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Lateral bearing characteristics of subsea wellhead assembly in the hydrate trial production engineering

China Geology 2023年第3期6卷 455-465页

作者： Jing Zeng wen-wei xie Bei-bei Kou Jing-an Lu Xing-chen Li De-jun Cai Hao-xian Shi Ke-wei Zhang Hua-qing Liu Jin Li Bo Li Guangzhou Marine Geological Survey China Geological SurveyMinistry of Natural ResourcesGuangzhou 510075China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China National Engineering Research Center of Gas Hydrate Exploration and Development China Geological SurveyMinistry of Natural ResourcesGuangzhou 510075China Drilling Engineering Division Offshore Engineering Company LimitedCNPCTianjin 300280China

Conductor and suction anchor are the key equipment providing bearing capacity in the field of deep-water drilling or offshore engineering,which have the advantages of high operation efficiency and short construction *** order to drill a horizontal well in the shallow hydrate reservoir in the deep water,the suction anchor wellhead assembly is employed to undertake the main vertical bearing capacity in the second round of hydrate trial production project,so as to reduce the conductor running depth and heighten the kick-off point ***,the deformation law of the deep-water suction anchor wellhead assembly under the moving load of the riser is not clear,and it is necessary to understand the lateral bearing characteristics to guide the design of its structural *** on 3D solid finite element method,the solid finite element model of the suction anchor wellhead assembly is *** the model,the seabed soil is divided into seven layers,the contact between the wellhead assembly and the soil is simulated,and the vertical load and bending moment are applied to the wellhead node to simulate the riser movement when working in the deep *** lateral bearing stability of conventional wellhead assembly and suction anchor wellhead assembly under the influence of wellhead load is *** analysis results show that the bending moment is the main factor affecting the lateral deformation of the wellhead string;the anti-bending performance from increasing the outer conductor diameter is better than that from increasing the conductor wall thickness;for the subsea wellhead,the suction anchor obviously improves the lateral bearing capacity and reduces the lateral *** conduct of the suction anchor wellhead assembly still needs to be lowered to a certain depth that below the maximum disturbed depth to ensure the lateral bearing stability,Thus,a method for the minimum conductor running depth for the suction anchor wellhead assembly is devel

关键词： Natural gas hydrate Deep-water Subsea wellhead Suction anchor Wellhead stability 3D solid finite element method Hydrate trial exploration engineering Natural gas hydrate trial production Shenhu area The South China Sea

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执行器饱和受限不确定系统的次序优化多步预测控制

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控制与决策 2017年第8期32卷 1499-1504页

作者：张浪文谢巍华南理工大学自动化科学与工程学院广州510640 华南理工大学自主系统与网络控制教育部重点实验室广州510640

设计一种次序优化机制,提出一类饱和受限不确定系统的次序优化多步预测控制方法.将系统的输入分解成多个子集合,在各采样周期仅对其中一个集合的输入进行优化,待优化的输入保持上一优化值.针对每个输入集合,确定闭环系统的不变集条件,... 详细信息

设计一种次序优化机制,提出一类饱和受限不确定系统的次序优化多步预测控制方法.将系统的输入分解成多个子集合,在各采样周期仅对其中一个集合的输入进行优化,待优化的输入保持上一优化值.针对每个输入集合,确定闭环系统的不变集条件,将次序优化预测控制器设计问题转化成"最小-最大"优化问题,通过求解一组线性矩阵不等式问题得到控制器.仿真算例表明,采用次序优化预测控制方法可以减少控制器的设计时间.

关键词：饱和受限不确定系统次序优化预测控制

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Fast multi-swarm optimization based-on Cauchy mutation and crossover operation

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黄冈师范学院学报 2008年第3期28卷 47-49,80页

作者： ZHANG Qing FENG Jie ZHANG Jun-wen xie wei College of Physical Science and Technology Huanggang Normal University Huangzhou 438000 Hubei China

The standard particle swarm optimization(PSO) algorithm is a novel evolutionary algorithm in which each particle studies its own previous best solution and the group's previous best solutions to optimization *** problem in PSO is its tendency of trapping into local *** this paper,a multi-swarm technique based on fast particle swarm optimization(FPSO) algorithm is proposed by introducing crossover *** is global search algorithm which can prevent PSO from trapping into local optima in light of Cauchy *** it can get high optimizing precision,the convergence rate is not *** can not only find satisfying solutions,but also speed up the search.

关键词：最佳化设计苛西定理操作性能计算方法

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The first offshore natural gas hydrate production test in South China Sea

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China Geology 2018年第1期1卷 5-16页

作者： Jin-fa Li Jian-liang Ye Xu-wen Qin Hai-jun Qiu Neng-you Wu Hai-long Lu wen-wei xie Jing-an Lu Fei Peng Zhen-qiang Xu Cheng Lu Zeng-gui Kuang Jian-gong wei Qian-yong Liang Hong-feng Lu Bei-bei Kou China Geological Survey Beijing 100037China Guangzhou Marine Geologtcal Survey China Geologtcal SurveyGuangzhou 510075China Qingdao Institute of Marine Geology China Geological SurveyQingdao 266071China Peking University Beijing 100871China Institute of Exploration Techmques China Academy of Geological SciencesLangfang 065000China CNPC Offshore Engineering Company Ltd Beijing 100102China Center of Oil & Natural Gas Resource Exploration China Geological SurveyBeijing 100083China

Natural gas hydrates (NGH)is one of key future clean energy *** industrialized development will help remit the huge demand of global natural gas,relieve the increasing pressure of the environment, and play a vital role in the green sustainable growth of human *** on nearly two decades' studying on the reservoir characteristics in the South China Sea (SCS)and the knowledge of reservoir system,the China Geological Survey (CGS)conducted the first production test on an optimal target selected in Shenhu area SCS in *** by the "three-phase control"exploitation theory which focused on formation stabilization,technologies such as formation fluid extraction,well drilling and completing, reservoir stimulating,sand controlling,environmental monitoring,monitoring and preventing of secondary formation of hydrates were *** test lasted for 60 days from May 10^th when starting to pump, drop pressure and ignite to well killing on July 9^th,with gas production of 3.09×10^5 m^3 in total,which is a world record with the longest continuous duration of gas production and maximal gas *** successful test brings a significant breakthrough on safety control of NGH production.

关键词： Natural gas hydrate (NGH) Production test Shenhu area South Chma Sea (SCS)

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Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan wei Yaru Qiao Jiming xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao Yuan Lingqi Yu Xudong Zhuang Dongjing wen Jin He Jingmei Hong Jiayu xie Shengan Ling Xiaoyue Du wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

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The second natural gas hydrate production test in the South China Sea

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China Geology 2020年第2期3卷 197-209页

作者： Jian-liang Ye Xu-wen Qin wen-wei xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian China Geological Survey Ministry of Natural ResourcesBeijing 100037China Guangzhou Marine Geological Survey China Geological SurveyMinistry of Natural ResourcesGuangzhou 510075China Institute of Exploration Techniques China Geological SurveyMinistry of Natural ResourcesLangfang 065000China Peking University Beijing 100871China CNPC Offshore Engineering Company Limited Beijing 100102China Oil and Gas Resources Survey China Geological SurveyMinistry of Natural ResourcesBeijing 100083China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 510000China

Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to *** are proved to be exploitable by the first NGH production test conducted in the South China Sea in *** on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the *** that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April *** the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate *** a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 ***,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production ***,both the cumulative gas production and the daily gas production were highly improved compared to the first production *** indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production *** successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH *** industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial *** second production test serves as an important step

关键词： Natural gas hydrates Second production test Horizontal well Reservoir stimulation Environmental impact NGH exploration trial engineering South China Sea

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The anti-endotoxic effect of o-aminobenzoic acid from Radix Isatidis

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Acta Pharmacologica Sinica 2005年第5期26卷 593-597页

作者： Jian-guo FANG~2,Yun-hai LIU,wen-qing WANG,wei xie,Shu-xian FANG,Hong-gang HANDepartment of Pharmacy,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China DepartmentofPharmacy TongjiHospitalTongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430030

Aim:To study the anti-endotoxic effect of o-aminobenzoic acid(OABA)isolatedfrom Banlangen(BLG).Methods:OABA was extracted and isolated from BLG anddiluted into 0.5% *** concentration of endotoxin(ET)pretreated withOABA was quantitatively detected using Limulus *** inhibition of ET-induced fever by OABA was measured in *** rates of lipopolysaccha-rides(LPS)-induced death in mice pretreated with or without OABA were *** influence of OABA on the release of TNF-α and NO from mac-rophages induced by LPS was examined in ***:After pretreatment withOABA,84.4% of ET was *** ET-induced fever in rabbits decreasedsignificantly and the rate of LPS-induced death in mice dropped from 70% to 20%.The release of TNF-α and NO induced by LPS in mice was inhibited dose-depen-dently when the concentration of OABA was between 0.125% and 0.5%.Conclusion:OABA isolated from BLG has an anti-endotoxic effect.

关键词： Radix Isatidis(Banlangen) o-aminobenzoic acid endotoxin lipopolysaccharides Tachypleus Amebocyte Lysale tumor necrosis factor-α nitric oxide

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Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology research 2025年第1期33卷 67-81页

作者： Xiang Li wenke Jin Lifeng Wu Huan Wang Xin xie wei Huang B O Liu State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical Technology Chengdu University of Traditional Chinese Medicine Chengdu 611137 China. Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China.

Background:Triple-negative breast cancer (TNBC), characterized by its lack of traditional hormone receptors and HER2, presents a significant challenge in oncology due to its poor response to conventional therapies. Autophagy is an important process for maintaining cellular homeostasis, and there are currently autophagy biomarkers that play an effective role in the clinical treatment of tumors. In contrast to targeting protein activity, intervention with protein-protein interaction (PPI) can avoid unrelated crosstalk and regulate the autophagy process with minimal interference pathways.Methods:Here, we employed Naive Bayes, Decision Tree, and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC, aiming to uncover novel therapeutic targets. Meanwhile, the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay, and the interaction relationship was verified by molecular docking and CO-IP experiments after intersection. Colony formation, cellular immunofluorescence, cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tests were used to predict the clinical therapeutic effects of manipulating candidate PPI.Results:By developing three PPI classification models and analyzing over 13,000 datasets, we identified 3733 previously unknown autophagy-related PPIs. Our network analysis revealed the central role of Beclin 2 in autophagy regulation, uncovering its interactions with 39 newly identified proteins. Notably, the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1, which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay results. Subsequently, investigations showed that overexpressing Beclin 2 increased Ubiquilin 1, promoted autophagy-dependent cell death, and inhibited proliferation and metastasis in MDA-MB-231 cells.

关键词： Artificial intelligence (AI) Autophagy Beclin 2 Protein-protein interactions (PPI) Triple-negative breast cancer (TNBC) Ubiquilin 1

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紫薯酒花色苷在贮藏中的降解动力学研究

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食品工业科技 2016年第21期37卷 96-99,104页

作者：吴文丽熊伟谢永文马爱民华中农业大学食品科技学院湖北武汉430070 湖北省稻花香集团湖北宜昌443112

以紫薯酒为原料,探究了紫薯酒中花色苷在不同贮藏温度、p H和光照条件下贮藏的稳定性和降解动力学。结果表明:紫薯酒在贮藏过程中,花色苷受不同温度、p H和光照条件的影响,其降解规律符合一级反应动力学规律,反应速率常数k越大,半衰期t... 详细信息

以紫薯酒为原料,探究了紫薯酒中花色苷在不同贮藏温度、p H和光照条件下贮藏的稳定性和降解动力学。结果表明:紫薯酒在贮藏过程中,花色苷受不同温度、p H和光照条件的影响,其降解规律符合一级反应动力学规律,反应速率常数k越大,半衰期t1/2越小。在5℃与25℃条件下较稳定,在37℃极易分解。p H为3.5时,紫薯酒花色苷稳定性最好。紫薯酒花色苷在避光条件下较稳定,在日光灯与室内散射光照射下易分解,在棕色玻璃瓶中贮藏可减少光照对花色苷的降解。因此紫薯酒在贮藏时应尽量保持低温和避光,将p H调整为3.5为宜。

关键词：紫薯酒花色苷贮藏稳定性反应动力学

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