检索结果-南通市图书馆

Serologic parameters in young patients with retinal vein occlusion treated with anti-vascular endothelial growth factor

引用

International Journal of Ophthalmology(English edition) 2025年第3期18卷 424-434页

作者： Tong-Tong Niu Yun Xiao wen-juan Lyu Hao Zhou Department of Ophthalmology Xinjiang 474 HospitalUrumchi 830000Xinjiang Uygur Autonomous RegionChina

AIM:To assess the relationship between serological parameters and the prognosis of young patients with retinal vein occlusion(RVO)after intravitreal conbercept injection(IVC).METHODS:This study enrolled 100 young patients(≤50 years old)diagnosed with RVO-related macular edema(RVO-ME)who had been undergoing IVC at the 474 Hospital in Xinjiang between January 2022 and October *** were categorized into two groups:70 eyes in the effective group and 30 eyes in the ineffective *** effective group comprised patients exhibiting a visual acuity improvement of≥2 lines at the last follow-up,with resolved ME and central macular thickness(CMT)<300μ***,the ineffective group included patients with visual acuity improvement of<1 line,persistent ME,and CMT≥300μm at the last *** parameters,including white blood cell count,neutrophil count,lymphocyte count,monocyte count,and mean platelet volume were assessed before *** correlation between bestcorrected visual acuity(BCVA)and neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),systemic immune inflammation index(SII),and systemic immune response index(SIRI)was ***,the association between these serological parameters and the efficacy of IVC was ***:Three months after treatment,the effective group demonstrated a significant improvement in BCVA from 0.82±0.20 to 0.36±0.10,with a concurrent decrease in CMT from 661.28±163.90 to 200.61±82.45μm(P<0.001).Conversely,the ineffective group exhibited minimal changes in BCVA(0.86±0.25 to 0.82±0.14)and CMT(669.84±164.95 to 492.13±138.67μm,P<0.001).The differences in BCVA and CMT between the two groups were statistically significant(P<0.001).According to subgroup analysis,in patients with central RVO(CRVO),BCVA improved from 0.82±0.23 to 0.49±0.12 in the effective group and from 0.80±0.18 to 0.76±0.22 in the ineffective group(P<0.001).The CMT changes followed a similar *** patients with branc

关键词： retinal vein occlusion anti-vascular endothelial growth factor systemic immune-inflammatory index neutrophil-to-lymphocyte ratio

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intelligent interaction system based on multimodal conformal triboelectric nanogenerator patch for disabled sports and life

引用

Science China(Technological Sciences) 2025年第2期68卷 290-305页

作者： Yuzhang wen Mengqi ZHANG Zhenning xie Zida AN Bing LIU Fengxin SUN Tianming ZHAO Zuojun YU Fei WANG Yupeng MAO Physical Education Department Northeastern UniversityShenyang 110819China Faculty of Robot Science and Engineering Northeastern UniversityShenyang 110819China China Ice Sports College Beijing Sport UniversityBeijing 100084China State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016China Criminal Investigation Police University of China Shenyang 110035China

Intelligent interaction technology based on advanced sensing units has become a research *** this paper,an intelligent interaction system(IIS)based on a multimodal conformal triboelectric nanogenerator patch(MCTP)is reported for sports monitoring and life promotion of the *** IIS consists of a cloud-based smart sports recognition program and a smart life *** porous micro-reinforced structure of polyurethane(PU)Sponge&Ecoflex,and the surface modification of PTFE by coating it with MXene endows the MCTP with excellent electrical *** shows good angle and force sensitivities of 1.1 V/°and 1.61 V/N,respectively,and has an ultra-fast response time of 15 ms,meeting the needs of human motion *** MCTP can also capture the mechanical energy,producing a maximum output power of 139μ*** with the commercial inertial measuring unit(IMU),the MCTP shows better consistency in human joint angle sensing.A precise analysis of wheelchair curling sports monitoring points is achieved by combining the MCTP and the human anatomy *** cloud-based smart sports recognition program utilizes machine learning to achieve visual feedback on the three throwing technologies of draw,takeout and *** addition,the developed smart life application uses a highsensitivity MCTP-sensor array design to achieve a variety of smart home interactions through simple finger ***,the IIS integrates the three major functions of smart sports sensing,energy capture,and smart home control,providing important application prospects in the fields of smart sports and human-computer interaction for the disabled.

关键词： triboelectric nanogenerator machine learning smart sports smart home human-computer interaction

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genome-wide loss of 5-hmC is a novel epigenetic feature of huntington's disease

Genome-wide loss of 5-hmC is a novel epigenetic feature of h...

引用

中国神经科学学会第十届全国学术会议

作者： Feng-Li WANG Ye-Ran YANG Xi-wen LIN Jiu-Qiang WANG Yong-Sheng WU wen-juan xie Dan-Dan WANG Shu Zhu You-Qi LIAO Qin-Miao SUN Yun-Gui YANG Cai-Xia GUO Chun-Sheng HAN Tie-Shan TANG The State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of ZoologyChinese Academy of Sciences Laboratory of Disease Genomics and Individual Medicine Beijing Institute of GenomicsChinese Academy of Sciences State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of Sciences

Objective 5-hydroxymethylcytosine(5-hmC) may represent a new epigenetic modification of *** the dynamics of 5-hmC during neurodevelopment have recently been reported,little is known about its genomic distribution and function(s) in neurodegenerative diseases such as Huntington’s disease(HD).Methods To gain a genome-wide view of 5-hmC distribution,we employed a 5-hmC-specific chemical labeling and enrichment technology coupled with high-throughput deep sequencing of 5-hmC-containing DNA *** and cortical DNA samples from the brains of 3-month-old WT7YAC128 mice were prepared and deeply sequenced to determine the effect of HTT on the 5-hmC epigenome at the early stage of *** We observed a marked reduction of 5-hmC signal in YAC128 HD mouse brain *** genomic features of 5-hmC are highly conserved,not being affected by either disease or brain *** have identified disease-specific(YAC128 versus WT) differentially hydroxymethylated regions(DhMRs),and found that acquisition of DhmRs in gene body is a positive epigenetic regulator for gene *** pathway analysis of genotype-specific DhMR-annotated genes revealed that alternation of a number of canonical pathways involving neuronal development/differentiation(Wnt/β-catenin/Sox pathway,axonal guidance signaling pathway) and neuronal function/survival(glutamate receptor/calcium/CREB,GABA receptor signaling,dopamine-DARPP32 feedback pathway etc.) could be important for the onset of *** Genome-wide Loss of 5-hmC is a Novel Epigenetic Feature of Huntington’s Disease and the first genome-wide maps of 5-hmC in striatum and cortex from both WT and YAC128 HD mice brains were generated.

关键词： 5-hydroxymethylcytosine Huntington’s disease differentially hydroxymethylated regions(DhMRs) pathway analysis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Stepwise assembly to construct stable copper(I) cluster-based circularly polarized luminescent MOFs

引用

Science China Chemistry 2025年

作者： Jing-wen xie Meng-Ting Wang Yan Jin Si Li Jian-Hua Qin Shuang-Quan Zang Tomas C.W.Mak College of Chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University College of Chemistry and Chemical Engineering Luoyang Normal University Department of Chemistry The Chinese University of Hong Kong

Circularly polarized luminescence （CPL） materials have been extensively studied in recent years owing to their widespread applications in 3D display,optical storage,optical anti-counterfeiting,and biological imaging,***（I） clusters have emerged as a promising candidate for CPL materials,driven by their cost-effectiveness,superior luminescent properties,precise structure,and low ***,the poor environmental stability of copper（I） clusters renders their synthesis and preservation challenging,thereby significantly impeding their ***,we have designed and synthesised a chiral double-coordinated ligand in order to construct copper（I） cluster nodes that can be further *** anticipated,by utilizing stepwise assembly strategy,a Cu4cluster node co-modified by chiral alkynyl ligands and triphenylphosphine was further assembled with Cd2+ions to obtain 2D layers structure,L/*** L/D-Cu4-Cd exhibits excellent stability and optical properties,including bright yellow emission,solvent-responsive luminescence,and CPL activity with a maximum glumup to 2.0×10-3,which shows potential applications in the WLED and *** interestingly,the material also exhibits deflection ability towards different wavelengths of linearly polarized light,showing certain potential in the preparation of circular polarizer.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Elevated CXCL1 triggers dopaminergic neuronal loss in the substantia nigra of C57BL/6J mice: Evaluation of a novel Parkinsonian mouse model

引用

Zoological Research 2025年第01期 225-235页

作者： Xi-Zhen Ma Guo-Rui Jia Meng-Yu Li Sheng-Han Zhang Zhao-Xin Wang Ning Song Ying-juan Liu Jun-Xia xie Institute of Brain Science and Disease School of Basic Medicine Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders Qingdao University College of Life Sciences and Health University of Health and Rehabilitation Science

Substantial evidence points to the early onset of peripheral inflammation in the development of Parkinson's disease(PD), supporting the “body-first” hypothesis. However,there remains a notable absence of PD-specific animal models induced by inflammatory cytokines. This study introduces a novel mouse model of PD driven by the proinflammatory cytokine CXCL1, identified in our previous research. The involvement of CXCL1 in PD pathogenesis was validated using subacute and chronic MPTP-induced mouse models. Based on these findings, 2-month-old C57BL/6J mice were intravenously administered CXCL1(20 ng/kg/day) for 2 weeks(5 days per week), successfully replicating motor deficits and pathological alterations in the substantia nigra observed in the chronic MPTP *** results demonstrate the potential of CXCL1-induced inflammation as a mechanism for PD modeling. The model revealed activation of the PPAR signaling pathway in CXCL1-mediated neuronal damage by CXCL1. Linoleic acid, a PPAR-γ activator, significantly mitigated MPTPand CXCL1-induced toxicity and reduced serum CXCL1levels. In addition, the CXCL1-injected mouse model shortened the timeline for developing chronic PD mouse model to 2 weeks, offering an efficient platform for studying inflammation-driven processes in PD. The findings provide critical insights into the inflammatory mechanisms underlying PD and identify promising therapeutic targets for intervention.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Hotspots and trends in stem cell therapy for liver fibrosis and cirrhosis: A bibliometric analysis

引用

World Journal of Hepatology 2025年第1期17卷 112-131页

作者： wen-Yan Zhu Xiang Li Jia-Ling xie Qin Lu Ying-Jie Ma Zhao-Jing Zhu juan Liu Chongqing Engineering Research Center of Pharmaceutical Sciences Chongqing Medical and Pharmaceutical CollegeChongqing 401331China College of Pharmacy Chongqing Medical UniversityChongqing 400016China Department of Cardiology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Immunology Research Center of Medical Research Institute Southwest UniversityChongqing 402460China Office of Scientific Research of Army Medical Center Army Medical UniversityChongqing 400042China

BACKGROUND Liver fibrosis and cirrhosis are global medical challenges that require safe and effective *** the past two decades,there has been a surge in research on stem cell therapy for liver fibrosis and *** study aimed to conduct a comprehensive analysis of the research hotspots and trends in this field through *** was *** As of September 20,2024,a total of 1935 documents were retrieved dating from 2004 to 2024,with 1186 strongly relevant publications obtained after ***,the United States,and Japan were the major contributors in this *** University,Zhejiang University and Yamaguchi University were the major institution in this *** journal Stem Cell Research&Therapy published the most *** were 686 authors,with Shuji Terai,Isao Sakaida,Soon Koo Baik,and Lanjuan Li publishing the most *** research focused on alcoholic cirrhosis and nonalcoholic fatty liver *** emerging areas of interest were extracellular vesicles,exosomes,and their enriched *** field is experiencing rapid growth due to the changing research trends and increasing *** These findings provide a thorough overview of stem cell therapy in the field of liver fibrosis and cirrhosis.

关键词： Liver fibrosis Cirrhosis Stem cell therapy Mesenchymal stromal cell Extracellular vesicles Exosomes Bibliometrics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Behavior and outcomes of 141 acquired lacrimal sac mucoceles treated via endoscopic dacryocystorhinostomy

引用

International Journal of Ophthalmology(English edition) 2025年第2期18卷 244-250页

作者： Ying-Jie Ma Guang-Ming Zhou Zhi-Rong Liu Jin-Fei Wei Xin-Yu Li Bin Dong Lin-juan Wu wen-Can Wu Bo Yu National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina The Eye Hospital School of Ophthalmology&OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To investigate the clinical profile of patients with acquired lacrimal sac mucocele(ALSM)and evaluate the efficacy of endoscopic dacryocystorhinostomy(En-DCR)for this ***:En-DCRs were performed on 141 patients with ALSM patients from January 2016 to March *** clinical baseline information and magnetic resonance imaging(MRI)images were recorded and *** assess the effectiveness of En-DCR therapy,both anatomical and functional success rate was assessed during a 12mo ***:A total of 141 patients,with a mean age of 57.70±14.11y,were enrolled in this *** of the patients were female(n=91;64.54%)and all had unilateral *** patients had a previous history of epiphora and purulent secretion,and the duration from lacrimal duct obstruction to mucocele formation ranged from 6 to *** findings consistently revealed an enlarged sac diameter,fluid accumulation separated by a thin rim from adjacent tissues,which is indicative of lacrimal sac ***-DCR was performed with an anatomical success rate of 93.62%and a functional success rate of 81.56%.CONCLUSION:ALSM is more commonly seen in females and *** is essentially a complication of lacrimal duct *** characteristics can be used for precise clinical diagnosis,while En-DCR emerges as an optimal therapy for this *** results provide a comprehensive reference for the diagnosis and treatment of ALSM.

关键词： acquired lacrimal sac mucocele clinical profile magnetic resonance imaging endoscopic dacryocystorhinostomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

消费者估值不确定下众筹定价策略及退款机制研究

引用

管理工程学报 2025年第1期39卷 256-270页

作者：徐扬毕功兵宋文吴娟安徽财经大学金融学院安徽蚌埠233030 中国科学技术大学管理学院安徽合肥230026 南京审计大学金融学院江苏南京211815

众筹作为最受欢迎的互联网金融产品之一,受到工业界和学术界的广泛关注。基于现实背景,本文建立了两阶段众筹模型,研究了消费者估值不确定下消费者的策略性选择行为及其对众筹定价策略的影响。结论表明,若消费者参与众筹的额外效用较低... 详细信息

众筹作为最受欢迎的互联网金融产品之一,受到工业界和学术界的广泛关注。基于现实背景,本文建立了两阶段众筹模型,研究了消费者估值不确定下消费者的策略性选择行为及其对众筹定价策略的影响。结论表明,若消费者参与众筹的额外效用较低,消费者估值不确定会造成“搭便车”现象,导致最优众筹价格不是关于项目所需资金的单增函数。当项目所需资金较低或较高时,发起人应该设置较高的众筹价格,否则应该降低价格以激励更多的消费者参与众筹。通过对比传统销售模式,本文揭示了发起人可以利用消费者估值不确定性及众筹的预售机制增加销量或边际收益以提升利润。进一步,本文证明了退款机制可以有效增加消费者参与众筹的意愿,从而提高众筹的可行域。最后,本文将基本模型拓展到更加一般的情形,研究发现众筹市场大小、项目运作风险和生产能力均对最优定价决策有不可忽视的影响。

关键词：众筹定价决策估值不确定策略型消费者退款机制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

两种镍钛器械根管预备效果的评价

引用

牙体牙髓牙周病学杂志 2012年第6期22卷 330-334页

作者：闫文娟谢苗苗吴补领南方医科大学南方医院南方医科大学口腔医学院广东广州510515

目的:比较机用ProTaper、MTwo与手用ProTaper根管预备效率和根管壁清洁效果。方法:选择新鲜拔除的下颌第一前磨牙80个,随机分为A、B、C、D 4组,分别采用机用ProTaper、MTwo、手用ProTaper和不锈钢K锉进行根管预备,记录每一根管预备完成... 详细信息

目的:比较机用ProTaper、MTwo与手用ProTaper根管预备效率和根管壁清洁效果。方法:选择新鲜拔除的下颌第一前磨牙80个,随机分为A、B、C、D 4组,分别采用机用ProTaper、MTwo、手用ProTaper和不锈钢K锉进行根管预备,记录每一根管预备完成总时间;收集根管预备过程中推出根尖孔的碎屑,干燥后称重;采用扫描电镜观察预备后根管壁的清洁效果,并进行碎屑和玷污层评分。结果:B组根管预备时间最少,平均41 s,推出根尖孔的牙本质碎屑量也最少,平均为3.1 mg,与其他各组相比有统计学差异(P<0.05)。D组预备时间最多,平均为204 s,推出根尖孔的碎屑量平均为10.35 mg。A组和C组预备时间分别是68 s,73 s,推出根尖孔的碎屑量各为5.45 mg和5.3 mg。用扫描电镜观察根管壁并对各部位进行碎屑和玷污层的评分,各组冠1/3均比根尖部评分低。在同一部位,B组的评分低于其他3组,D组的评分高于其他3组,差异均有统计学意义(P<0.05)。结论:与ProTaper和传统不锈钢K锉相比,Mtwo器械完成根管预备时间、推出根尖孔的牙本质碎屑量、根管壁清洁度等均优于前两者。

关键词： Mtwo 机用ProTaper 手用ProTaper 根尖推出物碎屑

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

引用

World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：