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Antiviral activity of mangiferin from the rhizome of Anemarrhena asphodeloides against herpes simplex virus type 1

Asian Pacific Journal of Tropical Biomedicine 2023年第3期13卷 112-120页

作者： wen-da wang Gang Chen Huzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Traditional Chinese Medicine Huzhou 313001China

Objective:To evaluate the antiviral activity of pure compounds against herpes simplex virus type 1(HSV-1)from the rhizome of Anemarrhena ***:Bioassay-guided isolation was conducted to separate the active compound and its chemical structure was elucidated by spectral *** vitro antiviral efficacy of active compound was detected by Cell Counting Kit-8 assay,plaque reduction assay,and fluorescence ***-PCR was used to determine the viral load and the cytokine-related gene expression after HSV-1 *** vivo study was also conducted to further determine antiviral efficacy of an active compound against ***:An active compound was isolated and elucidated as *** significantly inhibited the replication of HSV-1 in Vero cells with a half maximal inhibitory concentration(IC_(50))of 64.0 mg/***-of-addition and time-of-removal assays demonstrated that mangiferin could effectively inhibit the replication of HSV-1 in the early stage(8 h).UL12,UL42,and UL54 gene expression levels of HSV-1 in the 64 mg/L mangiferin-treated group were markedly reduced as compared with the HSV-1 group(Pdamage maintainingΔΨm induced by HSV-1 in Vero *** expression of inflammatory factors TNF-α,IL-1β,and IL-6 was remarkably increased in the virus-infected group as compared with that in the normal group(P<0.05),the levels of these inflammatory factors dropped after treatment with *** significantly decreased the viral load and attenuated the HSV-1-induced up-regulation of TNF-α,IL-1β,and *** relative protection rate of HSV-1-infected mice could reach up to55.5%when the concentration of mangiferin was 4 g/***:Mangiferin exhibits promising antiviral activity against HSV-1 in vitro and in vivo and could be a potential antiviral agent for HSV-1.

关键词： Anemarrhena asphodeloides Herpes simplex virus Antiviral activity Mangiferin

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Huge brown tumor of the rib in an unlocatable hyperparathyroidism patient with “self-recovered” serum calcium and parathyroid hormone: A case report

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World Journal of Clinical Cases 2019年第24期7卷 4321-4326页

作者： wen-da wang Ning Zhang Qiang Qu Xiao-Dong He Department of Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND The brown tumor is a kind of complication of hyperparathyroidism(HPT). The ultimate therapy usually is the resolution of HPT. We herein report an unlocatable HPT patient who received resection of a huge brown tumor of the rib, and experienced "self-recovery" of serum calcium and parathyroid *** SUMMARY A 34-year-old female patient who suffered from a gradually increasing mass of the left chest wall since 2007 came to our hospital for treatment. The patient had a history of serum Ca and parathyroid hormone(PTH) increasing since June 2015 and received zoledronic acid treatment for 17 mo. When she came to our hospital in November 2017 after discontinuing medical treatment for 3 mo, the serum Ca and PTH levels were within normal ranges. The patient had no imaging abnormalities of parathyroid ultrasound or 99 m Tc-methoxyisobutyl *** computed tomography revealed a local soft tissue mass of 96 mm × 113 mm with bone erosion of the left 8 th rib, and the mass presented irregular enhancement with an unclear boundary between the mass and spleen. The mass was thought to likely be caused by HPT, but a malignancy could not be ruled *** of the mass was performed, and the pathology proved that the mass was a brown tumor. A diagnosis of unlocatable HPT was considered. Since the serum Ca and PTH levels were both normal pre-and post-operation, the patient did not receive exploratory surgery for HPT, and received regular *** The huge brown tumor of the rib and "self-recovered" serum PTH and Ca levels are relatively rare in HPT patients. An exploratory operation may be deferred for these patients, and long-term follow-up should be performed.

关键词： Brown tumor Hyperparathyroidism Unlocatable Self-recovered Resection Case report

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A complicated case of innominate and right common arterial aneurysms due to Takayasu’s arteritis

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World Journal of Clinical Cases 2019年第13期7卷 1671-1676页

作者： wen-da wang Rui Sun Meng-Xin Zhou Xing-Rong Liu Yue-Hong Zheng Yue-Xin Chen Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Cardiac Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

BACKGROUND Innominate artery aneurysms (IAAs) are relatively rare. Endovascular therapy has been an alternative to open surgery in some IAA cases, but open repair is still necessary in complicated cases. CASE SUMMARY We report a 35-year-old female who suffered from Takayasu’s arteritis. The patient did not get regular treatment, and IAA and right common carotid artery aneurysm developed, which complicated with occlusion of the left carotid artery, subclavian artery, and the initial part of the left vertebral artery. The patient also had moderate aortic valve insufficiency. With inflammation being controlled well, the patient received the surgery for arterial aneurysms of innominate and right common carotid arteries and aortic valve insufficiency. The shunts for cerebral blood supply were designed to protect the brain and the surgery was conducted successfully under extracorporeal circulation. CONCLUSION The case illustrates that open surgery may be appropriate for some complicated IAAs, and brain protection is important.

关键词： Case report Innominate artery aneurysm Takayasu's arteritis Shunts Brain protection

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Effect of Surface Modification on Corrosion Resistance of Pure *** in Vivo Observation

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Chinese Journal of Biomedical Engineering(English Edition) 2006年第2期15卷 62-68页

作者： LI Xiao-mei GUO Tian-wen wang da-lin Stomatology of Changhai Hospital Second Military Medical UniversityShanghai 200433 Department of ProstheticsSchool of DentistryFourth Military Medical UniversityXi''an 710032 Stomatology of Changhai HospitalSecond Military Medical UniversityShanghai 200433

Objective: The aim of this experiment is to study the effect of three methods of surface modification on the corrosion resistance of commercial pure Titanium when used in oral environment for half a ***:48 specimens of pure titanium were made and divided into four groups randomly, one group was selected randomly as Group I (control group), the other three groups were treated by three methods of surface modification individually, GroupⅡ:heating oxidation in air(400℃,30min.), GroupⅢ:anodization (45 volts, 10 min.),GroupⅣ:TiN coating(firing temperature 200℃ , total coating time 62min.). Six edentulous volunteers with healthy oral mucosa participated in the in vivo study. One testing piece from each group was selected and fixed in the polished surface of upper complete dentures. Dynamic polarization curves were traced with electrochemical method after the specimens were placed either in oral cavity or in air for 6 months. Results: After all specimens were used, Ecorr altered in every group , Ecorr from high to low were in turn: TiN coating group>heating oxidation group> anodization group>control group, no obvious passive potential Ep and Ip was found in control group. Heating oxidation in air exhibited similar Ep to anodization, but Ip was remarkably lower than that of anodization; TiN coating showed obviously different polarization curves compared with heating-oxidation group and anodization group, Ecorr was positive, and no Ep and Ip was found. Conclusion: Under present experimental condition, all the three treatment methods could enhance corrosion resistance of pure titanium in oral environment, heating oxidation in air exhibited better resistance to corrode than anodization, TiN coating possessed the most excellent corrosion resistance, even after exposed in oral condition for 6 months, there was little change of corrosion resistance. Therefore TiN coating could be adopted to improve corrosion resistance of pure titanium in oral environment.

关键词： Surface modification,Pure Titanium,Corrosion,Heating oxidation,Anodization,TiN coating

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A network-based predictive gene expression signature for recurrence risks in stage Ⅱ colorectal cancer

A network-based predictive gene expression signature for rec...

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中国生物工程学会第十三届学术年会暨2019年全国生物技术大会

作者： wen-Jing Yang Hai-Bo wang wen-da wang Gan-Lin Zhang Guo-wang Yang Department of Oncology Beijing Hospital of Traditional Chinese Medicine Capital Medical University Department of Biochemistry and Molecular Biology Capital Medical University Department of Anorectal Surgery Shanxi Cancer Hospital

The current criteria for defining recurrence risks of stage II colorectal cancer(CRC) are unrobust, so we aimed to explore novel gene signature to predict recurrence risks and reveal underlying mechanisms in stage II CRC. First, 124 patients’ gene-expression profiles dataset of stage II CRC from The Cancer Genome Atlas(TCGA) database were obtained to screen Differentially Expressed Genes(DEGs). 202 DEGs including 128 up-regulated and 74 down-regulated were identified in recurrence group(n=24) compared to non-recurrence group(n=100). Furthermore, the top five(ZNF561, WFS1, SLC2 A1, MFI2, PTGR1) DEGs were identified by random forest variable hunting, and four(ZNF561, WFS1, SLC2 A1, PTGR1) of them were selected to create a four-gene recurrent model(GRM) with the area under the curve(AUC) 0.882 by receiver operating characteristic(ROC), and the robust diagnostic effectiveness of GRM were further validated by another gene expression profiling date from GEO(GSE12032) with the AUC of 0.943. The diagnostic effectiveness of GRM about recurrence was confirmed associated with poor disease-free survival(DFS) to all stage CRC. In addition, gene ontology(GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis suggested 18 functions and 6 pathways were enrichment. Four genes as ABCG2, CACNA1 F, CYP19 A1, TF were identified as hub genes by Protein-Protein Interaction(PPI) network, which further validated they were correlated with poor pathologic stage and overall survival(OS) in all stage CRC. In conclusion, the GRM can effectively classify stage II CRC into groups at high and low risks of recurrence, thereby making up for the prognostic value of the traditional clinicopathological risk factors defined by the NCCN guidelines. And the hub genes may be the useful therapeutic targets for recurrence. Thus, the GRM and hub genes potentially offer clinical values in directing individualized and precision therapeutic regimen for stage II CRC

关键词： Colorectal cancer bioinformatics analysis recurrence risks recurrence mechanisms

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Treatment of advanced rectal cancer after renal transplantation

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World Journal of Gastroenterology 2011年第15期17卷 2058-2060页

作者： Hai-Yi Liu Xiao-Bo Liang Yao-Ping Li Yi Feng Dong-Bo Liu wen-da wang Department of Anal and Colorectal Surgery Shanxi Cancer Hospital Affiliated Cancer Hospital of Shanxi Medical University Taiyuan 030013 Shanxi Province China

Renal transplantation is a standard procedure for endstage renal disease today. Due to immunosuppressive drugs and increasing survival time after renal transplantation, patients with transplanted kidneys carry an increased risk of developing malignant tumors. In this case report, 3 patients with advanced rectal cancer after renal transplantation for renal failure were treated with anterior resection or abdominoperineal resection plus total mesorectal excision, followed by adjuvant chemotherapy. One patient eventually died of metastasized cancer 31 mo after therapy, although his organ grafts functioned well until his death. The other 2 patients were well during the 8 and 21 mo followup periods after rectal resection. We therefore strongly argue that patients with advanced rectal cancer should receive standard oncology treatment, including operation and adjuvant treatment after renal transplantation. Colorectal cancer screening in such patients appears justified.

关键词： Rectal cancer Renal transplantation Endstage renal disease Treatment Screening

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Heterocyclic pyrrolizinone and indolizinones derived from natural lactam as potential antifungal agents

Heterocyclic pyrrolizinone and indolizinones derived from na...

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中国化学会第十二届全国天然有机化学学术会议

作者： Shuang-Shuang wang Long-Zhu Bao wen-da wang Di Song Jing-Jing wang Xiu-Fang Cao College of Science Huazhong Agricultural University

Leading optimization based on natural products with excellent biological properties has always been an efficient way to discovery and synthesize better performance *** is well known that lactams(pyrrolidine-2,4-dione) are natural product fragments that are widely found in terrestrial and marine *** to now,many heterocyclic derivatives containing lactam unit presented extensively remarkable pharmacological and biological activities,including antibacterial,antifungal,antiviral,herbicidal,antitumor activities,and cytogenetic toxicity,*** this study,with the aim to develop highly potential active heterocyclic compounds,two series of multi-substituted pyrrolizinone and indolizinone derivatives were designed,synthesized and evaluated for their potential antifungal activities against six species of the plant pathogen fungi(Fusarium graminearum,Sclerotinia sclerotiorum,Phomopsis adianticola,Gloeosporium theae-sinensis,Alternaria tenuis Nees,Magnaporthe oryzae).The structure of all the newly molecules were confirmed by analytical spectroscopic data,including H NMR,C NMR and *** to the systemic studies on bio-evaluation assay,most target compounds exhibited moderate and broad-spectrum activities especially against for phomopsis adianticola and Magnaporthe oryzae compared to the intermediates and the *** is hoped that these pyrrolizinone and indolizinone derivatives containing lactam scaffolds will provide a certain theoretical basis and useful information for the creation and innovation of novel antifungal agents.

关键词： Pyrrolizinone Indolizinone Structural diversity Plant pathogen fungi Antifungal activities Structure-activity relationships

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Design,synthesis and fungicidal activity of the 3-arylfuran-4-hydroxy-2(5H)-one derivatives containing acrylate moiety

Design,synthesis and fungicidal activity of the 3-arylfuran-...

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中国化学会第十二届全国天然有机化学学术会议

作者： Long-zhu Bao Shuang-shuang wang wen-da wang Di Song Jing-jing wang Xiu-fang Cao College of Science Huazhong Agricultural University

3-Aryl-4-hydroxy-2(5 H)-furanone belongs to the class of *** core structure of these compounds,tetronic acid,is not only a structural fragment contained in many natural products,but also the core structure of a class of insecticides .Especially,Many butenolide compounds containing tetronic acid unit exhibit anti-tumor,anti-inflammatory,antioxidant and other biological *** acrylate structure is also a kind of pharmacophore component of a broad spectrum,high-efficiency *** type of fungicide is mainly derived from structural optimization by taking the sterilizing active natural antibiotic Strobilurin A as a ***,this work focused on the design,synthesis,and bio-evaluation of a series of novel3-aryl-4-hydroxy-2(5 H)-furanone containing acrylate scaffold by a chemical method of intermediate *** these synthesized compounds were determined by H NMR,C NMR and *** vitro fungicidal activity test showed that some of the compounds had broad-spectrum fungicidal activity against phytopathogenic fungi of tea,rape,peach,wheat,cotton and other major economic crops,and the activity of a few compounds even exceeded the control *** results demonstrated these novel3-aryl-4-hydroxy-2(5 H)-furanone derivatives might be considered as promising scaffolds for further optimization of potential antifungal agents.

关键词： 3-Aryl-4-hydroxy-2(5H)-furanone Acrylate Fungicidal activity Natural products

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Prospective Randomized Study of Sarpogrelate Versus Clopidogrel-based Dual Antiplatelet Therapies in Patients Undergoing Femoropopliteal Arterial Endovascular Interventions： Preliminary Results

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Chinese Medical Journal 2015年第12期128卷 1563-1566页

作者： Yue-Xin Chen wen-da wang Xiao-Jun Song Yong-Quan Gu Hong-Yan Tian He-Jie Hu Ji-Chun Zhao Xiao-Qiang Li Chang-Wei Liu Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100068 China Department of Vascular Surgery Peking XuanWu Hospital Beijing 100053 China Department of Vascular Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Vascular Surgery Anhui Provincial Hospital Hefei Anhui 230001 China Department of Vascular Surgery West China Hospital Chengdu Sichuan 510100 China Department of Vascular Surgery The Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China

Background：Sarpogrelate is a selective 5-hydroxytryptamine （5-HT） receptor subtype 2A antagonist which blocks 5-HT induced platelet aggregation and proliferation of vascular smooth muscle *** compared the efficacy of sarpogrelate-based dual antiplatelet therapies for the prevention of restenosis and target lesion revascularization （TLR） rates comparing with that of clopidogrel after percutaneous endovascular interventions （EVIs） of femoropopliteal （FP） arterial ***：This prospective,multicenter,randomized clinical trial recruited a total of 120 patients with successful EVI of FP lesions at seven centers across China between January 2011 and June *** were randomized to receive either sarpogrelate （100 mg trice daily for 6 months,n =63） or clopidogrel （75 mg once daily for 6 months,n =57）.All patients also received oral aspirin （100 mg once daily for 12 months）.Clinical follow-up was conducted up to 12 months ***：There was no significant difference between the two groups in basic demographic *** restenosis rate was higher in the clopidogrel group （22.80%） than in sarpogrelate group （17.50%）,but there was no significant difference between these two groups （P =0.465）.The TLR rate,ipsilateral amputation rate,mortality in all-cause and bleeding rate were also similar in the two groups （P 〉 0.05）.Conclusions：Aspirin plus sarpogrelate is a comparable antithrombotic regimen to aspirin plus clopidogrel after EVI of FP arterial *** antiplatelet therapies might play an important role in preventing restenosis after successful EVI of FP lesions.

关键词： Clopidogrel Femoropopliteal Artery Percutaneous Endovascular Interventions Restenosis Sarpogrelate

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科层制市场机制:对口支援机制的反思

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西北师大学报（社会科学版） 2017年第5期54卷 67-73页

作者：张文礼王达梅西北师范大学社会发展与公共管理学院甘肃兰州730070 广东外语外贸大学政治与公共管理学院广东广州510006

对口支援机制是对口支援的重要内容,合理有效的机制能够显著提高对口支援效果。"科层制机制"是对口支援中最早被采用、最常用的机制,具有稳定性、职责分工明确等优点,缺点是无偿性、被动性。市场机制在"科层制机制"基础上形成,具有动力... 详细信息

对口支援机制是对口支援的重要内容,合理有效的机制能够显著提高对口支援效果。"科层制机制"是对口支援中最早被采用、最常用的机制,具有稳定性、职责分工明确等优点,缺点是无偿性、被动性。市场机制在"科层制机制"基础上形成,具有动力强劲、方式多样、效果明显等优点,而缺点则是脆弱性明显、稳定性不足。两种机制各有优缺点,在对口支援中应将两种机制有机结合,取长补短,形成机制合力,提高对口支援效果。

关键词：对口支援科层制机制市场机制

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