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In situ construction of ligand nano-network to integrin αvβ3 for angiogenesis inhibition

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Chinese Chemical Letters 2020年第12期31卷 3107-3112页

作者： Ziming Chen Kuo Zhang Jiaqi fan Yu fan Chao Yang wen tian Yuan Li wenliang Li Jingping Zhang Hao Wang Lei Wang Faculty of Chemistry Northeast Normal UniversityChangchun 130024China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Angiogenesis occurs during the process of tumor growth,invasion and metastasis,and is essential for the survival of solid *** an integrin significantly ove rexpressed in human tumor vascular endothelial cells,αvβ3 is a suitable targeting site for anti-angiogenesis of *** designed and prepared a selfassembling peptide(SAP)with the ability to targeting αvβ3 and *** formed nanoparticles in solution and transformed into nanofibrous network once specifically binding to integrin αvβ3 on the surface of human umbilical vein endothelial cells(HUVECs).The SAP network stably anchored on HUVECs over 24h,which consequently resulted in high-efficient inhibition of *** vitro anti-angiogenesis experiment displayed that the inhibition rate of tube-formation reached 94.9%.In vivo anti-angiogenesis array based on chick chorioallantoic membrane(CAM)model exhibited that the SAP had an inhibition rate up to 63.1%.These results indicated the outstanding anti-angiogenic ability of SAP,potentially for tumor therapy.

关键词： Self-assembly Integrinαvβ3 Peptide Anti-angiogenesis Tumor

Static and Ultrafast Transient Photophysics of Mono- and Dual-Branched Triarylamines

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Chinese Physics Letters 2010年第6期27卷 246-249页

作者： LI Feng-Ming MENG fan-Shun FENG wen-Ke WANG Shu-Feng tian He GONG Qi-Huang State Key Laboratory for Mesoscopic Physics and Department of Physics Peking University Beijing 100871 Labs for Advanced Materials and Institute of Fine Chemicals East China University of Science and Technology Shanghai 200237

Mono- and dual-branched molecules, { 4-[2-（4-benzothiazol-2-yl-phenyl）-vinyl]-phenyl}-（4-methoxy-phenyl）-phenyl- amine （BS1） and bis-{4-[2- （4-benzothiazol-2-yl-phenyl）-vinyI]-phenyl}-（4-methoxy-phenyI）-phenyl-amine （BS2）, are investigated with one- and two-photon static spectroscopy, and the femtosecond fluorescence up-conversion technique. The molecules show branch-based fluorescence emission at low quantum yield. U1trafast non-radiative decay on a picosecond time scale is found and is attributed to intramolecular charge-transfer bridged by the central triphenylamine. The two-photon absorption cross-sections of BS1 and BS2 are 19.1 and 19.4 GM, respectively.

关键词： Branching Branches Fluorescence

Effects of sodium-glucose cotransporter 2 inhibitors on cardiovascular outcomes in elderly patients with comorbid coronary heart disease and diabetes mellitus

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Journal of Geriatric Cardiology 2021年第6期18卷 440-448页

作者： Hu XU wen-Zhe CAO Yong-Yi BAI Rui-Hua CAO Lei tian Feng CAO Li fan Chinese PLA Medical School Chinese PLA General HospitalBeijingChina Department of Cardiology the Second Medical CenterNational Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijingChina Institute of Geriatrics the Second Medical CenterChinese PLA General HospitalBeijingChina

OBJECTIVE To investigate the effects of sodium-glucose cotransporter 2 inhibitors(SGLT2i)on cardiovascular outcomes in elderly Chinese patients with comorbid coronary heart disease(CHD)and type 2 diabetes mellitus(T2DM).METHODS A retrospective cohort study was conducted on 501 elderly inpatients(≥60 years)with comorbid CHD/T2DM in Department of Cardiovascular Medicine and Endocrinology,Chinese PLA General Hospital from January 2018 to December *** patients were divided into two groups according to the administration of *** the demographic characteristics and clinical data were *** outcomes,including all-cause mortality,major adverse cardiovascular events(MACE),and hospitalization for heart failure(HHF),were followed *** In the cohort,there were 167 patients in the SGLT2i group and 334 patients in the control *** the efficacy analyses,the incidence of MACE was lower in the SGLT2i group than in the control group:3.6%vs.9.3%(P=0.022).A lower risk of MACE was observed in the SGLT2i group[hazard ratio(HR)=0.40,95%CI:0.17-0.95].There was no significant difference in the incidence of all-cause mortality or HHF between the two *** significant difference of HR was observed for all-cause mortality(HR=0.41,95%CI:0.12-1.41)or HHF(HR=0.58,95%CI:0.12-2.81).CONCLUSIONS SGLT2i treatment exhibited benefits for elderly patients with comorbid CHD/T2DM with a lower risk for MACE.

关键词： patients morbid mortality

Spotted Sea Bass(Lateolabrax maculatus) cftr, nkcc1a, nkcc1b and nkcc2: Genome-Wide Identification, Characterization and Expression Analysis Under Salinity Stress

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Journal of Ocean University of China 2019年第6期18卷 1470-1480页

作者： ZHANG Kaiqiang ZHANG Xiaoyan wen Haishen QI Xin fan Hongying tian Yuan LIU Yang LI Yun College of Fisheries Ocean University of ChinaQingdao 266003China The Key Laboratory of Mariculture of Ministry of Education Ocean University of ChinaQingdao 266003China

The Na^+/K^+/2Cl^-cotransporter(NKCC)and the cystic fibrosis transmembrane conductance regulator(CFTR)proteins play crucial roles in the transportation of Na^+and Cl^-.In this study,we identified cftr,nkcc1 a,nkcc1 b and nkcc2 in spotted sea bass(Lateolabrax maculatus)genomic and transcriptomic *** also characterized these genes via phylogenetic and structural *** results showed that both cftr and nkcc were highly conservative in *** real-time polymerase chain reaction(qRT-PCR)analysis in ten tissues showed that cftr,nkcc1 a and nkcc2 highly express in osmoregulatory organs such as gill,kidney and ***,the expressions of cftr and nkcc1 a in gill as well as nkcc2 in intestine were up-regulated by high salinity,indicating that these genes function potentially in *** findings provided the insights into the cftr and nkcc functions in euryhaline teleost.

关键词： cftr nkccs Lateolabrax maculatus salinity gene expression

Machine learning driven rational design of dual atom catalysts on graphene for carbon dioxide electroreduction

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Nano Research 2025年第1期18卷 186-194页

作者： Dongxu Jiao Xinyi Li Mingzi Sun Lin Liu Jinchang fan Jingxiang Zhao Bolong Huang Xiaoqiang Cui State Key Laboratory of Automotive Simulation and Control School of Materials Science and Engineeringand Key Laboratory of Automobile Materials of MOEJilin UniversityChangchun 130012China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina College of Chemistry and Chemical Engineering and Key Laboratory of Photonic and Electronic Bandgap MaterialsMinistry of EducationHarbin Normal UniversityHarbin 150025China

The development of high-performance atomiccatalysts for the carbon dioxide reduction reaction(CO_(2)RR)is atime-consuming process due to the complexity of the reactionmechanism and the uncertainty of the active ***,wehave proposed combining density functional theory(DFT)andmachine learning(ML)to investigate the potential of topologicalgraphene-based dual-atom catalysts(DACs)as CO_(2)*** analyzing the ML results,we identify thenumber of d-orbital electrons in the active site as a key factorinfluencing the CO_(2)RR catalytic ***,wepropose a simple descriptor to measure the CO_(2)RR activity ofthese *** findings provide plausible explanations for thesynergistic interactions between bimetallic atoms in CO_(2)RR andallow us to screen the homogeneous Ni-Ni pair as the mostpromising dual-atom *** work offers a fast MLapproach based on limited DFT calculations to predict the mostelectroactive and stable DACs on carbon support for CO_(2)RR,facilitating rapid screening of high-performance dual-atomcatalysts.

关键词： CO_(2)reaction reduction dual-atom catalysts density functional theory machine learning

EXPONENTIAL CONVERGENCE OF SAMPLE AVERAGE APPROXIMATION METHODS FOR A CLASS OF STOCHASTIC MATHEMATICAL PROGRAMS WITH COMPLEMENTARITY CONSTRAINTS

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Journal of Computational Mathematics 2006年第6期24卷 733-748页

作者： fan-wen Meng Hui-fu Xu The Logistics Institute - Asia Pacific National University of Singapore 1 Law Link Singapore School of Mathematics University of Southampton Highfield Southampton S017 1B J UK School of Mathematics University of Southampton Highfield Southampton S017 1B J UK

In this paper, we propose a Sample Average Approximation （SAA） method for a class of Stochastic Mathematical Programs with Complementarity Constraints （SMPCC） recently considered by Birbil, G/irkan and Listes [3]. We study the statistical properties of obtained SAA estimators. In particular we show that under moderate conditions a sequence of weak stationary points of SAA programs converge to a weak stationary point of the true problem with probability approaching one at exponential rate as the sample size tends to infinity. To implement the SAA method more efficiently, we incorporate the method with some techniques such as Scholtes＇ regularization method and the well known smoothing NCP method. Some preliminary numerical results are reported.

关键词： Stochastic mathematical programs with complementarity constraints Sampleaverage approximation Weak stationary points Exponential convergence.

A Many-Objective Evolutionary Algorithm with Spatial Division and Angle Culling Strategy

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Chinese Journal of Electronics 2021年第3期30卷 437-443页

作者： WANG Hongbo YANG fan tian Kena TU Xuyan School of Computer and Communication Engineering Beijing Key Lab.of Knowledge Engineering for Materials ScienceUniversity of Science and Technology Beijing

In a specific project, how to find a reasonable balance between a plurality of objectives and their optimal solutions has always been an important aspect for researchers. As a trade off between fast convergence and a rich diversity, a Many-objective evolutionary algorithm based on a spatial division and angle-culling strategy(Ma OEA-SDAC) is proposed. In the reorganization stage, a restricted matching selection can enhance the reproductivity. In the environment selection stage, a space division and angle-based elimination strategy can effectively improve the convergence and diversity imbalance of its solution set. Through detailed experiments and a comparative analysis of the proposed Ma OEA-SDAC with five other state-of-the-art algorithms on classical benchmark problems, the effectiveness of Ma OEA-SDAC in solving high-dimensional optimization problems has been verified.

关键词： reasonable balance many-objective evolutionary algorithm convergence environment selection stage angle culling strategy elimination strategy spatial division rich diversity Pareto optimisation angle-culling strategy diversity imbalance restricted matching selection specific project evolutionary computation fast convergence reorganization stage MaOEA-SDAC space division optimal solutions

Microstructure and Mechanical Properties of Ductile Cast Iron in Lost Foam Casting with Vibration

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Journal of Iron and Steel Research International 2014年第11期21卷 1049-1054页

作者： Bo-tao XIAO Zi-tian fan wen-ming JIANG Xin-wang LIU Wei LONG Qiang HU State Key Laboratory of Material Processing and Die & Mould Technology Huazhong University of Science and Technology School of Materials Science and Engineering Jiangxi Science and Technology Normal University School of Mechanical & Electrical Engineering Wuhan Institute of Technology Jiangxi Key Laboratory for Advanced Copper and Tungsten Materials Jiangxi Academy of Sciences

The microstructures and mechanical properties of the ductile cast iron （DI） specimens obtained by lost foam casting （LFC） with and without vibration were investigated. The results indicate that the number of the graphite nodule increases from 175 mm 2 of the specimens produced by LFC without vibration to 334 mm^-2 of the specimens produced by LFC with vibration, and the thickness of the ferrite shell increases. Meanwhile, the amount of the carbides decreases in the specimens produced by LFC with vibration and the granule structure then forms. These are mainly attributed to the ＂crystal shower＂ caused by the vibration. In addition, the tensile strength and elongation of DI specimens produced by LFC with vibration are improved due to the dispersion-strengthening of refined carbide and Dearlite colonv, uniform distribution of the graphite nodule, and increase of the amount of dimples and tearing edges.

关键词： ductile cast iron (DI) microstructure mechanical property mechanical vibration lost foam casting (LFC)

Effect of vibration frequency on primary phase and properties of grey cast iron fabricated by lost foam casting

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China Foundry 2020年第1期17卷 1-7页

作者： Bo-tao Xiao Zi-tian fan wen-ming Jiang Jun-huai Xiang Xue-fang Yan Jiangxi Key Laboratory of Surface Engineering Jiangxi Science and Technology Normal UniversityNanchang 330013China State Key Laboratory of Material Processing and Die&Mould Technology Huazhong University of Science&TechnologyWuhan 430074China

The properties of gray cast iron(GCI)are affected by density of matrix,size of flake graphite and primary *** this paper,the Y-type specimen of GCI was prepared by lost foam casting(LFC)with and without vibration,and the influence of vibration frequency on the density of matrix,size of primary phase,and properties of the GCI was *** results show that the length of the flake graphite and the size of the primary austenite in GCI firstly decrease and then increase with the increase of the vibration *** a vibration frequency of 35 Hz,the length of the flake graphite is the shortest,the primary austenite is the finest and the density of the matrix is the *** addition,the tensile strength,elongation and hardness of the GCI firstly increase and then decrease with the increase of the vibration frequency,due to the refinement of the primary phase and the increase of the matrix *** order to analyze the refinement mechanism of the primary phase of the GCI fabricated by the LFC with vibration,the solidification temperature fields of the GCI fabricated by the LFC with the vibration frequency of 0 and 35 Hz were *** results show that the vibration reduces the eutectic point of the GCI and increases the supercooling degree during the eutectic *** a result,the length of the flake graphite and the size of the primary austenite in GCI fabricated by LFC with the vibration frequency of 35 Hz decrease.

关键词： vibration frequency lost foam casting grey cast iron flake graphite properties