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Machine learning-based comparison of factors influencing estimated glomerular filtration rate in Chinese women with or without nonalcoholic fatty liver

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World Journal of Clinical Cases 2024年第15期12卷 2506-2521页

作者： I-chien Chen Lin-Ju Chou Shih-Chen Huang Ta-wei Chu Shang-Sen Lee Department of Nursing Kaohsiung Armed Forces General HospitalKaohsiung 802Taiwan Department of Obstetrics and Gynecology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Chief Executive Officer's Office MJ Health Research FoundationTaipei 114Taiwan Department of Urology Taichung Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTaichung 427Taiwan School of Medicine Tzu Chi UniversityHualian 970Taiwan Department of Urology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND The prevalence of non-alcoholic fatty liver(NAFLD)has increased *** with NAFLD are known to have higher chance for renal function *** past studies used traditional multiple linear regression(MLR)to identify risk factors for decreased estimated glomerular filtration rate(eGFR).However,medical research is increasingly relying on emerging machine learning(Mach-L)*** present study enrolled healthy women to identify factors affecting eGFR in subjects with and without NAFLD(NAFLD+,NAFLD-)and to rank their *** To uses three different Mach-L methods to identify key impact factors for eGFR in healthy women with and without *** A total of 65535 healthy female study participants were enrolled from the Taiwan MJ cohort,accounting for 32 independent variables including demographic,biochemistry and lifestyle parameters(independent variables),while eGFR was used as the dependent *** from MLR,three Mach-L methods were applied,including stochastic gradient boosting,eXtreme gradient boosting and elastic *** of estimation were used to define method accuracy,where smaller degree of error indicated better model *** Income,albumin,eGFR,High density lipoprotein-Cholesterol,phosphorus,forced expiratory volume in one second(FEV1),and sleep time were all lower in the NAFLD+group,while other factors were all significantly higher except for smoking ***-L had lower estimation errors,thus outperforming *** Model 1,age,uric acid(UA),FEV1,plasma calcium level(Ca),plasma albumin level(Alb)and T-bilirubin were the most important factors in the NAFLD+group,as opposed to age,UA,FEV1,Alb,lactic dehydrogenase(LDH)and Ca for the *** the importance percentage was much higher than the 2nd important factor,we built Model 2 by removing *** The eGFR were lower in the NAFLD+group compared to the NAFLD-group,with age being was the most important impact factor in both groups of he

关键词： Non-alcoholic fatty liver Estimated glomerular filtration rate Machine learning Chinese women

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Preservation of superior rectal artery in laparoscopically assisted subtotal colectomy with ileorectal anastomosis for slow transit constipation

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World Journal of Gastroenterology 2021年第22期27卷 3121-3129页

作者： chien-wei Wu Ta-wei Pu Jung-Cheng Kang Cheng-Wen Hsiao Chao-Yang Chen Je-Ming Hu Kuan-Hsun Lin Tzu-Chiao Lin Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Colon and Rectal Surgery Department of SurgerySongshan BranchTri-Service General HospitalNational Defense Medical CenterTaipei 10581Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 10556Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Colorectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan

BACKGROUND Slow transit constipation(STC)has traditionally been considered as a functional ***,evidence is accumulating that suggests that most of the motility alterations in STC might be of a neuropathic *** the patient does not meet the diagnosis of pelvic outlet obstruction and poorly response to conservative treatment,surgical intervention with subtotal colectomy may be *** most unwanted complication of the procedure is anastomotic leakage,however,preservation of the superior rectal artery(SRA)may reduce its *** To evaluate the preservation of the SRA in laparoscopically assisted subtotal colectomy with ileorectal anastomosis in STC *** This was a single-center retrospective observational *** was diagnosed after a series of examinations which included a colonic transit test,anal manometry,a balloon expulsion test,and a barium *** patients underwent laparoscopically assisted total colectomy with ileorectal anastomosis and were examined between January 2016 and January *** operation time,blood loss,time to first flatus,length of hospital days,and incidence of minor or major complications were *** A total of 32 patients(mean age,42.6 years)who had received laparoscopic assisted subtotal colectomy with ileorectal artery anastomosis and preservation of the *** patients were diagnosed with STC after a series of *** mean operative time was 151 min and the mean blood loss was 119 *** mean day of first time to flatus was 3.0 d,and the mean hospital stay was 10.6 *** were no any patients conversions to ***-operative minor complications including 1 wound infection and 1 case of *** was no surgical *** anastomosis leakage was noted in any of the *** Laparoscopically assisted subtotal colectomy with ileorectal anastomosis and preservation of the SRA can significantly improve bowel function with careful patient selection

关键词： Slow transit constipation Superior rectal artery Anastomosis leakage Laparoscopic-assisted colorectal surgery Iliorectal anastomosis Colonic transit time

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Nanoscale plasma-activated aerosol generation for in situ surface pathogen disinfection

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Microsystems & Nanoengineering 2022年第2期8卷 161-173页

作者： Nicholas S.L.Chew Kiing S.Wong wei S.Chang chien W.Ooi Leslie Y.Yeo Ming K.Tan Mechanical Engineering Discipline School of EngineeringMonash University MalaysiaBandar SunwaySelangorMalaysia Chemical Engineering Discipline School of EngineeringMonash University MalaysiaBandar SunwaySelangorMalaysia Micro/Nanophysics Research Laboratory RMIT UniversityMelbourneVICAustralia

Plasma treatment constitutes an efficient method for chemical-free disinfection.A spray-based system for dispensing plasma-activated aerosols onto surfaces would facilitate disinfection of complex and/or hidden surfaces inaccessible to direct line-of-sight(for example,UV)*** complexity and size of current plasma generators(for example,plasma jet and cometary plasma systems)-which prohibit portable operation,together with the short plasma lifetimes,necessitate a miniaturized in situ technique in which a source can be simultaneously activated and administered on-demand onto ***,we demonstrate this possibility by combining two nanoscale technologies for plasma and aerosol generation into an integrated device that is sufficiently small and *** is generated on a carpet of zinc oxide nanorods comprising a nanoneedle ensemble,which when raised to a high electric potential,constitutes a massive point charge array with near-singular electric fields to effect atmospheric *** plasma is then used to activate water transported through an underlying capillary wick,that is subsequently aerosolized under MHz-order surface acoustic *** show that the system,besides being amenable to miniaturization and hence integration into a chipscale device,leads to a considerable improvement in plasma-activation over its macroscale cometary discharge predecessor,with up to 20%and 127%higher hydrogen peroxide and nitrite ion concentrations that are respectively generated in the plasma-activated ***,in turn,leads to a 67%reduction in the disinfection time to achieve 95%bacterial load reduction,therefore demonstrating the potential of the technology as an efficient portable platform for on-demand field-use surface disinfection.

关键词： surface portable aerosol

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Association between the elderly frequent attender to the emergency department and 30-day mortality： A retrospective study over 10 years

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World Journal of Emergency Medicine 2018年第1期9卷 20-25页

作者： Yuzeng Shen Yee chien Tay Edward Wee Kwan Too Nan Liu Shao wei Lam Marcus Eng Hock Ong Department of Emergency Medicine Singapore General Hospital Singapore Department of Emergency Medicine Sengkang Health Singapore Business Analytics Program National University of Singapore Singapore Singhealth Health Selvices Research Centre Singapore

BACKGROUND: To determine if elderly frequent attenders are associated with increased 30-day mortality, assess resource utilization by the elderly frequent attenders and identify associated characteristics that contribute to mortality. METHODS: Retrospective observational study of electronic clinical records of all emergency department(ED) visits over a 10-year period to an urban tertiary general hospital in Singapore. Patients aged 65 years and older, with 3 or more visits within a calendar year were identified. Outcomes measured include 30-day mortality, admission rate, admission diagnosis and duration spent at ED. Chi-square-tests were used to assess categorical factors and Student t-test was used to assess continuous variables on their association with being a frequent attender. Univariate and multivariate logistic regressions were conducted on all significant independent factors on to the outcome variable(30-day mortality), to determine factor independent odds ratios of being a frequent ***: 1.381 million attendance records were analyzed. Elderly patients accounted for 25.5% of all attendances, of which 31.3% are frequent attenders. Their 30-day mortality rate increased from 4.0% in the first visit, to 8.8% in the third visit, peaking at 10.2% in the sixth visit. Factors associated with mortality include patients with neoplasms, ambulance utilization, male gender and having attended the ED the previous ***: Elderly attenders have a higher 30-day mortality risk compared to the overall ED population, with mortality risk more marked for frequent attenders. This study illustrates the importance and need for interventions to address frequent ED visits by the elderly, especially in an aging society.

关键词： Frequent attenders Elderly Emergency department Mortality

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Fecal calprotectin correlated with endoscopic remission for Asian inflammatory bowel disease patients

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World Journal of Gastroenterology 2015年第48期21卷 13566-13573页

作者： wei-Chen Lin Jau-Min Wong chien-Chih Tung Ching-Pin Lin Jen-wei Chou Horng-Yuan Wang Ming-Jium Shieh Chin-Hao Chang Heng-Hsiu Liu Shu-Chen wei Division of Gastroenterology Department of internal MedicineMackay Memorial Hospital Departments of Internal Medicine National Taiwan University Hospital Integrated Diagnostics and Therapeutics National Taiwan University Hospital Division of Gastroenterology Department of internal MedicineChung Shan Medical University Hospital Division of Gastroenterology Department of internal MedicineChina Medical University Hospital Medical Research National Taiwan University Hospital Institute of Epidemiology and Preventive Medicine College of Public HealthNational Taiwan University

AIM: To evaluate the correlation between fecal calprotectin(f C), C-reactive protein(CRP), and endoscopic disease score in Asian inflammatory bowel disease(IBD) ***: Stool samples were collected and assessed for calprotectin levels by Quantum Blue Calprotectin High Range Rapid test. Crohn's disease endoscopic index of severity(CDEIS) and ulcerative colitis endoscopic index of severity(UCEIS) were used for endoscopic lesion scoring. RESULTS: A total of 88 IBD patients [36 patients with Crohn's disease(CD) and 52 with ulcerative colitis(UC)] were enrolled. For CD patients, f C correlated with CDEIS(r = 0.465, P = 0.005) and CRP(r = 0.528, P = 0.001). f C levels in UC patients correlated with UCEIS(r = 0.696, P < 0.0001) and CRP(r = 0.529, P = 0.0005). Calprotectin could predict endoscopic remission(CDEIS < 6) with 50% sensitivity and 100% specificity(AUC: 0.74) in CD patients when using 918 μg/g as the cutoff. When using 191 μg/g as the cut-off in UC patients, calprotectin could be used for predicting endoscopic remission(UCEIS < 3) with 88% sensitivity and 75% specificity(AUC: 0.87). CONCLUSION: f C correlated with both CDEIS and UCEIS. f C could be used as a predictor of endoscopic remission for Asian IBD patients.

关键词： Inflammatory bowel disease Endoscopicscore Fecal calprotectin Crohn's disease Ulcerativecolitis

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Treatment of a rotator cuff tear combined with iatrogenic glenoid fracture and shoulder instability:A rare case report

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World Journal of Orthopedics 2020年第11期11卷 516-522页

作者： Chen-Hao Chiang Ting-chien Tsai Kuan-Kai Tung wei-Hsing Chih Ming-Long Yeh wei-Ren Su Department of Biomedical Engineering National Cheng Kung UniversityTainan 70428Taiwan Department of Orthopaedic Surgery Ditmanson Medical Foundation Chia-Yi Christian HospitalChia-Yi 60002Taiwan Department of Orthopaedic Surgery Taichung Veterans General HospitalTaichung 40705Taiwan Department of Orthopaedic Surgery National Cheng Kung University HospitalTainan 70428Taiwan

BACKGROUND The brisement manipulation is an effective treatment for refractory shoulder *** cuff tears can sometimes exist in combination with adhesive *** capsular release combined with rotator cuff repair has achieved good outcomes in published *** SUMMARY We report the case of a patient with right shoulder pain for more than 1 year that was suspected to have adhesive capsulitis and a rotator cuff tear that was treated with brisement manipulation and arthroscopic *** iatrogenic glenoid fracture with shoulder instability occurred during the *** treatment for fracture fixation,capsular release,and rotator cuff repair was performed,and the functional results are *** Arthroscopic fixation for iatrogenic glenoid fracture and repairing coexisting rotator cuff tear can provide the stability needed for early rehabilitation.

关键词： Frozen shoulder Bursitis Arthroscopy Fracture Glenoid fracture Manipulation Iatrogenic Case report

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Pediatric gastric cancer presenting with massive ascites

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World Journal of Gastroenterology 2015年第11期21卷 3409-3413页

作者： chien-Heng Lin wei-Ching Lin I-Hsiu Lai Shu-Fen Wu Kang-Hsi Wu An-Chyi Chen Department of Pediatrics Children’s HospitalChina Medical University Hospital College of Medicine School of MedicineChina Medical University Department of Radiology China Medical University Hospital College of Chinese Medicine School of Chinese MedicineChina Medical University

Gastric adenocarcinoma is quite rare in children and as a result very little experience has been reported on with regards to clinical presentation,treatment and *** describe the case of a 16-year-old boy presenting with abdominal fullness and poor appetite for 7 *** showed massive ascites and computed tomography imaging revealed the presence of gastric mucosa thickness with omentum *** diagnosis of gastric adenocarcinoma was biopsyproven *** gastric adenocarcinoma being quite rare in the pediatric patient population,we should not overlook the possibility of gastric adenocarcinoma when a child presents with distended abdomen and massive ascites.

关键词： Gastric adenocarcinoma Ascites Children

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Crystallization Behavior and Tensile Property of Poly(trimethyleneterephthalate)/Styrene-Ethylene-Buthylene-Styrene Composites

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Journal of Wuhan University of Technology(Materials Science) 2016年第2期31卷 474-480页

作者： TSOU Chi-Hui SUEN Maw-Cherng WU Wen-Yen KAO Bo-jlyue YANG Ming-chien TSOU Chih-Yuan HUNG wei-Song Department of Materials and Textiles Oriental Institute of Technology New Taipei City Taiwan 22064 China Center for Thin FilmTechnologies and Applications Department of Materials Engineering Ming Chi University of Technology New Taipei City Taiwan 24301China R&D Center for Membrane Technology Department of Chemical Engineering Chung Yuan University Jongli Taoyuan Taiwan 32023 China Department of Creative Fashion Design Taoyuan Innovation Institute of Technology Jhongli Taiwan 32091 China Department of Fashion Design and Merchandising Shih Chien University Kaohsiung Taiwan 84550 China Department of Materials Science and Engineering National Taiwan University of Science and Technology Taipei Taiwan 10607 China

Poly（trimethyleneterephthalate）（PTT）/styrene-ethylene-buthylene-styrene（SEBS）composites were prepared by melt *** opticalmicroscopy was used to observe the spherulitic morphology and the crystalstructure of PTT and PTT/SEBS *** electron microscopy was used to determine the dispersion and the compatibility of fracture surfaces of PTT and *** curves of thermalgravimetric analysis illustrated that the thermo stability decreased with increasing SEBS *** calorimetry was used to investigate the crystallization behavior;and the result showed that the glass transition temperature of the compound increased with the SEBS *** Avramiequation described the isothermalcrystallization ***-strain curves for PTT and PTT/SEBS composites showed that the elongation at break was enhanced with increasing SEBS content.

关键词： poly(trimethyleneterephthalate)(PTT) styrene-ethylene-buthylene-styrene(SEBS) crystallization

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Continuous Symmetry Analysis of the Effects of City Infrastructures on Invariant Metrics for House Market Volatilities

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 619-638页

作者： chien-Wen Lin Jen-Cheng Wang Bo-Yan Zhong Joe-Air Jiang Ya-Fen Wu Shao-wei Leu Tzer-En Nee Department of Electrical Engineering Taiwan Ocean UniversityKeelung20224Taiwan Department of Computer Science National Taipei University of EducationTaipei10671Taiwan Department of Electronic Engineering Chang Gung UniversityTao-Yuan City33302Taiwan Department of Biomechatronics Engineering National Taiwan UniversityTaipei10617Taiwan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40447Taiwan Department of Electronic Engineering Ming Chi University of TechnologyNew Taipei City24301Taiwan Artificial Intelligence Research Center Chang Gung UniversityTao-Yuan City33302Taiwan

The invariant metrics of the effects of park size and distance to public transportation on housing value volatilities in Boston,Milwaukee,Taipei and Tokyo are *** reveal a Cobb-Douglas-like *** scaleinvariant exponents corresponding to the percentage of a green area(a)are 7.4,8.41,14.1 and 15.5 for Boston,Milwaukee,Taipei and Tokyo,respectively,while the corresponding direct distances to the nearest metro station(d)are−5,−5.88,−10 and−10,for Boston,Milwaukee,Taipei and Tokyo,*** multiphysics-based analysis provides a powerful approach for the symmetry characterization of market *** scaling exponent ratio between park area percentages and distances to metro stations is approximately 3/*** scaling exponent ratio expressed in the perceptual stimuli will remain invariant under group *** to Stevens’power law,the perception-dependent feature spaces for parks and public transportation can be described as two-and three-dimensional conceptual *** on the prolongation structure of the Schroinger equation,the SL(2,R)models are used to analyze the house-price *** with Shepard’s law,the rotational group leads to a Gaussian pattern,exhibiting an extension of the special linear group structure by embedding SO(3)■R(3)in SL(2,R).The influencing factors related to cognitive functioning exhibit substantially different scaleinvariant characteristics corresponding to the complexity of the socio-economic ***,the contour shapes of the price volatilities obtained from the group-theoretical analysis not only corroborate the impact of the housing pricing estimation in these cities but also reveal the invariant features of their housing markets are faced with the forthcoming sustainable development of big data technologies and computational urban science research.

关键词： Invariant metrics Schroinger equation group theory

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Impact of disease severity on gastric residual volume in critical patients

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World Journal of Gastroenterology 2011年第15期17卷 2007-2012页

作者： chien-wei Hsu Shu-Fen Sun David Lin Lee Shoa-Lin Lin Kam-Fai Wong Hsiu-Hua Huang Hung-Ju Li Department of Medicine School of Medicine National YangMing University Taipei Taiwan China Intensive Care Unit Department of Medicine Kaohsiung Veterans General Hospital Kaohsiung City 813 Taiwan China Department of Physical Medicine and Rehabilitation Kaohsiung Veterans General Hospital Kaohsiung City 813 Taiwan China Institute of Statistics National University of Kaohsiung Kaohsiung City 813 Taiwan China Department of Nutrition Kaohsiung Veterans General Hospital Kaohsiung City 813 Taiwan China

AIM: To investigate whether illness severity has an impact on gastric residual volume (GRV) in medical critically ill patients. METHODS: Medical intensive care unit (ICU) patients requiring nasogastric feeding were enrolled. Sequential Organ Failure Assessment (SOFA) score was assessed immediately preceding the start of the study. Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ scores were recorded on the first, fourth, seventh, and fourteenth day of the study period. GRV was measured every 4 h during enteral feeding. The relationship be-tween mean daily GRV and SOFA scores and the correlation between mean daily GRV and mean APACHE Ⅱ score of all patients were evaluated and compared. RESULTS: Of the 61 patients, 43 patients were survivors and 18 patients were non-survivors. The mean daily GRV increased as SOFA scores increased (P < 0.001, analysis of variance). Mean APACHE Ⅱ scores of all patients correlated with mean daily GRV (P = 0.011, Pearson correlation) during the study period. Patients with decreasing GRV in the first 2 d had better survival than patients without decreasing GRV (P = 0.017, log rank test). CONCLUSION: GRV is higher in more severely ill medical ICU patients. Patients with decreasing GRV had lower ICU mortality than patients without decreasing GRV.

关键词： Critical care Outcome Residual volume Severity of illness index Tube feeding

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