Laparoscopic hepatectomy using indocyanine green attenuates postoperative inflammatory response for hepatocellular carcinoma:A propensity score matching analysis

作     者：Wei-Xun Wu Ming-Bin Huang Mei-Xia Wang Li-Hua Chen Bo Hu Zhen-Bin Ding 

作者机构：Department of Liver SurgeryZhongshan Hospital(Xiamen)Fudan UniversityXiamen 361006Fujian ProvinceChina Department of Infection ManagementZhongshan Hospital(Xiamen)Fudan UniversityXiamen 361015Fujian ProvinceChina Department of Liver Surgery and TransplantationLiver Cancer InstituteZhongshan HospitalFudan UniversityShanghai 200032China Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Fudan UniversityShanghai 200032China 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志(英文))

年 卷 期：2025年第17卷第1期

页      面：193-202页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the Incubation Project of Zhongshan Hospital(Xiamen),Fudan University,No.2019ZSXMYS15 the Clinical Research Center for Precision Medicine of Abdominal Tumor of Fujian Province the Key Clinical Specialty Discipline Construction Program of Fujian Province Xiamen Medical and Health Guidance Project,No.3502Z20244ZD1103 

主　　题：Hepatocellular carcinoma Laparoscopic hepatectomy Indocyanine green fluorescence Postoperative inflammatory response attenuation Propensity score matching analysis 

摘      要：BACKGROUND Improving the intraoperative and postoperative performance of laparoscopic hepatectomy was quite a challenge for liver *** To determine the benefits of indocyanine green(ICG)fluorescence imaging in patients with hepatocellular carcinoma(HCC)who underwent laparoscopic hepatectomy during and after *** We retrospectively collected the clinicopathological data of 107 patients who successfully underwent laparoscopic hepatectomy at Zhongshan Hospital(Xiamen),Fudan University from June 2022 to June *** using the ICG fluorescence imaging technique,we divided them into the ICG and non-ICG *** eliminate statistical bias,a 1:1 propensity score matching analysis was *** comparison of perioperative outcomes,including inflammationrelated markers and progression-free survival,was analyzed *** Intraoperatively,the ICG group exhibited lower blood loss,a shorter surgical time,lower hepatic inflow occlusion(HIO)frequency,and a shorter total HIO ***,the participation of ICG resulted in a shorter duration of hospitalization(6.5 vs 7.6 days,P=0.03)and postoperative inflammatory response attenuation(lower neutrophil-lymphocyte ratio on the first day after surgery and platelet-lymphocyte ratio on the third day,P0.05).Although the differences were not significant,the levels of all inflammation-related markers were lower in the ICG *** rates of postoperative complications and the survival analyses,including progression-free and overall survivals showed no significant difference between the *** The involvement of ICG fluorescence imaging may lead to improved perioperative outcomes,especially postoperative inflammatory response attenuation,and ultimately improve HCC patients’recovery after surgery.