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Indocyanine green retention is a potential prognostic indicator after splenectomy and pericardial devascularization for cirrhotic patients

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Hepatobiliary & Pancreatic Diseases International 2016年第4期15卷 386-390页

作者： Yuan-Biao Zhang Yi Lu wei-ding wu Cheng-wu Zhang Guo-Liang Shen De-Fei Hong Department of Hepatopancreaticobiliary Surgery&Laparoscopic Minimally hwasive Surgery Zhejiang Provincial People's HospitalHangzhou 310014China

BACKGROUND：Splenectomy and pericardial devascularization（SPD）is an effective treatment of upper gastrointestinal bleeding and hypersplenism in cirrhotic patients with portal *** green retention at 15 minutes（ICGR15）was reported to offer better sensitivity and specificity than the Child-Pugh classification in hepatectomy,but few reports describe ICGR15 in *** present study was to evaluate the prognostic value of ICGR15 for cirrhotic patients with portal hypertension who underwent ***：From January 2012 to January 2015,43 patients with portal hypertension and hypersplenism caused by liver cirrhosis were admitted in our center and received *** ICGR15,Child-Pugh classification,model for end-stage liver disease（MELD）score,and perioperative characteristics were analyzed ***：Preoperative liver function assessment revealed that 34 patients were Child-Pugh class A with ICGR15 of13.6%-43.0%and MELD score of 7-20;8 patients were class B with ICGR15 of 22.8%-40.7%and MELD score of 7-17;1patient was class C with ICGR15 of 39.7%and MELD score of *** optimal ICGR15 threshold for liver function compensation was 31.2%,which offered a sensitivity of 68.4%and a specificity of 70.8%.Univariate analysis showed preoperative ICGR15,MELD score,surgical procedure,intraoperative blood loss,and autologous blood transfusion were significantly different between postoperative liver function compensated and decompensated *** regression analysis revealed that ICGR15 was an independent risk factor of postoperative liver function recovery（P=0.020）.CONCLUSIONS：ICGR15 has outperformed the Child-Pugh classification for assessing liver function in cirrhotic patients with portal ***15 may be a suitable prognostic indicator for cirrhotic patients after SPD.

关键词： indocyanine green liver function test liver cirrhosis splenectomy pericardial devascularization

Is laparoscopic radical cholecystectomy an effective and safe approach for advanced gallbladder cancer?

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Hepatobiliary & Pancreatic Diseases International 2020年第3期19卷 203-204页

作者： Li-Ming Jin Yu-Hua Zhang Cheng-wu Zhang wei-ding wu Jia wu Chang-wei Dou Fang-Qiang wei Zhi-Fei Wang Zhi-Ming Hu Shu-Sen Zheng Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary and Pancreatic Surgery Zhejiang Provincial People’s HospitalAffiliated People’s Hospital of Hangzhou Medical CollegeHangzhou 310014China Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China

Although laparoscopy has been widely used in the surgical field and is even considered the first-line to diagnose various diseases,laparoscopic radical cholecystectomy(LRC)for gallbladder cancer(GBC)has always been relatively *** lymphadenectomy,complicated liver resection,specific biological behavior of GBC cells,and chimney and aerosol effects from the pneumoperitoneum are the previously misunderstood areas in laparoscopic surgery[1].Initially,laparoscopic approach was used for intra-abdominal GBC exploration to determine the presence of peritoneal metastasis,intraoperative staging,and palliative *** the advancement of laparoscopic surgery,laparoscopic liver resection,laparoscopic pancreaticoduodenectomy,and laparoscopic radical gastrectomy have been routinely performed in several medical *** et al.[2]recently demonstrated that laparoscopic technique is feasible for ***,the feasibility of LRC depends on the following factors.

关键词： laparoscopic gallbladder routine

Rare cause of upper gastrointestinal bleeding owing to hepatic cancer invasion:A case report

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World Journal of Gastroenterology 2014年第35期20卷 12704-12708页

作者： wei-ding wu Jia wu Hong-Guo Yang Yuan Chen Cheng-wu Zhang Da-Jian Zhao Zhi-Ming Hu Department of Hepatopancreatobiliary surgery and Minimally invasive surgery Zhejiang Provincial People’s Hospital Department of General Surgery Haining branch of Zhejiang Provincial People’s Hospital Department of Pathology Zhejiang Provincial People’s Hospital

Upper gastrointestinal bleeding refers to bleeding that arises from the gastrointestinal tract proximal to the ligament of *** primary reason for gastrointestinal bleeding associated with hepatocellular carcinoma is rupture of a varicose vein owing to pericardial *** report a rare case of gastrointestinal bleeding with hepatocellular carcinoma in a patient who presented with recurrent gastrointestinal *** initial diagnosis was gastric cancer with metastasis to the multiple lymph nodes of the lesser *** patient underwent exploratory laparotomy,which identified two lesions in the gastric *** gastrectomy and hepatic local excision was then *** results indicated that the hepatocellular carcinoma had invaded the stomach directly,which was confirmed *** patient is alive with a disease-free survival of 1 year since the *** carcinoma with gastric invasion should be considered as a rare cause of upper gastrointestinal bleeding in hepatocellular carcinoma patients,especially with lesions located in the left lateral hepatic *** is the best solution.

关键词： Bleeding Cancer Gastrointestinal tract Liver Neoplasm invasion

Integrated Medicine Treatment of Rare Bone Marrow Tuberculosis in Systemic Lupus Erythematosus and Potentiating and Detoxifying Effects of Chinese Medicine:A Case Report

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Chinese Journal of Integrative Medicine 2025年第2期31卷 153-156页

作者： CHEN wu HUANG Lin SHI wei-man MA Ke WEN Cheng-ping DAI Qiao-ding School of Basic Medical Science Zhejiang Chinese Medical UniversityHangzhou(310000)China The Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province Hangzhou(310000)China Department of Rheumatology and Immunology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou(310000)China

Systemic lupus erythematosus(SLE)is an autoimmune disease that affects multiple organ systems.(1,2)Patients with SLE who undergo long-term immunosuppressive and glucocorticoids therapy are at an elevated risk of devel... 详细信息

关键词： Systemic tuberculosis erythematosus

Water quality analysis and source apportionment in estuaries along the coast of the Bohai Sea,North China

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Journal of Oceanology and Limnology 2025年第1期43卷 73-89页

作者： Guanghong wu Dan YE wei LUO Tianjin Key Laboratory of Water Resources and Environment Tianjin Normal UniversityTianjin 300387China Laboratory of Solid Waste Treatment and Recycling Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

High-dimensional data(a dataset with many features)were collected from 64 sampling sites to analyze the water quality in estuaries along the coast of the Bohai Sea,North *** twenty-five water quality parameters analyzed were collected monthly from January 2021 to December *** statistical techniques,such as the absolute principal component score-multiple linear regression model(APCS-MLR),correlation analysis,and analysis of variance were used to identify and quantify the potential sources or factors affecting water quality and to analyze the spatial-temporal variation in water *** water quality indices(WQIs),ranging from 67.96 to 70.67,showed that the water quality was at an intermediate level in the estuaries during both the flood and nonflood *** concentrations of total phosphorus(TP),ammonia N(AN),and organic pollutants were greater in the Haihe River Basin than in the Liaohe River and Huanghe-Huaihe River *** concentration of total nitrogen(TN)in the Haihe River Basin was lower than that in the Liaohe River and Huanghe-Huaihe River *** metal concentrations in the Liaohe River Basin were greater than those in the Haihe River and Huanghe-Huaihe River *** annual mean concentrations of AN in the estuaries of the Haihe,Liaohe,and Huanghe(Yellow)rivers exhibited significant decreasing trends from 2013 to 2022,but no significant decreasing trends were found for permanganate index(COD_(Mn))or the *** concentrations of TN and AN were lower in the flood season than in the nonflood season,and the TP concentration was greater in the flood season than in the nonflood ***,the concentrations of organic pollutants did not exhibit significant *** sewage and industrial wastewater,substance exchange between air and water,nonpoint sources from rural and urban areas,and aquaculture wastewater were the major sources or factors responsible for water pollution in the estuaries.

关键词： water quality spatial-temporal variation source apportionment absolute principal component score-multiple linear regression estuary Bohai Sea

Laparoscopic hepatectomy using indocyanine green attenuates postoperative inflammatory response for hepatocellular carcinoma:A propensity score matching analysis

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World Journal of Gastrointestinal Surgery 2025年第1期17卷 193-202页

作者： wei-Xun wu Ming-Bin Huang Mei-Xia Wang Li-Hua Chen Bo Hu Zhen-Bin ding Department of Liver Surgery Zhongshan Hospital(Xiamen)Fudan UniversityXiamen 361006Fujian ProvinceChina Department of Infection Management Zhongshan Hospital(Xiamen)Fudan UniversityXiamen 361015Fujian ProvinceChina Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai 200032China Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education) Fudan UniversityShanghai 200032China

BACKGROUND Improving the intraoperative and postoperative performance of laparoscopic hepatectomy was quite a challenge for liver *** To determine the benefits of indocyanine green(ICG)fluorescence imaging in patients with hepatocellular carcinoma(HCC)who underwent laparoscopic hepatectomy during and after *** We retrospectively collected the clinicopathological data of 107 patients who successfully underwent laparoscopic hepatectomy at Zhongshan Hospital(Xiamen),Fudan University from June 2022 to June *** using the ICG fluorescence imaging technique,we divided them into the ICG and non-ICG *** eliminate statistical bias,a 1:1 propensity score matching analysis was *** comparison of perioperative outcomes,including inflammationrelated markers and progression-free survival,was analyzed *** Intraoperatively,the ICG group exhibited lower blood loss,a shorter surgical time,lower hepatic inflow occlusion(HIO)frequency,and a shorter total HIO ***,the participation of ICG resulted in a shorter duration of hospitalization(6.5 vs 7.6 days,P=0.03)and postoperative inflammatory response attenuation(lower neutrophil-lymphocyte ratio on the first day after surgery and platelet-lymphocyte ratio on the third day,Pding progression-free and overall survivals showed no significant difference between the *** The involvement of ICG fluorescence imaging may lead to improved perioperative outcomes,especially postoperative inflammatory response attenuation,and ultimately improve HCC patients’recovery after surgery.

关键词： Hepatocellular carcinoma Laparoscopic hepatectomy Indocyanine green fluorescence Postoperative inflammatory response attenuation Propensity score matching analysis

Curvularin derivatives from hydrothermal vent sediment fungus Penicillium ***-50 guided by molecular networking and their antiinflammatory activity

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Chinese Journal of Natural Medicines 2025年第1期23卷 119-128页

作者： Chunxue Yu Zixuan Xia Zhipeng Xu Xiyang Tang Wenjuan ding Jihua wei Danmei Tian Bin wu Jinshan Tang Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drug Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China Jinan University School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Ocean College Zhejiang UniversityZhoushan Campus

Guided by molecular networking, nine novel curvularin derivatives（1-9） and 16 known analogs（10-25） were isolated from the hydrothermal vent sediment fungus Penicillium sp. HL-50. Notably, compounds 5-7 represented a hybrid of curvularin and purine. The structures and absolute configurations of compounds 1-9 were elucidated via nuclear magnetic resonance（NMR） spectroscopy, X-ray diffraction, electronic circular dichroism（ECD） calculations,13C NMR calculation, modified Mosher's method, and chemical derivatization. Investigation of anti-inflammatory activities revealed that compounds 7-9, 11, 12, 14, 15, and 18 exhibited significant suppressive effects against lipopolysaccharide（LPS）-induced nitric oxide（NO）production in murine macrophage RAW264.7 cells, with IC50values ranging from 0.44 to 4.40μmol·L-1. Furthermore, these bioactive compounds were found to suppress the expression of inflammation-related proteins, including inducible NO synthase（i NOS）, cyclooxygenase-2（COX-2）, NLR family pyrin domain-containing protein 3（NLRP3）, and nuclear factor kappa-B（NF-κB）. Additional studies demonstrated that the novel compound 7 possessed potent antiinflammatory activity by inhibiting the transcription of inflammation-related genes, downregulating the expression of inflammation-related proteins, and inhibiting the release of inflammatory cytokines, indicating its potential application in the treatment of inflammatory diseases.

关键词： Anti-inflammatory activity Curvularin derivatives Molecular networking Penicillium sp. HL-50

The N-terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism

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Animal Models and Experimental Medicine 2025年第1期8卷 114-125页

作者： Xue Wang Chunyou Ning Xingyi Cheng Zhengzhong wu Dongbo wu Xuemei ding Cunxiang Ju Zhihang Zhou Lingfeng Wan wei Zhao Peiliang Shi GemPharmatech Chengdu Co. Ltd.ChengduChina Center of Infectious Diseases West China HospitalSichuan UniversityChengduChina Gempharmatech Shanghai Co. Ltd.ShanghaiChina Department of Gastroenterology the Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Fatty Liver Disease Center of Integrated Chinese and Western Medicine Affiliated Hospital of Nanjing University of Chinese MedicineNanjingChina School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College ChengduChina Department of Clinical Biochemistry School of Laboratory MedicineChengdu Medical CollegeChengduChina GemPharmatech Co. Ltd.GuangdongChina

Background:The emerging incidence of pathogenic liver conditions is turning into a major concern for global *** of pyroptosis in hepatocytes instigates cel-lular disintegration,which in turn liberates substantial quantities of pro-inflammatory intracellular substances,thereby accelerating the advancement of liver ***,directing therapeutic efforts towards inhibiting pyroptosis could po-tentially serve as an innovative approach in managing inflammation related chronic hepatic ***:GSDMD-NT^(ki/wt)mice and Alb-cre^(ki/wt)mice were generated using CRISPR/Cas9 *** crossing the two strains together,we induced conditional cell death by doxycycline to construct a mouse model of liver *** analyzed differ-entially expressed genes by RNA sequencing and explored their biological *** efficacy of obeticholic acid(OCA)in the treatment of liver fibrosis was ***:Doxycycline-treated GSDMD-NT^(ki/wt)×Alb-cre^(ki/wt)mice showed severe liver damage,vacuolation of hepatocytes,increased collagen fibers,and accumulation of lipid *** expression of liver fibrosis related genes was greatly increased in the doxycycline-treated mouse liver compared with untreated mouse ***-sequencing showed that upregulated differentially expressed genes were involved in inflammatory responses,cell activation,and metabolic *** with OCA alleviated the liver fibrosis,with reduced ALT and AST levels seen in the GSDMD-NT^(ki/wt)×Alb-cre^(ki/wt)***:We successfully constructed a novel mouse model for liver *** GSDMD-NT-induced fibrosis may be mediated by abnormal lipid *** re-sults demonstrated that we successfully constructed a mouse model of liver fibrosis,and GSDMD-NT induced fibrosis by mediating lipid metabolism.

关键词： GSDMD-NT lipid metabolism liver fibrosis NASH pyroptosis

Approved delivery strategies for biopharmaceuticals

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Chinese Chemical Letters 2025年第02期36卷 69-79页

作者： Makhloufi Zoulikha Zhongjian Chen Jun wu wei He School of Pharmacy China Pharmaceutical University Shanghai Skin Disease Hospital Tongji University School of Medicine Department of Geriatric Cardiology Jiangsu Provincial Key Laboratory of Geriatrics The First Affiliated Hospital of Nanjing Medical University

In recent years, biopharmaceuticals have witnessed remarkable advancements, transforming the landscape of therapeutic interventions. Biopharmaceuticals encompassing therapeutics generated through cutting-edge biotechnological methods have shown promising therapeutic outcomes. However, their clinical success hinges significantly on overcoming drug delivery challenges related to stability, intracellular delivery, immunogenicity, and pharmacokinetic properties. Herein, we provide an overview of various marketed macromolecules, including nucleic acids, and immunotherapeutic agents such as cytokines and monoclonal antibodies, as well as other therapeutic peptides/proteins like enzymes, hormones, and coagulation factors. Our primary focus is on elucidating the delivery challenges associated with these macromolecules and highlighting the pivotal role played by drug delivery platforms in the development of currently marketed products, offering valuable insights for both scientific research and the pharmaceutical industry.

关键词： Biopharmaceuticals Drug delivery Monoclonal antibodies Nucleic acids Proteins