检索结果-南通市图书馆

DNA-nanostructure-templated precise biomineralization

在线全文

学校读者我要写书评

暂无评论

National Science Review 2018年第6期5卷 789-791页

作者： Liping Qiu Hui Liu Jianhui Jiang weihong tan Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Bio-sensing and Chemometrics College of Chemistry and Chemical Engineering and College of Biology Institute of Molecular Medicine Renji HospitalSchool of Medicine and College of Chemistry and Chemical Engineering Shanghai Jiao Tong University

As the best designer in material science,nature has developed unique strategies for synthesizing various ingenious materials with highly controlled structural features and outstanding biophysical properties to fit dif... 详细信息

关键词： DNA-nanostructure-templated precise biomineralization flexible

Bioconjugated Silica Nanoparticles: Development and Applications

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2008年第2期1卷 99-115页

作者： Lin Wang Wenjun Zhao weihong tan Lilly Research Laboratories Eli Lilly and CompanyIndianapolisIN 46285USA Chinese Academy of Inspection and Quarantine Huixinli 241Chaoyang DistrictBeijing 100029China Center for Research at the Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional GenomicsShands Cancer CenterUF Genetics Institute and McKnight Brain InstituteUniversity of FloridaGainesvilleFL 32611-7200USA

Advanced bioanalysis,including accurate quantitation,has driven the need to understand biology and medicine at the molecular *** silica nanoparticles have the potential to address this emerging *** intriguing diagnostic and therapeutic applications in cancer and infectious disease as well as uses in gene and drug delivery,have also been found for silica *** this review,we describe the synthesis,bioconjugation,and applications of silica nanoparticles in different bioanalysis formats,such as selective tagging,barcoding,and separation of a wide range of biomedically important ***,we envisage that further development of these nanoparticles will provide a variety of advanced tools for molecular biology,genomics,proteomics and medicine.

关键词： Nanoscience nanotechnology silica nanoparticles bioanalysis biomedicine

Nanocarrier based on the assembly of protein and antisense oligonucleotide to combat multidrug resistance in tumor cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2017年第10期60卷 1318-1323页

作者： Xuan Yu Liang Gong Jing Zhang Zilong Zhao Xiaobing Zhang weihong tan Molecular Science and Biomedicine Laboratory State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering College of Life Sciences and Aptamer Engineering Center of Hunan Province Hunan University Changsha 410082 China

Chemotherapy-induced multi-drug resistance(MDR) in tumors poses a huge challenge for clinical treatment of tumors. The downregulation of the multi-drug resistance relative protein, represented by P-glycoprotein(P-gp), can reverse MDR of cancer cells. In this study, we developed doxorubicin-loading nanocarrier based on the assembly of protein and antisense oligonucleotide(ASO) to combat MDR of cancer cells. The data demonstrate that the nanocarrier can efficiently deliver ASO to cytoplasm and downregulate the P-glycoprotein expression, subsequently improving the therapeutic effects of Dox in doxorubicin-resistant MCF-7/ADR cancer cells. The preparation is simple and effective, providing a powerful tool for gene delivery. Therefore, our nanocarrier shows high promise in cancer treatment.

关键词： multi-drug resistance P-glycoprotein antisense oligonucleotide nanocarrier

Self-assembled amphiphilic NIR-Ⅱ emissive nano-micelles for imaging-guided photothermal therapy of colorectal cancer

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第8期67卷 2767-2774页

作者： Axin He Fangfang Xia Da Han Qinglai Yang weihong tan Institute of Molecular Medicine(IMM) Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200240China Center for Molecular Imaging Probe Hunan Province Key Laboratory of Cancer Cellular and Molecular PathologyCancer Research InstituteHengyang Medical SchoolUniversity of South ChinaHengyang 421001China The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer Hospital Hangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082China

Colorectal cancer(CRC) is one of the major causes of cancer-related mortality worldwide. Most near-infrared(NIR) agents used in clinical CRC treatment are at NIR-I(700–900 nm) window, which has limitations on deep tissue, and fluorescent probes in the second NIR(1,000–1,700 nm) allow high-resolution bioimaging with deep tissue penetration. However, existing NIR-II fluorophores used in clinical are still rare. Herein, based on shielding-donor-acceptor-donor-shielding(S-D-A-D-S) scaffold, we developed an organic small-molecule fluorophore IR-BTGP with NIR-II emission for imaging-guided photothermal therapy(PTT) in CRC mice model. Amphiphilic IR-BTGP can be self-assembled into spherical nano-micelles, which presents reliable water solubility and photothermal conversion efficiency(30.2%). In vitro experiments indicate that cancer cells treated with IRBTGP were significantly killed upon 808 nm light irradiation. Furthermore, in vivo NIR-II fluorescence imaging confirms that IR-BTGP accumulates in the tumor region. Remarkably, a significant tumor inhibition rate(78.5%) was observed in tumorbearing mice when treated with IR-BTGP plus 808 nm irradiation. Therefore, this work shows that IR-BTGP holds great promise as an NIR-II fluorescence imaging-guided PTT platform for CRC in the future.

关键词： photothermal therapy(PTT) second near-infrared(NIR-Ⅱ)imaging organic molecule

New Researches of State Key Laboratories in Analytical Chemistry

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2016年第7期59卷 781-782页

作者： Huangxian Ju weihong tan Lehui Lu Maili Liu state key laboratory of analytical chemistry for life science the university of michigan in the us the changchun institute of applied chemistry chinese academy of sciences (ciaccas) the changchun institute of applied chemistry chinese academy of sciences (ciaccas)the state key laboratory of electroanalytical chemistry the state key laboratory of magnetic resonance and atomic and molecular physics

In the past two decades,as the eyes of fundamental scientific research and social activities relative to human security and health,analytical chemistry has made great progress in both analytical methodologies and detection instruments by integrating multidisciplinary research *** State Key Laboratories were successively established in this rapidly developing *** order to publish some of the excellent results together,we have organized this special topic with 10 Articles and Reviews from these State Key Laboratories.

关键词：国家重点实验室分析化学社会活动基础科学检测仪器安全性科研

Mechanism of Preparation of Platform Compounds from Lignocellulosic Biomass Liquefaction Catalyzed by Bronsted Acid: A Review

在线全文

学校读者我要写书评

暂无评论

Journal of Bioresources and Bioproducts 2019年第4期4卷 202-213页

作者： Kang GUO Qiyuan GUAN Junming XU weihong tan Institute of Chemical Industry of Forest Products Chinese Academy of ForestryNational Engineering Lab for Biomass Chemical UtilizationKey and Open Lab of Forest Chemical EngineeringState Forestry AdministrationKey Lab of Biomass Energy and MaterialJiangsu ProvinceNanjing 210042China

Over the past two decades, research on transforming lignocellulosic biomass into small molecule chemicals byusing catalytic liquefaction has made great progress. Notably, in recent years it has been found the production of smallmolecule chemicals through directional liquefaction of lignocellulosic biomass. Understanding the liquefactionmechanism of lignocellulosic biomass is highly important. In this review, the liquefaction mechanism of lignocellulosicbiomass and model compounds of cellulose are described, and some problems and suggestions to address them aredescribed.

关键词： lignocellulosic biomass liquefaction product platform chemical bronsted acid liquefaction mechanism

Cell-SELEX-based aptamer-conjugated nanomaterials for cancer diagnosis and therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2015年第1期2卷 71-84页

作者： Hong-Min Meng Ting Fu Xiao-Bing Zhang weihong tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyCollaborative Innovation Center for Molecular Engineering for TheranosticsHunan University

Nucleic acid aptamers, which are generated by a novel technique called SELEX(systematic evolution of ligands by exponential enrichment), have recently atracted signiicant atention in the ield of early detection and treatment of cancer based on their numerous merits, such as high ainity, high speciicity,small size, litle immunogenicity, stable structures, and ease of chemical modiication. Furthermore,aptamers can gain more lexibility as cancer cell targeting tools when conjugated to nanomaterials,including metallic nanoparticles, carbon nanomaterials, DNA nanodevices, and polymeric *** discuss the progress achieved in cancer diagnosis and therapy through the conjugation of cell-SELEX-based aptamers with diferent nanomaterials.

关键词： aptamer cell-SELEX nanomaterial cancer cells cancer diagnosis and therapy

Construction of nanocarriers based on nucleic acids and their applications in nanobiology delivery systems

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2022年第5期9卷 181-195页

作者： Yingshu Guo Xiuping Cao Xiaofei Zheng Sk Jahir Abbas Juan Li weihong tan Shandong Provincial Key Laboratory of Molecular Engineering School of Chemistry and Chemical EngineeringQilu University of Technology (Shandong Academy of Sciences) School of Chemistry and Chemical Engineering Linyi University Institute of Molecular Medicine State Key Laboratory of Oncogenes and Related Genes Renji Hospital Shanghai Jiao Tong University School of MedicineCollege of Chemistry and Chemical Engineering Shanghai Jiao Tong University Institute of Cancer and Basic Medicine Chinese Academy of Sciences The Cancer Hospital of the University of Chinese Academy of Sciences

In recent years,nanocarriers based on nucleic acids have emerged as powerful and novel nanocarriers that are able to meet the demand for cancer-cell-specific *** dynamics analysis revealed good bio compatibility,low toxicity and programmable structures,and their advantages include controllable size and *** development of novel hybrids has focused on the distinct roles of biosensing,drug and gene delivery,vaccine transport,photosensitization,counteracting drug resistance and functioning as carriers and logic *** review is divided into three parts:(ⅰ) DNA nanocarriers,(ⅱ) RNA nanocarriers and(ⅲ) DNA/RNA hybrid nanocarriers and their applications in nanobiology delivery *** also provide perspectives on possible future directions for growth in this field.

关键词： nanocarriers based on nucleic acids biosensing targeted delivery cell

Single-molecule DNA logic nanomachines based on origami

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2019年第4期62卷 407-408页

作者： Yunyi Liu Xiaoxiao Hu Ting Fu Ruowen Wang weihong tan Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Biosensing and Chemometrics College of BiologyCollege of Chemistry and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan University Institute of Molecular Medicine (IMM) Renji Hospital Shanghai Jiao Tong University School of Medicine and College of Chemistry and Chemical Engineering Shanghai Jiao Tong University Department of Chemistry and Department of Physiology and Functional Genomics Center for Research at the Bio/Nano Interface Health Cancer Center UF Genetics Institute McKnight Brain Institute University of Florida

Nowadays,it is a truism that chemists,bioengineers and others must be schooled in cell and molecular biology,including knowledge of the cellular,elemental and molecular building blocks of living *** by exquisite and efficient biomolecular machines in living cells,such as ATPases that catalyze the decomposition of ATP into ADP and free phosphate ion,researchers representing multiple disciplines are actively engaged in developing artificial nanostructures with well-defined geometry and nanoscale addressability.A successful outcome of these studies could lead to the development and clinical application of smart molecular machines for the drug delivery of theranostics in vivo.

关键词： Single-molecule DNA logic nanomachines origami