检索结果-南通市图书馆

Efficient Synthesis of 3,5,6,8-Tetrahydro-4H-thiopyrano[4′,3′:4,5]· thieno[2,3-d]pyrimidin-4-ones via an Iminophosphorane

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2010年第1期26卷 60-65页

作者： LI wen-jing liu Min FENG Ling-ling DING Ming-wu Key Laboratory of Pesticide ＆ Chemical Biology of Ministry of Education Central China Normal University Wuhan 430079 P. R. China

3,5,6,8-Tetrahydro-4H-thiopyrano[4＇,3＇：4,5]thieno[2,3-d]pyrimidin-4-ones（7） were synthesized via the base catalytic reactions of amines or phenols with carbodiimides（5）, which were obtained from the aza-Wittig ... 详细信息

关键词： 3,5,6,8-Tetrahydro-4H-thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidin-4-one Aza-Wittig reaction Carbodii- mide Isocyanate

Influence of h-BN particle size on fracture behavior and thermal shock resistance of Al2O3-C refractories

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2022年第7期29卷 1129-1137页

作者： Zi-xu Ji wen-jing liu Ning Liao Ya-wei Li Tian-bin Zhu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina National-Provincial Joint Engineering Research Center of High Temperature Materials and Lining Technology Wuhan 430081HubeiChina School of Chemical Engineering Qinghai UniversityXining 810016QinghaiChina

h-BN can be applied in Al_(2)O_(3)–C refractories to substitute graphite due to their similar crystal structure and better resistance to molten steel and *** effects of h-BN particle size on the mechanical properties and fracture behavior of Al_(2)O_(3)–C refractories were investigated through wedge splitting test and microstructural *** obtained results demonstrated that the addition of larger-sized h-BN was conducive to the growth of in situ formed SiC whiskers,which contributed to the highest flexural strength(42.63±3.10 MPa)of specimen *** comparison,the smaller-sized h-BN can induce more crack propagation paths along the interface and within matrix,leading to more tortuous crack propagation paths,and thus the thermal shock-related parameters such as specific fracture energy,characteristic length,and thermal shock resistance were ***,the residual strength ratio of Al_(2)O_(3)–C refractories was increased from 35.5%to 42.5%with decreasing the h-BN particle size from 10 to 0.1μm.

关键词： Al_(2)O_(3)–C refractory h-BN Fracture behavior Thermal shock resistance

Pretreatment with H_2O_2 Alleviates Aluminum-induced Oxidative Stress in Wheat Seedlings

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2011年第1期53卷 44-53页

作者： Fang Jie Xu Chong Wei Jin wen jing liu Yong Song Zhang Xian Yong Lin Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health College of Environmental & Resource Sciences Zhejiang University Hangzhou 310029 China Zhejiang Key Laboratory of Subtropical Soil Science and Plant Nutrition College of Environmental & Resources Science Zhejiang University Hangzhou 310029 China

Hydrogen peroxide （H2O2） is a key reactive oxygen species （ROS） in signal transduction pathways leading to activation of plant defenses against biotic and abiotic stresses. In this study, we investigated the effects of H2O2 pretreatment on aluminum （AI） induced antioxidant responses in root tips of two wheat （Triticum aestivum L.） genotypes, Yangmai-5 （AI-sensitive） and Jian-864 （AI-tolerant）. AI increased accumulation of H2O2 and O2^- leading to more predominant lipid peroxidation, programmed cell death and root elongation inhibition in Yangmai-5 than in Jian-864. However, H2O2 pretreatment alleviated AI- induced deleterious effects in both genotypes. Under AI stress, H2O2 pretreatment increased the activities of superoxide dismutase, catalase, peroxidase, ascorbate peroxidase and monodehydroascorbate reductase, glutathione reductase and glutathione peroxidase as well as the levels of ascorbate and glutathione more significantly in Yangmai-5 than in Jian-864. Furthermore, H2O2 pretreatment also in- creased the total antioxidant capacity evaluated as the 2, 2-diphenyl-l-picrylhydrazyl-radical scavenging activity and the ferric reducing/antioxidant power more significantly in Yangmai-5 than in Jian-864. Therefore, we conclude that H2O2 pretreatment improves wheat AI acclimation during subsequent AI exposure by enhancing the antioxidant defense capacity, which prevents ROS accumulation, and that the enhancement is greater in the AI-sensitive genotype than in the AI-tolerant genotype.

关键词： WHEAT OXIDATIVE stress HYDROGEN peroxide PLANT defenses EFFECT of aluminum on plants BIOACCUMULATION SEEDLINGS

Xuebijing injection,a Chinese patent medicine,against severe pneumonia:Current research progress and future perspectives

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2023年第5期21卷 413-422页

作者： Mei Zhang Rui Zheng wen-jing liu Jun-ling Hou Yu-lei Yang Hong-cai Shang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamilton L8S 4K1Canada

Severe pneumonia is one of the most common infectious diseases and the leading cause of sepsis and septic *** infection,balancing the patient’s immune status,and anti-coagulation therapy are all important elements in the treatment of severe *** multi-target agents,Xuebijing injection(XBJ)has shown unique advantages in targeting complex conditions and saving the lives of patients with severe *** review outlines progress in the understanding of XBJ’s anti-inflammatory,endotoxin antagonism,and anticoagulation *** the hundreds of publications released over the past few years,the key results from representative clinical studies of XBJ in the treatment of severe pneumonia were selected and *** was observed to effectively suppress the release of pro-inflammatory cytokines,counter the effects of endotoxin,and assert an anticoagulation effect in most clinical trials,which are consistent with experimental ***,this evidence suggests that XBJ could play an important and expanding role in clinical medicine,especially for sepsis,septic shock and severe pneumonia.

关键词： Xuebijing injection Severepneumonia Pneumonia,bacterial Pneumonia,viral Treatmentmechanism Clinical trial

Effect of concentration and adsorption time on the formation of a large-scale origami pattern

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2019年第7期30卷 62-67页

作者： wen-jing liu Ping Zhang Tong Sun Lin Li Yu-Hui Wei Kai-Zhe Wang Lin liu Bin Li Division of Physical Biology and Bioimaging Centre Shanghai Synchrotron Radiation Facility CAS Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China University of Chinese Academy of Sciences Beijing 100049 China Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201204 China School of Science Ningbo University Ningbo 315211 China

The arrangement of DNA-based nanostructures into the desired large-scale periodic pattern with the highest possible accuracy and control is essential for the DNA application in functional biomaterials;however, formation of a DNA nanostructure pattern without utilizing the molecular interactions in nanotechnology field remains difficult. In this article, we use the optimal concentration and adsorption time of origami to induce DNA origami in the form of a large-scale 2D pattern on mica without changing the origami itself. DNA origami structures can form a pattern by close packing of symmetric and electrostatic interactions between ions, which was confirmed by the atomic force microscopy images. Furthermore, we identified favorable conditions for the concentration of enable pattern formation with DNA origami. This work provides an insight to understand the adsorption of DNA on mica and guides researches on regular DNA nanostructure pattern, which can serve as templates for pattern formation of proteins or other biomolecules.

关键词： DNA Origami Pattern Atomic force microscopy Close packing

Diabetes and susceptibility to COVID-19:Risk factors and preventive and therapeutic strategies

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第8期15卷 1663-1671页

作者： jing-wen liu Xiao Huang Ming-Ke Wang Ji-Shun Yang School of Pharmacy Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Naval Medical Center Naval Medical UniversityShanghai 200052China

Coronavirus disease 2019(COVID-19)is a highly infectious disease caused by a novel human coronavirus called severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Diabetes is a well-known risk factor for infectious diseases with high prevalence and increased ***,we elucidated the possible factors for the increased vulnerability of diabetic patients to SARS-CoV-2 infection and the more severe COVID-19 *** worsened prognosis of patients with both COVID-19 and diabetes may be attributable to host receptor angiotensinconverting enzyme 2-assisted viral ***,insulin resistance is often associated with impaired mucosal and skin barrier integrity,resulting in microbiota dysbiosis,which increases susceptibility to viral *** may also be associated with higher levels of pro-inflammatory cytokines resulting from an impaired immune system in diabetics,inducing a cytokine storm and excessive *** review describes diabetes mellitus and its complications,explains the risk factors,such as disease characteristics and patient lifestyle,which may contribute to the high susceptibility of diabetic patients to COVID-19,and discusses preventive and therapeutic strategies for COVID-19-positive diabetic patients.

关键词： Diabetes mellitus SARS-CoV-2 COVID-19 Susceptibility Prevention Treatment

A quasi-distributed dynamic and static strain sensor system

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optoelectronics Letters 2008年第4期4卷 243-247页

作者： jing wen-cai liu Tao ZHANG Pei-song liu Kun JIA Da-gong ZHANG Yi-mo College of Precision Instrument ＆ Optoelectronics Engineering Key Laboratory for Optoelectronic Information and Technical Science of Ministry of Education Tianjin Universiey Tianjin 300072 China

A quasi-distributed dynamic and static strain sensor system consisting of 16 FBG sensors is designed by using an amplified-sponteneous emission （ASE） optical source, an optical tunable falter and a tunable laser. Aresolution of about 5 με has been achieved for dynamic strain measurement. The resolution for static strain measurement is about 1 με.

关键词：静应力传感器系统准分布式动力学光纤布拉格光栅光源

Hyaluronic acid derivative-modified nano-structured lipid carrier for cancer targeting and therapy

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第7期21卷 571-580页

作者： Xiao liu Hai liu Su-lan WANG jing-wen liu Department of Pharmacy Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Department of Radiotherapy Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Department of Pharmacological and Pharmaceutical Sciences College of PharmacyUniversity of HoustonHangzhou 310016China

To reduce the problems of poor solubility,high in vivo dosage requirement,and weak targeting ability of paclitaxel(PTX),a hyaluronic acid-octadecylamine(HA-ODA)-modified nano-structured lipid carrier(HA-NLC)was ***-ODA conjugates were synthesized by an amide reaction between HA and *** hydrophobic chain of HA-ODA can be embedded in the lipid core of the NLC to obtain *** HA-NLC displayed strong internalization in cluster determinant 44(CD44)highly expressed MCF-7 cells,and endocytosis mediated by the CD44 receptor was *** HA-NLC had an encapsulation efficiency of PTX of 72.0%.The cytotoxicity of the PTXloaded nanoparticle HA-NLC/PTX in MCF-7 cells was much stronger than that of the commercial preparation *** vivo,the HA-NLC exhibited strong tumor targeting *** distribution of the NLCs to the liver and spleen was reduced after HA modification,while more nanoparticles were aggregated to the tumor *** results suggest that HA-NLC has excellent properties as a nano drug carrier and potential for in vivo targeting.

关键词： Paclitaxel(PTX) Hyaluronic acid-octadecylamine(HA-ODA) Nano-structured lipid carrier(NLC) Tumor targeting In vivo distribution

Analytical solution for upheaval buckling of shallow buried pipelines in inclined cohesionless soil

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2021年第5期22卷 369-381页

作者： Bo HUANG jing-wen liu Ji-ying FAN Dao-sheng LING institute of Geotechnical Engineering College of Architectural and Civil EngineeringZhejiang UniversityHangzhou 310058China Geoengineering Centre at Queen's-RMC Queen's UniversityKingstonONK7L 3N6Canada Bureau of Housing and Urban-Rural Development of Chengdu Chengdu 610094China

Upheaval buckling of pipelines can occur under thermal expansion and differential ground *** on this phenomenon has usually assumed the pipes are buried in horizontal *** long-distance transmission pipelines across mountainous areas,the ground surface is commonly *** on the Rankine earth pressure theory and Mohr-Coulomb failure criterion,analytical formulae for calculating the peak uplift resistance and the slip surface angles for a buried pipe in inclined ground are presented in this *** indicate that the slip surfaces in inclined ground are asymmetric and rotate towards the downhill *** a shallow burial depth,the failure plane angle is highly impacted by the ground *** the embedment ratio(H/D)is more than 4,the influence of the ground slope on the failure plane angle is *** peak uplift resistance reduces in inclined ground,especially when H/D is less than ***,a simple equation considering the impact of ground inclination is proposed to predict the peak uplift resistance.

关键词： Shallow buried pipe Upheaval buckling Inclined ground Analytical formulation Soil deformation mechanism