范围再扩大,病人手术后仍然有较高的复发率、转移率,预后未能达到人们的期望值.这些事实表明,晚期消化道肿瘤应当视为全身性疾病,因此单独手术对疗效的提高是有限度的,应该进行手术之外的、以化学药物和放射治疗为主的辅助治疗.……

关键词：循证医学消化道肿瘤消化系统化疗反应