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Experts’Consensus on the Management of Respiratory Disease Syndemic

China CDC weekly 2024年第8期6卷 131-138页

作者： weizhong yang Zhongjie Li Ting yang Yanming Li Zhengde Xie Luzhao Feng Zhibin Peng Jue Liu School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Respiratory Health and Multimorbidity BeijingChina Key Laboratory of Pathogen Infection Prevention and Control Peking Union Medical CollegeMinistry of EducationBeijingChina National Center for Respiratory Diseases State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Pulmonary and Critical Care MedicineCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijingChina Department of Pulmonary and Critical Care Medicine National Center of GerontologyBeijing HospitalInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016National Key Discipline of Pediatrics(Capital Medical University)Beijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Chinese Center for Disease Control and Prevention BeijingChina Department of Epidemiology and Biostatistics School of PublicHealthKey Laboratory of Epidemiology of Major DiseasesMinistry of EducationPeking University Health Science Center-Weifang Joint Research Center for Maternal and Child HealthPeking UniversityBeijingChina

The global burden of respiratory diseases is a significant and increasing threat to individuals worldwide.In 2017,there were 544.9 million cases of chronic respiratory diseases,a 39.8%increase since 1990(1).These diseases were the third leading cause of global mortality in 2017,accounting for 7.0%of all deaths,an 18.0%increase compared to 1990.

关键词： diseases respiratory mortality

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City-Specific Effects of Lifting Mobility Restrictions—China, February–March 2020

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China CDC weekly 2022年第31期4卷 673-679页

作者： Shasha Han Libing Ma Ting Zhang Luzhao Feng weizhong yang Xiaoying Zheng Beijing International Center for Mathematical Research Peking UniversityBeijingChina School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of Respiratory and Critical Care Medicine the Affiliated Hospital of Guilin Medical UniversityGuilin CityGuangxi Zhuang Autonomous RegionChina

Summary What is already known about this topic?Government used mobility restrictions to help contain the first wave of coronavirus disease 2019(COVID-19)across cities in China.The restrictions were lifted during times of non-zero incidence in response to a return to work order that went into effect on February 10,2020.What is added by this report?The effect of lifting mobility restrictions on COVID-19 death rate and incidence varied by city,with smaller increases or even reductions in cities with low community connectivity and small floating volume,and larger increases in cities with high community connectivity and large floating volume.Effects on recovery rates were similar across cities.What are the implications for public health practice?City-specific mobility restriction lifting is likely to be beneficial.Two indexes,community connectivity and floating volume,can inform the design of city-specific mobility restriction lifting policies.

关键词： lifting floating China.

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Reconfigurable and orthogonal stiffness-structure patterning of dynamically crosslinked amphigels

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SmartMat 2024年第2期5卷 145-155页

作者： Chen yang weizhong Zheng Chujun Ni Ye Li Di Chen Tao Xie Qian Zhao State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhouChina Ningbo Innovation Center Zhejiang UniversityNingboChina School of Chemical Engineering East China University of Science and TechnologyShanghaiChina

Patterning diversified properties and surface structure of polymer materials are of great importance toward their potential in biology,optics,and electronics.However,achieving both the patternability of stiffness and microstructure in a reconfigurable manner remains challenging.Here,we prepare amphigels crosslinked by dynamic disulfide bonds,which can be reversibly swollen by immiscible water or liquid paraffin.In the paraffingel form,the materials exhibited a high modulus of 130 MPa due to densified hydrogen bonds.Whereas swollen by water,the modulus fell over two orders of magnitude owing to the destruction of the hydrogen bonds.Via regionalized swelling of the solvents,well-controlled and rewritable soft/stiff mechanical patterns can be created.On the other hand,the dynamic exchange of the disulfide crosslinking enables mechanophoto patterning to fabricate sophisticated macrogeometries and microstructures.The reconfigurable stiffness-structure patterning can be manipulated orthogonally,which will create more application opportunities beyond conventional hydrogels and organogels.

关键词： amphigels dynamic crosslinking hydrogels organogels surface patterning

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Space truss construction modeling based on on-orbit assembly motion feature

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Chinese Journal of Aeronautics 2024年第3期37卷 365-379页

作者： Changjie ZHAO weizhong GUO Meng CHEN Jiaxing HU Youcheng HAN Rongfu LIN State Key Lab of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Institute of Aerospace System Engineering Shanghai Shanghai 201109China

More space truss construction has been planned to develop and utilize space resources.These trusses are designed in the way of large-scale,complex,modular,and on-orbit assembly.To meet the upcoming challenge of large-scale space infrastructure construction,it is necessary to study space truss automation design and robotic construction.This paper proposes an ordinal finite screw adjacency matrix model(OFSAMM),focusing on the relationship between assembly motions,to express and compute a space truss structure.In this model,a space truss is abstracted as a set of ordered assembly motions,each of which is recorded as a finite screw as the basic element of the truss and its assembly.The operation of truss transformation is also derived under this model.Therefore,the truss configuration,the assembly sequence,the truss sub-assembly,the truss components,and the on-orbit assembly task can be expressed and calculated in a unified model,which is calculated and stores the truss topology and assembly with the minimum storage cost.At the end of this paper,we introduce how to synthesize and optimize space truss design through two cases.The study will help to improve design efficiency.Furthermore,it provides a theoretical basis for the automatic construction of space truss structures,especially in the next stage.

关键词： Adjacency matrix Finite screw On-orbit construction modeling Space applications Space trusses Topology design

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Redefining human health:physical wellbeing,mental wellbeing,social wellbeing,and environmental wellbeing

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Chinese Medical Journal 2023年第20期136卷 2395-2396页

作者： Chen Wang Simiao Chen Ruitai Shao weizhong yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China National Clinical Research Center for Respiratory Diseases Beijing 100029China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina–Japan Friendship HospitalBeijing 100029China State Key Laboratory of Respiratory Health and Multimorbidity Beijing 100730China Heidelberg Institute of Global Health(HIGH) Faculty of Medicine and University HospitalHeidelberg UniversityHeidelberg 69120Germany

In 1948,the World Health Organization(WHO)identified three dimensions of human health—physical wellbeing,mental wellbeing,and social wellbeing.^([1])Physical wellbeing is distinguished by the absence of disease as well as the active pursuit of fitness,while mental wellbeing is distinguished by a lack of depressive symptoms and the presence of calm and happy mental states.The notion of social wellbeing arose following World War II and emerged from a belief that good health not only entailed wellness of the body and mind but also required a society in which sexism,chauvinism,and extremism ceased to exist.This concept recognized individual responsibility for living in peace and contributing to the welfare of others.The definition of health as a composite of these three facets—physical wellbeing,mental wellbeing,and social wellbeing—has been adopted since then.

关键词： sexism being peace

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Association between influenza vaccination and SARS-CoV-2 infection and its outcomes: systematic review and meta-analysis

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Chinese Medical Journal 2022年第19期135卷 2282-2293页

作者： Binshan Jiang Qiangru Huang Mengmeng Jia Xinai Xue Qing Wang weizhong yang Luzhao Feng School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBejing 100730China Department of Medical Records Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China.

Background:World Health Organization recommends that influenza vaccines should benefit as much of the population as possible,especially where resources are limited.Corona virus disease 2019(COVID-19)has become one of the greatest threats to health systems worldwide.The present study aimed to extend the evidence of the association between influenza vaccination and COVID-19 to promote the former.Methods:In this systematic review,four electronic databases,including the Cochrane Library,PubMed,Embase,and Web of Science,were searched for related studies published up to May 2022.All odds ratios(ORs)with 95%confidence intervals(CIs)were pooled by meta-analysis.Results:A total of 36 studies,encompassing 55,996,841 subjects,were included in this study.The meta-analysis for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection provided an OR of 0.80(95%CI:0.73–0.87).The statistically significant estimates for clinical outcomes were 0.83(95%CI:0.72–0.96)for intensive care unit admission,0.69(95%CI:0.57–0.84)for ventilator support,and 0.69(95%CI:0.52–0.93)for fatal infection,while no effect seen in hospitalization with an OR of 0.87(95%CI:0.68–1.10).Conclusion:Influenza vaccination helps limit SARS-CoV-2 infection and severe outcomes,but further studies are needed.Registration:PROSPERO,CRD42022333747.

关键词： Influenza vaccine COVID-19 Infection Outcomes Prevention

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Decreased influenza vaccination coverage among Chinese healthcare workers during the COVID-19 pandemic

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Infectious Diseases of Poverty 2022年第5期11卷 63-73页

作者： Libing Ma Xuan Han Yuan Ma Yuan yang Yunshao Xu Di Liu weizhong yang Luzhao Feng School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Respiratory and Critical Care Medicine The Afliated Hospital of Guilin Medical UniversityGuilinGuangxi 541001China “Breath Circles”Network Platform BeijingChina.

Background:Healthcare workers(HCWs)were the priority group for influenza vaccination,in China during the 2020/2021 and 2021/2022 influenza seasons.However,vaccination rates in HCWs have always been low.This study investigated influenza vaccination status among Chinese HCWs and analyzed the factors driving vaccination.Methods:We provided electronic questionnaires to HCWs from January 27,2022 to February 21,2022,using the WeChat platform"Breath Circles".HCWs who received the link could also forward it to their colleagues.Binary logistic regression models were used to analyze vaccination-associated factors among HCWs.Results:Among the 1697 HCWs surveyed,vaccination coverage was 43.7%(741/1697)during the 2020/2021 influenza season,and 35.4%(600/1697)during the 2021/2022 influenza season,as of February 21,2022.Additionally,22.7%(385/1697)and 22.1%(358/1697)of HCWs reported that their workplaces implemented a free vaccination policy for all employees during the 2020/2021 and 2021/2022 influenza seasons.HCWs who were required to be vaccinated according to hospital regulations,and whose hospitals implemented the free influenza vaccine policy were more likely to be vaccinated(2020/2021 and 2021/2022;P<0.05).In addition,the economic level of the HCWs'province(2021/2022,P<0.05)and the HCWs’knowledge about vaccination and willingness to get vaccinated,such as active learning about vaccines(2020/2021,P<0.05),supportive attitude toward vaccination for all HCWs(2020/2021 and 2021/2022;P<0.05),also had an impact on vaccine coverage.Conclusions:A free influenza vaccination policy and workplace required vaccination are effective in improving influenza vaccination coverage among HCWs.Influenza vaccination coverage of Chinese HCWs remained low and showed a downward trend after the COVID-19 outbreak.Further effective measures,such as advocacy campaigns,free vaccine policies,and on-site vaccination could be implemented to improve influenza vaccination coverage.

关键词： Influenza Healthcare worker Vaccination Coverage Internet-based survey China

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Identification and global characterization of eccDNA reveals hallmarks in iron nanoparticles-treated breast cancer cells

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Genes & Diseases 2024年第2期11卷 532-534页

作者： Wenxiang Lu Ying Wang Tao Luo Fuyu Li Yali Jiang Jinke Wang weizhong Zhang Yunfei Bai State Key Lab of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China The Friendship Hospital of Ili Kazakh Autonomous Prefecture Ili & Jiangsu Joint Institute of HealthYiningXinjiang 835000China Department of Ophthalmology First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

The biogenesis and functions of extrachromosomal circular DNA(eccDNA)have been studied for several decades.However,the heterogeneity of eccDNA is largely ignored.In this study,we purified and sequenced eccDNA and RNA using a method that simultaneously extracts DNA and RNA from cultured cells treated with iron nanoparticles.We discovered that the characteristics of eccDNA are altered by iron stress,particularly on genic and CpG islands regions,suggesting a biogenesis mechanism induced by transcription.

关键词： breast nanoparticles characterization

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Quantitative Analysis of the Effectiveness of Antigen-and Polymerase Chain Reaction-Based Combination Strategies for Containing COVID-19 Transmission in a Simulated Community

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Engineering 2023年第9期28卷 234-242页

作者： Qiangru Huang Yanxia Sun Mengmeng Jia Ting Zhang Fangyuan Chen Mingyue Jiang Qing Wang Luzhao Feng weizhong yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China School of Arts and Sciences Beijing Institute of Fashion TechnologyBeijing 100105China

The number of coronavirus disease 2019(COVID-19)cases continues to surge,overwhelming healthcare systems and causing excess mortality in many countries.Testing of infectious populations remains a key strategy to contain the COVID-19 outbreak,delay the exponential spread of the disease,and flatten the epidemic curve.Using the Omicron variant outbreak as a background,this study aimed to evaluate the effectiveness of testing strategies with different test combinations and frequencies,analyze the factors associated with testing effectiveness,and optimize testing strategies based on these influencing factors.We developed a stochastic,agent-based,discrete-time susceptible–latent–infectious–recovered model simulating a community to estimate the association between three levels of testing strategies and COVID-19 transmission.Antigen testing and its combination strategies were more efficient than polymerase chain reaction(PCR)-related strategies.Antigen testing also showed better performance in reducing the demand for hospital beds and intensive care unit beds.The delay in the turnaround time of test results had a more significant impact on the efficiency of the testing strategy compared to the detection limit of viral load and detection-related contacts.The main advantage of antigen testing strategies is the short turnaround time,which is also a critical factor to be optimized to improve PCR strategies.After modifying the turnaround time,the strategies with less frequent testing were comparable to daily testing.The choice of testing strategy requires consideration of containment goals,test efficacy,community prevalence,and economic factors.This study provides evidence for the selection and optimization of testing strategies in the post-pandemic era and provides guidance for optimizing healthcare resources.

关键词： COVID-19 Antigen testing PCR testing Testing strategies

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Strengthening population medicine to promote public health

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Chinese Medical Journal 2022年第10期135卷 1135-1137页

作者： Chen Wang Simiao Chen Guangliang Shan Zhiwei Leng Till Bärnighausen weizhong yang Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730China National Clinical Research Center for Respiratory Diseases Beijing 100029China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina–Japan Friendship HospitalBeijing 100029China School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Heidelberg Institute of Global Health(HIGH) Faculty of Medicine and University HospitalHeidelberg UniversityHeidelbergGermany Department of Epidemiology and Statistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences&School of Basic MedicinePeking Union Medical CollegeBeijing 100005China Department of Global Health and Population Harvard T.H.Chan School of Public HealthBostonMAUSA

As we enter.2022,we are facedwith the fact that coronavirus disease2019(CovID-19)has been devastating the world formore than 2full years.Since the original outbreak of COVID-19in December2019,the disease has proved to be a major threat to global health and,perhaps more importantly,one that is not likely to be resolved soon.Severe_acute respiratory syndrome coronavirus.

关键词： acute respiratory likely

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