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Distributions of crystals and gas bubbles in reservoir ice during growth period

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Water Science and Engineering 2011年第2期4卷 204-211页

作者： Zhi-jun LI wen-feng huang Qing JIA Matti LEPPARANTA State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 P. R. China College of Water Conservancy and Hydropower Heilongjiang University Harbin 150086 P. R. China Department of Physics University of Helsinki Helsinki FI-00014 Finland

In order to understand the dominant factors of the physical properties of ice in ice thermodynamics and mechanics, in-situ observations of ice growth and decay processes were carried out. Two samplings were conducted in the fast and steady ice growth stages. Ice pieces were used to observe ice crystals and gas bubbles in ice, and to measure the ice density. Vertical profiles of the type and size of ice crystals, shape and size of gas bubbles, and gas bubble content, as well as the ice density, were obtained. The results show that the upper layer of the ice pieces is granular ice and the lower layer is columnar ice; the average crystal size increases with the ice depth and remains steady in the fast and steady ice growth stages; the shape of gas bubbles in the upper layer of ice pieces is spherical with higher total content, and the shape in the middle and lower layers is cylinder with lower total content; the gas bubble size and content vary with the ice growth stage; and the ice density decreases with the increase of the gas bubble content.

关键词： ice crystal gas bubble crystal structure porosity ice density

Chidamide,Decitabine,Cytarabine,Aclarubicin,and Granulocyte Colony-stimulating Factor Therapy for Patients with Relapsed/Refractory Acute Myeloid Leukemia:A Retrospective Study from a Single-Center

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Current Medical Science 2023年第6期43卷 1151-1161页

作者： Fan-cong KONG Ling QI Yu-lan ZHOU Min YU wen-feng huang Fei LI Center of Hematology The First Affiliated Hospital of Nanchang UniversityNanchang330006China Jiangxi Clinical Research Center for Hematologic Diseases Nanchang330006China

Objective Preclinical evidence and clinical trials have suggested synergistic effects of epigenetic modifiers in combination with cytotoxic agents for the treatment of ***,their efficacy in patients with relapsed/refractory acute myeloid leukemia(R/R AML)remains *** Clinical data of R/R AML patients who received a CDCAG regimen(chidamide,decitabine,cytarabine,aclarubicin,and granulocyte colony-stimulating factor)from July 1,2018 to October 31,2021 at our center were retrospectively assessed,and the safety and efficacy of the CDCAG regimen were *** were followed up until November 30,2021,with a median follow-up of 21.6 months(95%CI:10.0–33.2 months).Results A total of 67 patients were *** patients died within 3 weeks after the initiation,and therefore only 65 patients underwent the assement for clinical response and *** was found that 56.9%patients achieved complete remission with a median overall survival(OS)of 9.6 *** median OS of responders was 25.9 months,while that of non-responders was 5.0 months(P<0.0001).Patients with gene mutations had a superior overall response rate(ORR)(80.4%vs.45.5%,P=0.043)compared to those without gene *** presence of DNA methyltransferase 3 A(DNMT3A),ten-eleven translocation-2(TET2),and isocitrate dehydrogenase 1/2(IDH1/2)mutations did not affect the response rate(88.2%vs.68.9%,P=0.220)and reflected a better OS(not attained vs.9.0 months,P=0.05).The most common non-hematologic adverse events were pulmonary infection(73.1%),followed by febrile neutropenia(23.9%)and sepsis(19.4%).Conclusions The CDCAG regimen was effective and well-tolerated in R/R AML patients,increasing the potential for allogeneic hematopoietic stem cell ***,patients with DNMT3A,TET2,and IDH1/2 mutations might benefit from this regimen.

关键词： relapsed/refractory acute myeloid leukemia histone deacetylase inhibitor DNA methyltransferase inhibitor salvage therapy

.eft-dominant Arrhythmogenic Cardiomyopathy： A Case Misdiagnosed as Pseudoaneurysm

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Chinese Medical Journal 2016年第14期129卷 1763-1764页

作者： Chao Yu Tian-Gang Zhu wen-Ling Liu wen-feng huang Department of Cardioloav Pekinq University People's Hospital Beijing 100044 China Department of Emergency Medicine Peking University PeopLe's Hospital Beijing 100044 China

To the Editor： A 60-year-old man was admitted to our emergency department with a new-onset sudden palpitation and precordial discomfort that occurred several times a day. Sustained monomorphic ventricular tachycardia （VT） of a right bundle-branch block （RBBB） pattern （245 beats/rain） was documented, which was reversed into a sinus rhythm after syncbronized cardioversion. Subsequent 12-lead electrocardiogram revealed a normal sinus rhythm with T-wave inversion in leads V4 to V6 and ST segment elevation in leads V 1 to V3 （78 beats/min）. He had been diagnosed with diabetes about 10 years ago which was well treated. There was no thmily history ofarrhythmogenic cardiomyopathy or either signs or symptoms of heart disease. Myocardial enzyme levels, including troponin l, creatine kinase isoenzyme MB, and myoglobin, were within normal level. The level of serum C-reactive protein and D-dimer was normal. Transthoracic two-dimensional echocardiography presented a normal left ventricular （LV） global systolic function （an end diastolic/systolic volume of 150/66 ml, an ejection fraction of 57%）, an LV pseudoaneurysm （apex, 4.2 cmx 2.6 cm） [Figure 1], and normal morphological right ventricle （RV）. Coronary angiography showed normal coronary arteries.

关键词： Left-dominant Arrhythmogenic Pseudoaneurysm

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-wen Alvin huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Angiographic leakage of polypoidal choroidal vasculopathy on indocyanine angiography

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Chinese Medical Journal 2010年第12期123卷 1548-1552页

作者： ZUO Cheng-guo wen feng huang Shi-zhou LUO Guang-wei YAN Hong WU Wei-ju WU De-zheng State Key Laboratory of Ophthalmology Zhongshan OphthalmicCenter Sun Yat-sen University Guangzhou Guangdong 510060China

Background There is no detailed report about the angiographic leakage of polypoidal choroidal vasculopathy （PGV） lesions on indocyanine green （ICG） angiography. This study aimed to investigate the angiographic leakage of polypoidal lesions in PCV on ICG angiography. Methods One hundred and forty-four eyes of 137 patients diagnosed as PCV were prospectively observed. Fundus examination, fluorescein angiography, and ICG angiography were performed. Leakage of polypoidal lesions and clinical features were recorded according to the angiograms. Results In all 144 eyes, 110 eyes showed angiographic leakage （leakage group） on ICG angiography and three subtypes of leakage group were noted, which were polypoidal dilations leakage （47 eyes, 42.7%）, branching vascular networks leakage （14 eyes, 12.7%） and leakage of both （49 eyes, 44.5%）. The other 34 eyes showed regression of polypoidal lesions （regression group）. In leakage group, the rates of pigment epithelial detachment （PED）, best corrected visual acuity （BCVA）〈0.1 and old subretinal hemorrhages were 56.4% （62 eyes）, 19.1% （21 eyes）, and 4.6% （5 eyes） respectively, compared with 8.8% （3 eyes）, 50% （17 eyes） and 38.2% （13 eyes） of regression group （P 〈0.001）. The history of regression group was significantly longer （P 〈0.001）. Conclusions Angiographic leakage and regression can be observed in PCV lesions. Leakage of both polypoidal dilations and branching vascular networks is the most common subtype in leakage group. PCV in leakage group is more likely to be related to PED, better BCVA and shorter history, while PCV regression group tends to relevant to old subretinal hemorrhage, worse BCVA and longer history. This may reflect that the former is active or in the early course while the later is resting or in the late phase of PCV.

关键词： classification indocyanine green angiography polypidal choroidal vasculopathy

Mechanical Properties of Railway High-strength Manufactured Sand Concrete: Typical Lithology, Stone Powder Content and Strength Grade

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 194-203页

作者： WANG Zhen LI Huajian huang Fali YANG Zhiqiang wen Jiaxin SHI Henan Railway Engineering Research Institute China Academy of Railway Science Corporation LimitedBeijing 100081China State Key Laboratory for Track Technology of High-Speed Railway Beijing 100081China

In order to achieve the large-scale application of manufactured sand in railway high-strength concrete structure,a series of high-strength manufactured sand concrete(HMC)are prepared by taking the manufactured sand lithology(tuff,limestone,basalt,granite),stone powder content(0,5%,10%,15%)and concrete strength grade(C60,C80,C100)as *** evolution of mechanical properties of HMC and the correlation between cubic compressive strength and other mechanical properties are *** to river sand,manufactured sand enhances the cubic compressive strength,axial compressive strength and elastic modulus of concrete,while its potential microcracks weaken the flexural strength and splitting tensile strength of *** powder content displays both positive and negative effects on mechanical properties of HMC,and the stone powder content is suggested to be less than 10%.The empirical formulas between cubic compressive strength and other mechanical properties are proposed.

关键词： manufactured sand concrete railway mechanical property lithology stone powder content

Dynamical complexity of Anosov systems driven by a quasi-periodic force

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Science China Mathematics 2025年第1期 89-136页

作者： wen huang Zeng Lian Kening Lu Department of Mathematics University of Science and Technology of China School of Mathematics Sichuan University

Consider C2Anosov systems on a compact manifold driven by a quasi-periodic *** study their dynamical complexity on various levels from the perspectives of both path-wise dynamics and stochastic *** that these systems are non-wandering（i.e.,every point in the phase space is nonwandering）,we prove a set of results:（1） the existence of abundance of random periodic points;（2） a random Liv?ic theorem;（3） a random Ma?é-Bousch-Conze-Guivarc'h lemma;（4） the existence of strong random ***,a concrete example constructed on a 2-dimensional torus is also given to uncover some interesting phenomena of the systems.

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Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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Journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu Deng Jie Shen Jinxing Lu Chuqiang huang Zhuoyuan Chen feng Peng Yunpeng Liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Anodes

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng feng Yaona Lai Kongli huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease