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Atomic-resolution Interfacial Microstructure and Thermo-electro-magnetic Energy Conversion Performance of Gd/Bi0.5Sb1.5Te3 Composites

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Energy & Environmental Materials 2024年第4期7卷 355-363页

作者： Chengshan Liu Wenjie Xu Ping Wei Shaoqiu Ke Wenjun Cui Longzhou Li Dong Liang Xianfeng ye Tiantian Chen Xiaolei Nie Wanting Zhu wenyu Zhao Qingjie Zhang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory

Thermo-electro-magnetic materials with simultaneously large magnetocaloric(MC) and thermoelectric (TE) effects are the core part for designing TE/MC all-solid-state cooling *** MC phase with TE material is an effective ***,the elemental diffusion and chemical reaction occurring at the two-phase interfaces could significantly impair the cooling performance.

关键词： interfacial reaction magnetocaloric performance thermoelectric performance thermo-electro-magnetic materials

The OsWRKY72-OsAAT30/OsGSTU26 module mediates reactive oxygen species scavenging to drive heterosis for salt tolerance in hybrid rice

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Journal of Integrative Plant Biology 2024年第4期66卷 709-730页

作者： Citao Liu Bigang Mao Yanxia Zhang Lei tian Biao Ma Zhuo Chen Zhongwei Wei Aifu Li ye Shao Gongye Cheng Lingling Li wenyu Li Di Zhang Xiaoping Ding Jiangxiang Peng Yulin Peng Jiwai He Nenghui ye Dingyang Yuan Chengcai Chu Meijuan Duan Hunan Provincial Key Laboratory of Stress Biology College of AgricultureHunan Agricultural UniversityChangsha 410128China State Key Laboratory of Hybrid Rice Hunan Hybrid Rice Research CenterChangsha 410125China College of Agriculture South China Agricultural UniversityGuangzhou 510642China State Key Laboratory of Wheat and Maize Crop Science Center for Crop Genome EngineeringCollege of AgronomyHenan Agricultural UniversityZhengzhou 450002China College of Horticulture Fujian Agriculture and Forestry UniversityFuzhou 350002China Department of Computational Medicine and Bioinformatics University of MichiganAnn ArborMI 48109 USA Biobin Data Science Co. Ltd.Changsha 410221China

Hybrid rice(Oryza sativa)generally outperforms its inbred parents in yield and stress tolerance,a phenomenon termed heterosis,but the underlying mechanism is not completely ***,we combined transcriptome,proteome,physiological,and heterosis analyses to examine the salt response of super hybrid rice Chaoyou1000(CY1000).In addition to surpassing the mean values for its two parents(mid-parent heterosis),CY1000 exhibited a higher reactive oxygen species scavenging ability than both its parents(over-parent heterosis or heterobeltiosis).Nonadditive expression and allele-specific gene expression assays showed that the glutathione S-transferase gene OsGSTU26 and the amino acid transporter gene OsAAT30 may have major roles in heterosis for salt tolerance,acting in an overdominant fashion in ***,we identified OsWRKY72 as a common transcription factor that binds and regulates OsGSTU26 and *** salt-sensitive phenotypes were associated with the OsWRKY72^(paternal)genotype or the OsAAT30^(maternal)genotype in core rice germplasm ***72^(paternal)specifically repressed the expression of OsGSTU26 under salt stress,leading to salinity sensitivity,while OsWRKY72^(maternal)specifically repressed OsAAT30,resulting in salinity *** results suggest that the OsWRKY72-OsAAT30/OsGSTU26 module may play an important role in heterosis for salt tolerance in an overdominant fashion in CY1000 hybrid rice,providing valuable clues to elucidate the mechanism of heterosis for salinity tolerance in hybrid rice.

关键词： allele-specific gene expression(ASE) heterosis hybrid rice nonadditive effect(NAE) salt tolerance transcriptome and proteome

A Neural-network-based Alternative Scheme to Include Nonhydrostatic Processes in an Atmospheric Dynamical Core

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Advances in Atmospheric Sciences 2024年第6期41卷 1083-1099,I0002,I0003页

作者： Yang XIA Bin WANG Lijuan LI Li LIU Jianghao LI Li DONG Shiming XU Yiyuan LI Wenwen XIA wenyu HUANG Juanjuan LIU Yong WANG Hongbo LIU ye PU Yujun HE Kun XIA Ministry of Education Key Laboratory for Earth System Modeling and Department of Earth System ScienceTsinghua UniversityBeijing 100084China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Innovation Group 311020008 Southern Marine Science and Engineering Guangdong LaboratoryZhuhai 519000China Shanghai Ecological Forecasting and Remote Sensing Center Shanghai 200030China Key Laboratory of Earth System Modeling and Prediction China Meteorological AdministrationBeijing 100081China College of Ocean Sciences University of Chinese Academy of SciencesBeijing 100049China

Here,a nonhydrostatic alternative scheme(NAS)is proposed for the grey zone where the nonhydrostatic impact on the atmosphere is evident but not large enough to justify the necessity to include an implicit nonhydrostatic solver in an atmospheric dynamical *** NAS is designed to replace this solver,which can be incorporated into any hydrostatic models so that existing well-developed hydrostatic models can effectively serve for a longer *** advances in machine learning(ML)provide a potential tool for capturing the main complicated nonlinear-nonhydrostatic *** this study,an ML approach called a neural network(NN)was adopted to select leading input features and develop the *** NNs were trained and evaluated with 12-day simulation results of dry baroclinic-wave tests by the Weather Research and Forecasting(WRF)*** forward time difference of the nonhydrostatic tendency was used as the target variable,and the five selected features were the nonhydrostatic tendency at the last time step,and four hydrostatic variables at the current step including geopotential height,pressure in two different forms,and potential temperature,***,a practical NAS was developed with these features and trained layer by layer at a 20-km horizontal resolution,which can accurately reproduce the temporal variation and vertical distribution of the nonhydrostatic *** by the NN-based NAS,the improved hydrostatic solver at different horizontal resolutions can run stably for at least one month and effectively reduce most of the nonhydrostatic errors in terms of system bias,anomaly root-mean-square error,and the error of the wave spatial pattern,which proves the feasibility and superiority of this scheme.

关键词： neural network nonhydrostatic alternative scheme atmospheric model dynamical core

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Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis

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Acta Pharmaceutica Sinica B 2024年第2期14卷 682-697页

作者： Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui Qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao Dongmei Zhang Wencai ye Minfeng Chen State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China School of Medicine Jinan UniversityGuangzhou 510632China School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510630China The First Affiliated Hospital of Jinan University Guangzhou 510632China State Key Laboratory of Chemical Oncogenomics Guangdong Provincial Key Laboratory of Chemical BiologyTsinghua Shenzhen International Graduate SchoolShenzhen 518055China

Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM.

关键词： Lymphaticmetastasis Colorectal cancer Fibroblastactivation proteinα FAPα-activated prodrug Epithelial-mesenchymal

中国精神分裂症病人使用奥氮平治疗时,参加体重控制项目是否也会提高临床和功能结局?

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中国精神分裂症病人使用奥氮平治疗时,参加体重控制项目是否也会...

巧借民间说唱,传播孔子之道——孔子故事在说唱鼓词中的传播

中华医学会第十次全国精神医学学术会议

作者： William Montgomery Tamas Treuer wendy wenyu ye 薛海波吴胜虎柳丽 Zbigniew Kadziola Haya Ascher-Svanum Eli Lilly and Company NSWAustralia Eli Lilly and Company BudapestHungary.EU 礼来苏州制药有限公司上海分公司

目的检验参加体重控制项目是否与临床和功能结局的改善相关。方法对一项为期6个月,前瞻性的,多国家参与的观察性研究中的中国亚组病人(N=330)的结果进行事后分析,这些病人要么开始奥氮平治疗,要么是换用口服奥氮平治疗。在进入研究时,...

目的检验参加体重控制项目是否与临床和功能结局的改善相关。方法对一项为期6个月,前瞻性的,多国家参与的观察性研究中的中国亚组病人(N=330)的结果进行事后分析,这些病人要么开始奥氮平治疗,要么是换用口服奥氮平治疗。在进入研究时,参加者接受临床总体印象严重度(CGI-S)评估,还有自知力和功能状态评估。根据是否参加体重

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中国文化研究 2024年第2期 107-116页

作者：纪德君叶文宇广州大学人文学院

孔子故事大约从唐代开始进入俗文学领域。此后演述孔子故事的俗文学作品不绝如缕。明清时期,孔子故事又借鼓词说唱传播开来。明末贾凫西《太师挚适齐》、清中叶曹汉阁《孔夫子鼓儿词》等,均秉持寓教于乐的动机,说唱孔子故事,传播孔子之... 详细信息

孔子故事大约从唐代开始进入俗文学领域。此后演述孔子故事的俗文学作品不绝如缕。明清时期,孔子故事又借鼓词说唱传播开来。明末贾凫西《太师挚适齐》、清中叶曹汉阁《孔夫子鼓儿词》等,均秉持寓教于乐的动机,说唱孔子故事,传播孔子之道。清末民初,新文化运动兴起,孔子之道遭受很大冲击。一些文人创作的鼓词,形象地揭示了孔子之道在乱世没落的命运。不过,民间鼓词仍在以鲜活可喜的艺术形式继续演绎孔子故事。总的说来,鼓词通过演绎孔子故事、传播孔子之道,有效地扩大了孔子在民间的影响。

关键词：孔子故事孔子之道说唱鼓词传播

Strategies for Video Producers to Tell Their Good Stories Under the 5W Model of Communication

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教育技术与创新 2024年第1期6卷 50-66页

作者： Wenqian Hong Yixuan Jiang Rui Wen wenyu Chen Nan Lou Jinxuan Deng Jiayun Li Hanfei Li Dan ye School of Foreign Studies Wenzhou UniversityChina

In recent years,with the rise of video media such as YouTube and Tik Tok,the short video creation industry has *** to spread China's excellent culture and how to“tell a good Chinese story”have become a hot *** the 5W Model of Communication as a framework for analysis,this paper selects Chinese short videos with high popularity on YouTube as the object of the *** found that the success of these videos was associated with five factors in the process of communication,which are communication main forces,communication content,communication channels,communication audience,and audience *** theoretical and data analysis,the study concluded five strategies in video production to help promote Intercultural communication.

关键词： International communication communication strategy video production

沉默circ-NDRG1对口腔鳞状细胞癌细胞恶性生物学行为的作用机制研究

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皖南医学院学报 2024年第3期43卷 210-214页

作者：陶冶肖锋杨文宇徐培安徽医学高等专科学校口腔医学院安徽合肥230601 安徽医科大学第二附属医院口腔颌面外科安徽合肥230601

目的:探究circ-NDRG1在口腔鳞状细胞癌组织中的表达及其通过靶向miR-1271对口腔鳞状细胞癌HSC-3细胞恶性生物学行为的影响。方法:利用TCGA数据库分析口腔鳞状细胞癌组织中circ-NDRG1的表达水平,分析circ-NDRG1表达与患者预后生存期的相... 详细信息

目的:探究circ-NDRG1在口腔鳞状细胞癌组织中的表达及其通过靶向miR-1271对口腔鳞状细胞癌HSC-3细胞恶性生物学行为的影响。方法:利用TCGA数据库分析口腔鳞状细胞癌组织中circ-NDRG1的表达水平,分析circ-NDRG1表达与患者预后生存期的相关性。实时荧光定量PCR(qPCR)检测circ-NDRG1在永生化口腔角质细胞(HOK)和口腔鳞状细胞癌HSC-3、SCC-25、CAL-27、Tca-8113细胞中的表达水平。利用Lipofectamine 2000将NC inhibitor、circ-NDRG1 inhibitor分别转染HSC-3细胞,分别为Anti-NC组和Anti-circ-NDRG1组。MTT法和Transwell小室实验分别检测各组HSC-3细胞增殖和侵袭能力。Western blot检测各组HSC-3细胞增殖蛋白(CDK3、Cyclin C)和上皮间质转化(EMT)蛋白(ZLF8、Notch、SIX1)表达。利用TCGA数据库分析口腔鳞状细胞癌组织中circ-NDRG1与miR-1271表达的关系。双荧光素酶报告实验验证circ-NDRG1和miR-1271的靶向关系。qPCR检测各组HSC-3细胞中miR-1271的表达。结果:TCGA数据库显示口腔鳞状细胞癌组织中circ-NDRG1的表达高于癌旁组织(P<0.01)。口腔鳞状细胞癌患者预后生存期与circ-NDRG1表达水平呈负相关(P<0.01)。与HOK细胞相比,HSC-3、SCC-25、CAL-27、Tca-8113细胞中circ-NDRG1呈高表达(P<0.01)。与Anti-NC组相比,低表达circ-NDRG1能够抑制HSC-3细胞的增殖能力(P<0.05)和侵袭能力(P<0.01)。与Anti-NC组相比,低表达circ-NDRG1能够下调HSC-3细胞中CDK3、Cyclin C、ZLF8、Notch、SIX1蛋白的表达(P<0.01)。口腔鳞状细胞癌组织中circ-NDRG1表达水平与miR-1271表达水平呈负相关(P<0.01)。circ-NDRG1能够靶向结合miR-1271(P<0.01)。与Anti-NC组相比,低表达circ-NDRG1能够上调HSC-3细胞中miR-1271的表达(P<0.01)。结论:口腔鳞状细胞癌组织中circ-NDRG1呈高表达,沉默circ-NDRG1通过靶向调控miR-1271表达抑制口腔鳞状细胞癌细胞的增殖、侵袭和EMT进程。

关键词：口腔鳞状细胞癌 circ-NDRG1 miR-1271 增殖侵袭上皮间质转化

Experimental and molecular level analysis of natural ester delaying degradation of cellulose insulation polymer

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High Voltage 2022年第5期7卷 1001-1015页

作者： Jian Hao wenyu ye Chenyu Gao Mengzhao Zhu Lijun Yang Ruijin Liao State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqingChina State Grid Shandong Electric Power Co. Shandong Electric Power Research InstituteJinanChina

Developing green insulation materials has become an important direction for future *** a new environmental insulation liquid,natural ester can effectively delay cellulose insulation polymer *** the mechanism of natural ester delaying the cellulose ageing could promote its application in power *** this study,based on the accelerated thermal ageing of pressboard immersed in natural ester and 25#mineral oil at 120°C for 221 days,the thermal ageing rate and the levelling off degree of polymerisation(LODP)for two kinds of oil-impregnated pressboards were *** molecular level mechanism of natural ester delaying cellulose degradation and keeping higher LODP value was proposed using molecular dynamics *** the early stage of thermal ageing,cellulose with a higher degree of polymerisation(DP)can form many hydrogen bonds with hydronium ions,and their binding energy is stronger,which can accelerate the acid hydrolysis of cellulose,causing the DP of pressboard immersed in natural ester and mineral oil to decrease *** the breaking of the cellulose molecular chain,the number of hydrogen bonds and binding energy between cellulose and hydronium ions becomes smaller and the thermal ageing rate decreases *** the end stage of ageing,it is difficult for the hydronium ions to enter the crystalline cellulose,acid hydrolysis of crystalline cellulose is hard to conduct,leading to the occurrence of the LODP *** degradation rate of cellulose in natural ester is only 50%of that in mineral *** cellulose LODP value in natural ester is over 200 larger than that in mineral *** with the mineral oil-cellulose system,natural ester can form hydrogen bonds with hydronium ions and lead to fewer hydronium ions in cellulose,fewer hydrogen bonds and smaller binding energy between cellulose and hydronium ions,which can reduce the acid hydrolysis reaction of *** study provides a theoretical explanation for

关键词： insulation delay cellulose