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Science China Chemistry 2024年第9期67卷 3050-3062页

作者： Yanxi Yang Xinru kong Xueli Ren Yandai Lin Zhe Liu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjin 300072China

It is desirable but always challenging to develop a cutting-edge tumor treatment strategy with high therapeutic efficacy,lesiontargeted precision and mild *** to traditional treatment modalities,photodynamic therapy has been widely studied since the generation of reactive oxygen species(ROS)at cancerous lesions unprecedentedly offers a convenient approach for localized tumor ***,the consumption of oxygen for ROS production in a hypoxic tumor microenvironment has dramatically limited its feasibility and ***,the engineered nanocomposites of BTO@PDA-ICGHA with photodynamic and pyroelectric performances have been fabricated and applied to the photodynamic-pyroelectric dynamic *** continuing ROS production derived from intracellular oxygen(O_(2))and water(H_(2)O)by laser irradiation contributed to the superb tumor cell apoptosis and significant tumor growth ***,this study has validated a new concept by depositing the engineered nanocomposites at the tumor just like Trojan horses,facilitating ROS release as killers and exerting the NIR-induced cell apoptosis and tumor growth inhibition with high therapeutic efficiency and expectable translational perspectives.

关键词： nanocomposites pyroelectric effect photodynamic therapy cell apoptosis tumor growth inhibition

Lactate regulates major zygotic genome activation by H3K18 lactylation in mammals

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National Science Review 2024年第2期11卷 124-134页

作者： Jingyu Li weibo Hou Qi Zhao wei Han Hongdi Cui Songling Xiao Ling Zhu Jiadan Qu Xiaoyu Liu weitao Cong Jingling Shen Yuzheng Zhao Shaorong Gao Guoning Huang Qingran kong Chongqing Key Laboratory of Human Embryo Engineering Center for Reproductive Medicine Chongqing Health Center for Women and ChildrenWomen and Children's Hospital of Chongqing Medical University Oujiang Laboratory Zhejiang Provincial Key Laboratory of Medical Genetics Key Laboratory of Laboratory MedicineMinistry of EducationSchool of Laboratory Medicine and Life Sciences Wenzhou Medical University Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University School of Pharmaceutical Science Wenzhou Medical University Institute of Life Sciences College of Life and Environmental Sciences Wenzhou University Optogenetics&Synthetic Biology Interdisciplinary Research Center State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism School of Pharmacy East China University of Science and Technology

Lactate is present at a high level in the microenvironment of mammalian preimplantation embryos in vivo and in vitro. However, its role in preimplantation development is unclear. Here, we report that lactate is highly enriched in the nuclei of early embryos when major zygotic genome activation(ZGA) occurs in humans and mice. The inhibition of its production and uptake results in developmental arrest at the 2-cell stage, major ZGA failure, and loss of lactate-derived H3K18lac, which could be rescued by the addition of Lac-Co A and recapitulated by overexpression of H3K18R mutation. By profiling the landscape of H3K18lac during mouse preimplantation development, we show that H3K18lac is enriched on the promoter regions of most major ZGA genes and correlates with their expressions. In humans, H3K18lac is also enriched in ZGA markers and temporally concomitant with their expressions. Taken together, we profile the landscapes of H3K18lac in mouse and human preimplantation embryos, and demonstrate the important role for H3K18lac in major ZGA, showing that a conserved metabolic mechanism underlies preimplantation development of mammalian embryos.

关键词： mammalian preimplantation development lactate epigenetic remodeling histone lactylation zygotic genome activation

Coupling of BiOCl Ultrathin Nanosheets with Carbon Quantum Dots for Enhanced Photocatalytic Performance

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Transactions of Tianjin University 2024年第3期30卷 211-220页

作者： Pin Song Xiaoyu Fang wei Jiang Yuyang Cao Daobin Liu Shiqiang wei Jun Du Lang Sun Lei Zhao Song Liu Yuzhu Zhou Jun Di Chade Lv Bijun Tang Jiefu Yang Tingting kong Yujie Xiong Key Laboratory of Functional Molecular Solids Ministry of EducationAnhui Engineering Research Center of Carbon NeutralityCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241000China National Synchrotron Radiation Laboratory CAS Center for Excellence in NanoscienceSchool of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230029China School of Chemistry and Chemical Engineering National Special Superfi ne Powder Engineering Research CenterNanjing University of Science and TechnologyNanjing 210094China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China School of Materials Science&Engineering Nanyang Technological UniversitySingapore 639798Singapore

Over the past few decades,photocatalysis technology has received extensive attention because of its potential to mitigate or solve energy and environmental pollution *** novel materials with outstanding photocatalytic activities has become a research hotspot in this *** this study,we prepared a series of photocatalysts in which BiOCl nanosheets were modified with carbon quantum dots(CQDs)to form CQDs/BiOCl composites by using a simple solvothermal *** photocatalytic performance of the resulting CQDs/BiOCl composite photocatalysts was assessed by rhodamine B and tetracycline degradation under visible-light *** with bare BiOCl,the photocatalytic activity of the CQDs/BiOCl composites was significantly enhanced,and the 5 wt%CQDs/BiOCl composite exhibited the highest photocatalytic activity with a degradation efficiency of 94.5%after 30 min of ***,photocatalytic N_(2)reduction performance was significantly improved after introducing *** 5 wt%CQDs/BiOCl composite displayed the highest photocatalytic N_(2)reduction performance to yield NH_3(346.25μmol/(g h)),which is significantly higher than those of 3 wt%CQDs/BiOCl(256.04μmol/(g h)),7 wt%CQDs/BiOCl(254.07μmol/(g h)),and bare BiOCl(240.19μmol/(g h)).Our systematic characterizations revealed that the key role of CQDs in improving photocatalytic performance is due to their increased light harvesting capacity,remarkable electron transfer ability,and higher photocatalytic activity sites.

关键词： Carbon quantum dots BiOCl Rhodamine B Tetracycline Photocatalysis

Distinct enhancer-promoter modes determine Sox2 regulation in mouse pluripotent cells

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Genes & Diseases 2024年第1期11卷 26-29页

作者： Lei Huang Xiusheng Zhu Qing Li Dashuai kong Qitong Huang Jing Luo Siyuan kong Yanling Peng Yubo Zhang Animal Functional Genomics Group Shenzhen BranchGuangdong Laboratory for Lingnan Modern AgricultureKey Laboratory of Livestock and Poultry Multi-omics of MAPAShenzhen Agricultural Genome Research InstituteChinese Academyof Agricultural SciencesShenzhenGuangdong 518120China Animal Breeding and Genomics Wageningen University&ResearchWageningen 6708PBNetherlands College of Life Science and Engineering Foshan UniversityFoshanGuangdong 528231China School of Life Sciences Henan UniversityKaifengHenan 475004China

Sox2 is a key transfer factor for maintaining pluripotency and self-renewal in embryonic stem cells(ESCs),1 though the mechanism of its transcriptional regulation in ESCs has not been fully *** enhancer-promoter interactions are vital for Sox2 transcription activity in ***,how these diverse interactions individually influence Sox2 gene regulation in mouse ESCs remains *** studies found that three distal enhancers(termed E1,E2,and E3)interact with Sox2 promoter?(Fig.1A;Fig.S1A,and Table S1).

关键词： Sox2 regulation distal

Pangenome and multi-tissue gene atlas provide new insights into the domestication and highland adaptation of yaks

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1832-1850页

作者： Daoliang Lan wei Fu Wenhui Ji Tserang‑Donko Mipam Xianrong Xiong Shi Ying Yan Xiong Peng Sheng Jiangping Ni Lijun Bai Tongling Shan Xiangdong kong Jian Li Ministry of Education of Key Laboratory of Qinghai‑Tibetan Plateau Animal Genetic Resource and Utilization Southwest Minzu UniversityChengduChina College of Animal&Veterinary Sciences Southwest Minzu UniversityChengduChina Institute of Qinghai‑Tibetan Plateau Southwest Minzu UniversityChengduChina Jiguang Gene Biotechnology Co. Ltd.NanjingChina chengdu Genepre Technology Co. Ltd.ChengduChina Shanghai Veterinary Research Institute Chinese Academy of Agricultural SciencesShanghaiChina

Background The genetic diversity of yak,a key domestic animal on the Qinghai-Tibetan Plateau(QTP),is a vital resource for domestication and breeding *** study presents the first yak pangenome obtained through the de novo assembly of 16 yak *** We discovered 290 Mb of nonreference sequences and 504 new *** pangenome-wide presence and absence variation(PAV)analysis revealed 5,120 PAV-related genes,highlighting a wide range of variety-specific genes and genes with varying frequencies across yak *** component analysis(PCA)based on binary gene PAV data classified yaks into three new groups:wild,domestic,and ***,we pro-posed a‘two-haplotype genomic hybridization model'for understanding the hybridization patterns among breeds by integrating gene frequency,heterozygosity,and gene PAV data.A gene PAV-GWAS identified a novel gene(Bos-Gru3G009179)that may be associated with the multirib trait in Jinchuan ***,an integrated transcrip-tome and pangenome analysis highlighted the significant differences in the expression of core genes and the muta-tional burden of differentially expressed genes between yaks from high and low *** analysis across multiple species revealed that yaks have the most unique differentially expressed m RNAs and lnc RNAs(between high-and low-altitude regions),especially in the heart and lungs,when comparing high-and low-altitude *** The yak pangenome offers a comprehensive resource and new insights for functional genomic studies,supporting future biological research and breeding strategies.

关键词： High-and low-altitude Novel genes Pangenome PAV-GWAS Yak

Expression of cyclin-dependent kinase 9 is positively correlated with the autophagy level in colon cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 314-330页

作者： Lei Zheng Jia Lu Da-Lu kong Department of Colorectal Cancer Surgery National Clinical Research Center for CancerKey Laboratory of Cancer Immunology and Biotherapy of TianjinTianjin Key Laboratory of Digestive CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Infection Management National Clinical Research Center for CancerKey Laboratory of Cancer Immunology and Biotherapy of TianjinTianjin Key Laboratory of Digestive CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 300060China

BACKGROUND Cyclin-dependent kinase 9(CDK9)expression and autophagy in colorectal cancer(CRC)tissues has not been widely ***9,a key regulator of transcription,may influence the occurrence and progression of *** expression of auto-phagy-related genes BECN1 and drug resistance factor ABCG2 may also play a role in *** normal physiological conditions,autophagy can inhibit tumorigenesis,but once a tumor forms,autophagy may promote tumor ***,understanding the relationship between autophagy and cancer,partic-ularly how autophagy promotes tumor growth after its formation,is a key motivation for this *** To investigate the relationship between CDK9 expression and autophagy in CRC,assess differences in autophagy between left and right colon cancer,and analyze the associations of autophagy-related genes with clinical features and *** We collected tumor tissues and paracarcinoma tissues from colon cancer patients with liver metastasis to observe the level of autophagy in tissues with high levels of CDK9 and low levels of *** also collected primary tissue from left and right colon cancer patients with liver metastasis to compare the autophagy levels and the expression of BECN1 and ABCG2 in the tumor and paracarcinoma *** The incidence of autophagy and the expression of BECN1 and ABCG2 were different in left and right colon cancer,and autophagy might be involved in the occurrence of chemotherapy *** analysis of the rela-tionship between the expression of autophagy-related genes CDK9,ABCG2,and BECN1 and the clinical features and prognosis of colorectal cancer showed that the high expression of CDK9 indicated a poor prognosis in colorectal *** This study laid the foundation for further research on the combination of CDK9 inhibitors and autophagy inhibitors in the treatment of patients with CRC.

关键词： Autophagy Tumorigenesis Tumor tissue Paracarcinoma tissue Expression Left/right colon cancer

Exploring differentiated improvement strategies of cultivated land quality in China

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Frontiers of Agricultural Science and Engineering 2024年第2期11卷 282-291页

作者： Wenguang CHEN Xiangbin kong Yubo LIAO College of Land Science and Technology China Agricultural UniversityBeijing 100193China

Quality is the core feature of cultivated land. In the face of deteriorating cultivated land quality and growing food demand, improving cultivated land quality is a top priority for guaranteeing the sustainable use of resources and national food security. Cultivated land quality in the new era can be considered in four dimensions: suitability, contiguity, resistance and ecological stress. Cultivated land suitability in China shows a decreasing trend from east to west, cultivated land contiguity is high in the north-east and low in the south-west. In terms of cultivated land resistance, the number of strongly and weakly resistant cropping fields is small and spatially clustered. Cultivated land with ecological stress is mainly located in the northern region. Based on the current situation of cultivated land quality and the strategic needs of national high-quality development, China's future goals for improving cultivated land quality include four aspects: promoting the sustainable use of resources,improving the economic benefits of farming, coping with extreme meteorological disasters and meeting the transition of the food *** the backdrop of a volatile international environment and high domestic demand for food, China should guarantee a safe supply of staples, a stable supply of animal feed and a moderate supply of high-nutrient food. In the future, China should create three major food production spaces: highstandard, low-to medium-yield, and marginal cultivated land. China urgently needs to construct three paths to implement the goal of improving cultivated land quality, namely the development of high-standard cultivated land with the core of spatial optimization, resilience enhancement and scale coupling,the transformation of low-to medium-yield cultivated land with the core of obstacle elimination, tenure adjustment, ecological sustainable, and the conservation development of marginal cultivated land with a focus on sustainable use.

关键词： China cultivated land quality differentiated improvement food security

Searching for the Highest Energy of Pulsation and Critical Luminosity of Swift J0243.6+6124 Observed by Insight-HXMT

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Research in Astronomy and Astrophysics 2024年第5期24卷 61-69页

作者： Qing-Xia Zhao Xian Hou Ming-Yu Ge Shuang-Nan Zhang Yun-Xiang Xiao You-Li Tuo Zi-Xu Yang Ling-Da kong Jin-Lu Qu Shu Zhang Jian-cheng Wang Yunnan Observatories Chinese Academy of SciencesKunming 650216China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences ChineseAcademy of SciencesBeijing 100049China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China Institut fur Astronomic und Astrophysik Sand 1D-72076 TabingenGemany School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255000China

Owing to the broad energy coverage of Insight-HXMT in the hard X-ray band,we detected the highest energy of pulsation exceeding 200 keV around the 2017–2018 outburst peak of the first Galactic pulsating ultraluminous X-ray source (PULX) Swift J0243.6+6124,which is the highest energy detected from PULXs to *** also obtained the highest energy of pulsation of every exposure during the outburst in 2017–2018,and found the highest energy is roughly positively correlated with *** our newly developed method,we identified the critical luminosity being 4×10^(38)erg s^(-1) when the main peaks of the low and high energy pulse profiles became aligned,which separates the fan-beam dominated and pencil-beam dominated accretion *** the critical luminosity,the phase of the main peak shifted gradually from 0.5 to 0.8 until the outburst peak in al energy bands is reached,which is in agreement with the phase shift found previously at low *** result is consistent with what is derived from spectral analysis.

关键词： (stars:)pulsars-individual(Swift J0243.6+6124)-X-rays binaries–stars neutron

随机Lur’e时滞网络的指数同步与脉冲控制

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控制理论与应用 2024年第1期41卷 127-135页

作者：孔纬升汤泽王艳纪志成江南大学物联网工程学院江苏无锡214122 江南大学物联网应用技术教育部工程研究中心江苏无锡214122

本文研究了一类具有不对称耦合和时变时滞随机Lur’e动态网络的全局指数同步问题.为了使网络中的所有Lur’e系统达到同步,文章提出了一种实用的脉冲控制策略,利用平均脉冲间隔概念、Perron-Frobenius定理、比较原理、参数变分法和无参... 详细信息

本文研究了一类具有不对称耦合和时变时滞随机Lur’e动态网络的全局指数同步问题.为了使网络中的所有Lur’e系统达到同步,文章提出了一种实用的脉冲控制策略,利用平均脉冲间隔概念、Perron-Frobenius定理、比较原理、参数变分法和无参照系统策略,给出了保证网络实现全局指数同步的充分条件.基于脉冲信号既能促进网络群聚行为同时也可能阻碍网络同步这一事实,本文分别讨论了积极脉冲效应和消极脉冲效应作用下网络实现同步的判定方法,同时给出了不同脉冲效应作用下网络的收敛速度.提供了数值仿真证明主要结果和控制策略的有效性.

关键词：全局指数同步 Lur’e网络脉冲控制无参照系统策略比较原理

“小田并大田”改革的生成逻辑、实践路向与政策价值——基于完善农村基本经营制度的视角

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经济学家 2024年第6期 107-116页

作者：魏广成孔祥智中国农业科学院农业经济与发展研究所中国人民大学农业与农村发展学院

当前阶段我国农村基本经营制度存在村集体“统”的职能发挥不充分、城镇化推动农户普遍“离农”“背农”、农地制度难以满足农业现代化的需要等问题与挑战。在建设农业强国与保障国家粮食安全的政策导向和人地分离第二次高峰的推动下,... 详细信息

当前阶段我国农村基本经营制度存在村集体“统”的职能发挥不充分、城镇化推动农户普遍“离农”“背农”、农地制度难以满足农业现代化的需要等问题与挑战。在建设农业强国与保障国家粮食安全的政策导向和人地分离第二次高峰的推动下,加之农村基本经营制度存在问题的拉动,“小田并大田”改革应运而生。本文在分析“小田并大田”改革形成动因与农村基本经营制度存在问题、制度框架的基础上,分析公安县“小田并大田”改革对完善农村基本经营制度的创新探索。本研究从制度、“分”、“统”三个层面展开分析,通过尊重农户意愿、开展调田并地、成立三类合作社的举措,解决了农户差异化诉求、农地细碎化和“统一”经营不足的问题,探索出完善农村基本经营制度新的实现形式。

关键词：小田并大田农村基本经营制度公安县